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See detailInnovative artificial fog production device - A technical facility for research activities.
Colomb, M.; Dufour, J.; Hirech, M. et al

Conference (2004)

A new innovative fog production device has been developed in close cooperation with partners of a European project called “FOG” funded by the EU. It is set up in the fog chamber of the road and bridges ... [more ▼]

A new innovative fog production device has been developed in close cooperation with partners of a European project called “FOG” funded by the EU. It is set up in the fog chamber of the road and bridges laboratory at Clermont-Ferrand. Most of the activities of this laboratory are dedicated to road safety but the facility is open to any other activity, such as environmental research. The recent developments consist in setting up a controllable device able to produce stable visibility levels and homogeneous fog, representative of various types of natural water droplet distribution. The fog characteristics were determined and compared to natural fog. Results are presented for a selection of conditions including stabilized visibility levels for dense fog, less than 50 metres meteorological visibility and two kinds of droplet distribution. [less ▲]

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See detailInnovative bolted beam-to-column joints for seismic resistant building frames
Coméliau, Ludivine ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg

in Dubina, Dan; Grecea, Daniel (Eds.) CONNECTIONS VII proceedings (2012)

In the present paper, innovative joint configurations leading to more economical solutions for full-strength beam-to-column joints for seismic building frames are detailed. The specificities of these ... [more ▼]

In the present paper, innovative joint configurations leading to more economical solutions for full-strength beam-to-column joints for seismic building frames are detailed. The specificities of these joints are due to the fact that (i) the column is made of high strength steel while the beam are made of mild carbon steel and (ii) the design of some components allows partially neglecting the overstrength factor. Also, methods for the characterisation of specific joint components not directly covered by the Eurocode recommendations are proposed. [less ▲]

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See detailINNOVATIVE BOLTED BEAM-TO-COLUMN JOINTS IN MOMENT RESISTANT BUILDING FRAME: FROM EXPERIMENTAL TESTS TO DESIGN GUIDELINES
Hoang, Van Long ULg; Demonceau, Jean-François ULg; Jaspart, Jean-Pierre ULg

in Dubina, Dan; Landolfo, Raffaele; Stratan, Aurel (Eds.) et al Application of High Strength Steels in Seismic Resistant Structures (2013)

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See detailInnovative Concepts in Navigation Lock Design
Rigo, Philippe ULg; Daniel, Ryszard

in The Port Infrastructure Seminar , 2010, TUDelft, NL (2010, June)

This paper presents the new report n°106 of PIANC InCom WG29 on Innovations in Navigation Lock Design, published by PIANC in August 2009, as well as some additional contributions on lock gates (gate ... [more ▼]

This paper presents the new report n°106 of PIANC InCom WG29 on Innovations in Navigation Lock Design, published by PIANC in August 2009, as well as some additional contributions on lock gates (gate contact technology). The paper highlights the main objectives and issues of his PIANC report with a specific emphasis on gates and specifically on the contact aspects. Locks are key structures for the development of the navigation in canals and in natural rivers where weirs regulate water levels to enable navigation. They may also be strategic infrastructure for port development. The core of this report has three major parts. The first part presents an exhaustive list of design goals associated with locks. This section is particularly important for decision makers who have to launch a new project. The second part reviews the design principles that must be considered by designers. This section is methodologically oriented. The third part is technically oriented. All main technical aspects (hydraulics, structures, foundations, including computational aspects, etc.) are reviewed, focussing on changes and innovations occurring since 1986. Perspectives and trends for the future are also listed. When appropriate, recommendations are listed. It is impossible to give the details of all lock innovation areas in this paper. As an example, the lock gates and, in particular, the modern views on their contact issues have been chosen. These new solutions are welcome to limit the maintenance and to extend the service life of lock gates. [less ▲]

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See detailInnovative designs for the imaging suite on Solar Orbiter
Auchere, Frederic; Song, Xueyen; Rouesnel, Frederic et al

in Society of Photo-Optical Instrumentation Engineers (SPIE) Conference Series (2005, August 01)

Orbiting around the Sun on an inclined orbit with a 0.2 UA perihelion, the Solar Orbiter probe will provide high resolution views of the Sun from various angles unattainable from Earth. Together with a ... [more ▼]

Orbiting around the Sun on an inclined orbit with a 0.2 UA perihelion, the Solar Orbiter probe will provide high resolution views of the Sun from various angles unattainable from Earth. Together with a set of high resolution imagers, the Full Sun Imager is part of the EUV Imaging suite of the Solar Orbiter mission. The mission's ambitious characteristics draw severe constraints on the design of these instruments. We present a photometrically efficient, compact, and lightweight design for the Full Sun Imager. With a 5 degrees field of view, this telescope will be able to see the global solar coronal structure from high viewing angles. Thermal solutions reducing the maximum power trapped in the High Resolution Imagers are also proposed. [less ▲]

