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See detailGenetic Determinants Of Bovine Leukemia Virus Pathogenesis
Willems, Luc ULg; Burny, A.; Collete, Delphine et al

in Aids Research and Human Retroviruses (2000), 16(16), 1787-95

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been ... [more ▼]

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been obtained in different species, such as rabbits, mice, rats, and monkeys, none of these systems was able to conciliate topics as different as viral infectivity, propagation within the host, and generation of leukemic cells. An alternate strategy is based on the understanding of diseases induced by viruses closely related to HTLV-1, like bovine leukemia virus (BLV). Both viruses indeed belong to the same subfamily of retroviruses, harbor a similar genomic organization, and infect and transform cells of the hematopoietic system. The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep. [less ▲]

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See detailGenetic determination and localization of multiple bacteriocins produced by Enterococcus faecium CWBI-B1430 and Enterococcus mundtii CWBI-B1431
Aguilar Galvez, Ana Consuelo; Dubois Dauphin, Robin ULg; Campos Gutierrez, David Carlos et al

in Food Science and Biotechnology (2011), 20(2), 289-296

Enterococcus faecium CWBI-B1430 and Enterococcus mundtii CWBI-B1431 from artisanalproduced Peruvian cheeses showed the presence of 4 putative bacteriocin genes: enterocin A, enterocin B, enterocin P, and ... [more ▼]

Enterococcus faecium CWBI-B1430 and Enterococcus mundtii CWBI-B1431 from artisanalproduced Peruvian cheeses showed the presence of 4 putative bacteriocin genes: enterocin A, enterocin B, enterocin P, and mundticin KS. The multiple bacteriocin producer E. faecium CWBI-B1430 presented 1 plasmid of 34.6 kb, whereas E. mundtii CWBI-B1431 contained 1 plasmid of 11.0 kb. The structural gene responsible for mundticin KS production was located on 5.6 and 3.1 kb HindIII plasmid fragments. The reverse transcription-PCR analysis showed the expression of the bacteriocin genes enterocin A, enterocin B, and mundticin KS in E. faecium CWBI-B1430 and the bacteriocin genes enterocin P and mundticin KS in E. mundtii CWBI-B1431. To our knowledge, this is the first report of the expression of mundticin KS in E. faecium and enterocin P in E. mundtii. [less ▲]

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See detailGenetic diagnosis of Duchenne and Becker muscular dystrophy using multiplex ligation-dependent probe amplification in Rwandan patients.
Uwineza, Annette ULg; Hitayezu, Janvier; Murorunkwere, Seraphine et al

in Journal of tropical pediatrics (2013)

Duchenne and Becker muscular dystrophies are the most common clinical forms of muscular dystrophies. They are genetically X-linked diseases caused by a mutation in the dystrophin (DMD) gene. A genetic ... [more ▼]

Duchenne and Becker muscular dystrophies are the most common clinical forms of muscular dystrophies. They are genetically X-linked diseases caused by a mutation in the dystrophin (DMD) gene. A genetic diagnosis was carried out in six Rwandan patients presenting a phenotype of Duchenne and Becker muscular dystrophies and six asymptomatic female carrier relatives using multiplex ligation-dependent probe amplification (MLPA). Our results revealed deletion of the exons 48-51 in one patient, an inherited deletion of the exons 8-21 in two brothers and a de novo deletion of the exons 46-50 in the fourth patient. No copy number variation was found in two patients. Only one female carrier presented exon deletion in the DMD gene. This is the first cohort of genetic analysis in Rwandan patients affected by Duchenne and Becker muscular dystrophies. This report confirmed that MLPA assay can be easily implemented in low-income countries. [less ▲]

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See detailGenetic disorders and cerebellar structural abnormalities in childhood
RAMAEKERS, Vincent ULg; Heimann, G.; Reul, J. et al

in Brain : a journal of neurology (1997), 120 ( Pt 10)

Amongst 78 patients with either unilateral or bilateral (ponto-) cerebellar hypoplasia, atrophy or lesions on neuro-imaging (CT and/or MRI), 16 showed unilateral hypoplasia or lesions, 15 vermis defects ... [more ▼]

Amongst 78 patients with either unilateral or bilateral (ponto-) cerebellar hypoplasia, atrophy or lesions on neuro-imaging (CT and/or MRI), 16 showed unilateral hypoplasia or lesions, 15 vermis defects, nine pontocerebellar hypoplasia, 10 non-progressive conditions with bilateral cerebellar hemisphere hypoplasia or lesions and 28 progressive cerebellar atrophy. Known genetic conditions did not occur with unilateral cerebellar involvement, whereas a high incidence of mostly autosomal recessively inherited diseases could be diagnosed in more than half of the patients with either pontocerebellar hypoplasia or progressive bilateral cerebellar atrophy. A minority of patients with vermis defects or non-progressive cerebellar hypoplasia suffered from genetic conditions. An overview of the literature is presented describing genetic and non-genetic syndromes, or metabolic disorders associated with cerebellar structural abnormalities. From these data, new proposals for improved diagnostic investigations will be presented. [less ▲]

