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See detailIns(1,3,4,5)P4 negatively regulates PtdIns(3,4,5)P3 signaling in neutrophils
Jia, Y.; Subramanian, K. K.; Erneux, C. et al

in Immunity (2007), 27

Many neutrophil functions are regulated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) that mediates protein membrane translocation via binding to pleckstrin homolog (PH) domains within ... [more ▼]

Many neutrophil functions are regulated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) that mediates protein membrane translocation via binding to pleckstrin homolog (PH) domains within target proteins. Here we show that inositol 1,3,4,5-tetrakisphosphate(Ins(1,3,4,5)P4), a cytosolic small molecule, bound the same PH domain of target proteins and competed for binding to PtdIns(3,4,5)P3. In neutrophils, chemoattractant stimulation triggered rapid elevation in Ins(1,3,4,5)P4 concentration. Depletion of Ins(1,3,4,5)P4 by deleting the gene encoding InsP3KB, which converts Ins(1,4,5)P3 to Ins(1,3,4,5)P4, enhanced membrane translocation of the PtdIns(3,4,5)P3-specific PH domain. This led to enhanced sensitivity to chemoattractant stimulation, elevated superoxide production, and enhanced neutrophil recruitment to inflamed peritoneal cavity. On the contrary, augmentation of intracellular Ins(1,3,4,5)P4 concentrationblockedPHdomainmediated membrane translocation of target proteins and dramatically decreased the sensitivity of neutrophils to chemoattractant stimulation. These findings establish a role for Ins(1,3,4,5)P4 in cellular signal transduction pathways and provide another mechanism for modulating PtdIns(3,4,5)P3 signaling in neutrophils. [less ▲]

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See detailL'insaisissabilité de la résidence principale de l'indépendant
Georges, Frédéric ULg

in Revue du Notariat Belge (2008)

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See detailL'insanité d'esprit en matière de libéralité
Desir, Sarah ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2011), 27

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See detailLes insaponifiables d'avocats/soja s'opposent aux effets délétères d'H2O2 sur le métabolisme du cartilage
Mathy-Hartet, Marianne; Devel, P; Piccardi, N et al

in Revue du Rhumatisme (2003), 70

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See detailInSAR Applied to the Study of Active Volcanic and Seismic Areas in Africa
Wauthier, Christelle ULg

Doctoral thesis (2011)

Two active volcanic areas situated in immature portions of the East African Rift System (EARS): the Lake Kivu (Dem. Rep. of Congo) and Lake Natron (Tanzania) regions, which are located in the western and ... [more ▼]

Two active volcanic areas situated in immature portions of the East African Rift System (EARS): the Lake Kivu (Dem. Rep. of Congo) and Lake Natron (Tanzania) regions, which are located in the western and eastern branch, respectively, are still poorly known. Both areas indeed lack of ground-based networks, due to security problems or difficult field accessibility. The Lake Kivu area includes two volcanoes erupting frequently: the Nyamulagira and Nyiragongo volcanoes. The SAR database covering these volcanoes in- cludes data from JERS, ERS-1&2, ENVISAT, ALOS, RADARSAT-1&2 satellites back from year 1996. SAR Interferometry (InSAR) is thus applied to study the ground de- formations. MT-InSAR approaches, such as the ”‘StaMPS”’ method, are used to give us new complementary information to better constrain the previous established eruption models, or gain new insights on eruptions missed by the conventional InSAR, as well as on magmatic and tectonic activity. When enough constrains are available, the ground displacements are modeled using a 3D-Mixed Boundary Elements Method combined with a neighborhood algorithm. Hence, the 1996, 2002, 2004 and 2010 eruptions of Nyamu- lagira are modeled. The modeling results, coupled with the StaMPS MT-InSAR results, bring new insights concerning the magma plumbing system of this poorly known volcano and its eruptive mechanisms. The collapse of the eastern flank of Nyamulagira, along the NNW-trend fractures network linking Nyamulagira and Nyiragongo volcanoes, can also be identified. InSAR also captures the ground displacements associated with the January 2002 Nyiragongo eruption. The modeling of this major event evidences a deep magma intrusion beneath the Lake Kivu. Such intrusions should be taken into account for hazard assessment. The magma could indeed finds its way to the Lake Kivu floor, as evidenced by the presence of several old phreato-magmatic cones, and causes a lake overturn. The low dikes overpressures found in the North Kivu and Lake Natron areas indicate that, although the rift is considered as immature, the rift extension is driven by the supply of magma from depth, rather than by the tectonics. A new criterion to identify the rifting stage is found to be the stress state. In the southern part of the rift, tectonic activity dominates, indicating that the tectonics is probably driving the rift opening there. [less ▲]

