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Peer Reviewed
See detailImpact of flexibility practices and changes in work environments on worker well-being.
Hansez, Isabelle ULg; De Keyser, Véronique ULg; D'Hoore, W. et al

Conference (2005, May 15)

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See detailImpact of follicular G-CSF quantification on subsequent embryo transfer decisions: a proof of concept study.
Ledee, N.; Gridelet, Virginie ULg; RAVET, Stéphanie ULg et al

in Human Reproduction (2013), 28(2), 406-13

BACKGROUND: Previous experiments have shown that granulocyte colony-stimulating factor (G-CSF), quantified in the follicular fluid (FF) of individual oocytes, correlates with the potential for an ongoing ... [more ▼]

BACKGROUND: Previous experiments have shown that granulocyte colony-stimulating factor (G-CSF), quantified in the follicular fluid (FF) of individual oocytes, correlates with the potential for an ongoing pregnancy of the corresponding fertilized oocytes among selected transferred embryos. Here we present a proof of concept study aimed at evaluating the impact of including FF G-CSF quantification in the embryo transfer decisions. METHODS: FF G-CSF was quantified with the Luminex XMap technology in 523 individual FF samples corresponding to 116 fresh transferred embryos, 275 frozen embryos and 131 destroyed embryos from 78 patients undergoing ICSI. RESULTS: Follicular G-CSF was highly predictive of subsequent implantation. The receiving operator characteristics curve methodology showed its higher discriminatory power to predict ongoing pregnancy in multivariate logistic regression analysis for FF G-CSF compared with embryo morphology [0.77 (0.69-0.83), P < 0.001 versus 0.66 (0.58-0.73), P = 0.01)]. Embryos were classified by their FF G-CSF concentration: Class I over 30 pg/ml (a highest positive predictive value for implantation), Class II from 30 to 18.4 pg/ml and Class III <18.4 pg/ml (a highest negative predictive value). Embryos derived from Class I follicles had a significantly higher implantation rate (IR) than those from Class II and III follicles (36 versus 16.6 and 6%, P < 0.001). Embryos derived from Class I follicles with an optimal morphology reached an IR of 54%. Frozen-thawed embryos transfer derived from Class I follicles had an IR of 37% significantly higher than those from Class II and III follicles, respectively, of 8 and 5% (P < 0.001). Thirty-five per cent of the frozen embryos but also 10% of the destroyed embryos were derived from G-CSF Class I follicles. Non-optimal embryos appear to have been transferred in 28% (22/78) of the women, and their pregnancy rate was significantly lower than that of women who received at least one optimal embryo (18 versus 36%, P = 0.04). CONCLUSIONS: Monitoring FF G-CSF for the selection of embryos with a better potential for pregnancy might improve the effectiveness of IVF by reducing the time and cost required for obtaining a pregnancy. [less ▲]

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See detailImpact of formic/acetic acid and ammonia pre-treatments on chemical structure and physico-chemical properties of Miscanthus x giganteus lignins
Vanderghem, Caroline ULg; Richel, Aurore ULg; Jacquet, Nicolas ULg et al

in Polymer Degradation & Stability (2011), 96(10), 1761-1770

Miscanthus x giganteus was treated with formic acid/acetic acid/water (30/50/20 v/v) for 3 h at 107 C and 80° C, and soaking in aqueous ammonia (25% w/w) for 6 h at 60 C. The effects of these ... [more ▼]

