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See detailIdentification of large selective sweeps associated with major genes in cattle.
Druet, Tom ULg; Perez-Pardal, L.; Charlier, Carole ULg et al

in Animal Genetics (2013), 44(6), 758-62

Selection for new favorable variants can lead to selective sweeps. However, such sweeps might be rare in the evolution of different species for which polygenic adaptation or selection on standing ... [more ▼]

Selection for new favorable variants can lead to selective sweeps. However, such sweeps might be rare in the evolution of different species for which polygenic adaptation or selection on standing variation might be more common. Still, strong selective sweeps have been described in domestic species such as chicken lines or dog breeds. The goal of our study was to use a panel of individuals from 12 different cattle breeds genotyped at high density (800K SNPs) to perform a whole-genome scan for selective sweeps defined as unexpectedly long stretches of reduced heterozygosity. To that end, we developed a hidden Markov model in which one of the hidden states corresponds to regions of reduced heterozygosity. Some unexpectedly long regions were identified. Among those, six contained genes known to affect traits with simple genetic architecture such as coat color or horn development. However, there was little evidence for sweeps associated with genes underlying production traits. [less ▲]

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See detailIdentification of lectins as virus competitors in aphid vectors: from fundamental to applied approaches
Bosquée, Emilie ULg; Chen, Ju Lian; Yong, Liu et al

Poster (2014, August)

Aphids remain difficult virus vectors to be controlled in many crops. Within this context of biological control against aphids and investigation on virus transmission (both non persistent Potato virus Y ... [more ▼]

Aphids remain difficult virus vectors to be controlled in many crops. Within this context of biological control against aphids and investigation on virus transmission (both non persistent Potato virus Y (PVY) and Cucumber Mosaic Virus (CMV) and persistent Barley Yellow Dwarf Virus, the use of lectins was developed. Indeed, the effects of lectin binding to glycoprotein aphid receptors on virus transmission were tested in laboratory via the use of artificial diets using different virus models. Differential effects on virus transmission efficiency were determined. By example, a strong interference between GNA and PVY was observed. In consequence, the lectin was considered as promising proteins and could be potential competitors to virus. For further research, a fast protein liquid chromatography was performed to identify aphid proteins related to binding to efficient lectin competitors. Moreover, to detect involved proteins in aphids, two-dimensional gel electrophoresis approach coupled to mass spectrometry was developped to identify the glycosylated proteins determining virus transmission efficiency. Use of lectins for both fundamental and applied approaches were discussed to investigate aphid – virus interactions [less ▲]

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See detailIdentification of Linear and Nonlinear Systems using Signal Processing Techniques
Kerschen, Gaëtan ULg; Poncelet, Fabien ULg; Golinval, Jean-Claude ULg et al

in 26th Benelux Meeting on Systems and Control, Lommel, 2007 (2007)

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See detailIdentification of lines in the spectra of B stars
Swings, Polydore ULg; Nicolet, M.

in Astrophysical Journal (1934), 80(3), 190-199

Identifications of lines in the spectra of B stars are given. About fifty lines for which no previous identifications had been made are interpreted.

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See detailIdentification of material parameters to predict Single Point Incremental Forming forces
Bouffioux, Chantal ULg; Eyckens, P.; Henrard, Christophe et al

in International Journal of Material Forming (2008)

The purpose of this article is to develop an inverse method for adjusting the material parameters for single point incremental forming (SPIF). The main idea consists in FEM simulations of simple tests ... [more ▼]

The purpose of this article is to develop an inverse method for adjusting the material parameters for single point incremental forming (SPIF). The main idea consists in FEM simulations of simple tests involving the SPIF specificities (the “line test”) performed on the machine used for the process itself. This approach decreases the equipment cost. It has the advantage that the material parameters are fitted for heterogeneous stress and strain fields close to the ones occurring during the actual process. A first set of material parameters, adjusted for the aluminum alloy AA3103 with classical tests (tensile and cyclic shear tests), is compared with parameters adjusted by the line test. It is shown that the chosen tests and the strain state level have an important impact on the adjusted material data and on the accuracy of the tool force prediction reached during the SPIF process. [less ▲]