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See detailInnovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoïds in cannabis plant material
De Backer, Benjamin ULg; Debrus, Benjamin ULg; Lebrun, Pierre ULg et al

Poster (2009, August)

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their ... [more ▼]

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their neutral counterparts. Converely, HPLC permits the determination of the original composition of plant cannabinoids by direct analysis. Several HPLC methods have been described in the literature, but most of them failed to separate efficiently all the cannabinoids or were not validated according to general guidelines. By use of an innovative methodology for modelling chromatographic responses, a simple and accurate HPLC/DAD method was develop [less ▲]

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See detailInnovative development and validation of an HPLC/DAD method for the qualitative and quantitative determination of major cannabinoids in cannabis plant material
De Backer, Benjamin ULg; Debrus, Benjamin ULg; Lebrun, Pierre ULg et al

in Journal of Chromatography. B : Analytical Technologies in the Biomedical & Life Sciences (2009), 877(32), 4115-4124

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their ... [more ▼]

GC is commonly used for the analysis of cannabis samples, e.g. in forensic chemistry. However, as this method is based on heating of the sample, acidic forms of cannabinoids are decarboxylated into their neutral counterparts. Conversely, HPLC permits the determination of the original composition of plant cannabinoids by direct analysis. Several HPLC methods have been described in the literature, but most of them failed to separate efficiently all the cannabinoids or were not validated according to general guidelines. By use of an innovative methodology for modelling chromatographic responses, a simple and accurate HPLC/DAD method was developed for the quantification of major neutral and acidic cannabinoids present in cannabis plant material: Δ9-tetrahydrocannabinol (THC), THC-acid (THCA), cannabidiol (CBD), CBD-acid (CBDA), cannabigerol (CBG), CBG-acid (CBGA) and cannabinol (CBN). Δ8-tetrahydrocannabinol (∆8-THC) was determined qualitatively. Following the practice of design of experiments, predictive multilinear models were developed and used in order to find optimal chromatographic analytical conditions. The method was validated following an approach using accuracy profiles based on β-expectation tolerance intervals for the total error measurement, and assessing the measurements uncertainty. This analytical method can be used for diverse applications, e.g. plant phenotype determination, evaluation of psychoactive potency and control of material quality. [less ▲]

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See detailInnovative green supercritical fluid chromatography development for the determination of polar compounds
Dispas, Amandine ULg; Lebrun, Pierre ULg; Sassiat, Patrick et al

in Journal of Chromatography. A (2012), 1256

In the context of green analytical chemistry, a supercritical fluid chromatography method was developed. In order to prove the potential of this technology, a worst case was selected, i.e. the separation ... [more ▼]

In the context of green analytical chemistry, a supercritical fluid chromatography method was developed. In order to prove the potential of this technology, a worst case was selected, i.e. the separation of very polar compounds. For that purpose, an innovative methodology based on design of experiments (DoE) and design space (DS) was previously developed and successfully tested on liquid chromatography. For the first time, this methodology was applied to a supercritical fluid chromatography (SFC) separation. First, a screening design was used to select the stationary phase and the nature of the mobile phase based on a maximization of the number of peaks eluted and a minimization of the number of co-eluted peaks. Then, a central composite design with orthogonal blocks defined a set of experiments used to model the retention times of each peak at the beginning, the apex, and the end. The gradient slope, the isocratic plateau before the gradient, the temperature, and the concentration of trifluoroacetic acid (TFA) in the mobile phase were the potentially influential factors. The critical quality attributes (CQAs), i.e. the separation (S) between peaks of the most critical pair, and the analysis time were the responses considered to assess the quality of the separation. The DS was computed as the multidimensional subspace where the probability for the separation and analysis time criteria to be within acceptance limits was higher than a defined quality level. The DS was computed propagating the prediction error from the modeled responses to the quality criterion using Monte Carlo simulations. The optimal condition was predicted at a gradient slope of 3.8% min−1 to linearly modify the modifier proportion between 5 and 40%, an isocratic time of 3 minutes, a concentration of TFA of 25 mM, and a temperature of 60.5 °C. This optimal condition was experimentally tested to confirm the prediction. Furthermore, chromatographic conditions included in the DS and on the limits of the DS were experimentally tested to assess the robustness of the developed SFC method. [less ▲]

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See detailInnovative high-performance liquid chromatography method development for the screening of 19 antimalarial drugs based on a generic approach, using design of experiments, independent component analysis and design space
Debrus, Benjamin ULg; Lebrun, Pierre ULg; Mbinze Kindenge, Jérémie et al

in Journal of Chromatography. A (2011), 1218

An innovative methodology based on design of experiments (DoE), independent component analysis (ICA) and design space (DS) was developed in previous works and was tested out with a mixture of 19 ... [more ▼]