Miscanthus x giganteus was treated with formic acid/acetic acid/water (30/50/20 v/v) for 3 h at 107 C and 80° C, and soaking in aqueous ammonia (25% w/w) for 6 h at 60 C. The effects of these fractionation processes on chemical structure, physico-chemical properties and antioxidant activity of extracted lignins were investigated. Lignins were characterized by their purity, carbohydrate composition, thermal stability, molecular weight and by Fourier transform infrared (FTIR), 1H and quantitative 13C nuclear magnetic resonance (NMR), adiabatic broadband {13C-1H} 2D heteronuclear (multiplicity edited) single quantum coherence (g-HSQCAD). The radical scavenging activity towards 2,2-diphenyl-1-picrylhydrazyl (DPPH) was also investigated. Formic/acetic acid pretreatment performed in milder conditions (80° C for 3 h) gave a delignification percentage of 44.7% and soaking in aqueous ammonia 36.3%. Formic/acetic acid pretreatment performed in harsh conditions (107°C for 3 h) was more effective for extensive delignification (86.5%) and delivered the most pure lignin (80%). The three lignin fractions contained carbohydrate in different extent: 3% for the lignin obtained after the formic/acetic acid pretreatment performed at 107 C (FAL-107), 5.8% for the formic/acetic acid performed at 80°C (FAL-80) and 13.7% for the ammonia lignin (AL). The acid pretreatment in harsh conditions (FAL-107) resulted in cleavage of b-O-4' bonds and aromatic C-C. Repolymerisation was thought to originate from formation of new aromatic C-O linkages. Under milder conditions (FAL-80) less b-O-4' linkages were broken and repolymerisation took place to a lesser extent. Ammonia lignin was not degraded to a significant extent and resulted in the highest weight average 3140 g mol -1. Despite the fact of FAL-107 repolymerisation, significant phenolic hydroxyls remained free, explaining the greater antioxidant activity. [less ▲]

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See detailImpact of freezing and thawing processes on wheat and potato starch gel syneresis
Freschi, Jérôme; Doran, Lynn ULg; Malumba Kamba, Paul ULg et al

in Stärke = Starch (2013), 65

With the globalization of the market, food industries need to adapt their processes to establish their presence in far away countries. Long transports are problematic for fresh food products as they ... [more ▼]

With the globalization of the market, food industries need to adapt their processes to establish their presence in far away countries. Long transports are problematic for fresh food products as they drastically reduce the already short shelf life. To counter this problem, the idea to freeze food for ransport and thaw it on arrival could be an alternative solution to propose an acceptable shelf life to the consumer. This brings new challenges as although freezing is thoroughly mastered, thawing is not. The main visible alteration of thawing is a water syneresis phenomenon leaving the product unfit for consumption. Indeed, water affects foods at several levels such as safety, stability, quality, and physical properties [1]. To investigate this problem, starch, a common polymer encountered in a wide variety of food, seemed to be a good model in gel form considering the three main food complexity dimensions which are: compositional, structural, and dynamical complexity [2, 3]. [less ▲]

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See detailImpact of future Greenland deglaciation on global weathering fluxes and atmospheric CO2
Munhoven, Guy ULg; Brovkin, Victor; Ganopolski, A. et al

Conference (2007)

About 1.76×10^6 km2 of Greenland are currently covered by ice. It is expected that this large ice mass will melt away over the next 3000 years if anthropogenic CO2 emissions continue to rise (Alley et al ... [more ▼]

About 1.76×10^6 km2 of Greenland are currently covered by ice. It is expected that this large ice mass will melt away over the next 3000 years if anthropogenic CO2 emissions continue to rise (Alley et al., 2006). As a result, the bedrock currently covered by ice will lie free and become subject to chemical weathering. The resulting weathering fluxes will contribute to increase both the consumption rate of atmospheric CO2 and the production rate of riverine bicarbonate. Increasing these two fluxes will tend to decrease the atmospheric CO2 partial pressure, as a result of the modified ocean-atmosphere carbon cycle. Chemical weathering may thus possibly act as a negative feedback in the Greenhouse World. Other changes (e.g., vegetation cover and additional climate change) concomitant with the melting of the Greenland ice-sheet may either amplify or dampen, if not reverse the weathering effect. Here we use the intermediate complexity Earth System model CLIMBER-2 to quantify and analyse the weathering flux changes that result from the projected melting of the Greenland ice sheet and the implications for atmospheric CO2. The biogeochemical module of CLIMBER-2 has been extended to account for the consumption of atmospheric CO2 and the production of riverine bicarbonate by continental weathering processes, as a function of geographically distributed runoff (interactively provided by the CLIMBER-2 climate module) and lithology (derived from Amiotte Suchet et al., 2003). We find that the increased weathering processes alone would lead to a sustained 0.2 ppm/kyr decrease in atmospheric pCO2. The climate change resulting from the deglaciation of Greenland reduces the magnitude of this trend to 0.1 ppm/kyr. Only in the case where the effect of freshly comminuted bedrock is taken into account (Clark et al., 2006) does the weathering feedback help to reduce atmospheric pCO2 by about 10 ppm in 5000 years. Alley R.B. et al. (2005) Science 310, 456–460. Amiotte Suchet P. et al. (2003) Global Biogeochemical Cycles 17, 1139, doi:10.1029/2002GB001891. Clark P.U. et al. (2006) Quaternary Science Reviews 25, 3150–3184. [less ▲]

