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See detailGlaucome ou cataracte ? Sur l’emploi des dérivés de glaukos en ophtalmologie antique
Marganne, Marie-Hélène ULg

in History & Philosophy of the Life Sciences (1979), 1(2), 199-214

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See detailGlial but not neuronal development in the cochleo-vestibular ganglion requires Sox10.
Breuskin, Ingrid ULg; Bodson, Morgan ULg; Thelen, Nicolas ULg et al

in Journal of Neurochemistry (2010), 114(6), 1827-39

The cochleo-vestibular ganglion contains neural crest-derived glial cells and sensory neurons that are derived from the neurogenic otic placode. Little is known about the molecular mechanisms that ... [more ▼]

The cochleo-vestibular ganglion contains neural crest-derived glial cells and sensory neurons that are derived from the neurogenic otic placode. Little is known about the molecular mechanisms that regulate the tightly orchestrated development of this structure. Here, we report that Sox10, a high-mobility group DNA-binding domain transcription factor that is required for the proper development of neural crest cell derivatives, is specifically expressed in post-migratory neural crest cells in the cochleo-vestibular ganglion. Using Sox10-deficient mice, we demonstrate that this transcription factor is essential for the survival, but not the generation, of the post-migratory neural crest cells within the inner ear. In the absence of these neural crest-derived cells, we have investigated the survival of the otocyst-derived auditory neurons. Surprisingly, auditory neuron differentiation, sensory target innervation and survival are conserved despite the absence of glial cells. Moreover, brain-derived neurotrophic factor expression is increased in the hair cells of Sox10-deficient mice, a compensatory mechanism that may prevent spiral ganglion neuronal cell death. Taken together, these data suggest that in the absence of neural crest-derived glial cells, an increase trophic support from hair cells promotes the survival of spiral ganglion neurons in Sox10 mutant mice. [less ▲]

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See detailGlial control of neuronal excitability in mammals: I. Electrophysiological and isotopic evidence in culture.
Moonen, Gustave ULg; FRANCK, G.; SCHOFFENIELS, E.

in Neurochemistry International (1980), 2c

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See detailGlial organization in the developing reeler neocortex
Gadisseux, J.-F.; Evrard, Ph; Misson, Jean-Paul ULg et al

in Neuroscience (1988)

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See detailGlial process elongation and branching in the developing murine neocortex: A qualitative and quantitative immunohistochemical analysis
Takahashi, Takao; Misson, Jean-Paul ULg; Caviness, Verne S

in Journal of Comparative Neurology (The) (1990), 302

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See detailLa gliceraldehido-3-fosfato deshidrogenasa plastidial es esencial para el desarrollo de polen maduro en Arabidopsis thaliana
Muñoz-Bertomeu, Jesús; Cascales - Miñana, Borja ULg; Flores-Tornero, Maria et al

Poster (2009, September)

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See detailGLIMMER – Global-Local Information Merging for Maturing Emergency Response
Binon, Kris; Brunet, Sébastien ULg; Cornélis, Bernard et al

Report (2008)

Un guide, d’accord... mais pour quoi faire ? Nous tous sommes quotidiennement exposés à une variété inimaginable de risques. Au niveau individuel, ces risques sont liés à notre constitution personnelle, à ... [more ▼]

