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See detailExploring new achievements in olefin metathesis catalysts. Part 2 - Compelling innovations in ruthenium complexes
Dragutan, Ileana; Dragutan, Valerian; Delaude, Lionel ULiege et al

in Chimica Oggi = Chemistry Today (2009), 27(3), 13-16

This part of the survey introduces recent developments on de novo designed types of ruthenium complexes used as promoters in olefin metathesis reactions. Encompassing diversity-oriented initiators not ... [more ▼]

This part of the survey introduces recent developments on de novo designed types of ruthenium complexes used as promoters in olefin metathesis reactions. Encompassing diversity-oriented initiators not illustrated in Part 1, in this second part of the review emphasis is placed on the leading role played by distinct ligands in an exquisite control of metathesis reactions. [less ▲]

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See detailExploring new dimensions in cadaveric decomposition odour analysis
Stefanuto, Pierre-Hugues ULiege; Perrault, Katelynn; Lloyd, Rebecca et al

in Analytical Methods (2015), 7

This study demonstrates the first documented use of comprehensive two-dimensional gas chromatography – high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS) for volatile organic compound ... [more ▼]

This study demonstrates the first documented use of comprehensive two-dimensional gas chromatography – high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS) for volatile organic compound analysis in the forensic sciences. High-resolution mass spectral data provided higher confidence in analyte identification. GC×GC-HRTOFMS will be valuable for future studies of decomposition odour and other complex volatile matrices. [less ▲]

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See detailExploring new dimensions in cadaveric decomposition odour profiling using GC×GC-HRTOFMS
Perrault, Katelynn ULiege; Stefanuto, Pierre-Hugues ULiege; Lloyd, R et al

Conference (2015, September)

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See detailExploring PNS in Fabry disease
WANG, François-Charles ULiege; BOUQUIAUX, Olivier ULiege

Scientific conference (2013, November 19)

Detailed reference viewed: 18 (4 ULiège)
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See detailExploring possibilities through imagination. What can be conceived and what can be seen
Leclercq, Bruno ULiege

Conference (2017, September 29)

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See detailExploring potentialities of RanbP2-type Zinc Fingers in RNA-binding proteins design
De Franco, Simona ULiege; Vandenameele, Julie ULiege; Galleni, Moreno ULiege et al

Poster (2016, June 29)

Transcriptomes consist of several classes of RNAs, whose roles are central to innumerable biological processes as well as diseases. These observations justify the increasing interest in the engineering of ... [more ▼]

Transcriptomes consist of several classes of RNAs, whose roles are central to innumerable biological processes as well as diseases. These observations justify the increasing interest in the engineering of functionalized RNA-binding proteins (RBPs) to specifically manipulate RNA function. In this context, the RanBP2-type Zinc Finger (ZF) domain emerged as a suitable scaffold for single-stranded RBPs design. The present study aimed to identify the sequence-specificity of several naturally occurring RanBP2-type ZFs by in vitro selection and use the natural variation in their substrate to create arrays of ZF domains displaying customized specificity. A parallel kinetic and thermodynamic characterization of ssRNA-ZFs interaction was performed by Isothermal Titration Calorimetry (ITC) and BioLayer Interferometry (BLI), respectively. Although our data showed that only little variations in the recognized sequence could be observed for the studied ZFs, they contribute to elucidate the molecular basis for the RanBP2-type ZF-ssRNA interaction. [less ▲]

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See detailExploring self-defining memories in schizophrenia.
Raffard, Stephane; D'Argembeau, Arnaud ULiege; Lardi, Claudia et al

in Memory (2009), 17(1), 26-38

Previous studies have shown that patients with schizophrenia are impaired in recalling specific events from their personal past. However, the relationship between autobiographical memory impairments and ... [more ▼]

Previous studies have shown that patients with schizophrenia are impaired in recalling specific events from their personal past. However, the relationship between autobiographical memory impairments and disturbance of the sense of identity in schizophrenia has not been investigated in detail. In this study the authors investigated schizophrenic patients' ability to recall self-defining memories; that is, memories that play an important role in building and maintaining the self-concept. Results showed that patients recalled as many specific self-defining memories as healthy participants. However, patients with schizophrenia exhibited an abnormal reminiscence bump and reported different types of thematic content (i.e., they recalled less memories about past achievements and more memories regarding hospitalisation and stigmatisation of illness). Furthermore, the findings suggest that impairments in extracting meaning from personal memories could represent a core disturbance of autobiographical memory in patients with schizophrenia. [less ▲]