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See detailGenetic diversity among some wild populations of lima bean (Phaseolus lunatus L.) proceeding from Central Valley of Costa Rica
Maquet, Alain; Wathelet, Bernard ULg; Dubois, Sophie et al

in Annual Report of the Bean Improvment Cooperative (1994)

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See detailGenetic diversity analysis of wild Arracacia species according to morphological and molecular markers
Blas, R.; Ghislain, M.; del Rosario Herrera, M. et al

in Genetic Resources and Crop Evolution (2008), 55(5), 625-642

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See detailGenetic diversity and amplification of different clostridial [FeFe] hydrogenases by group-specific degenerate primers
Calusinska, Magdalena ULg; Joris, Bernard ULg; Wilmotte, Annick ULg

in Letters in Applied Microbiology (2011), 53

Aims: The aim of this study was to explore and characterize the genetic diversity of [FeFe] hydrogenases in a representative set of strains from Clostridium sp. and to reveal the existence of neither yet ... [more ▼]

Aims: The aim of this study was to explore and characterize the genetic diversity of [FeFe] hydrogenases in a representative set of strains from Clostridium sp. and to reveal the existence of neither yet detected nor characterized [FeFe] hydrogenases in hydrogen-producing strains. Methods and Results: The genomes of 57 Clostridium strains (34 different genotypic species), representing six phylogenetic clusters based on their 16S rRNA sequence analysis (cluster I, III, XIa, XIb, XIV and XVIII), were screened for different [FeFe] hydrogenases. Based on the obtained alignments, ten pairs of [FeFe] hydrogenase cluster-specific degenerate primers were newly designed. Ten Clostridium strains were screened by PCRs to assess the specificity of the primers designed and to examine the genetic diversity of [FeFe] hydrogenases. Using this approach, a diversity of hydrogenase genes was discovered in several species previously shown to produce hydrogen in bioreactors: Clostridium sartagoforme, Clostridium felsineum, Clostridium roseum and Clostridium pasteurianum. Conclusions: The newly designed [FeFe] hydrogenase cluster-specific primers, targeting the cluster-conserved regions, allow for a direct amplification of a specific hydrogenase gene from the species of interest. Significance and Impact of the Study: Using this strategy for a screening of different Clostridium ssp. will provide new insights into the diversity of hydrogenase genes and should be a first step to study a complex hydrogen metabolism of this genus. [less ▲]

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See detailGenetic diversity and germplasm conservation of three minor Andean tuber crop species
Malice, Marie ULg; Baudoin, Jean-Pierre ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2009), 13(3), 441-448

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See detailGenetic diversity and joint-pedigree analysis of two importing Holstein populations.
Hammami, Hedi ULg; Croquet, Coraline; Stoll, Jean et al

in Journal of Dairy Science (2007), 90(7), 3530-41

Genetic diversity and relatedness between 2 geographically distant Holstein populations (in Luxembourg and Tunisia) were studied by pedigree analysis. These 2 populations have similar sizes and structures ... [more ▼]

Genetic diversity and relatedness between 2 geographically distant Holstein populations (in Luxembourg and Tunisia) were studied by pedigree analysis. These 2 populations have similar sizes and structures and are essentially importing populations. Edited pedigrees included 140,392 and 151,381 animals for Tunisia and Luxembourg, respectively. To partially account for pedigree completeness levels, a modified algorithm was used to compute inbreeding. The effective numbers of ancestors were derived from probabilities of gene origin for the 2 populations of cows born between 1990 and 2000. The 10 ancestors with the highest contributions to genetic diversity in the cow populations accounted for more than 32% of the genes. Eight of these 10 ancestors were the same in both populations. The rates of inbreeding were different in the 2 populations but were generally comparable to those found in the literature for the Holstein breed. Average inbreeding coefficients per year, estimated from the data, ranged from 0.91 and 0.50 in 1990 to 3.10 and 2.12 in 2000 for the Tunisian and Luxembourg populations, respectively. Genetic links have also strengthened with time. Average additive relationships between the 2 populations were as high as 2.2% in 2000. Results suggest that it would be possible to investigate genotype by environment interactions for milk traits using the Tunisian and Luxembourg dairy populations. [less ▲]

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See detailGenetic diversity and population structure of the Eurosian otte (Lutra lutra) in France
Geboes, Anne-Laure ULg; Rosoux, René; Lemarchand, Charles et al

in Mammal Research (2016), 61(1),

During the last century, the Eurasian otter (Lutra lutra) suffered a dramatic decline in Europe. In France, the same pattern of sharp decline was observed with local extinctions in many regions. Before ... [more ▼]

