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See detailFrom shallow water to deep mound - sedimentology and stromatoporoids paleoecology from the Frasnian (Upper Devonian) of Belgium
Da Silva, Anne-Christine ULg; Kershaw, Stephen; Boulvain, Frédéric ULg

in Kölner Forum für Geologie und Paläontologie (2011), 19

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See detailFrom shared competences to institutional heteronomy. The constitutional architecture of supranationally structured market supervision
Van Cleynenbreugel, Pieter ULg

Doctoral thesis (2013)

The European Union plays an ever increasing role in the institutional organisation of market supervision, by either creating new supranational supervisory bodies or by circumscribing Member States ... [more ▼]

The European Union plays an ever increasing role in the institutional organisation of market supervision, by either creating new supranational supervisory bodies or by circumscribing Member States autonomy in designing national supervisory authorities. European Union law draws particularly volatile legal boundaries that create a playing field between supranational policymaking and national institutional choices. This dissertation aims to identify those legal boundaries. In doing so, it additionally seeks to analyse the role of European Union law in the determination and delineation of such boundaries as part of the EU s larger federalism project. The dissertation comprises two main parts. The first part structures the key characteristics of supranationally structured market supervision in the European Union. To that extent, the dissertation studies whether and to what extent supervisory powers are being shared betweensupranational and national actors, the institutional actors responsibleand cooperative mechanisms created by supranational law across different sectors of market regulation. The part particularly focuses on two differently structured market supervision regimes: competition law supervision and financial market supervision. The second part builds upon the key characteristics identified by structuring them into a constitutional framework of competence attribution and competence exercise engaged upon by EU institutions. In particular, this part seeks to assess to what extent the key characteristics reflect a translation of EU constitutional principles in accordance with a particular model of European federalism. Identifying that model allows to better explain and predict institutional evolutions across differently regulated market segments. [less ▲]

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See detailFrom skin microrelief to wrinkles. An area ripe for investigation.
Pierard, Gérald ULg; Uhoda, Isabelle; Pierard, Claudine ULg

in Journal of Cosmetic Dermatology (2003), 2(1), 21-8

Skin microrelief alters progressively with age. Wrinkles do not result from these changes but are superimposed upon them. Wrinkles result from structural changes in the epidermis, dermis and hypodermis ... [more ▼]

Skin microrelief alters progressively with age. Wrinkles do not result from these changes but are superimposed upon them. Wrinkles result from structural changes in the epidermis, dermis and hypodermis. Four types of wrinkles can be recognized. Type 1 wrinkles are atrophic. Type 2 wrinkles are elastotic. Type 3 wrinkles are expressional. Type 4 wrinkles are gravitational. Each type of wrinkle is characterized by distinct microanatomical changes and each type of wrinkle develops in specific skin regions. Each is likely to respond differently to treatment. Skin microrelief and skin folds can be identified on histological examination. By contrast, only minimal dermal changes are found beneath permanent or reducible wrinkles compared with immediately adjacent skin. A series of objective and non-invasive methods is available to quantify the severity of wrinkling. [less ▲]

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See detailFrom some obscurity to clarity in Boom clay behavior: Analysis of its coupled hydro-mechanical response in the presence of strain localization
Salehnia, Fatemeh ULg

Doctoral thesis (2015)

Deep disposal of the high-level and high-lived radioactive wastes in the potential geological formations is envisaged as a possible solution in the framework of long-term management of these wastes. The ... [more ▼]