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See detailExploring sex differences in the adult zebra finch brain: in vivo diffusion tensor imaging and ex vivo super-resolution track density imaging
Hamaide, J.; De Groof, G.; Van Steenkiste, G. et al

in NeuroImage (2017), 146

Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural ... [more ▼]

Zebra finches are an excellent model to study the process of vocal learning, a complex socially-learned tool of communication that forms the basis of spoken human language. So far, structural investigation of the zebra finch brain has been performed ex vivo using invasive methods such as histology. These methods are highly specific, however, they strongly interfere with performing whole-brain analyses and exclude longitudinal studies aimed at establishing causal correlations between neuroplastic events and specific behavioral performances. Therefore, the aim of the current study was to implement an in vivo Diffusion Tensor Imaging (DTI) protocol sensitive enough to detect structural sex differences in the adult zebra finch brain. Voxel-wise comparison of male and female DTI parameter maps shows clear differences in several components of the song control system (i.e. Area X surroundings, the high vocal center (HVC) and the lateral magnocellular nucleus of the anterior nidopallium (LMAN)), which corroborate previous findings and are in line with the clear behavioral difference as only males sing. Furthermore, to obtain additional insights into the 3-dimensional organization of the zebra finch brain and clarify findings obtained by the in vivo study, ex vivo DTI data of the male and female brain were acquired as well, using a recently established super-resolution reconstruction (SRR) imaging strategy. Interestingly, the SRR-DTI approach led to a marked reduction in acquisition time without interfering with the (spatial and angular) resolution and SNR which enabled to acquire a data set characterized by a 78μm isotropic resolution including 90 diffusion gradient directions within 44h of scanning time. Based on the reconstructed SRR-DTI maps, whole brain probabilistic Track Density Imaging (TDI) was performed for the purpose of super resolved track density imaging, further pushing the resolution up to 40μm isotropic. The DTI and TDI maps realized atlas-quality anatomical maps that enable a clear delineation of most components of the song control and auditory systems. In conclusion, this study paves the way for longitudinal in vivo and high-resolution ex vivo experiments aimed at disentangling [less ▲]

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See detailExploring Structure and Reformulations in Different Integer Programming Algorithms
Louveaux, Quentin ULiege

Doctoral thesis (2004)

In this thesis we consider four topics all related to using problem reformulations in order to solve integer programs, i.e. optimization problems in which the decision variables must be integer. We first ... [more ▼]

In this thesis we consider four topics all related to using problem reformulations in order to solve integer programs, i.e. optimization problems in which the decision variables must be integer. We first consider the polyhedral approach. We start by addressing the ques- tion of lifting valid inequalities, i.e. finding a valid inequality for a set Y from the knowledge of a valid inequality for a lower-dimensional restriction X of Y . We simplify and clarify the presentation of the procedure. This allows us to derive conditions under which the computation of the lifting is tractable. The second topic is the study of valid inequalities for the single node flow set. The single node flow set is the problem obtained by considering one node of a fixed charge network flow problem. We derive valid inequalities for this set and various generalizations. Our approach is a systematic procedure using only basic tools of integer programming: fixing and complementing variables, mixed- integer rounding and lifting. The method allows us to explain and generate a large range of inequalities describing the convex hull of such sets. The last two topics are based on non-standard approaches for integer pro- gramming. We first show how the group relaxation approach can be used to provide reformulations for the integral basis method. This is based on a study of extended formulations for the group problem. We present four extended for- mulations and show that the projections of three of these formulations provide the convex hull of the original group problem. Initial computational tests of the approach are also reported. Finally we consider a problem that is difficult for the standard branch-and- bound approach even for small instances. A reformulation based on lattice basis reduction is known to be more effective. However the step to compute the re- duced basis is O(n4) and becomes a bottleneck for small to medium instances. By using the structure of the problem, we show that we can decompose the problem and obtain the basis by taking the kronecker product of two smaller bases easier to compute. Furthermore, if the two small bases are reduced, the kronecker product is also reduced up to a reordering of the vectors. Computa- tional results show the gain from such an approach. [less ▲]

