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See detailL'hormone placentaire somato-mammotrope bovine
Beckers, Jean-François ULg

Post doctoral thesis (1983)

Nos études ont porté en premier lieu sur l’isolement et la purification de l’hormone somato-mammotrope (HPSM) bovine à partir des cotylédons fœtaux de placentas provenant de vaches gestantes de 3 à 6 mois ... [more ▼]

Nos études ont porté en premier lieu sur l’isolement et la purification de l’hormone somato-mammotrope (HPSM) bovine à partir des cotylédons fœtaux de placentas provenant de vaches gestantes de 3 à 6 mois. La préparation d’HPSM purifiée s’est avérée homogène à l’électrophorèse en gel de polyacrylamide. Déterminé par comparaison avec celui de différentes protéines connues, le poids moléculaire de l’HPSM se situe à 33.000 daltons. Son point isolélectrique est de 5,2. Dans les dosages de la prolactine et de l’hormone de croissance par liaison radiocompétitive aux récepteurs membranaires, l’HPSM présente une activité bifonctionnelle, supérieure à celle de s préparations de référence (prolactine PRL-NIH-B4 et hormone de croissance GN-NIH-B18). Marquée à l’iode 125, une partie de l’HPSM conserve intactes ses caractéristiques de liaison. L’HPSM 125 I se lie aux récepteurs hépatiques et mammaires, confirmant l’activité bifonctionnelle de l’hormone. Une liaison spécifique de l’HPSM 125 I est observée chez la vache au niveau de différents tissus tels la glande mammaire, le foie, le corps jaune, l’endomètre et le tissus adipeux. La glande mammaire bovine comporte des sites de liaison différents et spécifiques pour la prolactine et l’hormone de croissance. L’immunisation de lapins au moyen de l’HPSM purifiée a permis l’obtention d’antisérums spécifiques, autorisant la mise au point d’un dosage radioimmunologique sensible. Les cotylédons fœtaux sont trois à quatre fois plus riches en hormone que les cotylédons maternels. Le dosage de l’HPSM dans les liquides amniotiques et allantoïdiens révèle leur faible teneur en hormone. La concentration en HPSM du sérum est élevée chez les fœtus jeunes, elle diminue ensuite régulièrement en fonction de l’âge. L’HPSM apparaît dans le sérum maternel entre le 26ème et le 110ème jour de la gestation. Ensuite, sa concentration s’élève régulièrement jusqu’à la parturition. [less ▲]

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See detailHormone Therapy and Breast Cancer Risk
Foidart, Jean-Michel ULg; Desreux, Joëlle ULg; Pintiaux, Axelle ULg et al

in Climacteric : The Journal of the International Menopause Society (2007), 10(Suppl 2), 54-61

Hormone therapy (HT) is the most efficacious intervention for the relief of climacteric symptoms. Controversies surrounding HT have left many women puzzled and afraid. Gynecologists are faced with long ... [more ▼]

Hormone therapy (HT) is the most efficacious intervention for the relief of climacteric symptoms. Controversies surrounding HT have left many women puzzled and afraid. Gynecologists are faced with long-standing beneficial assumptions challenged by an abundance of robust detrimental new data, with little guidance on how to interpret these findings. Prescriptions for HT (and incidence of breast cancers in some areas) have fallen over the last 3 years due to anxiety provoked about breast cancer risk and recurrence. The current 'clinical climate' is against HT. Due to a lack of effective alternatives, women suffering from estrogen-deficiency symptoms are still requesting objective information about HT, particularly those at higher risk of breast cancer or those with a past history of breast cancer. In this situation, discussion of the current clinical uncertainty surrounding the use of HT must be undertaken to ensure that women are adequately informed. The objective of this presentation is to provide a framework for understanding breast cancer risk associated with HT. What are the precise molecular mechanisms of estrogen and progestin in the initiation of breast cancer? Does the risk of estrogen-only therapy on breast cancer vary by dose, constituent, route and duration of administration and cessation of use? Does HT, in addition to increasing risk for breast cancer, affect the type of breast cancer (lobular and ductal) diagnosed? Is HT associated with breast cancers that have better prognostic factors? How relevant are the changes in mammographic breast density associated with HT for the evaluation of breast cancer risk? What is the additional global health risk/benefit ratio associated with the selective use of progesterone or progestin that may confer a significant cardiovascular benefit, such as drospirenone? It is currently assumed and tested that new hormones with particular pharmacological profiles may ultimately achieve their therapeutic goal of relieving climacteric symptoms without an associated moderate increased risk of breast cancer. [less ▲]

