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See detailGAIMS: a powerful gait analysis system satisfying the constraints of clinical routine
Pierard, Sébastien ULg; PHAN BA, Remy ULg; DELVAUX, Valérie ULg et al

in Multiple Sclerosis Journal (2013, October), 19(S1), 359

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See detailGAIMS: A Reliable Non-Intrusive Gait Measuring System
Pierard, Sébastien ULg; Azrour, Samir ULg; PHAN BA, Remy ULg et al

in ERCIM News (2013), 95

Gait observation and analysis can provide invaluable information about an individual [1]. Studies that have interpreted gait using traditional imaging devices have demonstrated that it is difficult to ... [more ▼]

Gait observation and analysis can provide invaluable information about an individual [1]. Studies that have interpreted gait using traditional imaging devices have demonstrated that it is difficult to make reliable measurements with colour cameras. GAIMS, our new system resulting from a multidisciplinary project born from collaboration between engineers and neurologists, aims at developing non-intrusive and reliable tools to provide quantitative measures of gait and interpretations of the acquired data. Following a current trend in imaging, it takes advantage of imaging sensors that measure distance instead of colour. While its principles are general, GAIMS is currently used for the diagnosis of multiple sclerosis (MS) and the continued evaluation of disease progression [2]. It is the first available system to fully satisfy the clinical routine and its associated constraints. [less ▲]

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See detailGAIMS: a tool specifically developed for the clinical gait analysis of patients with multiple sclerosis
Pierard, Sébastien ULg; Phan-Ba, Rémy; Giet, Amaury et al

in Multiple Sclerosis Journal (2015, April), 21(4), 498-499

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See detailGain baro-réflexe calculé lors d’un test d’orthostatisme (« squatting ») : reproductibilité et effet de l’âge dans une population normale
PHILIPS, Jean-Christophe ULg; MARCHAND, Monique ULg; Estrella, F. et al

in Archives des Maladies du Coeur et des Vaisseaux (2004), 97(suppl), 5392

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See detailGain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells.
Ali, Amjad ULg; Shah AS; Ahmad A

in Cancer Letters (2014)

Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and epithelial-mesenchymal-transition (EMT). However, its expression is downregulated in metastatic breast cancer that contains p53 ... [more ▼]

Kruppel-like-factor 17 (KLF17) is a negative regulator of metastasis and epithelial-mesenchymal-transition (EMT). However, its expression is downregulated in metastatic breast cancer that contains p53 mutations. Here, we show that mutant-p53 plays a key role to suppress KLF17 and thereby enhances cancer progression, which defines novel gain-of-function (GOF) of mutant-p53. Mutant-p53 interacts with KLF17 and antagonizes KLF17 mediated EMT genes transcription. Depletion of KLF17 promotes cell viability, decreases apoptosis and induces drug resistance in metastatic breast cancer cells. KLF17 suppresses cell migration and invasion by decreasing CD44, PAI-1 and Cyclin-D1 expressions. Taken together, our results show that KLF17 is important for the suppression of metastasis and could be a potential therapeutic target during chemotherapy. [less ▲]

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See detailGain-scheduled, model-based anti-windup for LPV systems
Forni, Fulvio ULg; Galeani, Sergio

in Automatica (2010), 46(1), 222-225

The aim of this paper is to show that a recently proposed technique for anti-windup control of exponentially unstable plants can be easily extended to solve the corresponding robust anti-windup problem ... [more ▼]

The aim of this paper is to show that a recently proposed technique for anti-windup control of exponentially unstable plants can be easily extended to solve the corresponding robust anti-windup problem for linear parameter varying systems, for which the time varying parameters are measured online. The proposed technique is minimally conservative with respect to the size of the resulting operating region (which coincides, up to an arbitrarily small quantity, with the largest set on which asymptotic stability can be guaranteed for the considered plant with the given saturation level and uncertainty characteristics), and is not limited to plants having only small uncertainties or being open-loop stable. [less ▲]

