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See detail51. Telmisartan Plus HCTZ vs. Amlodipine Plus HCTZ in older patients with systolic hypertension : results from a large ambulatory blood pressure monitoring study
Neldam, Steen; Edwards, Colin; The ATHOS study group et al

in American Journal of Geriatric Cardiology (2006), 15

Systolic hypertension often requires combination therapy. Few data exist comparing angiotensin receptor blocker plus diuretic therapy with other combinations in older patients. In a prospective ... [more ▼]

Systolic hypertension often requires combination therapy. Few data exist comparing angiotensin receptor blocker plus diuretic therapy with other combinations in older patients. In a prospective, randomized, open-label, blinded-end point trial, patients (≥60 years of age) with predominantly systolic hypertension received telmisartan 40–80 mg or amlodipine 5–10 mg for 8 weeks, before the addition of hydrochlorothiazide (HCTZ) 12.5 mg for a further 6 weeks. Twenty-four-hour ambulatory blood pressure monitoring showed that telmisartan plus HCTZ (n =448) and amlodipine plus HCTZ (n =424) changed systolic blood pressure for the last 6 hours of the dosing interval by −18.3 and −17.4 mm Hg, respectively (p =0.2520). Over the 24-hour period, telmisartan plus HCTZ was superior (−19.3 and −17.2 mm Hg, respectively; p =0.001) and provided higher systolic control rates (65.9% and 58.3%, respectively; p =0.0175). Adverse events (41.2% and 53.7%, respectively) and discontinuations (5.0% and 11.3%, respectively) were lower (p<0.0001) with telmisartan than with amlodipine, mainly due to peripheral edema (1.2% and 24.3%, respectively). [less ▲]

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See detail[51] Exocellular dd-carboxypeptidases-transpeptidases from Streptomyces
Frère, Jean-Marie ULg; Leyh-Bouille, Mélina; Ghuysen, Jean-Marie ULg et al

in Lorand, Laszlo (Ed.) Part B: Proteolytic Enzymes (1976)

Strains R39 and R61 are soil isolates. Their designations are arbitrary. In strain R39, the cross-link between the peptide units of the wall peptidoglycan extends from the C-terminal D-alanine of one unit ... [more ▼]

Strains R39 and R61 are soil isolates. Their designations are arbitrary. In strain R39, the cross-link between the peptide units of the wall peptidoglycan extends from the C-terminal D-alanine of one unit to the amino group at the D-center of meso-diaminopimelic acid of another unit (peptidoglycan of chemotype I). The interpeptide bond is in position to a free carboxyl group. In strain R61, the cross-link extends from a C-terminal D-alanine of a peptide unit to a glycine residue attached to the amino group of LL-diaminopimelic acid of another peptide unit (peptidoglycan of chemotype II). The exocellular DD carboxypeptidases-transpeptidases produced by both strains catalyze hydrolysis, react with β-lactam antibiotics. This chapter explains the assay methods for DD-Carboxypeptidase activity like the standard reaction, chemical estimation of free Alanine, as well as, assay method for β-Lactamase. It also discusses the Excretion of DD-Carboxypeptidase-Transpeptidase and β -Lactamase by Streptomyces R39, Excretion of DD-Carboxypeptidase-Transpeptidase and β-Lactamase by Streptomyces R61, purification of the DD-Carboxypeptidase-Transpeptidase from Streptomyces R39 (for 500 Liters of Culture Fluid), Purification of the DD-Carboxypeptidase-Transpeptidase from Streptomyces R61 (for 400 Liters of Culture Fluid), Physicochemical Properties of DD-Carboxypeptidases-Transpeptidases from Streptomyces R39 and R61, Interaction between DD-Carboxypeptidases-Transpeptidases from Streptomyces R39 and R61 and β-Lactam Antibiotics , Titration of DD-Carboxypeptidases-Transpeptidases from Streptornyces R39 and R61 by β-Lactam Antibiotics, Hydrolysis Reactions Catalyzed by the DD-Carboxypeptidases-Transpeptidases from Streptomyces R39 and R61, Concomitant Hydrolysis and Transfer Reactions Involving Distinct Donor and Acceptor Peptides, Catalyzed by the DD-Carboxypeptidases-Transpeptidases from Streptonayces R39 and R61, Concomitant Hydrolysis and Transfer Reactions Catalyzed by the DD-Carboxypeptidases-Transpeptidases from Streptomyces R39 and R61 and in Which the Same Peptide Acts as Donor and Acceptor and Inhibition of DD-Carboxypeptidases-Transpeptidases from Streptomyces R39 and R61 by β-Lactam Antibiotics in the Presence of Substrates. Copyright © 1976 Published by Elsevier Inc. [less ▲]