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See detailHormonelle Befunde bei Störungen der Ovarialfunktion des Rindes
Derivaux, Jules; Ectors, Francis ULg; Beckers, Jean-François ULg

in Deutsche Tierärztlich Wochenschrift (1976), 83

The hormonal pattern was studied in 54 animals: 34 heifers with seasonal anoestrus, 13 cows with post-partum anoestrus, 5 cows with nymphomania and 2 cows superovulated. Seasonal and post partum anoestrus ... [more ▼]

The hormonal pattern was studied in 54 animals: 34 heifers with seasonal anoestrus, 13 cows with post-partum anoestrus, 5 cows with nymphomania and 2 cows superovulated. Seasonal and post partum anoestrus are characterized by basal levels of progesterone, FSH and LH, while oestradiol level is more variable and higher in post partum anoestrus due to the proper activity of the ovary. Nymphomania is a hyperfolliculinemic syndrome; cystic puncture leads to a fall in oestradiol and a surge in FSH and LH but of inequal intensity. The level of the latter hormone is often too low to induce luteinization; cystic degeneration of the ovary is associated with LH deficiency. In superovulated cows, hormonal pattern is like in normal cyclic cows but more pronounced. [less ▲]

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See detailHormones and sexual impotence
Legros, Jean-Jacques ULg; Chiodera, P.; Mormont, Christian ULg et al

in De Wied, D.; Van Keer, P.A. (Eds.) Hormones and the brain (1980)

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See detailHormones modulate the concentration of cytoplasmic progestin receptors in the brain of male ring doves (Streptopelia risoria).
Balthazart, Jacques ULg; Blaustein, J. D.; Cheng, M. F. et al

in Journal of Endocrinology (1980), 86(2), 251-61

A cytoplasmic progestin receptor has been characterized in the brain of castrated ring doves using an in-vitro assay that measures the binding of a synthetic progestin, [3H]17 alpha,21-dimethyl-19-nor ... [more ▼]

A cytoplasmic progestin receptor has been characterized in the brain of castrated ring doves using an in-vitro assay that measures the binding of a synthetic progestin, [3H]17 alpha,21-dimethyl-19-nor-pregna-4,9-diene-3,20-dione(promegestone; R5020). The affinity of the receptor was similar in both the hyperstriatum and the hypothalamus (Kd approximately equal to 4 X 10(-10) mol/l). Its concentration was higher in the anterior hypothalamus-preoptic area (63 +/- 4 fmol/mg (S.E.M.) protein) than in other brain regions (posterior hypothalamus, 33 +/- 5; hyperstriatum, 28 +/- 3; midbrain, 17 +/- 4 fmol/mg protein; n = 7). Progesterone and R5020 competed well for binding but oestradiol and 5 beta-dihydrotestosterone did not. Corticosterone and, to a lesser extent, testosterone and 5 alpha-dihydrotestosterone completed for binding but much higher concentrations were required than for progestins. Injections of testosterone (200 micrograms testosterone propionate daily for 7 days) significantly increased the concentration of progestin receptors in the anterior and posterior hypothalamus without having any significant effect on other brain areas. Shorter treatment, lasting for 2 days, with testosterone propionate (200 micrograms daily), 5 alpha-dihydrotestosterone (200 micrograms daily) or oestradiol benzoate (50 micrograms daily) did not always cause this increase but seven injections of oestradiol benzoate (50 micrograms daily for 7 days) were even more effective than seven injections of testosterone propionate (200 micrograms daily for 7 days). These data suggested that the sensitivity to progesterone of the brain of the bird changes as a consequence of increases in the level of testosterone in the circulation. [less ▲]

