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See detailGENIEsim: the GENIE Science Simulator
Absil, Olivier ULg

Master of advanced studies dissertation (2003)

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See detailGENIEsim: the GENIE simulation software
Absil, Olivier ULg; den Hartog, R.; Erd, C. et al

in Fridlund, Malcolm; Henning, Thomas (Eds.) Towards Other Earths: DARWIN/TPF and the Search for Extrasolar Terrestrial Planets (2003, October 01)

GENIEsim, the GENIE simulation software, is an IDL-based code to simulate future observations with the Ground-based European Nulling Interferometer Experiment, which should be commissioned on the Very ... [more ▼]

GENIEsim, the GENIE simulation software, is an IDL-based code to simulate future observations with the Ground-based European Nulling Interferometer Experiment, which should be commissioned on the Very Large Telescope Interferometer (VLTI) in 2007. The code simulates operation in the mid-infrared (L' and N bands) and includes all major noise sources. The atmospheric turbulence is described by a Kolmogorov power spectrum, from which random time series are computed for perturbations to the optical paths. The effect of turbulence is reduced by means of control loops, which are either included in the VLTI facility (MACAO, PRIMA) or specific to the GENIE instrument. The output of GENIEsim is a time series of fluxes computed by integration of a source field multiplied by the GENIE transmission map, projected onto the plane of the sky. Simulations have already allowed to identify critical points in the design of the instrument, such as OPD and dispersion control, calibration of stellar leakage and background subtraction. [less ▲]

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See detailGenital re-excretion of Murid gammaherpesvirus 4 following intranasal infection
François, Sylvie ULg; Vidick, Sarah ULg; Sarlet, Michaël ULg et al

Poster (2011, November 16)

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. As the human gammaviruses have no well-established in vivo infection model ... [more ▼]

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. As the human gammaviruses have no well-established in vivo infection model, related animal gammaherpesviruses are an important source of information. We are studying Murid herpesvirus 4 (MuHV-4) in inbred laboratory mouse strains which are commonly accepted as a good model for studying gammaherpesviruses in vivo. To date, it has however never been possible to monitor viral reexcretion and virus transmission in this species. In order to identify potential re-excretion sites, intranasally infected mice were followed through global luciferase imaging for up to six months after infection. Surprisingly, we detected transient viral replication in mice genital tract at various times after latency establishment. Ex vivo imaging, quantitative PCR and immunohistochemistry revealed that virus genomes were present in high quantity in the vaginal tissue and that viral replication occurred mainly at the vaginal external border. Moreover, we highlighted the presence of free infectious viruses in the vaginal cavity at the moment of the observation of viral replication. As this ephemeral viral reexcretion could reveal a link with reproductive cycle, we compared reexcretion in normal and ovariectomized mice. Interestingly, no viral reactivation was observed in absence of hormonal cycle. In conclusion, we experimentally indentified for the first time a reexcretion site for MuHV-4 in mice that had been intranasaly infected. In the future, these results could help us to better understand the biology of gammaherpesviruses but should also allow us to develop strategies that could prevent the spread of these viruses in natural populations. [less ▲]

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See detailGenital re-excretion of Murid gammaherpesvirus 4 following intranasal infection
François, Sylvie ULg; Vidick, Sarah ULg; Sarlet, Michaël ULg et al

Poster (2010, November 18)

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. They are host-range specific and establish persistent, productive infections ... [more ▼]

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. They are host-range specific and establish persistent, productive infections of immunocompetent hosts. Thus, infected individuals simultaneously both elicit antiviral protective immune response and secrete infectious virions. The best studied gammaherpesviruses are Human herpesvirus 4 and Human herpesvirus 8. As these viruses have no well-established in vivo infection model, related animal gammaherpesviruses are an important source of information. We are studying Murid herpesvirus 4 (MuHV-4), a virus that has originally been isolated from bank voles (Myodes glareolus). Although MuHV-4 has not been isolated from house mice (Mus musculus), infection of inbred laboratory mouse strains is commonly accepted as a good model for studying gammaherpesviruses in vivo. To date, it has however never been possible to monitor viral reexcretion and virus transmission in this species suggesting that this model could be imperfect. In order to identify potential re-excretion sites, intranasally infected mice were followed through global luciferase imaging for up to six months after infection. By this technique, we were able to detect appearance of viral replication in mice genital tract at various times post-infection. Typically, it firstly occurred between days 20 to 30 after infection, a period at which it is admitted that latency is established. Ex vivo imaging, quantitative PCR and immunohistochemistry helped us to determine that virus genomes were present in high quantity in the vaginal tissue and that viral replication occurred mainly at the vaginal external border. Finally, we highlighted the presence of free infectious viruses in the vaginal cavity at the moment of the observation of viral replication. In conclusion, we experimentally indentified for the first time a reexcretion site for MuHV-4 in mice that had been intranasaly infected. It therefore suggests potential genital transmission, either horizontal or vertical, of this virus in mice populations. In the future, these results could help us to better understand the biology of gammaherpesviruses but should also allow us to develop vaccinal strategies that could prevent the spread of these viruses in natural populations. [less ▲]