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See detailGainers and losers of the implementation of the new Common Agricultural Policy in Wallonia
Burny, Philippe ULg; Terrones Gavira, François ULg

in Agriculture and Agricultural Science Procedia (2015), 7

The new Common Agricultural Policy (CAP) defined in 2013 is implemented since 2015. It offers several options to the Member States/Regions. This paper describes the choices which have been made in ... [more ▼]

The new Common Agricultural Policy (CAP) defined in 2013 is implemented since 2015. It offers several options to the Member States/Regions. This paper describes the choices which have been made in Wallonia and their consequences on direct payments. It appears that 42% of the farmers will lose between 2014 and 2019, while 44% will gain and a quasi-status quo is observed for the remaining 14%. Finally, the new situation is politically acceptable and gives more support to small farms, young farmers and cattle breeders, though the global envelope for direct payments will decline in Wallonia. [less ▲]

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See detailGaining speed in molecular dynamics simulations by implicit representation of water and membrane molecules
Steinhauer, Sven ULg; Crowet, Jean-Marc ULg; Brasseur, Robert ULg et al

Poster (2013, June 19)

Molecular dynamics (MD) is an appropriate method for investigation of peptide-membrane systems and helps in analyzing results from experiments. In many cases, the ability of viral fusion proteins and ... [more ▼]

Molecular dynamics (MD) is an appropriate method for investigation of peptide-membrane systems and helps in analyzing results from experiments. In many cases, the ability of viral fusion proteins and toxins for destabilizing the membrane is due to their hydrophobic profile, leading to particular membrane insertion. By now, many relevant processes for drug design, toxicological studies and other fields of application, are not feasible by MD simulations, when each atom is represented over time. Processes such as protein folding, often take place above the time scales reachable by MD simulations, which are of the order of micro seconds. The necessary time effort for carrying out such simulations stays considerable and depends mainly on (1) the complexity of the simulated system (2) the simulated time scale (3) the simulation method (4) the efficiency of used hardware and software algorithms. Nowadays, MD simulations can still take weeks of calculation on high end computers. Impala is an implicit water and lipids forcefield, initially developed by our laboratory. Implicit forcefields replace water and/or lipid molecules by a couple of simple and partially precalculable equations. Using this method, thousands of water and lipid molecules can be replaced in MD simulations using Gromacs software. This leads to a considerable reduction of system complexity. The original Impala algorithm based on the assumption of rigid peptides and used a Monte Carlo algorithm with the aim of finding the insertion characteristics of these molecules in membranes. Our current work is the integration of the Impala forcefield into Gromacs, a freely accessible MD software. Replacing the aqueous and lipid phase atomic description in Gromacs MD by an implicit forcefield is supposed to lead to a gain of speed compared to full atomistic simulations. A gain of precision compared to Impala is expected, too. This will be achieved by turning molecules flexible, when implementing Impala into Gromacs. [less ▲]

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See detailGains d’efficience : La Cour AELE, peu sensible à l’approche économique, rejette le pourvoi de la poste norvégienne, condamnée à 12 millions d’euros d’amendes pour avoir empêché l’accès d’entreprises concurrentes au marché de la distribution de colis aux particuliers
Sibony, Anne-Lise ULg

in Concurrences : Revue des Droits de la Concurrence (2012), 4

Cour AELE, 18 avril 2012, Posten Norge/Autorité AELE, aff. E-15/10 Gains d’efficience : La Cour AELE, peu sensible à l’approche économique, rejette le pourvoi de la poste norvégienne, condamnée à 12 ... [more ▼]

Cour AELE, 18 avril 2012, Posten Norge/Autorité AELE, aff. E-15/10 Gains d’efficience : La Cour AELE, peu sensible à l’approche économique, rejette le pourvoi de la poste norvégienne, condamnée à 12 millions d’euros d’amendes pour avoir empêché l’accès d’entreprises concurrentes au marché de la distribution de colis aux particuliers. [less ▲]

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See detailGaio, l'insegnamento e il Belgio
Gerkens, Jean-François ULg

Conference (2012, June 11)

What was the impact of the discovery of the Veronese Palimpsest on the teaching methods in Belgium?