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See detailImpact of gender difference in hospital outcomes following percutaneous coronary intervention. Results of the Belgian Working Group on Interventional Cardiology (BWGIC) registry
LEMPEREUR, Mathieu ULg; Magne, Julien; Cornelis, Kristoff et al

in EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology (2014)

Aims: To determine whether there are gender-based differences in in-hospital outcomes among patients undergoing percutaneous coronary intervention (PCI). Methods and results: We studied a large cohort ... [more ▼]

Aims: To determine whether there are gender-based differences in in-hospital outcomes among patients undergoing percutaneous coronary intervention (PCI). Methods and results: We studied a large cohort using clinical data from a registry of 130,985 PCI procedures in Belgium, from January 2006 to February 2011. Compared to males, females were significantly older (70.3 vs. 64.8 years), and were more frequently diabetic or hypertensive. Men smoked more and more frequently had previous myocardial infarction (MI), previous PCI or previous coronary artery bypass graft (CABG) surgery. Coronary artery disease (CAD) was less severe in women, and PCI to the left anterior descending artery was more common in female patients. Unadjusted in-hospital mortality rates were higher in females versus males (2.5% for women and 1.6% for men, p<0.0001). After multivariable analysis, female gender remained an independent predictor of mortality (odds ratio 1.35, 95% CI: 1.22-1.49, p<0.0001). Conclusions: Gender-based differences in hospital mortality rates after PCI were observed in this large registry. Female sex remained an independent predictor of mortality after multivariable adjustment. [less ▲]

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See detailImpact of geomagnetic activity on high precision GNSS positioning. Galileo GALOCAD project
Warnant, René ULg; Bavier, Michaël; Lejeune, Sandrine et al

Conference (2006)

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See detailImpact of geometry and viewing angle on classification accuracy of 2D based analysis of dysmorphic faces
Vollmar, Tobias; Maus, Bärbel ULg; Wurtz, R. P. et al

in European Journal of Medical Genetics (2008), 51(1), 44-53

Digital image analysis of faces has been demonstrated to be effective in a small number of syndromes. In this paper we investigate several aspects that help bringing these methods closer to clinical ... [more ▼]

Digital image analysis of faces has been demonstrated to be effective in a small number of syndromes. In this paper we investigate several aspects that help bringing these methods closer to clinical application. First, we investigate the impact of increasing the number of syndromes from 10 to 14 as compared to an earlier study. Second, we include a side-view pose into the analysis and third, we scrutinize the effect of geometry information. Picture analysis uses a Gabor wavelet transform, standardization of landmark coordinates and subsequent statistical analysis. We can demonstrate that classification accuracy drops from 76% for 10 syndromes to 70% for 14 syndromes for frontal images. Including side-views achieves an accuracy of 76% again. Geometry performs excellently with 85% for combined poses. Combination of wavelets and geometry for both poses increases accuracy to 93%. In conclusion, a larger number of syndromes can be handled effectively by means of image analysis. [less ▲]

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See detailImpact of germline AIP mutations on tumor characteristics and Management in young acromegalic patients : results of an age-and tumor diameter matched cohort study
Tichomirowa, Maria A.; Theodoropoulou, Marily; Daly, Adrian ULg et al

in Abstract book - Endo 2011 (2011)

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See detailImpact of global climate change and desertification on the environment and society in Southern Centre of Vietnam (a case study in Binh Thuan province). Climate today and tomorrow: state of play and perception.
Ozer, Pierre ULg

Report (2012)

The Province of Binh Thuan is the driest area of Vietnam. It is felt as being affected by desertification processes that are mainly resulting from the ongoing „climate change‟, especially shortening ... [more ▼]