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See detailGenital re-excretion of Murid gammaherpesvirus 4 following intranasal infection
François, Sylvie ULg; Vidick, Sarah ULg; Sarlet, Michaël ULg et al

in Proceedings of the 1st Scientific Meeting of the Faculty of Veterinary Medicine (2011, December 09)

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. As the human gammaviruses have no well-established in vivo infection model ... [more ▼]

Gammaherpesviruses are the archetypes of persistent viruses that have been identified in a range of animals from mice to man. As the human gammaviruses have no well-established in vivo infection model, related animal gammaherpesviruses are an important source of information. We are studying Murid herpesvirus 4 (MuHV-4) in inbred laboratory mouse strains which are commonly accepted as a good model for studying gammaherpesviruses in vivo. To date, it has however never been possible to monitor viral reexcretion and virus transmission in this species. In order to identify potential re-excretion sites, intranasally infected mice were followed through global luciferase imaging for up to six months after infection. Surprisingly, we detected transient viral replication in mice genital tract at various times after latency establishment. Ex vivo imaging, quantitative PCR and immunohistochemistry revealed that virus genomes were present in high quantity in the vaginal tissue and that viral replication occurred mainly at the vaginal external border. Moreover, we highlighted the presence of free infectious viruses in the vaginal cavity at the moment of the observation of viral replication. As this ephemeral viral reexcretion could reveal a link with reproductive cycle, we compared reexcretion in normal and ovariectomized mice. Interestingly, no viral reactivation was observed in absence of hormonal cycle. In conclusion, we experimentally indentified for the first time a reexcretion site for MuHV-4 in mice that had been intranasaly infected. In the future, these results could help us to better understand the biology of gammaherpesviruses but should also allow us to develop strategies that could prevent the spread of these viruses in natural populations. [less ▲]

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See detailGénitif -aes/-es pour -ae : hellénisme ou vulgarisme ?
Rochette, Bruno ULg

Conference (2012, September 07)

The origin of the genitive –aes/-es for –ae is difficult to establish. The most common opinion about this type of genitive, which occurs in epigraphical and, in more reduced proportions, in papyrological ... [more ▼]

The origin of the genitive –aes/-es for –ae is difficult to establish. The most common opinion about this type of genitive, which occurs in epigraphical and, in more reduced proportions, in papyrological sources (not, insofar as I know, in literary texts) especially for women’s personal names (but also in common nouns), is that it comes from the Greek. Beside the influence of Greek, several theories can be found about the origin of this particularity, commonly attested even in Republican Latin names. Indeed, in vulgar Latin, the –es ending genitive (used as dative as well) was frequently used from the 1st c. B.C. This phenomenon can be observed in Rome, in Italy and in the provinces (not only in western provinces, but also in eastern provinces, where the influence of Greek could have been stronger). In the epigraphical texts, this type of genitive occurs frequently in Greek personal names among some social groups (low classes). The origin of the dedicants (native, Greek or Oriental, i.e. Greek-speaking persons) must be taken into account and, for the common nouns, the contextualization is very important. I’ll focus on the inscriptions from Asia Minor and compare them with other regions as Italia X and Pannonia to see : 1° whether –aes/-es are two distinctive phenomena or two variants of the same phenomenon and 2° if this particularity has been used as a typical feature to point out the Greek origin of the person(s) mentioned in the inscription or the bilingual character of the community which has produced the text. [less ▲]

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See detailGénitif -aes/-es pour -ae : vulgarisme ou hellénisme ?
Rochette, Bruno ULg

in Molinelli, Piera; Cuzzolin, Pierluigi; Fedriani, Chiara (Eds.) Latin vulgaire latin tardif X. Actes du Xe colloque international sur le latin vulgaire et tardif (Bergamo, 4-9 settembre 2012) (2014)

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See detailGenitori Gay et GPA: cogenitorialità, sviluppo dei bambini e stress psicosociali
D'Amore, Salvatore ULg

Scientific conference (2015, October 24)

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See detailGeno viewer, a SAM/BAM viewer tool
Laczik, Miklos ULg; Tukacs, Edit; Uzonyi, Béla et al

in Bioinformation (2012)

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See detailLe génocide arménien en débat
Grandjean, Geoffrey ULg

Article for general public (2007)

This short article considers the debate around the punishment of armenian genocide-denial in Belgium.