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See detailExploring The Active Site Cavity Of Human Pancreatic Lipase
Colin, Damien Yann; Deprez-Beauclair, Paule; Allouche, Maya et al

in Biochemical and Biophysical Research Communications (2008), 370(3), 394-8

Within the scope of improving the efficiency of pancreatic enzyme replacement therapy in cystic fibrosis, the feasibility of shifting the pH-activity profile of pancreatic lipase toward acidic values was ... [more ▼]

Within the scope of improving the efficiency of pancreatic enzyme replacement therapy in cystic fibrosis, the feasibility of shifting the pH-activity profile of pancreatic lipase toward acidic values was investigated by site specific mutagenesis in different regions of the catalytic cavity. We have shown that introducing a negative charge close to the catalytic histidine induced a shift of the pH optimum toward acidic values but strongly reduced the lipase activity. On the other hand, a negative charge in the entrance of the catalytic cleft gives rise to a lipase with improved properties and twice more active than the native enzyme at acidic pH. [less ▲]

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See detailExploring the Antarctic soil metagenome as a source of novel cold-adapted enzymes and genetic mobile elements
Berlemont, Renaud ULiege; Pipers; Delsaute, Maud ULiege et al

in Revista Argentina de Microbiologia (2011)

Metagenomic library PP1 was obtained from Antarctic soil samples. Both functional and genotypic metagenomic screening were used for the isolation of novel cold-adapted enzymes with potential applications ... [more ▼]

Metagenomic library PP1 was obtained from Antarctic soil samples. Both functional and genotypic metagenomic screening were used for the isolation of novel cold-adapted enzymes with potential applications, and for the detection of genetic elements associated with gene mobilization, respectively. Fourteen lipase/esterase-, 14 amylase-, 3 protease-, and 11 cellulase-producing clones were detected by activity-driven screening, with apparent maximum activities around 35 °C for both amylolytic and lipolytic enzymes, and 35-55 °C for cellulases, as observed for other cold-adapted enzymes. However, the behavior of at least one of the studied cellulases is more compatible to that observed for mesophilic enzymes. These enzymes are usually still active at temperatures above 60 °C, probably resulting in a psychrotolerant behavior in Antarctic soils. Metagenomics allows to access novel genes encoding for enzymatic and biophysic properties from almost every environment with potential benefits for biotechnological and industrial applications. Only intI- and tnp-like genes were detected by PC R, encoding for proteins with 58-86%, and 58-73% amino acid identity with known entries, respectively. Two clones, BAC 27A-9 and BAC 14A-5, seem to present unique syntenic organizations, suggesting the occurrence of gene rearrangements that were probably due to evolutionary divergences within the genus or facilitated by the association with transposable elements. The evidence for genetic elements related to recruitment and mobilization of genes (transposons/integrons) in an extreme environment like Antarctica reinforces the hypothesis [less ▲]

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See detailExploring the bacterial diversity of Belgian steak tartare using metagenetics and qPCR analysis
Delhalle, Laurent ULiege; Korsak Koulagenko, Nicolas ULiege; Taminiau, Bernard ULiege et al

in Journal of Food Protection (2016), 79(2), 220-229

Steak tartare is a popular meat dish in Belgium. It is prepared with raw ground minced beef and eaten with sauce, vegetables, and spiced. Since it contains raw meat, steak tartare is highly prone to ... [more ▼]

Steak tartare is a popular meat dish in Belgium. It is prepared with raw ground minced beef and eaten with sauce, vegetables, and spiced. Since it contains raw meat, steak tartare is highly prone to bacterial spoilage. The objective of this study was to explore the bacterial flora diversity in steak tartare in Belgium according to the source and to determine which bacteria are able to grow during the shelf life. A total of 58 samples from butchers’ shops, restaurants, sandwich shops and supermarkets were collected. These samples were analyzed using 16S rDNA metagenetics, a classical microbiological technique, and quantitative real-time PCR (qPCR) targeting the Lactobacillus genus. Samples were analyzed at the beginning and at the end of their shelf life, except for those from restaurants and sandwich shops analyzed only at the purchase date. Metagenetic analysis identified up to 180 bacterial species and 90 genera in some samples. But only seven bacterial species were predominant in the samples, depending on the source: Brochothrix thermosphacta, Lactobacillus algidus, Lactococcus piscium, Leuconostoc gelidum, Photobacterium kishitani, Pseudomonas spp. and Xanthomonas oryzae. With this work, an alternative method is proposed to evaluate the total flora in food samples based on the number of reads from metagenetic analysis and the results of qPCR. The degree of underestimation of aerobic plate counts (APCs) at 30°C estimated with the classical microbiology method was demonstrated in comparison with the proposed culture independent method. Compared to culture-based methods, metagenetic analysis combined with qPCR targeting Lactobacillus provides valuable information for characterizing the bacterial flora of raw meat. [less ▲]