Un guide, d’accord... mais pour quoi faire ? Nous tous sommes quotidiennement exposés à une variété inimaginable de risques. Au niveau individuel, ces risques sont liés à notre constitution personnelle, à nos activités, à nos relations sociales, et à nos biens matériels et immatériels. Ce n'est que lorsqu'ils se concrétisent que nous en subissons les effets, par exemple respectivement: allergie, chute à ski, divorce, panne de gsm ou trou de mémoire. À ces risques touchant la sphère privée, s'ajoutent les risques touchant tout ou partie de la société. Ces derniers proviennent soit de la société ellemême ou de ses composantes (e.g. pollution atmosphérique, émeute), soit de l'environnement naturel (e.g. tremblement de terre). 2. Pour les risques concernant la société, les autorités publiques ont mis en oeuvre une série de politiques pour rencontrer les attentes et besoins de la population. En cas de sinistres, l’intervention d’acteurs organisés (services d'incendie, de secours, de police, cellule de crise,...) permet de répondre aux situations d'urgence. De façon à améliorer cette réponse, des plans d'intervention et d'urgence sont établis. Ces plans trouvent leur fondement dans une démarche pro-active: l'analyse de risques. Le nombre des risques étant quasiment infini, il importe d’opérer des choix. Les objectifs de ce guide sont multiples : - aider les acteurs des cellules de sécurité à travailler ensemble; - proposer des moyens permettant d’opérer un choix à bon escient; - contribuer à la prise de décisions rationnelles en matière de planification; - favoriser les échanges entre les autorités territoriales et avec les entreprises privées; - ... 3. La démarche suivie par le projet GLIMMER repose sur l'apprentissage organisationnel. Cela implique d'une part le partage d'expériences, mais aussi de franchir des paliers avec l'ensemble des autorités publiques. Ce manuscrit est l'embryon d'un manuel plus développé. Vu la demande des autorités locales de commencer leur travail d'analyse de risques avec la présente méthode, le comité d'accompagnement a décidé de mettre à leur disposition ce guide qui contient le coeur de la méthode élaborée. Des bribes d'une version ultérieure peuvent donc apparaître de temps à autre dans ce document. 4. Cette première version du guide est divisée en quatre parties principales. La première partie vise à replacer le guide dans un contexte général (celui de la gestion des risques et de la planification) et particulier (celui la mise en place de cellules de sécurité). La deuxième partie a pour objectif de fournir un cadre théorique. Il s’agit principalement de rendre compréhensible des concepts parfois flous, polysémiques ou mal maîtrisés et de constituer un cadre de référence commun. La troisième partie n’a pour autre ambition que de fournir une aide à la mise en place des cellules de sécurité et à leur bon fonctionnement. La quatrième partie est dédiée aux méthodes d'analyse de risques. Enfin, le guide est agrémenté d’annexes dans lesquelles se trouvent outils, renseignements utiles, etc. [less ▲]

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See detailA Glimpse from the Imaginaries of a Nanofuture Conference in Leuven, Belgium
Van Oudheusden, Michiel ULg

Article for general public (2007)

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See detailGlioblastoma cellular architectures are predicted through the characterization of two-cell interactions
Kravchenko-Balasha, Nataly; Wang, Jun; Remacle, Françoise ULg et al

in Proceedings of the National Academy of Sciences (2014), 111

To understand how pairwise cellular interactions influence cellular architectures, we measured the levels of functional proteins associated with EGF receptor (EGFR) signaling in pairs of U87EGFR variant ... [more ▼]

To understand how pairwise cellular interactions influence cellular architectures, we measured the levels of functional proteins associated with EGF receptor (EGFR) signaling in pairs of U87EGFR variant III oncogene receptor cells (U87EGFRvIII) at varying cell separations. Using a thermodynamics-derived approach we analyzed the cell-separation dependence of the signaling stability, and identified that the stable steady state of EGFR signaling exists when two U87EGFRvIII cells are separated by 80–100 μm. This distance range was verified as the characteristic intercellular separation within bulk cell cultures. EGFR protein network signaling coordination for the U87EGFRvIII system was lowest at the stable state and most similar to isolated cell signaling. Measurements of cultures of less tumorigenic U87PTEN cells were then used to correctly predict that stable EGFR signaling occurs for those cells at smaller cell–cell separations. The intimate relationship between functional protein levels and cellular architectures explains the scattered nature of U87EGFRvIII cells relative to U87PTEN cells in glioblastoma multiforme tumors. [less ▲]

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See detailGlioblastoma Circulating Cells: Reality, Trap or Illusion?
LOMBARD, Arnaud ULg; Goffart, Nicolas ULg; Rogister, Bernard ULg

in Stem Cells International (2015)

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See detailGlioblastoma metastases:case report and literature review
REUTER, Gilles ULg; Lombard, Arnaud ULg; SCHOLTES, Félix ULg et al

Poster (2013, March 30)

