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See detailHypoxia-inducible Factor-1-dependent Overexpression of Myeloid Cell Factor-1 Protects Hypoxic Cells against tert-Butyl Hydroperoxide-induced Apoptosis
Piret, Jean-Pascal; Minet, Emmanuel; Cosse, Jean-Philippe ULg et al

in Journal of Biological Chemistry (2005), 280

Increased levels of Mcl-1 (myeloid cell factor-1) have been reported in several cancers, suggesting an important role played by Mcl-1 in cancer cell survival. Mcl-1 is an anti-apoptotic protein shown to ... [more ▼]

Increased levels of Mcl-1 (myeloid cell factor-1) have been reported in several cancers, suggesting an important role played by Mcl-1 in cancer cell survival. Mcl-1 is an anti-apoptotic protein shown to delay or block apoptosis. In this work, using semiquantitative immunofluorescence, real-time PCR, and RNase protection assay, an increase in Mcl-1 expression was detected in hepatoma HepG2 cells incubated under hypoxia or in the presence of cobalt chloride. Through analysis of the Mcl-1 promoter sequence, a putative HIF-1 (hypoxiainducible factor-1) binding site was identified. A Mcl-1 promoter fragment containing this hypoxia-responsive element was able to bind HIF-1 in vitro. It also induced hypoxia-dependent transcription of a luciferase reporter gene, which was suppressed by anti-HIF-1 short interfering RNA. Finally, overexpression of Mcl-1 protected HepG2 cells against apoptosis induced by tertbutyl hydroperoxide as shown by inhibition of caspase-3 activation and DNA fragmentation. All these data suggest a potential anti-apoptotic role of HIF-1 that could protect cells against apoptosis under hypoxia by overexpression of the Mcl-1 protein. [less ▲]

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See detailHypoxic pulmonary vasoconstriction and anaesthesia
Brichant, Jean-François ULg

Conference (2002, April)

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See detailHysteretic behavior in metallic granular matter
Dorbolo, Stéphane ULg; Ausloos, Marcel ULg; Vandewalle, Nicolas ULg

in Applied Physics Letters (2002), 81(5), 936-938

Various packings made of metallic grains have been electrically characterized. Electrical breakdown is observed in I-V curves. A well defined critical point separates the insulating and the conducting ... [more ▼]

Various packings made of metallic grains have been electrically characterized. Electrical breakdown is observed in I-V curves. A well defined critical point separates the insulating and the conducting regime of the packing. The breakdown is reversible by submitting the packing to a small tap. This unusual property leads to hysteretic loops in I-V diagrams. The study of the behavior of I-V curves allows us to describe the system as a network of weak lossy contacts. The key parameter is the inner electrical field controlling the diode-like or diffusion-like state of the packing. (C) 2002 American Institute of Physics. [less ▲]

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See detailHysteretic behavior in three-dimensional soap film rearrangements
Vandewalle, Nicolas ULg; noirhomme, matial; Schockmel, Julien ULg et al

in Physical Review. E : Statistical, Nonlinear, and Soft Matter Physics (2011), 83

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See detailHysteroscopic myomectomy.
Donnez, Jacques; Polet, Roland; Smets, Mireille et al

in Current Opinion in Obstetrics & Gynecology (1995), 7(4), 311-6

Transhysteroscopic myomectomy has proved to be safe and effective with experienced operators. The use of the continuous flow hysteroscope and preoperative monitoring of intrauterine pressure has ... [more ▼]

Transhysteroscopic myomectomy has proved to be safe and effective with experienced operators. The use of the continuous flow hysteroscope and preoperative monitoring of intrauterine pressure has contributed to the prevention of fluid intravasion accidents. Effectiveness has been demonstrated in a number of recently published long-term studies. [less ▲]

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See detailHysteroscopic resection of abnormally invasive placenta residuals.
Nisolle, Michelle ULg; DELBECQUE, Katty ULg; PERRIER d'HAUTERIVE, Sophie ULg et al

in Acta Obstetricia et Gynecologica Scandinavica (2013), 92(4), 451-6

OBJECTIVE: To present our experience in hysteroscopic removal of abnormally invasive placenta (AIP) residuals using bipolar energy. DESIGN: Case series. SETTING: University hospital. POPULATION: Sixteen ... [more ▼]