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See detailIdentification of material parameters using bi-axial machine
Flores, Paulo; de Montleau, P.; Mathonet, V. et al

in Stören, Sigurd (Ed.) Proceedings of the 7th ESAFORM conference on Materials Forming (2004)

Experimental testing equipment is built in order to identify material parameters of complex phenomenological constitutive laws. This equipment consists in a bi-axial test machine able to perform plane ... [more ▼]

Experimental testing equipment is built in order to identify material parameters of complex phenomenological constitutive laws. This equipment consists in a bi-axial test machine able to perform plane strain and simple shear tests separately or simultaneously and a Miyauchi simple shear test device; an optical extensometer is used to identify the strain field. The article focus on the validation of the results of this new equipment by comparing with results obtained by standard machines and/or by using FEM simulations of already identified materials. The first results show that the bi-axial machine performs the plane strain test optimally and some modifications are proposed in order to improve the results for the simple shear test. Miyauchi device shows a good performance and the experimental results are compared with a FEM simulation. [less ▲]

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See detailIdentification of mechanical systems with local nonlinearities through discrete-time Volterra series and Kautz functions
Shiki, Sidney Bruce; Noël, Jean-Philippe ULg; Kerschen, Gaëtan ULg et al

in Proceedings of the 11th International Conference on Recent Advances in Structural Dynamics (2013, July)

Mathematical modeling of mechanical structures is an important research area in structural dynamics. One of the goals of this area is to obtain a model that accurately predicts the dynamics of the system ... [more ▼]

Mathematical modeling of mechanical structures is an important research area in structural dynamics. One of the goals of this area is to obtain a model that accurately predicts the dynamics of the system. However, the nonlinear eff ects caused by large displacements and boundary conditions like gap, backlash or joint are not as well understood as the linear counterpart. This paper identifies a non-parametric discrete-time Volterra model of a benchmark nonlinear structure consisting of a cantilever beam connected to a thin beam at its free end. Time-domain data experimentally measured are used to identify the Volterra kernels, which are expanded with orthogonal Kautz functions to facilitate the identification process. The nonlinear parameters are then estimated through a model updating process involving optimization of the residue between the numerical and experimental kernels. The advantages and drawbacks of the Volterra series for modeling the behavior of nonlinear structures are finally indicated with suggestions to overcome the disadvantages found during the tests. [less ▲]

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See detailIdentification of mechanisms involved in the acute airway toxicity induced by parathion.
Segura, P.; Chavez, J.; Montano, L. M. et al

in Naunyn-Schmiedeberg's Archives of Pharmacology (1999), 360(6), 699-710

Organophosphates are still widely used worldwide and cause thousands of intoxications every year. In this work we investigated the mechanisms of parathion (Pth) airway toxicity, using biochemical and ... [more ▼]