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See detailGlioblastoma stem cells: new insights in therapeutic strategies
Goffart, Nicolas ULg; Dedobbeleer, Matthias ULg; Rogister, Bernard ULg

in Future Neurology (2014), 9(6), 639-653

Despite notable achievements in glioblastoma diagnosis and treatment, the prognosis of glioblastoma patients remains poor and reflects the failure of current therapeutic modalities. In this context ... [more ▼]

Despite notable achievements in glioblastoma diagnosis and treatment, the prognosis of glioblastoma patients remains poor and reflects the failure of current therapeutic modalities. In this context, innovative therapeutic strategies have recently been developed to specifically target glioblastoma stem cells, a subpopulation of tumor cells involved in experimental tumorigenesis and known to be critical for tumor recurrence and therapeutic resistance. The current review summarizes the different trails which make glioblastoma stem cells resistant to treatments, mainly focusing on radio-, chemo- and immunotherapy. This broad overview might actually help to set up new bases for glioblastoma therapy in order to better fight tumor relapses and to improve the patients’ prognosis. [less ▲]

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See detailGlioblastoma-derived extracellular vesicles induce tumor-supportive phenotypes in monocytic cells
de Vrij, Jeroen; Maas, Sybren; Kwappenberg, Kitty et al

in International Journal of Cancer = Journal International du Cancer (in press)

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See detailGlioblastoma-Initiating Cells: Relationship with Neural Stem Cells and the Micro-Environment
Goffart, Nicolas ULg; KROONEN, Jérôme ULg

in Cancers (2013)

Glioblastoma multiforme (GBM, WHO grade IV) is the most common and lethal subtype of primary brain tumor with a median overall survival of 15 months from the time of diagnosis. The presence in GBM of a ... [more ▼]

Glioblastoma multiforme (GBM, WHO grade IV) is the most common and lethal subtype of primary brain tumor with a median overall survival of 15 months from the time of diagnosis. The presence in GBM of a cancer population displaying neural stem cell (NSC) properties as well as tumor-initiating abilities and resistance to current therapies suggests that these glioblastoma-initiating cells (GICs) play a central role in tumor development and are closely related to NSCs. However, it is nowadays still unclear whether GICs derive from NSCs, neural progenitor cells or differentiated cells such as astrocytes or oligodendrocytes. On the other hand, NSCs are located in specific regions of the adult brain called neurogenic niches that have been shown to control critical stem cell properties, to nourish NSCs and to support their self-renewal. This “seed-and-soil” relationship has also been adapted to cancer stem cell research as GICs also require a specific micro-environment to maintain their “stem cell” properties. In this review, we will discuss the controversies surrounding the origin and the identification of GBM stem cells and highlight the micro-environment impact on their biology. [less ▲]

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See detailLes glioblastomes, un exemple de recherche translationnelle?
Kroonen, Jérôme ULg; Nguyen-Khac, Minh-Tuan ULg; Deprez, Manuel ULg et al

in Revue Médicale de Liège (2008), 63(5-6), 251-6

Among patients which develop glioblastoma multiform (GBM), recurrence is the rule despite continuous progress in surgery, radiotherapy and chemotherapy. In the adult, GBM is the most frequent and most ... [more ▼]

Among patients which develop glioblastoma multiform (GBM), recurrence is the rule despite continuous progress in surgery, radiotherapy and chemotherapy. In the adult, GBM is the most frequent and most aggressive tumour of the Central Nervous System. A better understanding of the mechanisms by which these tumours relapse could promote the use of preventive therapy and could increase patients' survival. GBM stem cells have been recently described and it was demonstrated that they are specifically implied in the experimental tumorigenesis. It is thus very attractive to speculate on a possible relationship between these GBM stem cells and the neural stem cells which are persisting in the neurogenic zones of the adult brain. In this review, we formulate and discuss the hypothesis by which, in a patient with GBM, malignant stem cells might be present in the neurogenic zones, away from the tumour mass. This hypothesis could explain the tumour relapse observed after the first treatments. [less ▲]