The Province of Binh Thuan is the driest area of Vietnam. It is felt as being affected by desertification processes that are mainly resulting from the ongoing „climate change‟, especially shortening rainfall. But has climate, and especially precipitations, really changed in recent years? Or is the recent increase of agricultural activities with higher water needs may explain such perception of a changing climate? In the collection of four papers presented hereafter, we try to answer to these questions. Yet, the first paper investigates recent trends in precipitation and temperatures using daily data from the weather station of Phan Thiet. It appears that the area did not experience any significant precipitation decrease (rainfall have, at the contrary, globally increased) but a very significant increase in temperature. The second paper focuses on future climate projections (that is 2046-2065 and 2081-2100 compared to historical data 1970-1999). It shows that the Province of Binh Thuan will face an increase of mean temperature of about 1.6°C (over 2046-2065) and 2.5°C (over 2081-2100) and an increase of extreme temperatures and extreme rainfall events. However, no significant changes about the evolution of the annual amount of precipitation were found. It also indicates that the dry season is likely to be longer in 2046-2065 owing to a delay in the onset of the rainy season (up to 15 days) accompanied by an earlier end of the rainy season (up to 30 days). The third paper explores recent land use and land cover changes in the Province of Binh Thuan. Comparisons of the land cover maps reveal that a steady growth in population has caused extensive changes of land cover throughout the area. The maps also indicate that the loss of woody land (forest) and the extension of irrigated area, combined with built-up encroachment, remains one of the most serious environmental problems today. Yet, results showed over the 12-year span, approximately 115,120 ha of forests were converted respectively to brush, irrigated area, cropland and built-up. This is an overall average decrease of approximately 9,594 ha of forested area per year. Based on the identified causes of these changes, we made policy recommendations for better management of land use and land cover. Such results show that water needs are always increasing due to the extension of irrigated areas. The last paper concludes with a case study of a fishing village disappearing as a result of shoreline erosion. It shows that the term “climate change” is misused probably because it is easier to blame a global issue rather than the local mismanagement of natural resources, the lack of land use planning and the nonexistence of policies focused on natural hazard management in the uncontrolled construction the seaside resort of Mui Ne. This reflexion about the wrong perception of climate change which may cause several economic problems could be extended to water availability which may not be sufficient to support recent developments of irrigated agriculture. Understanding current problems may help developing adaptation strategies in the next decades. Further research is needed to understand such perception of climate change, especially when knowing that future climate may be really affected by an increase of extreme rainfall events and an extended dry season. [less ▲]

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See detailImpact of global left ventricular afterload on left ventricular function in asymptomatic severe aortic stenosis: a two-dimensional speckle-tracking study.
Lancellotti, Patrizio ULg; Donal, Erwan; Magne, Julien ULg et al

in European Journal of Echocardiography (2010), 11(6), 537-543

Aims: The present study sought to assess the effect of global left ventricular (LV) afterload on LV myocardial systolic function in patients with aortic stenosis (AS) and preserved LV ejection fraction ... [more ▼]

Aims: The present study sought to assess the effect of global left ventricular (LV) afterload on LV myocardial systolic function in patients with aortic stenosis (AS) and preserved LV ejection fraction. <br />Methods and results: We prospectively examined the LV myocardial deformation (i.e. longitudinal, radial, and circumferential) by two-dimensional speckle tracking in 173 patients with asymptomatic severe AS. Thirty-eight patients (22%) had lowflow as determined by a low stroke volume index (􏰀35 mL/m2). By multivariable analysis, four variables emerged as independently associated with low-flow AS: peak Ea velocity (P 1⁄4 0.01), left atrial area index (P 1⁄4 0.017), global LV afterload (P 1⁄4 0.024), and circumferential myocardial deformation (P 1⁄4 0.04). Forty-nine patients (28%) had an increased global LV afterload (􏰁5 mmHg mL/m2). Systemic arterial compliance (P 1⁄4 0.001), circumferential myocardial deformation (P 1⁄4 0.024), and left atrial area index (P 1⁄4 0.04) were independently associated with increased global LV load in multivariable analysis. <br />Conclusion: In asymptomatic patients with severe AS, LV ejection fraction markedly underestimates the extent of myocardial sys- tolic impairment. Intrinsic myocardial dysfunction is particularly common in patients with increased global LV after- load, and especially in the subset of patients with low-flow AS. [less ▲]