Organophosphates are still widely used worldwide and cause thousands of intoxications every year. In this work we investigated the mechanisms of parathion (Pth) airway toxicity, using biochemical and functional approaches. A plethysmographic technique for unrestrained guinea pigs was used to analyze Pth-induced modifications of airway mechanics and responsiveness to acetylcholine (ACh: 0.1-3.2 mg/ml, 2-min inhalation each dose). The isolated perfused rabbit lung preparation was used to study the acute effects of Pth on airway responsiveness to ACh (10(-8)-10(-3) M), histamine (10(-8)-10(-3) M) and substance P (10(-10)-10(-6) M), pulmonary acetylcholinesterase inhibition and cytochrome P450 (P450) activity, and their modifications with previous administration of Pth (1 mg/kg s.c. daily, 7 days). We found that: (1) In guinea pigs Pth (3.2-17 mg/kg i.p.) produced a dose-dependent increase in a lung resistance index (iRL), which was greatly reverted (approximately 50%) by salbutamol (2 mg/ml, 2-min inhalation, or 10 microg/kg i.p.). This salbutamol effect was transient (5-10 min), suggesting that this bronchodilator triggered additional obstructive mechanisms. (2) Pth increased the water content in lung parenchyma samples, but not in trachea or bronchi, and augmented the respiratory secretions measured through monosaccharide content in bronchoalveolar lavage. (3) The increase in iRL was greater in female animals, probably due to a higher P450 basal activity, and completely blocked by pharmacological inhibition of P450 with piperonyl butoxide (500 mg/kg i.p.). (4) In male guinea pigs a subclinical dose of Pth (10 mg/kg i.p.) induced airway hyperresponsiveness to ACh. In isolated perfused rabbit lung Pth (10(-6) M) produced airway hyperresponsiveness to ACh and histamine, the latter prevented by atropine (10(-5) M). (5) Repetitive exposure to subclinical doses (1 mg/kg s.c.) of Pth during 1 week caused approximately 80% inhibition of P450 activity in rabbits, which was not enough, however, to prevent the functional manifestation of Pth toxicity in the airways. [less ▲]

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See detailIdentification of Metabolic Pathways Expressed by Pichia anomala KH6 in the Presence of the Pathogen Botrytis cinerea on Apple: New Possible Targets for Biocontrol Improvement
Kwasiborski, Anthony; Bajji, Mohammed; Renaut, J. et al

in PLoS ONE (2014), 9(3),

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See detailIdentification of Metabolites in a Human Plasma Standard Reference Material by Comprehensive two Dimensional Gas Chromatography-Time-of-Flight Mass Spectrometry
Eppe, Gauthier ULg; Mc Gaw, Elizabeth; Dodder, Nathan et al

in 57th ASMS Conference on Mass Spectrometry and Allied Topics (2009)

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See detailIDENTIFICATION OF METABOLITES IN A HUMAN PLASMA STANDARD REFERENCE MATERIAL BY MULTIPLE GC/MS APPROACHES
Eppe, Gauthier ULg; Benner, Bruce; White, Edward et al

Poster (2010, January)

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See detailIdentification of methylenecyclopropyl acetic acid in serum of European horses with atypical myopathy
Votion, Dominique ULg; van Galen, G; Sweetan et al

in Equine Veterinary Journal (2013)

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See detailIdentification of micrometastasis of breast carcinomas by presence of basement membrane collagen.
Liotta, L. A.; Foidart, Jean-Michel ULg; Gehron Robey, P. et al

in Lancet (1979), 2(8134), 146-7

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See detailIdentification Of Mitochondrial Plasmid Like Dnas In Picea Abies (L.) Karst.
Chandelier, A.; Du Jardin, Patrick ULg; Avril, C. et al

in Plant Cell Reports (1999), 18(10),

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See detailIdentification of multi-degree of freedom non-linear systems using an extended modal space model
Platten, Michael F; Wright, Jan Robert; Dimitriadis, Grigorios ULg et al

in Mechanical Systems & Signal Processing (2009), 23(1), 8-29

The identification of non-linear dynamic systems is an increasingly important area of research, with potential application in many industries. Current non-linear identification methodologies are, in ... [more ▼]

The identification of non-linear dynamic systems is an increasingly important area of research, with potential application in many industries. Current non-linear identification methodologies are, in general, mostly suited to small systems with few degrees of freedom and few non-linearities. In order to develop a practical identification approach for real engineering structures, the capability of such methods must be significantly extended. In this paper, it is shown that such an extension can be achieved using multi-exciter techniques in order to excited specific modes or degrees of freedom of the system under investigation. A novel identification method for large non-linear systems is presented, based on the use of a multi-exciter arrangement using appropriated excitation applied in bursts. This proposed Non-linear Resonant Decay Method is applied to a simulated system with 5 degrees of freedom and an experimental clamped panel structure. The technique is essentially a derivative of the Restoring Force Surface method and involves a non-linear curve fit performed in modal space. The effectiveness of the resulting reduced order model in representing the non-linear characteristics of the system is demonstrated. The potential of the approach for the identification of large continuous non-linear systems is also discussed. [less ▲]