Deep disposal of the high-level and high-lived radioactive wastes in the potential geological formations is envisaged as a possible solution in the framework of long-term management of these wastes. The argillaceous materials, namely Boom Clay, are potential to constitute the natural barrier aimed at confining the nuclear waste and protecting the biosphere from it. Around galleries excavated at depth in these media, the creation of a damaged zone with significant irreversible deformation is generally unavoidable. A considerable change in the host rock properties could be likely resulted in this zone, which may potentially be important with respect to the long-term evolution and the performance of the system. In this context, a paramount interest addresses characterization of the so-called Excavation Damaged Zone (EDZ), predicting its extent, and development of localized fracturing during and after the underground excavation in the host rock. This constitutes the foundation of this work, focusing on the Boom Clay formation as the reference potential host rock in Belgium. Dealing with this purpose, providing a state of knowledge on the hydro-mechanical behavior of Boom Clay, and validating a set of parameters which could realistically reproduce its response through the numerical modelings are firstly addressed as the requisites. Moreover, a special focus is made on the dilatation factor of the rock, commonly described through the dilatancy angle parameter. Correct estimation of the dilatant behavior of a rock has an essential role in a realistic simulation of its volumetric behavior, fracturing threshold during the rock deformation process and its post-failure response. Therefore, a new formula is developed for consideration of the variable dilatancy angle, incorporated into an internal frictional elasto-plastic hardening/softening model, within the LAGAMINE finite element code. This development overcomes the inconveniences associated to using a constant dilatancy angle, for instance encountered in our numerical simulations of some laboratory small-scale tests as well as a large-scale excavation. This study then focuses more particularly on simulation of EDZ extension at the large scale excavation, around the Connecting gallery (in the HADES URL, Mol, Belgium), through analyzing the evolution of strain localization in shear bands mode. The modeling takes into account of the initial anisotropic stresses, mechanical cross-anisotropy, anisotropic permeabilities, and gravity effects. As a result, an eye-shape extension of EDZ accompanied by an anisotropic convergence of the rock is predicted. A coupled analysis addresses the pore water pressure distribution during the excavation period and in long-term while no more evolution of the localized shear bands is predicted. To assess the reliability of the numerical results, some available in-situ measurements and observations, within the clay, during the gallery's construction and afterwards are precisely analyzed, and then compared with the corresponding numerical predictions. As a result, a good agreement is found between the in-situ data and simulated results. Moreover, the above study is integrated with a particular analysis of the contact mechanism on the interface between the clay and the gallery's lining. Thence, the coupled interface element is introduced to deal with the contact phenomenon. The obtained results reveal some interesting features regarding the development of contact pressure on the interface linked to the evolution pattern of strain localization within the clay around the gallery. Furthermore, with regard to the own lining behavior, a development of the modeling with the aim of consideration of a discontinuous lining (made of the segments as the real case) is performed. We propose an approach to realistically reproduce the response of the lining's segments and their contact phenomena in the course of a long-term simulation. Defining the interface elements between the neighboring segments, with respect to the real installation procedure of the lining during the gallery construction, this process is aimed to be simulated through some evolution of the contact pressure on the segments' interfaces. As a result, a considerable improvement is achieved in reproducing the in-situ measurements provided in the lining. The numerical and measured evolution of strain and displacement are in a good agreement. [less ▲]

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See detailFrom spectrophotometry to multispectral imaging of ore minerals in visible and near infrared (VNIR) microscopy.
Pirard, Eric ULg; Bernhardt, Heinz-Juergen; Catalina, Juan-Carlos et al

in GU; BUTCHER (Eds.) Proceedings of ICAM 2008 (2008)

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See detailFrom spherical to cyclindrical micelles formed by polystyrene-b-poly(2-vinylpyridine)-b-poly(ethylene oxide) copolymer in water
Lei, Liangcai; Gohy, Jean-François; Willet, Nicolas ULg et al

Poster (2003, May 16)

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See detailFrom Sputnik to Beanie Babies & CubeSats to OUFTI
Verly, Jacques ULg

Conference given outside the academic context (2014)

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See detailFrom standard logic to logic programming: introducing a logic based approach to artificial intelligence
Gochet, Paul; Grégoire Eric; Gribomont, Pascal ULg et al

Book published by John Wiley & Sons (1988)

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See detailFrom Statistical to Biological Interactions via Omics Integration
Bessonov, Kyrylo ULg

Doctoral thesis (2016)

The XXI century opened a new ‘Big Data’ era in which, thanks to rapid technological advancements and appearance of high throughput technologies, vast amounts of omics data (e.g., transcriptomic, genomic ... [more ▼]

