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See detailIA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry.
Gorus, F. K.; Goubert, P.; Semakula, C. et al

in Diabetologia (1997), 40(1), 95-9

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody ... [more ▼]

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody (IA-2-Ab) assay in 474 IDDM patients and 482 non-diabetic control subjects aged 0-3 years. IA-2-Ab were detected in 58% of the patients and 0.8% of control subjects. Their prevalence in patients was lower than that of islet cell autoantibodies (ICA; 73%) or glutamic acid decarboxylase (M(r) 65 kDa)-autoantibodies (GAD65-Ab; 82%) but higher than that of insulin autoantibodies (IAA; 42%). IA-2-Ab were more frequent in patients under age 20 years (70%) than between 20 and 40 years (45%; p < 0.001). In the whole IDDM group, 92% of patients were positive for at least one of the three molecular assays, which is higher than the positivity for the ICA assay (73%). Only 1% was negative in the molecular assays and positive in the ICA assay. IA-2-Ab levels were positively correlated with ICA titres (p < 0.001) and HLA DQ A1*0301-DQ B1*0.02 (p < 0.003) by multivariate analysis. In a group of 481 non-diabetic siblings (age 0-39 years) of IDDM patients only 7 were IA-2-Ab positive (1.5%). All seven were under age 20 years and positive for at least two other autoantibodies and for DQ A1*0301-DQB1*0302. Four of these seven developed IDDM during the 6-70-month follow-up period. The positive predictive value of IA-2-Ab (57%) was higher than that of ICA, GAD65-Ab or IAA alone, or in combination (< or = 20%) but these calculations are restricted by the relatively short observation period and the small number of cases. The only IA-2-Ab-negative case of pre-diabetes was also negative for IAA and GAD65-Ab, while it was strongly positive for ICA. In conclusion, IA-2-Ab show a high diagnostic specificity for IDDM and are predictive markers of impending diabetes in siblings of patients. In combination with other molecular antibody assays they may replace ICA testing in future. Our data also indicate that other autoantibodies than IA-2-Ab, GAD65-Ab and IAA contribute to ICA. [less ▲]

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See detailIAA-oxidase activity and auxin protectors in nonrooting, rac, mutant shoots of tobacco in vitro
Faivre-Rampant, Odile; Kevers, Claire ULg; Gaspar, Thomas ULg

in Plant Science (2000), 153(1), 73-80

The peroxidase and IAA-oxidase activities, the degree of auxin protection and the amount of soluble phenolics were determined in in vitro cultured shoots of a nonrooting mutant, inc, of tobacco compared ... [more ▼]

The peroxidase and IAA-oxidase activities, the degree of auxin protection and the amount of soluble phenolics were determined in in vitro cultured shoots of a nonrooting mutant, inc, of tobacco compared to its wild homologue. The mutant and wild shoots showed similar peroxidase variations along the growth cycle of 21 days, but with higher levels of activity for the I ac mutant. During this growth cycle, the minimum of peroxidase activity occurred at day 14 for both tobacco whole shoots. However. this minimum of activity did not occur at the same day in the basal part of the stem, where roots may appear, of the two types of tobacco. Both mutant and wild whole shoots showed about the same IAA-oxidase activity in the fractions resulting from a gel filtration of the crude extracts through a sephadex G-100 column but differed in the degree of auxin protection. The rac shoots exhibited a very high level of auxin protectors of low molecular weight, among which chlorogenic acid. They were also characterized by eight to nine times higher level of soluble phenolics. The relationships between these biochemical aspects in relation to the absence of root formation in the me mutant are discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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See detailIan McEwan: Saturday – Roman eines herausragenden europäischen Erzählers
Pontzen, Alexandra ULg

in Deutsch in der Oberstufe – Ein Arbeits- und Methodenbuch – Neubearbeitung. Lehrer- und Materialienband (2008)

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See detailIAS Mesoscale Surface Circulation Observed Through Satellite Altimetry and its Influence in a Small Scale, Coastal Domain, Studied with a ROMS Model of the Cariaco Basin
Alvera Azcarate, Aïda ULg; Barth, Alexander ULg; Virmani, J. I. et al

Conference (2007)