OBJECTIVE: To present our experience in hysteroscopic removal of abnormally invasive placenta (AIP) residuals using bipolar energy. DESIGN: Case series. SETTING: University hospital. POPULATION: Sixteen patients with AIP residuals after 17 pregnancies. METHODS: Cases were identified by ultrasound, treated with hysteroscopic bipolar electrosurgery and oral contraceptives, and followed up by ultrasound or hysteroscopy. Nine subsequent pregnancies were described. MAIN OUTCOME MEASURES AND RESULTS: Complete removal of AIP residuals was achieved by hysteroscopic bipolar electrosurgery in all cases except one. No peroperative complications occurred. AIP residual recurred in one patient after a subsequent pregnancy and was successfully treated using the same procedure. CONCLUSIONS: AIP residual is a rare condition. Management by hysteroscopic resection using bipolar energy is save and feasible. [less ▲]

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See detailHysteroscopic sterilization with the Nd:YAG laser.
Donnez, Jacques; Malvaux, Vincent; NISOLLE, Michelle ULg et al

in Journal of Gynecologic Surgery (1990), 6(3), 149-53

In 10 rabbits, ablation of the uterine horn endometrium and the fallopian tube was performed with the Nd:YAG laser at a power of 60 W using the touch technique. Eight weeks postsurgery, biopsies of the ... [more ▼]

In 10 rabbits, ablation of the uterine horn endometrium and the fallopian tube was performed with the Nd:YAG laser at a power of 60 W using the touch technique. Eight weeks postsurgery, biopsies of the tissue site were obtained showing that the endometrium and tubal mucosa were completely destroyed. Thirty women were sterilized using a similar technique hysteroscopically. Tubal occlusion was demonstrated by hysterosalpingography in all cases at 3 months postoperatively. [less ▲]

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See detailHysteroscopic surgery
Donnez, Jacques; NISOLLE, Michelle ULg

in Current Opinion in Obstetrics & Gynecology (1992), 4(3), 439-46

Because a wide variety of conditions can be diagnosed hysteroscopically, hysteroscopy has become a diagnostic gold standard. Through "operative" hysteroscopes, both the electrical current of the ... [more ▼]

Because a wide variety of conditions can be diagnosed hysteroscopically, hysteroscopy has become a diagnostic gold standard. Through "operative" hysteroscopes, both the electrical current of the resectoscope and the energy of the neodymium:yttrium-aluminum-garnet laser have been effective tools in many cases and presented a new alternative to laparotomy and hysterectomy. The most frequent procedures are 1) endometrial ablation and partial endometrial ablation, 2) myomectomy for submucous myomas, 3) two-step myomectomy for large submucosal and intramural myomas, 4) hysteroscopic management of müllerian defects, and 5) hysteroscopic management of intrauterine adhesions. [less ▲]

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See detailHystéroscopie opératoire ou hystérectomie dans le traitement des lésions utérines bénignes. Que choisir en 1998?
Herman, Philippe ULg; Gaspard, Ulysse ULg; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (1998), 53(12), 756-61

In the past, the treatment of benign uterine lesions required, in many instances, a hysterectomy. These days, most cases can be successfully treated by hysteroscopy. To be reliable, this technique must ... [more ▼]

In the past, the treatment of benign uterine lesions required, in many instances, a hysterectomy. These days, most cases can be successfully treated by hysteroscopy. To be reliable, this technique must lead to a significant reduction in the number of hysterectomies performed for benign uterine lesions. The electroresection technique is preferred to that using the Nd-YAG laser because of its lower cost and its equivalent efficacy. By using the uterine perfusion pump device, the risk of resorption syndrome can be reduced to its minimum. Submucosal myomas < 1 cm, benign endometrial hyperplasia and adenomyosis are the commonest benign lesions treated. Dysfunctional uterine bleeding can also be treated by an endometrectomy. A preoperative workup includes a transvaginal ultrasound and a biopsy. This ensures that only benign lesions that are accessible to a hysteroscopy will be submitted to this technique and that no cases of endometrial cancer or atypical hyperplasia would be ignored. This study presents 270 cases of operative hysteroscopy with a follow-up to 4 years. 82.8% of myomatous lesions were treated with success. The results for patients with benign endometrial polyps or benign endometrial hyperplasia are also excellent with only 4.6% and 5.6% rate of secondary surgery respectively. Adenomyosis does not appear to be a good indication for hysteroscopy as only 37% of patients did not need a definitive hysterectomy. Rates of operative complications (post-operative bleeding, uterine perforation, resorption syndrome and difficulty of access) are acceptable and get less frequent as the surgeon experience increases. [less ▲]