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See detail[56,4(+)] baryons in the 1/N-c expansion
Matagne, Nicolas; Stancu, Floarea ULg

in Physical Review D (2005), 71(1),

Using the 1/N-c expansion of QCD, we analyze the spectrum of positive parity resonances with strangeness S=0, -1, -2, and -3 in the 2-3 GeV mass region, supposed to belong to the [56,4(+)] multiplet. The ... [more ▼]

Using the 1/N-c expansion of QCD, we analyze the spectrum of positive parity resonances with strangeness S=0, -1, -2, and -3 in the 2-3 GeV mass region, supposed to belong to the [56,4(+)] multiplet. The mass operator is similar to that of [56,2(+)], previously studied in the literature. The analysis of the latter is revisited. In the [56,4(+)] multiplet we find that the spin-spin term brings the dominant contribution and that the spin-orbit term is entirely negligible in the hyperfine interaction, in agreement with constituent quark model results. More data are strongly desirable, especially in the strange sector in order to fully exploit the power of this approach. [less ▲]

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See detailThe [56,4+] baryon multiplet in the 1/N(c) expansion of QCD
Matagne, Nicolas; Stancu, Floarea ULg

in Large Nc QCD 2004 (2004)

We use the $1/N_c$ expansion of QCD to analyze the spectrum of positive parity resonances with strangeness $S = 0, -1, -2$ and -3 in the 2--3 GeV mass region, supposed to belong to the $[\textbf{56},4 ... [more ▼]

We use the $1/N_c$ expansion of QCD to analyze the spectrum of positive parity resonances with strangeness $S = 0, -1, -2$ and -3 in the 2--3 GeV mass region, supposed to belong to the $[\textbf{56},4^+]$ multiplet. The mass operator is similar to that of $[\textbf{56},2^+]$, previously studied in the literature. The analysis of the latter is revisited. In the $[\textbf{56},4^+]$ multiplet we find that the spin-spin term brings the dominant contribution and that the spin-orbit term is entirely negligible in the hyperfine interaction, in agreement with constituent quark model results. More data are strongly desirable, especially in the strange sector in order to fully exploit the power of this approach. [less ▲]

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See detail(596) Scheila
Jehin, Emmanuel ULg; Manfroid, Jean ULg; Hutsemekers, Damien ULg et al

in Central Bureau Electronic Telegrams (CBETs) (2011), 2632

E. Jehin, J. Manfroid, D. Hutsemekers, M. Gillon, and P. Magain, Fonds National de la Recherche Scientifique, Liege University, report on broad- and narrow-band imaging of the (596) Scheila outburst (CBET ... [more ▼]