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See detailExploring the cultural politics of labour in South China
Florence, Eric ULiege

Scientific conference (2013, June 20)

Detailed reference viewed: 19 (0 ULiège)
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See detailExploring the Deltaretrovirus Tumor Transcriptome: Lessons from RNA-Seq
Rosewick, Nicolas; Durkin, Keith ULiege; Thys, Wannes et al

Conference (2014, June)

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See detailExploring the Diversity of Fair Trade Social Enterprises
Huybrechts, Benjamin ULiege; Defourny, Jacques ULiege

E-print/Working paper (2010)

Fair trade (FT) organisations have been quite early taken as examples of social enterprises (SE) and have contributed to the shaping of the SE concept. The goal of this article is to examine more deeply ... [more ▼]

Fair trade (FT) organisations have been quite early taken as examples of social enterprises (SE) and have contributed to the shaping of the SE concept. The goal of this article is to examine more deeply, both at a conceptual and at an empirical level, to what extent FT organisations can be considered as social enterprises. First, we introduce different theoretical frameworks of SE and examine FT in the context of each of these frameworks. In a second step, we use an empirical study on fair trade social enterprises (FTSEs) across four European countries to illustrate and deepen the links between FT and SE, focusing on the goals and the governance structures of FTSEs. It appears that all FTSEs combine in some way economic, social and sometimes also political goals. FTSEs are thus in line with the "hybrid-goal" nature of SEs. FTSEs' governance is also quite specific and often innovative in terms of organisational architecture and stakeholders' involvement. Some FTSEs are closer to the European – participatory – approach of social enterprise, while others are closer to US – individual – approaches. Finally, the governance structures of FTSEs seem to reflect quite well their goal mix. This article provides a more solid basis for the often implicit link between FT and SE. Future researches could use our work to explore specific topics of the SE literature (e.g. stakeholders' involvement) in the context of FT. The FT example could also be used to examine further the shifting boundaries of the SE reality. The originality of this article is to apply the SE concept to a specific field and to show how, within this field, there is at the same time (1) a diversity of organisations, reflecting the diversity of SE approaches and (2) a range of specific features (especially in terms of goal mix and governance) distinguishing SEs from other types of organisations operating in the same field. [less ▲]

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See detailExploring the effect of a second closely-timed infiltration of platelet-rich plasma to treat proximal patellar tendinopathies
Kaux, Jean-François ULiege; CROISIER, Jean-Louis ULiege; FORTHOMME, Bénédicte ULiege et al

in European Journal of Physical and Rehabilitation Medicine (2016, April), 54(Suppl. 1 No. 2), 199

Intorduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to ... [more ▼]

Intorduction: Some clinical series have evaluated the effect of platelet-rich plasma (PRP) in the treatment of jumper’s knee. Although it is possible that a single infiltrative administration may prove to be an effective treatment for this indication, most of the existing studies evaluated the effects of 2 or 3 successive infiltrations. Purpose: The aim of this study was to evaluate whether 2 infiltrations of PRP proves more effective than a single treatment. Methods: Twenty patients suffering from chronic jumper’s knee were enrolled into the study and split into two randomized groups (1 or 2 infiltrations of PRP, respectively). The 3-month follow-up evaluation consisted of VAS, IKDC and VISA-P scores, along with algometer, isokinetic and ultrasounds evaluations. After 1 year, subjects were contacted to define their functional evolution. Results: The concentration of the PRP used for each infiltration was similar in both groups, and contained no red or white cells. Results revealed no difference in treatment efficacy between the groups. Discussion and Conclusion: The comparison between 1 or 2 infiltrations of PRP did not reveal any difference between the 2 groups at short to mid term. A second closely-timed infiltration of PRP to treat jumper’s knees is not necessary to improve the efficacy of this treatment in the short term. A second infiltration should perhaps be envisaged later, but this remains to be demonstrated. [less ▲]

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