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See detailI : L'apprentissage
Defays, Jean-Marc ULg

Conference given outside the academic context (2000)

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See detailI am (un)happy but I don't know why: Subliminal positive-self statements effects
Bustin, Gaëlle ULg; Weinberger, Joel

Poster (2013, January)

This study provides evidence that positive self-statements can increase mood among unhappy people if they are presented subliminally. In study 1, participants with low and high levels of dispositional ... [more ▼]

This study provides evidence that positive self-statements can increase mood among unhappy people if they are presented subliminally. In study 1, participants with low and high levels of dispositional happiness were presented subliminally with the two words I AM which were immediately paired with a positive word. Results revealed that being exposed to subliminal positive self-statements seems to provide a boost in mood for people with less happy dispositions. Surprisingly, opposite effects were found for participants who had joyful dispositions: exposure to subliminal positive self-statements tended to lower their mood. Study 2 confirmed these results with an implicit measure of mood. Such results suggest that subliminal messages can affect emotions and highlight the necessity of taking personality into account in unconscious cognition research. [less ▲]

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See detail"I Commentari di Giulio Cesare" (1575) : Andrea Palladio graveur ou l'exercice de l'illustration de l'histoire
Rusch, Arnaud ULg; Bobin, Sarah; Carlizza, Marie

in Costa, Sandra (Ed.) La gravure et l'Histoire : les livres illustrés de la Renaissance et du Baroque à la conquête du passé (2010)

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See detailI know what you did last summer - High resolution mapping of wild boar damages with drones
Michez, Adrien ULg; Morelle, Kevin ULg; Lehaire, François ULg et al

Poster (2014, September 01)

Wild boar ability to cause important damages to agricultural lands is not anymore to be demonstrated. These damages often raise conflicts between farmers and hunters due to the associated economic losses ... [more ▼]

Wild boar ability to cause important damages to agricultural lands is not anymore to be demonstrated. These damages often raise conflicts between farmers and hunters due to the associated economic losses. Objective and accurate method for real impact assessment of losses suffered by farmers is thus needed. Currently,in Wallonia damage assessment is performed from the ground by experts, asked to evaluate precisely the area impacted. This task is time and man power consuming. Moreover, damaged areas are often large and consequently, sampling is mandatory and can induce accuracy issues. Recent development of unmanned aerial vehicle (UAV / drone) toghether with lower cost and better accessibility for civil society and scientific community, makes now possible the use of this technology for wildlife researches. Through photogrammetric 3D reconstruction of the field crop, UAV can allow to objectively and precisely measure the area impacted by wild boar damages. In a context of increasing issues caused by wild boar to agriculture, and the need for stakeholders for accurate impact assessment, we tested an innovative approach to estimate more effectively the area impacted by wild boar. [less ▲]

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See detailI primi volgarizzamenti italiani delle Nozze di Mercurio e Filologia.
Moreno, Paola ULg

in Revue Belge de Philologie et d'Histoire (1999)

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See detailI see dead people. Les zombies au cinéma
Tomasovic, Dick ULg

Conference given outside the academic context (2012)

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See detailI-see-3D! An Interactive and Immersive System that dynamically adapts 2D projections to the location of a user’s eyes
Pierard, Sébastien ULg; Pierlot, Vincent ULg; Lejeune, Antoine ULg et al

in International Conference on 3D Imaging (IC3D) (2012, December)

This paper presents a system that gives the illusion of a 3D immersive and interactive environment with 2D projectors. The user does not need to wear glasses, nor to watch a (limited) screen. The virtual ... [more ▼]

This paper presents a system that gives the illusion of a 3D immersive and interactive environment with 2D projectors. The user does not need to wear glasses, nor to watch a (limited) screen. The virtual world is all around him, drawn on the floor. As the user is himself immersed in the virtual world, there is no need for a proxy like an avatar; he can move inside the virtual environment freely. Moreover, the Isee-3D system allows a user to manipulate virtual objects with his own body, making interactions with the virtual world very intuitive. Giving the illusion of 3D requires to render images insuch a way that the deformation of the image projected on thefloor is taken into account, as well as the position of the user’s “eye” in its virtual world. The resulting projection is neither perspective nor orthographic. Nevertheless, we describe how thiscan be implemented with the standard OpenGL pipeline, without any shader. Our experiments demonstrate that our system is effective in giving the illusion of 3D. Videos showing the results obtained with our I-see-3D system are available on our website http://www.ulg.ac.be/telecom/projector [less ▲]