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See detailIdentification of multiple pregnancy-associated glycoproteins (PAGs) purified from the European bison (Eb; Bison bonasus L.) placentas.
Kiewisz, J.; Melo de Sousa, Noelita ULg; Beckers, Jean-François ULg et al

in Animal Reproduction Science (2008), 112

This paper describes the first identified chorionic PAGs in the European bison (Eb), named EbPAGs, predominantly expressed during early and mid-pregnancy (45-120 day post-coitum; dpc). Many EbPAGs were ... [more ▼]

This paper describes the first identified chorionic PAGs in the European bison (Eb), named EbPAGs, predominantly expressed during early and mid-pregnancy (45-120 day post-coitum; dpc). Many EbPAGs were extracted from various cotyledonary tissues, precipitated, chromatographed (DEAE and VVA: Vicia villosa agglutinin), electrophoresed (1D- and 2D-PAGE), analysed by heterologous (cross-species) Western blotting and then micro-sequenced by Edman degradation. Finally, twelve selected VVA-purified isoforms (Ip 3.7-7.4) were entirely characterised. Nine identified NH(2)-terminal micro-sequences were found to be PAGs. On 45dpc, three identified forms were named: EbPAG(67AkDa) (RGSNLTHPLRNIGDLFYVGN), EbPAG(55BkDa) (RGSNLTHPL) and EbPAG(50CkDa) (SQISLRGSNLTI). On 60dpc, the next three forms were named: EbPAG(71DkDa) (RGSNLTIHPLRNIIDLFYVG), EbPAG(55EkDa) (RGSNLTHPLRNI) and EbPAG(50FkDa) (SQISLRGS). On 120dpc, three other forms were named: EbPAG(71GkDa) (RGSNLTHPLRNIRDLFYVG), EbPAG(60HkDa) (RGSNLTTHPLRNIKDLVVYM) and EbPAG(50IkDa) (SGSNLTTV). These EbPAG ((A-I)) sequences are unique, as they are not identical to any other PAGs purified previously in related species of the Bovidae family. However, the EbPAGs (A-I forms) have some sequence resemblance to internal sequences of various full-length polypeptide PAG precursors (in silico translated from cloned cDNAs) identified in domestic cattle. Three other novel native isoforms (J1, J2 and K): EbUPG(45kDa) J1 (SKDNYKNYIPLIVPFAT), EbUPG(45kDa) J2 (SKDNQKNYIPLIVPFAT) and EbUPG(76kDa) K (SPEFTV), were temporarily named 'unknown placental glycoproteins' (UPGs), due to their efficient VVA-purification (specific for glycoproteins only) and a lack of considerable consensus to previously sequenced placental glycoproteins in the Bovidae family. This is the first study identifying NH(2)-terminals of multiple/diverse EbPAGs and some EbUPGs purified from the synepitheliochorial cotyledonary placenta of the endangered Bison bonasus (Red list) [less ▲]

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See detailIdentification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with MHC class I molecules
Vanneste, Yves; Ntodou-Thomé, Agnès; Vandersmissen, Eric et al

in Journal of Neuroimmunology (1997), 76

This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain ... [more ▼]

This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain ± 5 ng immunoreactive (ir) NT/106 cells, of which 5% is associated with plasma cell membranes. HPLC analysis of NT-ir present in human TEC showed a major peak of NT-ir corresponding to NT1–13. NT-ir was not detected in the supernatant of human TEC cultures. Using an affinity column prepared with a anti-MHC class I monoclonal antibody, NT-ir-related peptides were retained on the column and eluted together with MHC class I-related proteins. According to the elution time on HPLC of these peptides, they correspond to intact NT1–13, as well as to smaller fragments of NT1–13. [less ▲]

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