E. Jehin, J. Manfroid, D. Hutsemekers, M. Gillon, and P. Magain, Fonds National de la Recherche Scientifique, Liege University, report on broad- and narrow-band imaging of the (596) Scheila outburst (CBET 2583) with the TRAPPIST 0.60-m telescope at La Silla, and on optical spectroscopy with the European Southern Observatory's Very Large Telescope (VLT) at Paranal. R-band imaging from 2010 Dec. 12.3 to 21.3 UT revealed two arc-like coma features expanding at a regular pace. The first such feature was 1' long on 2010 Dec. 12, oriented to the northeast and bending to p.a. 280 deg (the anti-solar direction). The second feature was shorter, 30" on Dec. 12, oriented to the south and bending to p.a. 230 deg. Both features were getting larger and fainter with time (4' and 2' long, respectively, on Dec. 21.3). A narrow 45"-long tail, opposite the sun (p.a. 280 deg), was also observed in good seeing. R-band images taken on 2011 Jan. 4.3 and 5.3 after the full moon allowed Jehin et al. to again observe these features, seen as 7' and 4' long, respectively -- and much fainter. This discards any sustained activity of the minor planet. Narrow-band images obtained on 2010 Dec. 12.3 with cometary filters do not show any contribution from gases. A 20-min optical spectrum was obtained with FORS2 at the VLT on Dec. 13.3; it does not show any extended cometary gaseous emissions, but only a spatially extended continuum due to dust-scattered sunlight. Short B, V, R, and I exposures performed nearly every two nights from 2010 Dec. 12.3 to 2011 Jan. 5.3 give a magnitude for the nuclear condensation of V = 14.2 +/- 0.1 over the whole period, in agreement with the "APmag" value reported in the Jet Propulsion Laboratory ephemeris. No flux variation of the nuclear condensation was observed. Those preliminary results are in favor of a collisional scenario to explain the outburst of (596) Scheila, rather than a cometary driven activity. This case might be similar to the outburst of comet P/2010 A2, which may have resulted from an impact of a minor planet (Snodgrass 2010, Nature 467, 814). [less ▲]

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See detail6 - Functional analysis of the lithics
Rots, Veerle ULg

in Vermeersch, Pierre M. (Ed.) The Ahrensburgian at Zonhoven-Molenheide (Belgium) (2013)

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See detailThe 6 kb c-erbB2 promoter contains positive and negative regulatory elements functional in human mammary cell lines.
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Dijkmans, Huguette et al

Conference (1994, September)

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See detail6,7-Disubstituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides: new potent ATP-sensitive potassium channel openers
De Tullio, Pascal ULg; Boverie, S.; Becker, B. et al

Poster (2002, September)

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See detailLe 6-(acetoxymethyl)-2-oxo-2H-1-benzopyrane-3-carboxylate de 3-chlorophényle agissant en tant qu’inhibiteur potentiel de l’invasion tumorale
Kempen, I.; Papapostolu, D.; Pochet, L. et al

Poster (2000, May)

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See detailA 6-hour nocturnal interruption of a continuous subcutaneous insulin infusion: 1. Metabolic and hormonal consequences and scheme for a prompt return to adequate control.
Krzentowski, G.; Scheen, André ULg; Castillo, M. et al

in Diabetologia (1983), 24(5), 314-8

Interruption of a continuous subcutaneous insulin infusion, most often due to technical problems occurring during the night, is a not uncommon event whose metabolic consequences have received relatively ... [more ▼]

Interruption of a continuous subcutaneous insulin infusion, most often due to technical problems occurring during the night, is a not uncommon event whose metabolic consequences have received relatively little attention until now. We have therefore investigated the changes in blood glucose, plasma non-esterified fatty acids, 3-hydroxybutyrate, glucagon and free insulin in eight C-peptide negative Type 1 diabetic patients whose pumps were deliberately stopped between 23.00 h and 05.00 h. A control test with the pump functioning normally was carried out in each patient and the studies were randomized. Considering the values at 23.00 h as reference, interruption of the insulin infusion resulted in (1) a rapid decrease in plasma free insulin significant after 1 h and reaching a nadir of 6 +/- 2 mU/l after 6 h; (2) a rise in blood glucose which was significant at hour 3 and reached 17.4 +/- 1.9 mmol/l at hour 6; (3) a moderate increase in plasma nonesterified fatty acids which remained in the range of 700-800 mumol/l; (4) an early and linear rise in plasma 3-hydroxybutyrate, significant after 1 h and averaging 1290 +/- 140 mumol/l after 6 h; (5) a late increase (hour 5) in plasma glucagon. The second aim of our study was to provide for the patient a precise scheme of insulin supplements administered via the pump and based on blood glucose monitoring (Dextrostix - Glucometer) and semi-quantitative evaluation of ketonuria (Acetest). Resetting the pump at its basal rate at 05.00 h and giving insulin supplements (2-8 U) at 06.45 h (with the usual breakfast dose) and again at 10.00 h have proved efficacious in restoring satisfactory metabolic control by noon the day after starting the experiment. These results form practical recommendations to patients undergoing this type of accident. [less ▲]

