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See detailFurther exploration of the mere exposure effect in Alzheimer's disease
Willems, Sylvie ULg; Adam, Stéphane ULg; Van der Linden, Martial et al

in Journal of Cognitive Neuroscience (2001, March 25), Suppl. 58

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See detailFurther heterogeneity demonstarted for serum creatine kinase isoenzyme MM
Chapelle, Jean-Paul ULg; Heusghem, C.

in Clinical Chemistry (1980), 26(3), 457-62

Serum creatine kinase (EC 2.1.3.2) isoenzyme MM was resolved by isoelectric focusing into a five-band pattern, a pattern that gradually changed after the onset of myocardial infarction. Similar changes ... [more ▼]

Serum creatine kinase (EC 2.1.3.2) isoenzyme MM was resolved by isoelectric focusing into a five-band pattern, a pattern that gradually changed after the onset of myocardial infarction. Similar changes were also demonstrated in patients undergoing coronary-bypass surgery. The evolution of two CK-MB sub-bands was studied in both cases. We found that three electrophoretic bands (CK-MM, pI 7.10; MM1, pI 6.88; MB1, pI 5.61) were predominant in patterns for sera collected during the early phase of myocardial infarction, but rapidly disappeared during the following hours, whereas bands of increased electrophoretic mobility (MM2, pI 6.70; MM3, pI 6.45; MM4, pI 6.25; MB2, pI 5.34) gradually increased. MM3 was always the major band at the end of the observation period in acute myocardial infarction (mean, 61.4% of total creatine kinase activity 36 h after the peak value for total creatine kinase in serum). The CK-MM bands were also present in the serum of patients without heart disease. Changes in the electrophoretic pattern were induced by a thermolabile factor in normal human serum, which transformed the muscular or myocardial MM and MM1 bands after their release into the blood stream [less ▲]

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See detailFurther insight into the role of metacognitive beliefs in schizophrenia and OCD patients: Testing a mediation model
Bortolon, C; Laroi, Frank ULg; Stephan, Y et al

in Psychiatry Research (2014), 220

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See detailFurther insight into the sound-producing mechanism of clownfishes: what structure is involved in sound radiation?
Colleye, Orphal ULg; Nakamura, Masaru; Frederich, Bruno ULg et al

in Journal of Experimental Biology (2012), 215

It was recently demonstrated that clownfishes produce aggressive sounds by snapping their jaw teeth. To date, only the onset of the sound has been studied, which raises the question, what structure is ... [more ▼]

It was recently demonstrated that clownfishes produce aggressive sounds by snapping their jaw teeth. To date, only the onset of the sound has been studied, which raises the question, what structure is involved in sound radiation? Here, a combination of different approaches has been used to determine the anatomical structure(s) responsible for the size-related variations observed in sound duration and frequency. Filling the swimbladder with physiological liquid specifically modified size-related acoustic features by inducing a significant decrease in pulse duration of approximately 3 ms and a significant increase in dominant frequency of approximately 105 Hz. However, testing the acoustics of the swimbladder by striking it with a piezoelectric impact hammer showed that this structure is a highly damped sound source prevented from prolonged vibrations. In contrast, the resonant properties of the rib cage seems to account for the size-related variations observed in acoustic features. For an equivalent strike on the rib cage, the duration and dominant frequency of induced sounds changed with fish size: sound duration and dominant frequency were positively and negatively correlated with fish size, respectively. Such relationships between sonic features and fish size are consistent with those observed in natural sounds emitted by fish. Therefore, the swimbladder itself does not act as a resonator; its wall just seems to be driven by the oscillations of the rib cage. This set of observations suggests the need for reassessment of the acoustic role of swimbladders in various fish species. [less ▲]

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See detailFurther insight on carapid - holothuroid relationships
Parmentier, Eric ULg; Vandewalle, Pierre ULg

in Marine Biology (2005), 146(3), 455-465

Carapidae (or pearlfish) are eel-like fishes that live inside different invertebrates, such as holothurians, sea stars, or bivalves. Those of the genus Carapus are commensal and use their host as a ... [more ▼]