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See detailGlioma metastatis : a case series and review
REUTER, Gilles ULg; LOMBARD, Arnaud ULg; SCHOLTES, Félix ULg et al

Poster (2014, March 29)

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See detailGliomatose méningée cérébro-spinale diffuse chez un enfant traité par hormone de croissance dans le cadre d!un syndrome de Turner
Dacier, Ph; Leroy, P.; Ernould, Ch et al

in Société Belge de Neurologie Pédiatrique (1995)

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See detailGliomatosis Cerebri: Clinical, Radiological and Pathological Report of a Case with a Stroke-Like Onset
Schoenen, Jean ULg; de Leval, L.; Reznik, M.

in Acta Neurologica Belgica (1996), 96(4), 294-300

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and ... [more ▼]

A 62 year-old man was admitted with a right hemiparesis, sensory aphasia and right hemianopia which appeared on awakening. He was initially thought to have a stroke, but EEG showed diffuse slowing and both CT scan and MRI irregular white matter lesion suggesting a leucoencephalopathy. His neurological deficit regressed, and he was discharged after 2 weeks. He was readmitted 6 months later because of mental confusion. MRI revealed diffuse white matter lesions extending up to the frontal lobes, these were hyperintense on T2 weighted images and suggested the diagnosis of gliomatosis cerebri (GC). The patient became progressively comatose and died 6 weeks later. At autopsy the brain looked diffusely swollen with irregular greyish areas of the white matter of both centrum ovale and brain stem. On microscopic examination the cerebrum and brain stem were diffusely and asymmetrically infiltrated by numerous neoplastic glial cells without angiogenesis or disruption of architectonic boundaries. There were no mitoses nor necrosis. Many tumour cells were GFAP- and S100-positive. A high proportion of cells contained the leucocyte antigen Leu-7. This case of gliomatosis cerebri is compared to the 9 published cases of GC with an initial focal neurological deficit and to the 19 publications reporting MRI results. The controversial nosological boundaries and etiopathogenetic hypotheses of this peculiar neoplastic disease are discussed. [less ▲]

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See detailGlipizide increases plasma insulin but not C-peptide level after a standardized breakfast in type 2 diabetic patients.
Scheen, André ULg; Lefebvre, Pierre ULg; Luyckx, A. S.

in European Journal of Clinical Pharmacology (1984), 26(4), 471-4

Peripheral blood glucose, plasma insulin and C-peptide levels were investigated after giving a standardized breakfast (500 kcal, 60 g carbohydrates) to 10 nonobese Type 2 diabetic patients previously ... [more ▼]

Peripheral blood glucose, plasma insulin and C-peptide levels were investigated after giving a standardized breakfast (500 kcal, 60 g carbohydrates) to 10 nonobese Type 2 diabetic patients previously treated by diet alone. Each patient received at random, at 1 week intervals, either 5 mg glipizide (meal + glipizide) or a placebo (meal alone) 30 min before breakfast. Basal values of blood glucose, plasma insulin and C-peptide were similar on both occasions. After meal + glipizide, the blood glucose increase was sharply limited whereas the rise in plasma insulin was steeper and reached twice as high a level. In contrast, the rise in plasma C-peptide was similar in both conditions. Consequently, the areas under the curves (0-300 min) showed a marked reduction in blood glucose after meal + glipizide (2289 +/- 149 versus 3101 +/- 169 mmol X min/1; 2p less than 0.001), associated with a significant increase in plasma insulin (14219 +/- 3261 versus 7591 +/- 1173 microU X min/ml; 2p less than 0.025) but no significant change in plasma C-peptide (342 +/- 45 versus 326 +/- 34 pmol X min/ml; N.S.). The insulin/C-peptide molar ratio was thus significantly increased after meal + glipizide (0.41 +/- 0.06 versus 0.23 +/- 0.04 at the 60th min; 2p less than 0.02). The dissociation between the responses of insulin and C-peptide suggests that a single dose of 5 mg glipizide in Type 2 diabetic subjects may enhance availability of peripheral insulin by extrapancreatic mechanism(s). This phenomenon may result in a higher circulating level of the hormone and therefore represent a further mode of action of sulphonylureas.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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