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See detailHormonosubstitution postmenopausique et risque de cancer mammaire: une mise a jour
van den Brule, F.; Lifrange, Eric ULg; Pintiaux, Axelle ULg et al

in Revue Médicale de Liège (2003), 58(4), 254-60

Numerous studies have examined the risk of breast cancer in patients with postmenopausal hormone substitution. Most of these studies are retrospective, and a few recent studies are prospective. The ... [more ▼]

Numerous studies have examined the risk of breast cancer in patients with postmenopausal hormone substitution. Most of these studies are retrospective, and a few recent studies are prospective. The observed results present with weak variations from baseline and major heterogeneity. Some studies highlight a slightly increased relative risk of breast cancer. A reanalysis of 51 studies demonstrates a relative risk of 1.35 for developing breast cancer during hormone substitution, with a 2.3% increased risk per year of use. Recently, the results of the WHI study have shown a slight increase of some risks of disease, including breast cancer (relative risk, 1.26). These results have induced the interruption of one of the 3 arms of the study (that of the patients treated with an estrogen-progestin combination), and have provoked a new discussion about the benefits and risks associated with hormone substitution. These facts have been largely related and commented in the general press. In this article, we review the important studies concerning this topic. [less ▲]

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See detailL'hormonothérapie de substitution transdermique: une mode ou un avantage?
Foidart, Jean-Michel ULg; Desreux, Joëlle ULg; Pintiaux, Axelle ULg et al

in Revue Médicale de Liège (1998), 53(4), 208-11

This review describes the clinical usefulness of transdermal hormone replacement therapy. This route of administration is particularly important in women with hypertriglyceridemia, in hypertensive ... [more ▼]

This review describes the clinical usefulness of transdermal hormone replacement therapy. This route of administration is particularly important in women with hypertriglyceridemia, in hypertensive postmenopausal women, in women who smoke or have an increased risk of biliary or liver disorder, for those who display a reduced glucose tolerance or in women who are at risk of thrombotic disorders. The avoidance of the "first passage effect" is ensured by the transdermal application of estrogen and probably explains the superiority of this route of steroid administration. [less ▲]

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See detailHormonothérapie du cancer du sein
LIFRANGE, Eric ULg; ANDRE, Chantal ULg; BLERET, Valerie ULg et al

in Revue Médicale de Liège (2011), 66(5-6), 367-371

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See detailHorner’s syndrome revealing spontaneous carotid artery dissection.
Verdin, Vanessa ULg; Holemans, Charlotte ULg; OTTO, Bernard ULg et al

in Revue Médicale de Liège (2012), 68

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See detailL'Horreur adolescente
Dejasse, Erwin ULg

in 9e Art : Les Cahiers du Musée de la Bande Dessinée (1999), 4

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See detailHors-cadre : quand le documentaire ne peut pas tout montrer
Hamers, Jérémy ULg

Scientific conference (2014, December 18)

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See detailHors-cadres : des images qui manquent. Quand le documentaire ne peut pas tout montrer.
Hamers, Jérémy ULg

Conference given outside the academic context (2014)

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See detailHorse production
Lekeux, Pierre ULg; Art, Tatiana ULg

in Proceedings: 53rd Annual Meeting of the European Association for Animal Production (2002)

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See detailHorseradish peroxidase electrode for phenothiazine analysis
Petit, C.; Quilinc, A.; Quilinc, E. et al

in Electroanalysis (1998), 10

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See detailHorses on pasture may be affected by equine motor neuron disease
McGorum, B. C.; Mayhew, I. G.; Amory, Hélène ULg et al

in Equine Veterinary Journal (2006), 38(1), 47-51

Reasons for performing study: Equine motor neuron disease (EMND) was diagnosed in 3 horses maintained on lush, grass-based pasture. This contrasted with North American studies which identified limited or ... [more ▼]