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See detailInSAR Coherence for Crop Parameter Monitoring
Blaes, Xavier; Defourny, Pierre; De Rauw, Dominique ULg et al

in ESA (Ed.) Proc. FRINGE'99 Symposium (1999)

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See detailL'inscription dédicatoire de l'église de Waha
Kurth, Godefroid ULg

in Bulletin de la Commission Royale d'Histoire (1900), X, 3(5e série), 29

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See detailL'inscription des protections environnementales dans les procédures d'urbanisme, Rapport de synthèse
Pâques, Michel ULg

in L'environnement dans le droit de l'urbanisme en Europe (2008)

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See detailL'inscription du patrimoine culturel immatériel dans la politique patrimoniale
Lempereur, Françoise ULg

in Cahiers de l'Urbanisme (Les) (2008), 69

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See detailL'inscription du patrimoine culturel immatériel dans la société contemporaine
Lempereur, Françoise ULg

Scientific conference (2010, March 02)

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See detailInscriptiones Lesbi, Nesi, Tenedi
Famerie, Etienne ULg

Report (2015)

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See detailInscriptiones Lesbi, Tenedi, Nesi. Concordance des éditions
Famerie, Etienne ULg

in Horos (2015), 26-29

Concordance of the whole corpus of inscriptions of Lesbus, in relation with the inventory of the collection stored in the Archaeological Museum (Lesbus)

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See detailInscriptions arabes d’Éthiopie
Bauden, Frédéric ULg

in Annales islamologiques (2012), 45(2011), 285-306

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See detailLes inscriptions juives de Venosa
Rochette, Bruno ULg

Scientific conference (2014, May 15)

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See detailLes inscriptions latines translittérées en caractères grecs
Purnelle, Gérald ULg

in XI Congresso Internazionale di Epigrafia Greca e Latina. Roma, 18-24 settembre 1997. Atti (1999)

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See detailInscrire la laïcité de l'Etat dans la Constitution ?
Matgen, J.C.; Husson, Jean-François ULg

Article for general public (2012)

Dans la rubrique "Ripostes" de la Libre Belgique, je suis invité à réagir à la proposition d'Olivier Maingain (FDF) visant à inscrire le principe de laïcité dans la Constitution.

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See detailLes insctruments de la fiscalité environnementale
Bourgeois, Marc ULg

Conference (2008)

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See detailInsect Chemical Defense
Laurent, Pascal ULg; Braekman, Jean-Claude; Daloze, Désiré

in Schulz, Stefan (Ed.) The Chemistry of Pheromones and Other Semiochemicals II (2005)

Research on the defensive chemistry of insects during the last decade is reviewed, with special emphasis on non-volatile compounds. The isolation and structure determination of defensive chemicals, of ... [more ▼]

Research on the defensive chemistry of insects during the last decade is reviewed, with special emphasis on non-volatile compounds. The isolation and structure determination of defensive chemicals, of glandular and non-glandular origins, are first discussed, followed by an overview of the synthesis and biological/pharmacological activities of some of them. Biosynthesis has been largely omitted since this topic has been addressed in a recent review. During the period covered, beetles (e.g., coccinellids and chrysomelids) and ants have undoubtedly been the most prolific producers of repellent and/or toxic compounds. This survey also shows that alkaloids are the most frequently encountered defensive compounds in insects. [less ▲]

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