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See detailImpact of glycerol and nitrogen concentration on Enterobacter A47 growth and exopolysaccharide production
Torres, Ch.; Marques, R.; Ferreira, A.R. et al

in International Journal of Biological Macromolecules (2014), 71

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See detailImpact of glycerol and storage temperature on gluatathione concentration and physiological state of Pseudomonas fluorescens BTP1 freeze-dried
Mputu Kanyinda, Jean-Noël ULg; Pierart, C.; Delvigne, Frank ULg et al

Poster (2012, February 15)

Pseudomonas fluorescens is commonly used as bio-fungicides in agriculture. For this use it requires formulations as either liquid or powder. Formulations have two advantages, storage and transport. Freeze ... [more ▼]

Pseudomonas fluorescens is commonly used as bio-fungicides in agriculture. For this use it requires formulations as either liquid or powder. Formulations have two advantages, storage and transport. Freeze-drying is a commonly used method to preserve bacteria. However, freeze-drying damages the cells, which results in loss of viability. Protective compounds are used to reduce loss of viability during process (freeze-drying and storage). In our study we used flow cytometry analysis to assess the physiological state in which cells are at the end of freeze-drying and Glutathione (GSH) was measured before and during storage. [less ▲]

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See detailImpact of GODAE products on nested HYCOM simulations of the West Florida Shelf
Halliwell, G. R.; Barth, Alexander ULg; Weiberg, R. H. et al

in Ocean Dynamics (2009), 59(1), 139-155

Nested non-assimilative simulations of the West Florida Shelf for 2004-2005 are used to quantify the impact of initial and boundary conditions provided by Global Ocean Data Assimilation Experiment ocean ... [more ▼]

Nested non-assimilative simulations of the West Florida Shelf for 2004-2005 are used to quantify the impact of initial and boundary conditions provided by Global Ocean Data Assimilation Experiment ocean products. Simulations are nested within an optimum interpolation hindcast of the Atlantic Ocean, the initial test of the US Navy Coupled Ocean Data Assimilation system for the Gulf of Mexico, and a global ocean hindcast that used the latter assimilation system. These simulations are compared to one that is nested in a non-assimilative Gulf of Mexico model to document the importance of assimilation in the outer model. Simulations are evaluated by comparing model results to moored Acoustic Doppler Current Profiler measurements and moored sea surface temperature time series. The choice of outer model has little influence on simulated velocity fluctuations over the inner and middle shelf where fluctuations are dominated by the deterministic wind-driven response. Improvement is documented in the representation of alongshore flow variability over the outer shelf, driven in part by the intrusion of the Loop Current and associated cyclones at the shelf edge near the Dry Tortugas. This improvement was realized in the simulation nested in the global ocean hindcast, the only outer model choice that contained a realistic representation of Loop Current transport associated with basin-scale wind-driven gyre circulation and the Atlantic Meridional Overturning Circulation. For temperature, the non-assimilative outer model had a cold bias in the upper ocean that was substantially corrected in the data-assimilative outer models, leading to improved temperature representation in the simulations nested in the assimilative outer models. [less ▲]

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See detailImpact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia : a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation
Baron, Frédéric ULg; Labopin, M.; Niederwieser, D. et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (2012), 26(12), 2462-2468

This report investigated the impact of graft-versus-host disease (GVHD) on transplantation outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem cells after reduced ... [more ▼]

