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See detailKainate and Nmda Toxicity for Cultured Developing and Adult Rat Spiral Ganglion Neurons: Further Evidence for a Glutamatergic Excitatory Neurotransmission at the Inner Hair Cell Synapse
Lefèbvre, Philippe ULg; Weber, T.; Leprince, Pierre ULg et al

in Brain Research (1991), 555(1), 75-83

In the inner ear, the excitatory amino acid glutamate is a proposed neurotransmitter acting at the synapse between hair cells and afferent auditory neurons. Using cultures of 5-day-old rat auditory ... [more ▼]

In the inner ear, the excitatory amino acid glutamate is a proposed neurotransmitter acting at the synapse between hair cells and afferent auditory neurons. Using cultures of 5-day-old rat auditory neurons, we show that the afferent auditory neuronal population can be divided, on the basis of its sensitivity to the neuronotoxic effect of glutamate and its analogs, in at least 3 subpopulations, one responding to N-methyl-D-aspartate (NMDA), one responding to kainate and a third minor one unresponsive to NMDA, kainic acid and glutamate. No toxic effect of quisqualate is observed. The use of specific antagonists (kynurenate and 2-amino-5-phosphonovalerate (DAP-5) demonstrates the specificity of the receptors to the excitatory amino acids on the afferent auditory neurons. Afferent auditory neurons from adult rats can also be cultured and in these preparations only the large neurons are sensitive to glutamate, kainate and NMDA while the small neurons are not responsive, suggesting that a glutamatergic neurotransmission occurs only at this synapse between the inner hair cells and the large radial afferent auditory neurons. We also show that, in vitro, the organ of Corti releases, in response to an increased potassium concentration and in the presence of calcium, a toxic activity for the afferent auditory neurons that is antagonized by kynurenate and DAP-5. Pathophysiological implications are discussed. [less ▲]

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See detailKainic acid sensitivity of mammalian Purkinje cells in monolayer cultures.
Gibbs, W.; Neale, E. A.; Moonen, Gustave ULg

in Brain Research (1982), 256(1), 103-108

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See detailKaiserschnitt beim Rind. Resultate einer internationalen Studie mit Beteiligung von gegen 700 Tierärzten
Hanzen, Christian ULg; Hirsbrunner Gaby

Scientific conference (2011, June 09)

Detailed reference viewed: 48 (3 ULg)
See detailKalk in de Wegenbouw. La chaux en construction routière
Vanham, L.; Marcoen, Jean Marie ULg

in Excavator (1991)

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See detailThe kallikrein-kinin system, angiotensin converting enzyme inhibitors and insulin sensitivity
Damas, Jacques ULg; Garbacki, Nancy ULg; Lefèbvre, P. J.

in Diabetes/Metabolism Research & Reviews (2004), 20(4, Jul-Aug), 288-297

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors, at a large scale, in arterial hypertension has showed that these molecules can exert, beneficial effects on insulin sensitivity and ... [more ▼]

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors, at a large scale, in arterial hypertension has showed that these molecules can exert, beneficial effects on insulin sensitivity and may reduce the occurrence of type 2 diabetes mellitus. One hypothesis explaining these effects of ACE inhibitors may relate to their capacity to interfere with bradykinin (BK) metabolism and action. BK may participate in the regulation of substrate utilization by, several tissues by improving blood flow and substrate delivery to the tissues and also by promoting translocation of glucose transporters. Moreover, BK has been shown to increase phosphorylation of insulin receptor and its cell substrates. BK also appears to improve the release of insulin. Furthermore, insulin may activate the kallikrein-kinin system, which consequently may increase its metabolic effects. However, in experimental diabetes mellitus, BK can participate to the inflammatory reaction leading to Langerhans islets destruction. In diabetes, whereas tissue kallikrein mRNA levels were reduced in several organs, an overexpression of kinin receptors, an increase in plasma levels of kininogens and kallikrein and an activation of the kinin system have all been reported. Lastly, kinins may be involved in the development of diabetic nephropathy. Reduction of kinin metabolism by ACE inhibitors might be involved in the beneficial effects exerted by these compounds in diabetic kidney functions. Copyright (C) 2004 John Wiley Sons, Ltd. [less ▲]