The XXI century opened a new ‘Big Data’ era in which, thanks to rapid technological advancements and appearance of high throughput technologies, vast amounts of omics data (e.g., transcriptomic, genomic, etc.) are generated every day. This thesis mainly focuses on solving the problems related diverse omics data integration and interaction identification tasks. Particular attention is given to useful knowledge extraction in the context of complex diseases including pathological mechanisms with the development of software tools and pipelines. The diseases covered included glioblastoma multiforme, asthma, and ankylosing spondylitis. Interactions detection in genomic data requires standardization of the protocols. In Chapter 3, we tested the impact of different settings in a genome-wide association interaction (GWAI) study. Some of the settings included marker selection strategy, the LD pruning, lower order effects adjustment, analytical tool. We were able to show that even small changes in each setting can have drastic impacts requiring careful assessment of proper settings and results comparisons across several analysis protocols. The greatest impact was attributed to the input dataset composition highlighting the importance of the marker selection strategy and use of prior knowledge. Expression of genes can be affected by nearby (‘cis’) or distant (‘trans’) genotypes. Thus, we developed methodology to identify complex trans/cis regulatory mechanisms between expression and genotype data in the context of asthma (CAMP data). Significant overlap between ‘trans’ and ‘cis’ gene regulatory components related to immune and signaling pathways was clearly identified matching asthma disease pathology. The semi-parametric Model-Based Multifactor Dimensionality Reduction (MB-MDR) method was applied for the first time in the context eQTL study achieving low false discovery and family-wise error rates (FDR and FWER). Identification of a meaningful data structure from omics data is a pressing topic nowadays. Gene regulatory networks (GRN) conveniently summarize large amounts of data allowing for useful knowledge generation. GRN inference is especially attractive for deciphering of complex diseases mechanisms allowing biologists to formulate a better hypothesis. We were able to generate GRNs from a single source (e.g., microarray expression data) using conditional inference forest (CIF) with more attractive features compared to classical Random-Forest (RF) including unbiased node variable selection even in the context of highly correlated variables particularly relevant in transcriptomics. The CIF methods provided attractive features and performance characteristics coupled to valuable pathological insights into type 1 diabetes. [less ▲]

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See detailFrom strokes to model: a bottom-up approach for sketching activities analysis. Workshop.
Safin, Stéphane ULg; Juchmes, Roland ULg; Elsen, Catherine ULg et al

Conference (2008)

This paper proposes a framework for sketches analysis that could be useful for sketch-based interfaces development, in the particular context of preliminary activity-centred design. We will first describe ... [more ▼]

This paper proposes a framework for sketches analysis that could be useful for sketch-based interfaces development, in the particular context of preliminary activity-centred design. We will first describe our previous works on sketch-based support tools for the preliminary design phases and the context of these researches. The next chapter declares the concrete objectives of our approach, then the methodology of sketches analysis we propose is presented with a concrete example, and finally the last section is dedicated to the expected results and specifications of a sketch-based support tool that would follow our framework. [less ▲]

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See detailFrom subspace learning to distance learning: a geometrical optimization approach
Meyer, Gilles ULg; Journée, Michel; Bonnabel, Silvère et al

in Proceedings of the 2009 IEEE Workshop on Statistical Signal Processing (SSP2009) (2009)

In this paper, we adopt a differential-geometry viewpoint to tackle the problem of learning a distance online. As this prob- lem can be cast into the estimation of a fixed-rank positive semidefinite (PSD ... [more ▼]

In this paper, we adopt a differential-geometry viewpoint to tackle the problem of learning a distance online. As this prob- lem can be cast into the estimation of a fixed-rank positive semidefinite (PSD) matrix, we develop algorithms that ex- ploits the rich geometry structure of the set of fixed-rank PSD matrices. We propose a method which separately updates the subspace of the matrix and its projection onto that subspace. A proper weighting of the two iterations enables to continu- ously interpolate between the problem of learning a subspace and learning a distance when the subspace is fixed. [less ▲]

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See detailFrom synchronous to asynchronous communication
Gribomont, Pascal ULg

in Specification and Verification of Concurrent Systems (1990)

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See detailFrom taboo to commodity: history and current situation of cavy culture in the Democratic Republic of the Congo
Maass; Metre, TK; Tsongo, F et al

in Livestock Research for Rural Development (2014), 26

For the first time, the status of cavy culture in the Democratic Republic of the Congo (DRC) is reviewed with emphasis on Sud-Kivu province. Cavy culture, as discussed in this paper, is the raising ... [more ▼]

