Microphysical characteristics of artificial fog produced in laboratory to study road visibility.

in Proceedings of the 23th Session of the International Commission of Illumination (1995)

Pour étudier la visibilité des équipements de la route dans le brouillard, une approche expérimentale a été choisie. On reproduit du brouillard artificiel en laboratoire par injection d'eau sous pression ... [more ▼]

Pour étudier la visibilité des équipements de la route dans le brouillard, une approche expérimentale a été choisie. On reproduit du brouillard artificiel en laboratoire par injection d'eau sous pression. Pour qualifier ces installations, il est nécessaire de connaître la granulométrie de ce brouillard. Le spectre dimensionnel des gouttelettes est mesuré avec un compteur optique de particules, en divers points de la salle. L'opacité du brouillard est contrôlée en permanence pendant les essais à l'aide d'un transmissiomètre. La concentration des gouttelettes varie avec l'opacité. La taille des particules se répartit suivant une distribution dont le pic en diamètre est de l'ordre de 1µm. Ces données sont comparées aux caractéristiques des brouillards naturels. [less ▲]

Micropore size distributions of activated carbons

in Langmuir (2000), 16(16), 6754-6756

Les microporosités dans les superalliages de nickel. Etude de leur formation en relation avec la composition, la séquence de solidification, les ségrégations et la microstructure

Doctoral thesis (1985)

Microporous and heterogeneous surface adsorption isotherms arising from Levy distributions

in Physica A: Statistical Mechanics and its Applications (2005), 349(1-2), 271-282

We show that for adsorption on heterogeneous and microporous surfaces, the Freundlich isotherm power-law exponent a is directly related to the Levy tail index of the distribution of the Langmuir parameter ... [more ▼]

We show that for adsorption on heterogeneous and microporous surfaces, the Freundlich isotherm power-law exponent a is directly related to the Levy tail index of the distribution of the Langmuir parameter b and to the expected value and the variance of the adsorption energy distribution. This allows us to view adsorption at low pressure in these systems as a rare event dominated phenomena. Based on this discussion, a generalized isotherm formulation is proposed and applied to the interpretation of recent data on activated carbons. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

Micropropagation and preliminary in vitro evaluation of antimicrobial activity of some chemicals on apple proliferation-infected shoots

Poster (2008)

MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy.

in Journal of Clinical Investigation (2013), 123(5), 2143-54

Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the 16-kDa N-terminal prolactin fragment (16K PRL ... [more ▼]

Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the 16-kDa N-terminal prolactin fragment (16K PRL), the underlying molecular mechanisms are poorly understood. We found that 16K PRL induced microRNA-146a (miR-146a) expression in ECs, which attenuated angiogenesis through downregulation of NRAS. 16K PRL stimulated the release of miR-146a-loaded exosomes from ECs. The exosomes were absorbed by cardiomyocytes, increasing miR-146a levels, which resulted in a subsequent decrease in metabolic activity and decreased expression of Erbb4, Notch1, and Irak1. Mice with cardiomyocyte-restricted Stat3 knockout (CKO mice) exhibited a PPCM-like phenotype and displayed increased cardiac miR-146a expression with coincident downregulation of Erbb4, Nras, Notch1, and Irak1. Blocking miR-146a with locked nucleic acids or antago-miRs attenuated PPCM in CKO mice without interrupting full-length prolactin signaling, as indicated by normal nursing activities. Finally, miR-146a was elevated in the plasma and hearts of PPCM patients, but not in patients with dilated cardiomyopathy. These results demonstrate that miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM. [less ▲]

MicroRNA-146a, a downstream effector of 16kDa prolactin, impairs the endothelium-cardiomyocyte cross-talk in peripartum cardiomyopathy

in FASEB meeting:the Growth Hormone/Prolactin Family in Biology and Disease. (2012)

MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells.

in PLoS ONE (2011), 6(2), 16979

BACKGROUND: MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the involvement of these RNAs in the ... [more ▼]

BACKGROUND: MicroRNAs (miRNAs) are endogenously expressed small non-coding RNAs that regulate gene expression at post-transcriptional level. The recent discovery of the involvement of these RNAs in the control of angiogenesis renders them very attractive in the development of new approaches for restoring the angiogenic balance. Whereas miRNA-21 has been demonstrated to be highly expressed in endothelial cells, the potential function of this miRNA in angiogenesis has never been investigated. METHODOLOGY/PRINCIPAL FINDINGS: We first observed in endothelial cells a negative regulation of miR-21 expression by serum and bFGF, two pro-angiogenic factors. Then using in vitro angiogenic assays, we observed that miR-21 acts as a negative modulator of angiogenesis. miR-21 overexpression reduced endothelial cell proliferation, migration and the ability of these cells to form tubes whereas miR-21 inhibition using a LNA-anti-miR led to opposite effects. Expression of miR-21 in endothelial cells also led to a reduction in the organization of actin into stress fibers, which may explain the decrease in cell migration. Further mechanistic studies showed that miR-21 targets RhoB, as revealed by a decrease in RhoB expression and activity in miR-21 overexpressing cells. RhoB silencing impairs endothelial cell migration and tubulogenesis, thus providing a possible mechanism for miR-21 to inhibit angiogenesis. Finally, the therapeutic potential of miR-21 as an angiogenesis inhibitor was demonstrated in vivo in a mouse model of choroidal neovascularization. CONCLUSIONS/SIGNIFICANCE: Our results identify miR-21 as a new angiogenesis inhibitor and suggest that inhibition of cell migration and tubulogenesis is mediated through repression of RhoB. [less ▲]

MicroRNAs tune cerebral cortical neurogenesis.

in Cell Death & Differentiation (2012), 19(10), 1573-81

MicroRNAs (miRNAs) are non-coding RNAs that promote post-transcriptional silencing of genes involved in a wide range of developmental and pathological processes. It is estimated that most protein-coding ... [more ▼]

MicroRNAs (miRNAs) are non-coding RNAs that promote post-transcriptional silencing of genes involved in a wide range of developmental and pathological processes. It is estimated that most protein-coding genes harbor miRNA recognition sequences in their 3' untranslated region and are thus putative targets. While functions of miRNAs have been extensively characterized in various tissues, their multiple contributions to cerebral cortical development are just beginning to be unveiled. This review aims to outline the evidence collected to date demonstrating a role for miRNAs in cerebral corticogenesis with a particular emphasis on pathways that control the birth and maturation of functional excitatory projection neurons. [less ▲]

Microsatellite Amplification in Plants: Optimization Procedure of Major PCR Components

in Kantartzi, Stella (Ed.) Methods in Molecular Biology™ series: Microsatllites (2013)