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See detailThe 6-Kilobase C-Erbb2 Promoter Contains Positive and Negative Regulatory Elements Functional in Human Mammary Cell Lines
Grooteclaes, Madeleine; Pasleau, Françoise ULg; Dijkmans, Huguette et al

in Cancer Research (1994), 54(15), 4193-9

A 6-kilobase fragment extending at the 5'-end of the c-erbB2 protooncogene was isolated from a normal human lymphocyte genomic DNA library. The full-length fragment and five subfragments with identical 3 ... [more ▼]

A 6-kilobase fragment extending at the 5'-end of the c-erbB2 protooncogene was isolated from a normal human lymphocyte genomic DNA library. The full-length fragment and five subfragments with identical 3'-ends were obtained by progressive unidirectional deletion from the 5'-end and were cloned in front of the luciferase reporter gene. The hybrid genes were analyzed for transcriptional activity in human mammary cell lines synthesizing low (HBL-100 and T-47D), moderate (MDA-MB-453), or high (BT-474) amounts of the c-erbB2 mRNA and were also analyzed in HeLa cells. Gene-specific expression was observed, indicating the presence of multiple cis-acting sequences in the c-erbB2 promoter. A major negative element is located in the -2- to -4-kilobase region. It is flanked on both sides by positive elements that display enhanced transcriptional activity in the BT-474 tumor cells only. While predominant in the low-expressing cells, the effect of the repressor appears to be overcome by the distal transactivator in the high-expressing BT-474 cells, resulting in a 15 to 50 times increase in luciferase activity relative to the HBL-100 and T-47D cells, respectively. Cell-specific expression relies on the trans-acting factors present in the different cell lines. The formation of cell-specific protein-DNA complexes was demonstrated by gel retardation assay. [less ▲]

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See detail6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for selective inhibitors of human leucocyte elastase
Doucet, C.; Pochet, L.; Thierry, N. et al

in Journal of Medicinal Chemistry (1999), 42

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See detail6-Substituted 2-Oxo-2h-1-Benzopyran-3-Carboxylic Acid Derivatives in a New Approach of the Treatment of Cancer Cell Invasion and Metastasis
Kempen, I.; Hemmer, Marc ULg; Counerotte, Stéphane ULg et al

in European Journal of Medicinal Chemistry (2008), 43(12), 2735-50

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure ... [more ▼]

Novel 6-substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives were synthesized and their potency in reducing the invasive behaviour of HT 1080 fibrosarcoma cells was evaluated. Structure-activity relationships were deduced from biological results and will be used in further design of new active compounds. In particular, the acetoxymethyl substituent found at the 6-position of previously described active compounds can be replaced by an acetamidomethyl substituent without loss of potency; while the presence of an aryl ester function at the 3-position was preferred to a thioester or an amide function to induce marked biological activity. This work confirms the interest of aryl esters of 6-substituted coumarin-3-carboxylic acids as potential new anti-cancer agents. [less ▲]

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See detail6-Substituted benzopyran derivatives as potent KATP channel openers: synthesis and biological in vitro evaluation
Florence, X.; De Tullio, Pascal ULg; Lebrun, P. et al

Poster (2008, May)

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See detail6. Lutte contre les maladies - 2.3. Réduire la pression des maladies: impact pratique des "leviers agronomiques"
Seutin, Benoit ULg; Vancutsem, Françoise ULg; Jacquemin, Guillaume et al

in Livre Blanc: Céréales - Gembloux (2011, February 23)

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See detail6. Lutte intégrée contre les maladies
Duvivier, Maxime; Bataille, Charlotte; Mahieu, Olivier et al

in Bodson, Bernard; Destain, Jean-Pierre (Eds.) Livre blanc céréales (2014, February 26)

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See detail6. Lutte intégrée contre les maladies
Duvivier, Maxime; Mahieu, Olivier; Heens, B. et al

in Bodson, Bernard; Destain, Jean-Pierre (Eds.) Livre Blanc - Céréales (2013, February 27)

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