Carapidae (or pearlfish) are eel-like fishes that live inside different invertebrates, such as holothurians, sea stars, or bivalves. Those of the genus Carapus are commensal and use their host as a shelter, while Encheliophis species are parasitic and eat the host's gonads. In areas where they live in sympatry, C. boraborensis, C. homei, C. mourlani and E. gracilis are able to inhabit the same host species. Infestation is considered as monospecific when several conspecifics are observed in the same host. However, many aspects of this particular relation remain obscure, e.g. communication between carapids and the defence systems of the different protagonists (carapids and hosts). Experiments have been conducted in the field and laboratory to investigate several aspects of the carapids' relationships with their hosts. Sampling carried out in the Bay of Opunohu (Moorea, French Polynesia) determined the sex ratio of C. boraborensis (3:1) and C. homei (1:1) and their distribution rate within different Echinodermata. Our study showed that neither species was capable of determining whether a heterospecific already occupied a sea cucumber or not. They were, however, able to locate the sea cucumber's cloaca, due to the excurrent resulting from respiration. The sea cucumber's defence system (Cuverian tubules) minimises predator attacks, but is not effective against carapid intrusion. The Carapidae defence system is twofold. Due to a passive system related to the sea cucumber's low cloacal position, the Cuverian tubules are not expelled when fish enter the cloaca. Moreover, carapids resist sea cucumber toxins better than other reef fish. Their increased resistance might be related to their gills rather than to their mucus coating; however, the latter may assist the fish in resisting the sticky substances emitted by the Cuverian tubules. [less ▲]

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See detailFurther insights in the mechanisms of interleukin-1beta stimulation of osteoprotegerin in osteoblast-like cells
Lambert, Cécile ULg; Oury, Cécile ULg; Dejardin, Emmanuel ULg et al

in Journal of Bone and Mineral Research (2007), 22(9), 1350-1361

The mechanisms of IL-1beta stimulation of OPG were studied in more detail. Whereas p38 and ERK activation was confirmed to be needed, NF-kappaB was not necessary for this regulation. We also found that ... [more ▼]

The mechanisms of IL-1beta stimulation of OPG were studied in more detail. Whereas p38 and ERK activation was confirmed to be needed, NF-kappaB was not necessary for this regulation. We also found that OPG production after IL-1beta stimulation was not sufficient to block TRAIL-induced apoptosis in MG-63 cells. INTRODUCTION: Osteoprotegerin (OPG) plays a key role in the regulation of bone resorption and is stimulated by interleukin (IL)-1beta. Herein, we defined the mechanisms of IL-1beta stimulation of OPG focusing on the potential involvement of MAPK and NF-kappaB. We also examined whether OPG production in response to IL-1beta influences TRAIL-induced apoptosis in MG-63 cells. MATERIALS AND METHODS: OPG mRNA levels in MG-63 cells were quantified by real-time RT-PCR and protein levels of OPG and IL-6 by ELISA. Cell viability was assessed using the methyltetrazidium salt (MTS) reduction assay. The role of the MAPK pathway was studied by both Western blotting and the use of specific chemical inhibitors. NF-kappaB function was studied using BAY 11-7085 and by siRNA transfection to inhibit p65 synthesis. Transcription mechanisms were analyzed by transiently transfecting MG-63 cells with OPG promoter constructs. Post-transcriptional effects were examined by using cycloheximide and actinomycin D. RESULTS: MG-63 cells treatment with IL-1beta resulted in the phosphorylation of c-Jun NH(2)-terminal kinase (JNK), p38, and extracellular signal-regulated kinase (ERK). The use of the specific inhibitors showed that p38 and ERK but not JNK were needed for IL-1beta-induced OPG production. In contrast, NF-kappaB was not essential for IL-1beta induction of OPG. We also showed a small transcriptional and a possible post-transcriptional or translational regulation of OPG by IL-1beta. Exogenous OPG blocked TRAIL-induced apoptosis, but IL-1beta induction of OPG did not influence TRAIL-induced cell death. CONCLUSIONS: IL-1beta stimulates OPG production by mechanisms dependent on p38 and ERK. In contrast, NF-kappaB was not essential for this regulation. Although the relevance of IL-1beta stimulation of OPG is still not fully understood, our data showed that IL-1beta stimulation of OPG does not modify TRAIL-induced cell death. [less ▲]