Reasons for performing study: Equine motor neuron disease (EMND) was diagnosed in 3 horses maintained on lush, grass-based pasture. This contrasted with North American studies which identified limited or no access to green herbage as an important risk factor for EMND. Hypothesis: Grazing horses that have an apparently adequate intake of pasture herbage to meet normal equine vitamin E requirements can develop EMND. Methods: Owners of 32 European horses diagnosed with EMND completed a questionnaire regarding intrinsic, managemental, nutritional and environmental factors that could potentially be risk factors for EMND, and also regarding clinical signs, treatments and case outcome. Plasma/serum vitamin E data for these horses were supplied by the veterinarians. No control population was studied. Results: Thirteen of 32 horses (termed the 'grazing' group) had part- or full-time access to grass-based pasture at the onset of EMND (median duration at pasture 12 h/day, range 3-24 h). Five of these horses were at pasture for at least 23.5 h/day at the onset of EMND, 2 of which were at pasture for at least 23.5 h/day throughout the year. Despite grazing, all these horses had a low vitamin E status. The remaining 19 horses resembled those cases reported from North America, in that they had no or limited access to pasture. Conclusions and potential relevance: A diagnosis of EMND should not be discounted on the basis that a horse has access, even full-time, to lush grass-based pasture. Inadequate vitamin E intake was probably not the sole cause of either the EMND or the low vitamin E status in the grazing horses; the latter was probably the result of abnormal bioavailability or excessive utilisation of vitamin E. [less ▲]

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See detailHorseshoeing styles comparison and detection of subclinic equine digit discomfort during movement
Noble, Prisca ULg; Lejeune, Jean-Philippe ULg; Serteyn, Didier ULg et al

Conference (2011, July 07)

Introduction: For the sound equine forelimb, ground reaction force (GRF) peaks to ~0.8-1 BodyWeight (BW) during the trot (4m/s). Little work investigates the effect of different horsehoeing styles ... [more ▼]

Introduction: For the sound equine forelimb, ground reaction force (GRF) peaks to ~0.8-1 BodyWeight (BW) during the trot (4m/s). Little work investigates the effect of different horsehoeing styles, directly on the limb GRF distribution and indirectly on the equine digit comfort during movement. This study investigates GRF distribution after application of different aluminium horseshoeing styles during movement. Methods: Two horses (H1,H2; mean 575kg) were used. However H2 had an old healed flexor tendons lesion, the horses were judged to be sound on locomotor examination (without lameness). According to the rules that respect the foot biomechanical balance, they were trimmed and shod with a non-broken foot-pastern axis. On the day of the tests, they were led on a treadmill at a trot (4m/s). Kinetics were collected, using a F-Scan system, during 3 following sessions : to both forehooves after application of classic roller, eggbarr and equi+ horseshoes. For each session, data from 3 strides for each left forelimb of each horse were averaged and kinetics (GRF) were obtained. Results: For the classic roller, eggbarr and equi+ horseshoes, GRF peaked respectively to 0.57+-0.006;0.36+-0.005;0.83+-0.009BW for H1 and 0.61+-0.007;0.84+-0.007;0.51+-0.009BW for H2. Theses horseshoes loading differences show a dynamic load transfer from the forelimbs to the hindlimbs, that is the result of a subclinic (without lameness) equine digit discomfort during movement. Conclusions: Subclinic equine digit discomfort after application of horshoes has been detected using the F-Scan system during movement. These results confirm the interest of the equi+ horseshoes on horses without flexor tendon lesion. [less ▲]

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See detailHorus sur les crocodiles
Winand, Jean ULg; Koemoth, Pierre

in Derriks, Claire; Delvaux, Luc (Eds.) Antiquités égyptiennes au Musée royal de Mariemont (2009)

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