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See detailThe kallikrein-kinin system: Current and future pharmacological targets
Moreau, Marie Eve; Garbacki, Nancy ULg; Molinaro, Guiseppe et al

in Journal of Pharmacological Sciences (2005), 99(1), 6-38

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors ... [more ▼]

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results in the release of vasoactive kinins (bradykinin-related peptides). This complex system includes the precursors of kinins known as kininogens and mainly tissue and plasma kallikreins. The pharmacologically active kinins, which are often considered as either proinflammatory or cardioprotective, are implicated in many physiological and pathological processes. The interest of the various components of this multi-protein system is explained in part by the multiplicity of its pharmacological activities, mediated not only by kinins and their receptors, but also by their precursors and their activators and the metal lopeptidases and the antiproteases that limit their activities. The regulation of this system by serpins and the wide distribution of the different constituents add to the complexity of this system, as well as its multiple relationships with other important metabolic pathways such as the renin-angiotensin, coagulation, or complement pathways. The purpose of this review is to summarize the main properties of this kallikrein-kinin system and to address the multiple pharmacological interventions that modulate the functions of this system, restraining its proinflammatory effects or potentiating its cardiovascular properties. [less ▲]

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See detailKalman-filter based decoder in spiking neural networks
Dethier, Julie ULg

Report (2010)

The initial focus of the project is on implementing an existing Kalman-filter based decoder algorithm that controls a 2D computer cursor [GIL2010] into Neurogrids 2D silicon- neuron arrays. Neurogrid ... [more ▼]

The initial focus of the project is on implementing an existing Kalman-filter based decoder algorithm that controls a 2D computer cursor [GIL2010] into Neurogrids 2D silicon- neuron arrays. Neurogrid realizes such functions at negligible energetic cost [BOA2010]. This document gives the necessary background for a Kalman-filter based decoder implementation in a spiking neurl network (SNN). [less ▲]

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See detailKalman-filter in a neural network
Dethier, Julie ULg

Report (2010)

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See detailKamau Brathwaite: A Voice out of Bounds
Pagnoulle, Christine ULg

in Debusscher, Gilbert; Maufort, Marc (Eds.) Union in Partition: Essays in Honour of Jeanne Delbaere (1997)

The article explores the concurrence between innovative forms and hybrid genres in Kamau Brathwaite's works after 1988, the year when his wife died and his archives were destroyed by hurricane Gilbert.

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See detailKamennaya industriya verkhnego paleolita stoyanki Kulbulak
Kolobova, K.A.; Flas, Damien ULg; Islamov, U.I. et al

in Problems of archaeology, ethnography, and anthropology of Siberian and adjacent territories. : material of the 16th annual session of the Institute of Archaeology and Ethnography, SBRAS (2008)

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See detail‘De kanker van een diepgewortelde droom’. Over Marcel van Maele
Spinoy, Erik ULg

in Van Maele, Marcel (Ed.) Scherpschuttersfeest (2003)

This is a general introduction to the work of the Flemish novelist and poet Marcel van Maele.

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See detailKann man den Erzähler übersetzen? Überlegungen zu Joseph Roths Roman 'Das falsche Gewicht'.
Viehöver, Vera ULg

in Hoffmann, Nora; Shchyhlevska, Natalia (Eds.) Joseph Roth als Stilist. (2013)

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See detailDer kanonisierte Heine
Pontzen, Alexandra ULg

in Literaturkritik.de (2004)

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See detailKansen op Vlaamlands : Kroniek van een centrifugale beweging
Vromans, Joseph ULg

Conference given outside the academic context (2005)

Detailed reference viewed: 11 (1 ULg)