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See detailFurther insights into the metamorphosis process in a carapid fish
Parmentier, Eric ULg

in Journal of Zoology (2015)

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See detailFurther investigation of the pair of quasars Q0107 - 025 A and B
Surdej, Jean ULg; Arp, H.; Gosset, Eric ULg et al

in Astronomy and Astrophysics (1986), 161

Low and intermediate dispersion spectroscopy of Q0107 - 025 A and B obtained at ESO, AAT, and MMT provide evidence for spectral differences between these two quasars. A redshift difference of 0.004 is ... [more ▼]

Low and intermediate dispersion spectroscopy of Q0107 - 025 A and B obtained at ESO, AAT, and MMT provide evidence for spectral differences between these two quasars. A redshift difference of 0.004 is found between the two objects, and forbidden emission lines due to O II (3727 A), Ne III (1815), and possibly Ne V (3426 A), are seen in the spectrum of Q0107 - 025 A, while only the forbidden Ne III line at 1815 A is possibly detected in the spectdrum of Q0107 - 025 B. No narrow absorption lines could be detected in the 3252 - 5616 A spectral range of the intermediate resolution data of either quasar, and the spectrum of quasar B is found to be steeper in the blue that of the quasar A. The possible presence of a highly redshifted cluster of galaxies in the field of these quasars is suggested by CCD photometry. [less ▲]

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See detailFurther investigation of the supervisory attentional system in schizophrenia: Planning, inhibition, and rule abstraction
Marczewski, P.; Van der Linden, Martial ULg; Laroi, Frank ULg

in Cognitive Neuropsychiatry (2001), 6(3), 175-192

Investigated supervisory attentional system (SAS) functions in schizophrenic patients. 15 schizophrenic outpatients (mean age 29.93 yrs) and 15 normal controls matched for age, gender, and educational ... [more ▼]

Investigated supervisory attentional system (SAS) functions in schizophrenic patients. 15 schizophrenic outpatients (mean age 29.93 yrs) and 15 normal controls matched for age, gender, and educational level were compared. Three tasks (Tower of London, Hayling, and Brixton tests) were used to examine 3 executive processes (planning, inhibition, and rule detection). Schizophrenic patients performed significantly worse than normal controls on all 3 tasks. In addition, patients' performances on selected measures of the three tests were correlated, even when age and medication were partialled out. It is concluded that patients are impaired on all SAS functions. The possible role of a general impairment (processing speed or cognitive resources) is discussed [less ▲]

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See detailA further locality with foliicolous lichens in Italy, with taxonomical and ecological data on foliicolous lichens in Western Europe
Puntillo, Domenico; Bricaud, Olivier; Sérusiaux, Emmanuël ULg

in Cryptogamie. Mycologie (2000), 21

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See detailFurther new lichen species producing campylidia or complex conidiomata
Sérusiaux, Emmanuël ULg

in Bibliotheca Lichenologica (1995), 58

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See detailA further new species in the lichen genus Arctomia: A. borbonica from Reunion (Mascarene archipelago)
Magain, Nicolas ULg; Sérusiaux, Emmanuël ULg

in MycoKeys (2012), 4

Arctomia borbonica sp. nov. is described as new for science from montane natural and secondary habitats in Reunion in the Mascarene archipelago (Indian Ocean). It has a sterile, foliose, usually wrinkled ... [more ▼]