The Intra-Americas Sea (IAS) surface circulation is characterized by large scale currents. The Caribbean current, which originates in the Lesser Antilles, travels westwards through the Caribbean Sea and ... [more ▼]

The Intra-Americas Sea (IAS) surface circulation is characterized by large scale currents. The Caribbean current, which originates in the Lesser Antilles, travels westwards through the Caribbean Sea and eastern Mexico and passes through the Gulf of Mexico to finally form the Gulf Stream. This complex system of currents is also characterized by a high mesoscale variability, such as eddies and meanders. The objectives of this work are twofold: first, the multi-scale surface circulation of the IAS is described using satellite altimetry. The topographic influence of the different basins forming the IAS, the characteristic time and spatial scales, and the time variability of the surface circulation will be addressed. The second objective is to analyze the influence of this large scale circulation on a small scale coastal domain with a ROMS-based model of the Cariaco basin (Venezuela). Cariaco is a deep (1400 m), semi-enclosed basin connected to the open ocean by two shallow channels (Tortuga and Centinela Channels). Its connection with the open sea, and therefore the ventilation of the basin, occurs in the surface layers. The Cariaco ROMS model will be used to study the exchanges of mass, heat and salt through the channels. A 1/60 degree ROMS model nested in the global 1/12 degree HYCOM model from the Naval Research Laboratory will be used for this study. In addition, a series of observations (satellite altimetry and in situ temperature, salinity and velocity data), will be used to assess the influence of the Caribbean circulation on the basin. [less ▲]

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See detailIATREION et ERGASTERION, les noms des lieux d’exercice des médecins privés dans le monde grec
Nissen, Cécile ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (2010), 79

À travers l’étude des termes grecs "iatreion" et "ergastèrion", cet article a pour objectif d’élucider non seulement les dénominations, mais aussi le statut et le fonctionnement des lieux d’exercice des ... [more ▼]

À travers l’étude des termes grecs "iatreion" et "ergastèrion", cet article a pour objectif d’élucider non seulement les dénominations, mais aussi le statut et le fonctionnement des lieux d’exercice des médecins grecs. L’enquête se fonde sur les occurrences de ces deux mots relevées dans la documentation papyrologique, épigraphique et littéraire. Malgré un corpus réduit, la confrontation des diverses sources permet de donner une image assez précise de l’organisation et du rôle joué par le "iatreion", des maux qui y étaient soignés et des traitements qui y étaient appliqués par les médecins. Quant à l’"ergastèrion", trois témoignages, un papyrus et surtout deux inscriptions découvertes à Métaponte et Magnésie du Méandre, suggèrent l’utilisation exceptionnelle de ce terme dans un contexte médical ; il semble alors désigner un centre de soins de taille plus importante, où exerçaient plusieurs médecins. [less ▲]

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See detailIatrogenic thyrotoxicosis. Causal circumstances, pathophysiology and principles of treatment. Review of the literature
Meurisse, Michel ULg; Preud'Homme, Laurence ULg; Lamberty, Geoffrey ULg et al

in Acta Chirurgica Belgica (2001), 101(6), 257-266

Thyrotoxicosis is the clinical syndrome that results when tissues are exposed to high levels of circulating thyroid hormones. In most instances, thyrotoxicosis is due to hyperthyroidism, a term reserved ... [more ▼]

Thyrotoxicosis is the clinical syndrome that results when tissues are exposed to high levels of circulating thyroid hormones. In most instances, thyrotoxicosis is due to hyperthyroidism, a term reserved for disorders characterized by overproduction of thyroid hormones by the thyroid gland. Nevertheless, thyrotoxicosis may also result from a variety of conditions other than thyroid hyperfunction. The present report focuses on the etiologies, pathophysiology and treatment of iatrogenic thyrotoxicosis. Iatrogenic thyrotoxicosis may be caused by 1) subacute thyroiditis (a result of lymphocytic infiltration, cellular injury, trauma or radiation) with release of preformed hormones into circulation, 2) excessive ingestion of thyroid hormones ("thyrotoxicosis factitia"), 3) iodine-induced hyperthyroidism (radiological contrast agents, topical antiseptics or other medications). Among these causes of iatrogenic thyrotoxicosis, that induced by the iodine overload and cytotoxicity associated with amiodarone represents a significant challenge. Successful management of amiodarone-induced thyrotoxicosis requires close cooperation between endocrinologists and endocrine Surgeons. Surgical treatment may have a leading yet often underestimated role in view of the potential life-threatening severity of this disease, whereas others kinds of iatrogenic thyrotoxicosis are usually treated conservatively. [less ▲]