An innovative methodology based on design of experiments (DoE), independent component analysis (ICA) and design space (DS) was developed in previous works and was tested out with a mixture of 19 antimalarial drugs. This global LC method development methodology (i.e. DoE–ICA–DS) was used to optimize the separation of 19 antimalarial drugs to obtain a screening method. DoE–ICA–DS methodology is fully compliant with the current trend of quality by design. DoE was used to define the set of experiments to model the retention times at the beginning, the apex and the end of each peak. Furthermore, ICA was used to numerically separate coeluting peaks and estimate their unbiased retention times. Gradient time, temperature and pH were selected as the factors of a full factorial design. These retention times were modelled by stepwise multiple linear regressions. A recently introduced critical quality attribute, namely the separation criterion (S), was also used to assess the quality of separations rather than using the resolution. Furthermore, the resulting mathematical models were also studied from a chromatographic point of view to understand and investigate the chromatographic behaviour of each compound. Good adequacies were found between the mathematical models and the expected chromatographic behaviours predicted by chromatographic theory. Finally, focusing at quality risk management, the DS was computed as the multidimensional subspace where the probability for the separation criterion to lie in acceptance limits was higher than a defined quality level. The DS was computed propagating the prediction error from the modelled responses to the quality criterion using Monte Carlo simulations. DoE–ICA–DS allowed encountering optimal operating conditions to obtain a robust screening method for the 19 considered antimalarial drugs in the framework of the fight against counterfeit medicines. Moreover and only on the basis of the same data set, a dedicated method for the determination of three antimalarial compounds in a pharmaceutical formulation was optimized to demonstrate both the efficiency and flexibility of the methodology proposed in the present study. [less ▲]

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See detailInnovative lactation stage specific prediction of CH4 from milk MIR spectra
Vanlierde, Amélie; Vanrobays, Marie-Laure ULg; Dehareng, Frédéric et al

in Book of abstracts of the 65th annual meeting of the European Federation of Animal Science (2014, August)

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See detailInnovative lactation stage specific prediction of CH4 from milk MIR spectra
Vanlierde, Amélie; Vanrobays, Marie-Laure ULg; Dehareng, Frédéric et al

Conference (2014, August 28)

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See detailInnovative Learning for Collaborative Design in Ergonomics
Folcher, Viviane; Zreik, Khaldoun; Ben Rajeb, Samia ULg et al

in Stouffs, Rudy; Sariyildiz, Sevil (Eds.) Computation and Performance (2013)

The proposed article deals with introducing collaborative architectural design into the training of ergonomists at the Master 2 level. The collaborative design workshop aims to confront ergonomists with ... [more ▼]

The proposed article deals with introducing collaborative architectural design into the training of ergonomists at the Master 2 level. The collaborative design workshop aims to confront ergonomists with the difficulties any design project involves, and which challenge architects, designers, engineers and so on: collaboration between people with different skills and different expertise; powerful time constraints; need for their work to converge; working together and/or at a distance; sharing documents; decision-making, etc. The article will present a short review of work carried out in the domains of architecture and design, and of the contribution of ergonomics within architectural projects. We shall then present the workshop’s educational aims, and give details of the way it functioned. Finally, observation results will be presented and discussed. [less ▲]

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See detailAn innovative lens surface functionalization to control Posterior Capsular Opacification
Huang, Yi-Shiang ULg

Poster (2014, May 26)

Cataract is the opacity of the lens, causing impairment of vision or even blindness and the surgery is still the only available treatment today. The intraocular lens (IOL) is a polymer implant designed to ... [more ▼]

Cataract is the opacity of the lens, causing impairment of vision or even blindness and the surgery is still the only available treatment today. The intraocular lens (IOL) is a polymer implant designed to replace the natural lens in the cataract surgery. However, the bio-inert materials could not satisfy the unmet need in the secondary cataract control. Posterior capsular opacification (PCO, or Secondary Cataract), characterized by a thick and cloudy layer of lens epithelial cells (LECs), is the most common postoperative complication. For the present study, a bioactive molecule is immobilized onto the conventional acrylic hydrophilic polymer pHEMA (Poly(2-hydroxyethyl methacrylate)) using oxygen plasma treatment followed by dip-coating deposition. The RGD peptide sequence, being well-known for its ability to promote cellular attachment by binding to integrin receptors, is designed to stimulate the adhesion of LECs on the IOL. The data have shown the peptide immobilized biomaterial not only exhibits similar optical and physical properties, but also reveals enhanced bio-logical properties in cell adhesion and cell morphology maintenance. By means of surface functionalization of IOL to stimulate LECs adhesion, the secondary cataract could be controlled. [less ▲]

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