Arctomia borbonica sp. nov. is described as new for science from montane natural and secondary habitats in Reunion in the Mascarene archipelago (Indian Ocean). It has a sterile, foliose, usually wrinkled, thallus whose margins produce goniocysts that disintegrate into a soredioid margin; it looks like a Leptogium species. Its phylogenetic position in the Arctomiaceae (Ostropomycetidae, Ascomycota) has been determined with 3 genes (nuLSU, mtSSU, RPB1) inferences. [less ▲]

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See detailA further new species of Monoblastia (lichenized ascomycetes: Monoblastiaceae) from Papua New Guinea
Sérusiaux, Emmanuël ULg; Aptroot, André

in Nova Hedwigia (1998), 67

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See detailA further new species of Strigula from Europe
Sérusiaux, Emmanuel ULg; Berger, F.; Coppins, B. J. et al

in Lichenologist (2005), 37(Part 6), 481-483

Strigula muscicola Berger, Coppins, Cl. Roux & Serus. is described as new to science; it is a muscicolous species with aggregated ascomata and 3-septate ascospores, growing in subalpine habitats in ... [more ▼]

Strigula muscicola Berger, Coppins, Cl. Roux & Serus. is described as new to science; it is a muscicolous species with aggregated ascomata and 3-septate ascospores, growing in subalpine habitats in Austria, Norway and Scotland. [less ▲]

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See detailFurther observational evidence that MG J0414+0534 is a gravitational mirage
Angonin-Willaime, M.-C.; Vanderriest, C.; Hammer, F. et al

in Astronomy and Astrophysics (1994), 281

Deep imaging of MG J0414+0534 with R and I filters reveals a faint, fuzzy and red object at the exact location expected for a lensing galaxy in the gravitational mirage hypothesis. Furthermore, the ... [more ▼]

Deep imaging of MG J0414+0534 with R and I filters reveals a faint, fuzzy and red object at the exact location expected for a lensing galaxy in the gravitational mirage hypothesis. Furthermore, the (extremely red and almost featureless) spectra of the 2 brightest components are very similar. These are strong indications that the system results from multiple gravitational imaging of a single source, but the nature of this source is not yet clear. It could be the nucleus of a low metallicity galaxy at a high redshift or a new type of object. Significant differences are observed between the flux ratios of the images at radio and optical wavelenghts. The most likely explanation for this effect is a differential amplification of the image pair A[SUB]1[/SUB]-A[SUB]2[/SUB] because of the large magnification gradient near a caustic. [less ▲]

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See detailFurther observations of the light echoes from SN 1987 A
Detal, Alain ULg; Surdej, Jean ULg; Hutsemekers, Damien ULg et al

in Astronomy and Astrophysics (1990), 229

Further direct observations of the light echoes from SN 1987 A were obtained on November 12 1988 with the 3.6-m telescope and EFOSC at ESO. In agreement with predictions made from earlier observations ... [more ▼]

Further direct observations of the light echoes from SN 1987 A were obtained on November 12 1988 with the 3.6-m telescope and EFOSC at ESO. In agreement with predictions made from earlier observations, the radii of the two light rings are measured to be 43.3 and 72.5 arcsec. However, a noticeable diaplacement of the center of the outer ring by 2.6 arcsec to the NE from the SN position is also reported. Application of the model of planar-like sheets of material located between the SN and the observer leads to improved results. [less ▲]

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See detailFurther observations on the endPermian mass extinction based on the palaeobotanical record
Cascales-Miñana, Borja ULg; Diez, José B.; Gerrienne, Philippe ULg et al

in Proceedings of the XXXI Annual Meeting of the Spanish Society of Palaeontology (abstract book) (2015, October)

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See detailFurther observations on the lichen genus Strigula in New Zealand
Sérusiaux, Emmanuël ULg

in Bryologist (1998), 101

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See detailFurther pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
Van de Veire, Sara; Stalmans, Ingeborg; Heindryckx, Femke et al

in Cell (2010), 141(1), 178-90

Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as ... [more ▼]

Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies. [less ▲]

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