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See detailL'iatrogénie cytostatique simulatrice. Apparence d'un pityriasis lichénoïde aigu induit par le pemetrexed.
SABATIELLO, Murielle ULg; Willemaers, Valentine; Lesuisse, Marianne et al

in Dermatologie Actualité (2011), 125

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See detailL'iatrogenie psoriasique.
Franchimont, Claudine ULg; PIERARD, Gérald ULg

in Revue Médicale de Liège (2012), 67(3), 139-42

Psoriasis is a common genetic disorder that may be initiated (drug-induced psoriasis) or exacerbated (drug-triggered psoriasis) by some drug intakes. Beta-blockers, lithium, some antimelarial drugs, non ... [more ▼]

Psoriasis is a common genetic disorder that may be initiated (drug-induced psoriasis) or exacerbated (drug-triggered psoriasis) by some drug intakes. Beta-blockers, lithium, some antimelarial drugs, non steroidal anti-inflammatory agents and tetracyclines are recognized to influence the clinical course of psoriasis. Other drugs are likely or possibly involved in this process. [less ▲]

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See detailThe IBA Guidelines on Party Representation in International Arbitration
Caprasse, Olivier ULg

in Revue de la Faculté de Droit de l'Université de Liège (2013), (305-318),

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See detailL'ibandronate (Bonviva), dans le traitement de l'osteoporose postmenopausique
Reginster, Jean-Yves ULg

in Revue Médicale de Liège (2006), 61(11), 783-6

Ibandronate is a nitrogen-containing bisphosphonate which has been shown to reduce vertebral fracture rates, when given orally either daily or intermittently. Non-vertebral antifracture efficacy of ... [more ▼]

Ibandronate is a nitrogen-containing bisphosphonate which has been shown to reduce vertebral fracture rates, when given orally either daily or intermittently. Non-vertebral antifracture efficacy of ibandronate has been derived from a post-hoc analysis focusing on patients at high risk of developing non-vertebral fractures (low bone mineral density at the femoral neck). Once-monthly administration of oral ibandronate has been linked to significantly greater increases in bone mineral density, at the spine, hip and femoral neck, compared to daily formulation. This monthly formulation has a safety profile similar to the one observed with the daily administration of the compound. Adherence to monthly bisphosphonates appears to be significantly higher than for daily or weekly administration. [less ▲]

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See detailIbandronate for the prevention of nonvertebral fractures: a pooled analysis of individual patient data.
Cranney, Ann; Wells, G. A.; Yetisir, E. et al

in Osteoporosis International (2009), 20(2), 291-7

SUMMARY: This analysis was conducted to assess the effect of high versus lower doses of ibandronate on nonvertebral fractures. The results were adjusted for clinical fracture, age, and bone density. The ... [more ▼]

SUMMARY: This analysis was conducted to assess the effect of high versus lower doses of ibandronate on nonvertebral fractures. The results were adjusted for clinical fracture, age, and bone density. The treatment effect was dose-dependent. Higher doses of ibandronate significantly reduced the risk of nonvertebral fractures more effectively compared with lower doses. INTRODUCTION: The objective of this study was to assess the efficacy of different doses of ibandronate on nonvertebral fractures in a pooled analysis. METHODS: Eight randomized trials of ibandronate were reviewed for inclusion. Alternative definitions of high versus low doses based on annual cumulative exposure (ACE) were explored. A time-to-event analysis was conducted using Kaplan-Meier methodology. Hazard ratios (HR) were derived using Cox regression and adjusted for covariates. RESULTS: Combining higher ACE doses of > or = 10.8 mg (150 mg once monthly, 3 mg i.v. quarterly, and 2 mg i.v. every 2 months) versus ACE doses of 5.5 mg, from two trials, resulted in an HR 0.62 (95% CI 0.396-0.974, p = 0.038). There was a dose-response trend with increasing ACE doses (7.2-12 mg) versus ACE of 5.5 mg. CONCLUSIONS: A dose-response effect on nonvertebral fractures was observed when comparing high with low ACE doses. A significant reduction in nonvertebral fractures was noted when pooling data from trials using ACE doses of > or = 10.8 mg versus ACE < or = 7.2 mg; and with ACE > or = 10.8 mg versus ACE of 5.5 mg (38% reduction). Higher ibandronate dose levels (150 mg monthly or 3 mg i.v. quarterly) significantly reduced nonvertebral fracture risk in postmenopausal women. [less ▲]