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See detailGait analysis during an original walking test
Croisier, Jean-Louis ULg; Crielaard, Jean-Michel ULg; Chapelier, Dominique et al

in Parkinsonism & Related Disorders (2008), 14

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See detailGait analysis during an original walking test: application in fibromyalgia syndrome
Maquet, Didier ULg; Chapelier, Dominique; Bouquegneau, Adeline ULg et al

in Journal of Rehabilitation Medicine Supplement (2008, June), 47

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See detailGait analysis during an original walking test: Comparison between control subjects and patients with Parkinson’s disease
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Robert, Fanny et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010, June), 25(Suppl 2), 355

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See detailGait analysis in elderly adult patients with mild cognitive impairment and patients with mild Alzheimer’s disease: simple versus dual task: A preliminary report
Maquet, Didier ULg; Lekeu, Françoise ULg; Warzee, Emmanuelle ULg et al

in Clinical Physiology & Functional Imaging (2010), 30(1), 51-56

Background ⁄ Aims: The aim of this study was to assess gait characteristics during simple and dual task in patients with mild cognitive impairment (MCI) and compare them with those of healthy elderly ... [more ▼]

Background ⁄ Aims: The aim of this study was to assess gait characteristics during simple and dual task in patients with mild cognitive impairment (MCI) and compare them with those of healthy elderly subjects and mild Alzheimer s disease (AD) patients. Methods: We proposed a gait analysis to appreciate walking (simple task and dual task) in 14 MCI, 14 controls and six AD subjects who walked at their preferred speed. A 20-second period of stabilized walking was used to calculated stride frequency, stride length, symmetry and regularity. Speed walking was measured by electrical photocells. Results: Variables measured during simple and dual tasks showed an alteration of motor function as well in mild AD patients as in MCI patients. Conclusion: At the end of this preliminary study, we defined a specific gait pattern for each cognitive profile. Further researches appear necessary to enlarge the study cohort. [less ▲]

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See detailGait analysis using a wearable accelerometer system: Comparison between control subjects and patients with Parkinson’s disease
Maquet, Didier ULg; Croisier, Jean-Louis ULg; Robert, Fanny et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2010, June), 25(S2), 355

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See detailGait feature extraction in Parkinson's disease using low-cost accelerometers
Stamatakis, Julien; Cremers, Julien ULg; Maquet, Didier ULg et al

Poster (2011)

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling ... [more ▼]

The clinical hallmarks of Parkinson’s disease (PD) are movement poverty and slowness (i.e. bradykinesia), muscle rigidity, limb tremor or gait disturbances. Parkinson’s gait include slowness, shuffling, short steps, freezing of gait (FoG) and/or asymmetries in gait. There are currently no validated clinical instruments or device that allow a full characterization of gait disturbances in PD. As a step towards this goal, a four accelerometer-based system is proposed to increase the number of parameters that can be extracted to characterize parkinsonian gait disturbances such as FoG or gait asymmetries. After developing the hardware, an algorithm has been developed, that automatically epoched the signals on a stride-by-stride basis and quantified, among others, the gait velocity, the stride time,the stance and swing phases, the single and double support phases or the maximum acceleration at toe-off, as validated by visual inspection of video recordings during the task. The results obtained in a PD patient and an healthy volunteer are presented. The FoG detection will be improved using time-frequency analysis and the system is about to be validated with a state-of-the-art 3D movement analysis system. [less ▲]

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See detailGait pattern of healthy old people for dual task walking condition
GILLAIN, Sophie ULg; Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg et al

in Gerontechnology (2016, September)

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See detailGait pattern of healthy old people for fast walking condition
GILLAIN, Sophie ULg; Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg et al

in Gerontechnology (2016, September)

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See detailGait pattern of healthy old people for fast walking condition
GILLAIN, Sophie ULg; Boutaayamou, Mohamed ULg; Schwartz, Cédric ULg et al

in Gerontechnology (2016, September)

Detailed reference viewed: 25 (7 ULg)