This report investigated the impact of graft-versus-host disease (GVHD) on transplantation outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem cells after reduced-intensity conditioning (RIC allo-SCT). Grade I acute GVHD was associated with a lower risk of relapse (hazards ratio (HR)¼0.7, P¼0.02) translating into a trend for better overall survival (OS; HR¼1.3; P¼0.07). Grade II acute GVHD had no net impact on OS, while grade III–IV acute GVHD was associated with a worse OS (HR¼0.4, Po0.0.001) owing to high risk of nonrelapse mortality (NRM; HR¼5.2, Po0.0001). In time-dependent multivariate Cox analyses, limited chronic GVHD tended to be associated with a lower risk of relapse (HR¼0.72; P¼0.07) translating into a better OS (HR¼1.8; Po0.001), while extensive chronic GVHD was associated with a lower risk of relapse (HR¼0.65; P¼0.02) but also with higher NRM (HR¼3.5; Po0.001) and thus had no net impact on OS. In-vivo T-cell depletion with antithymocyte globulin (ATG) or alemtuzumab was successful at preventing extensive chronic GVHD (Po0.001), but without improving OS for ATG and even with worsening OS for alemtuzumab (HR¼0.65; P¼0.001). These results highlight the role of the immune-mediated graft-versus-leukemia effect in the RIC allo-SCT setting, but also the need for improving the prevention and treatment of severe GVHD. [less ▲]

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See detailImpact of grazing by amphipods on the dynamics of the epiphytic cover of the Posidonia oceanica leaves : an in vitro experiment.
Michel, Loïc ULg; Gobert, Sylvie ULg; Dauby, Patrick ULg et al

Conference (2010, September 17)

It is now established that several species of amphipods associated to Mediterranean Posidonia oceanica meadows consume the epiphytes present on the leaves of the seagrass. However, little or no work has ... [more ▼]

It is now established that several species of amphipods associated to Mediterranean Posidonia oceanica meadows consume the epiphytes present on the leaves of the seagrass. However, little or no work has been undertaken to quantify this interaction. Here, we present the results of an in vitro experiment that used seagrass mimics to estimate the impact of grazing by the amphipods Apherusa chiereghinii, Dexamine spiniventris and Gammarus spp on the dynamics of the epiphytic cover. All species reduced epiphyte biomass in a significant way, and grazers preferentially fed on erected algae. Assimilation of epiphyte-derived carbon and nitrogen was monitored using stable isotopes (13C and 15N) labelling, and was obvious in the three taxa. Moreover, grazing activity of amphipods seemed to influence epiphyte physiology, notably by increasing nitrogen uptake by the erected algae. These results shed light on trophic interactions between the amphipods from Posidonia oceanica meadows and the seagrass epiphytic cover, and thus enhance our understanding of the role of these grazers in the functioning of the meadow as an ecosystem. [less ▲]

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See detailImpact of grazing by amphipods on the epiphytic cover of the Posidonia oceanica leaves: an in situ experiment.
Michel, Loïc ULg; Dupont, Alessandra; Gobert, Sylvie ULg et al

Poster (2010, October 22)

It is now established that several species of amphipods associated to Mediterranean Posidonia oceanica meadows consume the macro-epiphytes present on the leaves of the seagrass. Moreover, under controlled ... [more ▼]

It is now established that several species of amphipods associated to Mediterranean Posidonia oceanica meadows consume the macro-epiphytes present on the leaves of the seagrass. Moreover, under controlled in vitro conditions, three amphipod taxa (Apherusa chiereghinii,Dexamine spiniventris and Gammarus spp.) are able to drastically deplete the biomass of erected algae, thus influencing the epiphytic cover in both a quantitative and a qualitative way. Here, we tried to assess whether this strong and complex trophic interaction was realized in the field. We designed an in situ experiment that used microcosms placed directly in the meadow, at a depth of 10m, to estimate the impact of grazing by the aforementioned amphipod taxa on the dynamics of the epiphytic cover. Both Gammarus spp. and Dexamine spiniventris caused a significant decrease of the biomass of erected algae and erected animals (bryozoans and hydrozoans). Impact of grazing by Apherusa chiereghinii on these two epiphytic groups was less important, although strong but marginally non-significant (0,1>p>0,05) trends to lower biomasses were present. None of the considered taxa seemed to consume encrusting macro-epiphytes. In addition, assimilation of epiphyte-derived carbon and nitrogen by grazers was monitored using stable isotopes (13C and 15N), and epiphyte elemental content (C & N) was measured. Our results shed light on trophic interactions between the amphipods from Posidonia oceanica meadows and the seagrass epiphytic cover, and thus enhance our understanding of the role of these grazers in the functioning of the meadow as an ecosystem. [less ▲]

Detailed reference viewed: 54 (10 ULg)