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See detailIbandronate in profile: drug characteristics and clinical efficacy.
Reginster, Jean-Yves ULg; Neuprez, Audrey; Bruyère, Olivier ULg

in Expert Opinion on Drug Metabolism & Toxicology (2008), 4(7), 941-51

BACKGROUND: Postmenopausal osteoporosis is a serious, chronic condition, for which nitrogen-containing bisphosphonates are now one of the treatments of choice. OBJECTIVE: To review the profile of ... [more ▼]

BACKGROUND: Postmenopausal osteoporosis is a serious, chronic condition, for which nitrogen-containing bisphosphonates are now one of the treatments of choice. OBJECTIVE: To review the profile of ibandronate, a monthly oral (150 mg) or quarterly intravenous injection (3 mg) of bisphosphonate. METHODS: The literature search was limited to publications of ibandronate data. RESULTS/CONCLUSION: Ibandronate is rapidly absorbed and distributed in the bone; it is not metabolised and is excreted in urine. Clinical trial data have demonstrated the efficacy of ibandronate in reducing fracture risk, increasing bone mineral density and reducing bone turnover. These data are supported by recent meta-analyses and a large database study that have demonstrated antifracture efficacy with the ibandronate regimens used in clinical practice. Overall, ibandronate has generally been well tolerated. Therefore, ibandronate is a useful treatment for postmenopausal osteoporosis. [less ▲]

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See detailIbandronate in the management of postmenopausal osteoporosis
Reginster, Jean-Yves ULg; Hiligsmann, Mickaël ULg; Rabenda, Véronique ULg et al

in Clinical Medicine. Therapeutics (2009), 1

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See detailIbandronate: a new perspective in the treatment of osteoporosis
Reginster, Jean-Yves ULg; Burlet, N.; LECART, Marie-Paule ULg

in Therapy (2005), 2

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See detailIBD mapping of recessive traits in livestock: application to map the bovine syndactyly locus to chromosome 15
Charlier, Carole ULg; Farnir, Frédéric ULg; Berzi, P. et al

in Genome Research (1996), 6

Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single ... [more ▼]

Twelve animals affected with syndactyly or mulefoot were sampled in the Dutch black-and-white cattle population. Analysis of the pedigree data reveal that all of these individuals traced back to a single acknowledged carrier founder individual. Between seven and nine generations separated the founder from its 12 affected descendents. The 12 affected offspring were genotyped for a battery of 213 microsatellites spanning the 29 bovine autosomes. The resulting genotypes were analyzed using a maximum likelihood approach searching for shared homozygous haplotypes among affected individuals. Three candidate regions for the syndactyly locus emerged from this initial screening. syndactyly was shown to map to one of these candidate regions on chromosome 15 by genotyping 29 additional individuals linking founder and affected offspring and performing a conventional linkage analysis with the LINKAGE programs. This study illustrates the potential of identity-by-descent mapping in livestock populations. [less ▲]

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See detailIberian Margin: The Rias
Álvarez–Salgado, X. A.; Borges, Alberto ULg; Figueiras, F. G. et al

in Carbon and Nutrient Fluxes in Continental Margins (2009)

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See detailIBISCA-Panama, a large-scale study of arthropod beta-diversity and vertical stratification in a lowland rainforest: rationale, description of study sites and field methodology
Basset, Yves; Corbara, Bruno; Barrios, Hector et al

in Bulletin de l'Institut Royal des Sciences Naturelles de Belgique. Entomologie (2007), 77

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See detailIbn ʿAbd al-Ẓāhir, Muḥyī l-Dīn
Bauden, Frédéric ULg

in Encyclopaedia of Islam Three (2015)

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See detailIBR and BVD control : the key to successful herd management
Makoschey, B.; Franken, P.; Mars, J. M. H. et al

in Berliner und Munchener Tierarztliche Wochenschrift (2010), 123

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