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See detailGenome comparison of B. longum NCC-2705 and B. longum CRC-002 using suppressive subtractive hybridization
Delcenserie, Véronique ULg; lessard, Marie*-Helene; LaPointe, Gisele et al

Poster (2007)

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See detailGenome comparison of Bifidobacterium longum strains NCC2705 and CRC-002 using suppression subtractive hybridization.
Delcenserie, Véronique ULg; Lessard, Marie*-Helene; LaPointe, Gisele et al

in FEMS Microbiology Letters (2008), 280(1), 50-6

Because probiotic effects are strain dependent, genomic explanations of these differences will contribute to understanding their mechanisms of action. The genomic sequence of the Bifidobacterium longum ... [more ▼]

Because probiotic effects are strain dependent, genomic explanations of these differences will contribute to understanding their mechanisms of action. The genomic sequence of the Bifidobacterium longum probiotic strain NCC2705 was determined, but little is known about the genetic diversity between strains of this species. Suppression subtractive hybridization (SSH) is a powerful method for generating a set of DNA fragments differing between two closely related bacterial strains. The purpose of this study was to identify genetic differences between genomes of B. longum strains NCC2705 and CRC-002 using PCR-based SSH. Strain CRC-002 produces exopolysaccharides whereas NCC2705 is not known for reliable exopolysaccharide production. Thirty-five and 30 different sequences were obtained from the SSH libraries of strains CRC-002 and NCC2705, respectively. Specific CRC-002 genes found were predicted to be involved in the biosynthesis of exopolysaccharides and metabolism of other carbohydrates, and these genes were not present in the genome of strain NCC2705. The identification of an endo-1,4-beta-xylanase gene in the CRC-002 SSH library is an important difference because xylanase genes have previously been proposed as a defining characteristic of the NCC2705 strain. The results demonstrate that the SSH technique was useful to highlight potential genes involved in complex sugar metabolism that differ between the two probiotic strains. [less ▲]

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See detailGenome encyclopaedia of type strains of the genus Bifidobacterium
Milani, Christian; Lugli, Gabriele; Duranti, Sabrina et al

in Applied and Environmental Microbiology (2014)

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See detailGenome mapping of Clostridium perfringens strains with I-Ceul shows many virulence genes to be plasmid-borne.
Katayama, S.; Dupuy, B.; Daube, Georges ULg et al

in Molecular & General Genetics [=MGG] (1996), 251

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See detailThe genome of a gut strain of Bacillus subtilis
Schyns, G.; Pereira-Leal, J.; Serra, C. et al

Conference (2009, June)

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See detailGenome of a Gut Strain of Bacillus subtilis.
Schyns, Ghislain; Serra, Claudia R.; Lapointe, Thomas et al

in Genome announcements (2013), 1(1),

Bacillus subtilis is a Gram-positive, rod-shaped, spore-forming bacterium. We present the genome sequence of an undomesticated strain, BSP1, isolated from poultry. The sequence of the BSP1 genome supports ... [more ▼]

Bacillus subtilis is a Gram-positive, rod-shaped, spore-forming bacterium. We present the genome sequence of an undomesticated strain, BSP1, isolated from poultry. The sequence of the BSP1 genome supports the view that B. subtilis has a biphasic lifestyle, cycling between the soil and the animal gastrointestinal tract, and it provides molecular-level insight into the adaptation of B. subtilis to life under laboratory conditions. [less ▲]

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See detailThe genome of a tortoise herpesvirus (testudinid herpesvirus 3) has a novel structure and contains a large region that is not required for replication in vitro or virulence in vivo.
Gandar, Frederic ULg; Wilkie, Gavin S.; Gatherer, Derek et al

in Journal of Virology (2015), 89(22), 11438-11456

Testudinid herpesvirus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species. The threat that this virus poses to endangered animals is focusing efforts on ... [more ▼]

Testudinid herpesvirus 3 (TeHV-3) is the causative agent of a lethal disease affecting several tortoise species. The threat that this virus poses to endangered animals is focusing efforts on characterizing its properties, in order to enable the development of prophylactic methods. We have sequenced the genomes of the two most studied TeHV-3 strains (1976 and 4295). TeHV-3 strain 1976 has a novel genome structure and is most closely related to a turtle herpesvirus, thus supporting its classification into genus Scutavirus, subfamily Alphaherpesvirinae, family Herpesviridae. The sequence of strain 1976 also revealed viral counterparts of cellular interleukin-10 and semaphorin, which have not been described previously in members of subfamily Alphaherpesvirinae. TeHV-3 strain 4295 is a mixture of three forms (m1, m2, and M), in which, in comparison to strain 1976, the genomes exhibit large, partially overlapping deletions of 12.5 to 22.4 kb. Viral subclones representing these forms were isolated by limiting dilution assays, and each replicated in cell culture comparably to strain 1976. With the goal of testing the potential of the three forms as attenuated vaccine candidates, strain 4295 was inoculated intranasally into Hermann's tortoises (Testudo hermanni). All inoculated subjects died, and PCR analyses demonstrated the ability of the m2 and M forms to spread and invade the brain. In contrast, the m1 form was detected in none of the organs tested, suggesting its potential as the basis of an attenuated vaccine candidate. Our findings represent a major step toward characterizing TeHV-3 and developing prophylactic methods against it. [less ▲]

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See detailGenome of Bifidobacteria and Carbohydrate Metabolism
Bondue, Pauline ULg; Delcenserie, Véronique ULg

in Korean Journal for Food Science of Animal Resources (2015)

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See detailThe genome of cyprinid herpesvirus 3 encodes 40 proteins incorporated in mature virions
Michel, Benjamin ULg; Leroy, B.; Victor, Stalinraj ULg et al

in Journal of General Virology (The) (2010)

Detailed reference viewed: 49 (22 ULg)