For the first time, the status of cavy culture in the Democratic Republic of the Congo (DRC) is reviewed with emphasis on Sud-Kivu province. Cavy culture, as discussed in this paper, is the raising, production and utilization of the domestic cavy (i.e., Guinea pig, Cavia porcellus) for consumption. Many sources were used in the review, but published scientific research literature is extremely scarce. Nevertheless, it can be estimated that more than 2 million cavies are kept in DRC, contributing significantly to nutrition security, especially animal protein, and income generation of some hundreds of thousands of poor rural and urban households. The largest cavy populations are in the Kivu provinces, which is probably partly due to the inclusion of cavies in ‘rehabilitation kits’ of humanitarian NGOs and in the agricultural portfolio of development agencies who seek to address the challenges of widespread hunger and malnutrition in the area. The review covers the history of cavy culture in Sud-Kivu since colonial times based on oral tradition; it describes the current ‘cavy status’ in the country and identifies research and capacity building needs. We suggest that cavy culture in DRC is likely to become more widespread and important due to the activities of a new project on ‘Harnessing husbandry of domestic cavy for alternative and rapid access to food and income in Cameroon and the eastern Democratic Republic of the Congo’. Given the dimension, cavies should be included in livestock census as well as research and development agenda, honoring their role in the livelihoods of less endowed people, especially women. [less ▲]

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See detailFrom the Annales de la régie directe to Annals of Public and Cooperative Economics: 100 years of Transformations in an International Economic Journal
Geerkens, Eric ULg

in Annals of Public and Cooperative Economics = Annales de l'Economie Publique, Sociale et Coopérative (2008), 79(3/4), 417-460

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See detailFrom the Clinics to the Bench and back to the Clinics: design of a medical treatment for Cervical Intraepithelial Neoplasia (CIN)
Jost, Maud; Frankenne, Francis; Maillard, Catherine ULg et al

Conference (2011, May 20)

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See detailFrom the curriculum framework to its dissemination: the accompaniment of educational practices in care facilities for children under three years
Pirard, Florence ULg

in European Early Childhood Education Research Journal (2011), 19(2), 255-268

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See detailfrom the deepest mud mound to the shallowest palaeosoils: correlations and sequence stratigraphy
Da Silva, Anne-Christine ULg; Boulvain, Frédéric ULg

in Abstract book 13th Bathurst meeting of carbonate sedimentologists (2007)

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See detailFrom the design to the clinical application of thromboxane modulators
Dogné, Jean-Michel ULg; Hanson, Julien ULg; de Leval, Xavier et al

in Current Pharmaceutical Design (2006), 12(8), 903-923

Arachidonic acid (AA) metabolites are key mediators involved in the pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases. One of these bioactive metabolites of ... [more ▼]

Arachidonic acid (AA) metabolites are key mediators involved in the pathogenesis of numerous cardiovascular, pulmonary, inflammatory, and thromboembolic diseases. One of these bioactive metabolites of particular importance is thromboxane A(2) (TXA(2)). It is produced by the action of thromboxane synthase on the prostaglandin endoperoxide H-2 (PGH(2)) which results from the enzymatic transformation of AA by the cyclooxygenases. It is a potent inducer of platelet aggregation, vasoconstriction and bronchoconstriction, and has been involved in a series of major pathophysiological conditions. Therefore, TXA(2) receptor antagonists, thromboxane synthase inhibitors and drugs combining both properties have been developed by different laboratories since the early 1980s. Several Compounds have been launched on the market and others are tinder clinical evaluation. In the first part of this review. we will describe the physiological properties of TXA(2), thromboxane synthase and thromboxane receptors. The second part is dedicated to a description of each class of thromboxane modulators with the advantages and disadvantages they offer. In the third part. we aim to describe recent studies performed with the most interesting thromboxane modulators in major pathologies: myocardial infarction and thrombosis, atherosclerosis, diabetes, pulmonary embolism, septic shock.. preeclampsia, and asthma. Each pathology will be systematically reviewed. Finally, in the last part we will highlight the latest perspectives in drug design of thromboxane modulators and in their future therapeutic applications such as cancer, metastasis and angiogenesis. [less ▲]

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