During the last century, the Eurasian otter (Lutra lutra) suffered a dramatic decline in Europe. In France, the same pattern of sharp decline was observed with local extinctions in many regions. Before the recolonisation process, two main populations still remained along the Atlantic coast and in the Massif Central. To investigate the impact of this decline on the genetic diversity and structure of the French otter population, tissue samples of 144 otter carcasses from road kills that were found during 1992–2011 along the Atlantic coast and in the Massif Central were used. They were analysed using 10 microsatellites loci. Observed (Ho = 0.64) and expected heterozygosity (He = 0.62) were moderate, but consistent with results found in other European populations. The bottleneck test showed an excess of heterozygotes, providing evidence of a recent decline. There was evidence for weak but significant allelic frequencies divergence between otters from the Atlantic coast and those from the Massif Central (Fst=0.040, p<0.05), probably resulting from their isolation prior to the recolonisation process. As the French otter population has been expanding for several years, genetic intermixing is now occurring. Although this expansion has not yet genetically homogenised all populations, this is may be a matter a time. [less ▲]

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See detailGenetic diversity and structure within 6 European apple germplasm collections assessed by microsatellite markers
Durel, Charles-Eric; Denancé, C; Ravon, E et al

Conference (2013)

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See detailGenetic Diversity In Lima Bean (Phaseolus Lunatus L) As Revealed By Rapd Markers
Fofana, B.; Vekemans, X.; Du Jardin, Patrick ULg et al

in Euphytica (1997), 95(2),

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See detailGenetic Diversity In The Lima Bean (Phaseolus Lunatus L.) As Revealed By Chloroplast Dna (Cpdna) Variations
Fofana, B.; Du Jardin, Patrick ULg; Baudoin, Jean-Pierre ULg

in Genetic Resources and Crop Evolution (2001), 48(5),

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See detailGenetic Diversity of Andean Tuber Crop Species in the in situ Microcenter of Huanuco, Peru
Malice, Marie ULg; Bizoux, Jean-Philippe ULg; Blas, Raul et al

in Crop Science (2010), 50(5), 1915-1923

Andean tuber crop species oca (Oxalis tuberosa Molina), ulluco (Ullucus tuberosus Caldas), and mashua (Tropaeolum tuberosum Ruiz & Pav.) play major roles in Andean communities. These species show high ... [more ▼]

Andean tuber crop species oca (Oxalis tuberosa Molina), ulluco (Ullucus tuberosus Caldas), and mashua (Tropaeolum tuberosum Ruiz & Pav.) play major roles in Andean communities. These species show high variability but are threatened with genetic erosion. To study the management of genetic resources of neglected vegetatively propagated crop species, we studied genetic diversity and structure of these species in an in situ diversity microcenter (Huanuco, Peru). A sample of 15 varieties of oca, 15 of ulluco, and 26 of mashua was analyzed with the inter simple sequence repeats (ISSR) molecular markers. Mean genetic distances and global genetic diversities were high for the three species, with higher values for mashua than for oca and ulluco. Assignment technique divided both oca and ulluco samples into two genetic clusters; the mashua sample probably belongs to a single genetic cluster. Inter simple sequence repeats (ISSR) technique showed intravarietal genetic variability for most varieties, suggesting an underestimation of the in situ genetic variability. These results are discussed considering how variation in breeding systems and farmers' practice influenced patterns of genetic diversity. Our findings confirm the hypothesis of a considerable amount of variability found in neglected Andean tubers and are essential to deserve adequate conservation strategies and to maintain genetic resources of neglected Andean tuber crop species under a threat of genetic erosion. [less ▲]

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See detailGenetic diversity of flexiviruses infecting pome fruit trees
Gadiou, S.; Kundu, J.K.; Paunovic, S. et al

in Journal of Plant Pathology [=JPP] (2010), 92(3), 685-691

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See detailGenetic diversity of Lima bean in relation with phytogeography in the New World
Baudoin, Jean-Pierre ULg

in Annals of Arid Zone (2004), 43(3 & 4), 355-376

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See detailGenetic diversity of the african geocarpic legume kersting's groundnut, Macrotyloma geocarpum (Tribe Phaseoleae : Fabaceae)
Pasquet, R. S.; Mergeai, Guy ULg; Baudoin, Jean-Pierre ULg

in Biochemical Systematics & Ecology (2002), 30(10), 943-952

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See detailGenetic diversity of the andean tuber crop species ullucus tuberosus as revealed by molecular (ISSR) and morphological markers
Malice, Marie ULg; Villaroel Vogt, Carmen Licht; Pissard, Audrey et al

in Belgian Journal of Botany (2009), 142(1), 68-82

Detailed reference viewed: 36 (5 ULg)