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See detailIA-2-autoantibodies complement GAD65-autoantibodies in new-onset IDDM patients and help predict impending diabetes in their siblings. The Belgian Diabetes Registry.
Gorus, F. K.; Goubert, P.; Semakula, C. et al

in Diabetologia (1997), 40(1), 95-9

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody ... [more ▼]

IA-2 has been identified as an autoantigen that is recognized by immunoglobulins from insulin-dependent diabetic (IDDM) patients. Using a liquid phase radiobinding assay, we performed an IA-2-autoantibody (IA-2-Ab) assay in 474 IDDM patients and 482 non-diabetic control subjects aged 0-3 years. IA-2-Ab were detected in 58% of the patients and 0.8% of control subjects. Their prevalence in patients was lower than that of islet cell autoantibodies (ICA; 73%) or glutamic acid decarboxylase (M(r) 65 kDa)-autoantibodies (GAD65-Ab; 82%) but higher than that of insulin autoantibodies (IAA; 42%). IA-2-Ab were more frequent in patients under age 20 years (70%) than between 20 and 40 years (45%; p < 0.001). In the whole IDDM group, 92% of patients were positive for at least one of the three molecular assays, which is higher than the positivity for the ICA assay (73%). Only 1% was negative in the molecular assays and positive in the ICA assay. IA-2-Ab levels were positively correlated with ICA titres (p < 0.001) and HLA DQ A1*0301-DQ B1*0.02 (p < 0.003) by multivariate analysis. In a group of 481 non-diabetic siblings (age 0-39 years) of IDDM patients only 7 were IA-2-Ab positive (1.5%). All seven were under age 20 years and positive for at least two other autoantibodies and for DQ A1*0301-DQB1*0302. Four of these seven developed IDDM during the 6-70-month follow-up period. The positive predictive value of IA-2-Ab (57%) was higher than that of ICA, GAD65-Ab or IAA alone, or in combination (< or = 20%) but these calculations are restricted by the relatively short observation period and the small number of cases. The only IA-2-Ab-negative case of pre-diabetes was also negative for IAA and GAD65-Ab, while it was strongly positive for ICA. In conclusion, IA-2-Ab show a high diagnostic specificity for IDDM and are predictive markers of impending diabetes in siblings of patients. In combination with other molecular antibody assays they may replace ICA testing in future. Our data also indicate that other autoantibodies than IA-2-Ab, GAD65-Ab and IAA contribute to ICA. [less ▲]

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See detailIAA-oxidase activity and auxin protectors in nonrooting, rac, mutant shoots of tobacco in vitro
Faivre-Rampant, Odile; Kevers, Claire ULg; Gaspar, Thomas ULg

in Plant Science (2000), 153(1), 73-80

The peroxidase and IAA-oxidase activities, the degree of auxin protection and the amount of soluble phenolics were determined in in vitro cultured shoots of a nonrooting mutant, inc, of tobacco compared ... [more ▼]

The peroxidase and IAA-oxidase activities, the degree of auxin protection and the amount of soluble phenolics were determined in in vitro cultured shoots of a nonrooting mutant, inc, of tobacco compared to its wild homologue. The mutant and wild shoots showed similar peroxidase variations along the growth cycle of 21 days, but with higher levels of activity for the I ac mutant. During this growth cycle, the minimum of peroxidase activity occurred at day 14 for both tobacco whole shoots. However. this minimum of activity did not occur at the same day in the basal part of the stem, where roots may appear, of the two types of tobacco. Both mutant and wild whole shoots showed about the same IAA-oxidase activity in the fractions resulting from a gel filtration of the crude extracts through a sephadex G-100 column but differed in the degree of auxin protection. The rac shoots exhibited a very high level of auxin protectors of low molecular weight, among which chlorogenic acid. They were also characterized by eight to nine times higher level of soluble phenolics. The relationships between these biochemical aspects in relation to the absence of root formation in the me mutant are discussed. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved. [less ▲]

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