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See detailInduction of Sparc by Vegf in Human Vascular Endothelial Cells
Kato, Y.; Lewalle, J. M.; Baba, Y. et al

in Biochemical and Biophysical Research Communications (2001), 287(2), 422-6

SPARC/osteonectin/BM-40 is a matricellular protein that is thought to be involved in angiogenesis and endothelial barrier function. Previously, we have detected high levels of SPARC expression in ... [more ▼]

SPARC/osteonectin/BM-40 is a matricellular protein that is thought to be involved in angiogenesis and endothelial barrier function. Previously, we have detected high levels of SPARC expression in endothelial cells (ECs) adjacent to carcinomas of kidney and tongue. Although SPARC-derived peptide showed an angiogenic effect, intact SPARC itself inhibited the mitogenic activity of vascular endothelial growth factor (VEGF) for ECs by the inhibiting phosphorylation of flt-1 (VEGF receptor 1) and subsequent ERK activation. Thus, the role of SPARC in tumor angiogenesis, stimulation or inhibition, is still unclear. To clarify the role of SPARC in tumor growth and progression, we determined the effect of VEGF on the expression of SPARC in human microvascular EC line, HMEC-1, and human umbilical vein ECs. VEGF increased the levels of SPARC protein and steady-state levels of SPARC mRNA in serum-starved HMEC-1 cells. Inhibitors (SB202190 and SB203580) of p38, a mitogen-activated protein (MAP) kinase, attenuated VEGF-stimulated SPARC production in ECs. Since intact SPARC inhibits phosphorylation ERK MAP kinase in VEGF signaling, it was suggested that SPARC plays a dual role in the VEGF functions, tumor angiogenesis, and extravasation of tumors mediated by the increased permeability of endothelial barrier function. [less ▲]

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See detailInduction of superovulation in cattle
Beckers, Jean-François ULg; Wouters-Ballman, P.; Viviers-Donnay, I. et al

Conference (1987, September 04)

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See detailInduction of superovulation in domestic ruminants
Gonzalez, F.; Calero, P.; Beckers, Jean-François ULg

in Renaville, R.; BurnY, A. (Eds.) Biotechnology in Animal Husbandry (2001)

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See detailInduction of the 27-kDa heat shock protein (Hsp27) in the rat medulla oblongata after vagus nerve injury.
Hopkins, D. A.; Plumier, Jean-Christophe ULg; Currie, R. W.

in Experimental Neurology (1998), 153(2), 173-83

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular ... [more ▼]

The 27-kDa heat shock protein (Hsp27) is constitutively expressed in motor and sensory neurons of the brainstem. Hsp27 is also rapidly induced in the nervous system following oxidative and cellular metabolic stress. In this study, we examined the distribution of Hsp27 in the rat medulla oblongata by means of immunohistochemistry after the vagus nerve was cut or crushed. After vagal injury, rats were allowed to survive for 6, 12, 24 h, 2, 4, 7, 10, 14, 30, or 90 days. Vagus nerve lesions resulted in a time-dependent up-regulation of Hsp27 in vagal motor and nodose ganglion sensory neurons that expressed Hsp27 constitutively and de novo induction in neurons that did not express Hsp27 constitutively. In the dorsal motor nucleus of the vagus nerve (DMV) and nucleus ambiguus, the levels of Hsp27 in motor neurons were elevated within 24 h of injury and persisted for up to 90 days. Vagal afferents to the nucleus of the tractus solitarius (NTS) and area postrema showed increases in Hsp27 levels within 4 days that were still present 90 days postinjury. In addition, increases in Hsp27 staining of axons in the NTS and DMV suggest that vagus nerve injury resulted in sprouting of afferent axons and spread into areas of the dorsal vagal complex not normally innervated by the vagus. Our observations are consistent with the possibility that Hsp27 plays a role in long-term survival of distinct subpopulations of injured vagal motor and sensory neurons. [less ▲]

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See detailInduction of the adrenoleukodystrophy-related gene (ABCD2) by thyromimetics
Genin, Emmanuelle ULg; Gondcaille, Catherine; Trompier, Doriane et al

in Journal of Steroid Biochemistry & Molecular Biology (2009), 116 (1-2)

X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 (ALD) gene. The ABCD2 gene, its closest homolog, has been shown to compensate for ABCD1 deficiency when ... [more ▼]

X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by mutations in the ABCD1 (ALD) gene. The ABCD2 gene, its closest homolog, has been shown to compensate for ABCD1 deficiency when overexpressed. We previously demonstrated that the ABCD2 promoter contains a functional thyroid hormone response element. Thyroid hormone (T3) through its receptor TRbeta can induce hepatic Abcd2 expression in rodents and transiently normalize the VLCFA level in fibroblasts of Abcd1 null mice. In a therapeutic perspective, the use of selective agonists of TRbeta should present the advantage to be devoid of side effects, at least concerning the cardiotoxicity associated to TRalpha activation. In this study, we compared the effects of T3 with those of two thyromimetics (GC-1 and CGS 23425) specific of TRbeta. Using a gene reporter assay, we demonstrated that the rat Abcd2 promoter responds to the thyromimetics in a dose-dependent way similar to what is observed with T3. We then investigated the effects of 2-, 4- and 10-day treatments on the expression of ABCD2 and its paralogs ABCD3 and ABCD4 in human cell lines by RT-qPCR. Both thyromimetics trigger up-regulation of ABCD2-4 genes in HepG2 cells and X-ALD fibroblasts. Interestingly, in X-ALD fibroblasts, while T3 is associated with a transient induction of ABCD2 and ABCD3, the treatments with thyromimetics allow the induction to be maintained until 10 days. Further in vivo experiments in Abcd1 null mice with these thyromimetics should confirm the therapeutic potentialities of these molecules. [less ▲]

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See detailInduction of the Alternative NF-{kappa}B Pathway by Lymphotoxin {alpha}{beta} (LT{alpha}{beta}) Relies on Internalization of LT{beta} Receptor
Ganeff, Corine; Remouchamps, Caroline ULg; Boutaffala, Layla et al

in Molecular & Cellular Biology (2011), 21

Several tumor necrosis factor receptor (TNFR) family members activate both the classical and the alternative NF-κB pathways. However, how a single receptor engages these two distinct pathways is still ... [more ▼]

Several tumor necrosis factor receptor (TNFR) family members activate both the classical and the alternative NF-κB pathways. However, how a single receptor engages these two distinct pathways is still poorly understood. Using lymphotoxin β receptor (LTβR) as a prototype, we showed that activation of the alternative, but not the classical, NF-κB pathway relied on internalization of the receptor. Further molecular analyses revealed a specific cytosolic region of LTβR essential for its internalization, TRAF3 recruitment, and p100 processing. Interestingly, we found that dynamin-dependent, but clathrin-independent, internalization of LTβR appeared to be required for the activation of the alternative, but not the classical, NF-κB pathway. In vivo, ligand-induced internalization of LTβR in mesenteric lymph node stromal cells correlated with induction of alternative NF-κB target genes. Thus, our data shed light on LTβR cellular trafficking as a process required for specific biological functions of NF-κB. [less ▲]

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See detailInduction of Thymocyte Proliferation by Supernatants from a Mouse Thymic Epithelial Cell Line
Villa-Verde, Dea; Defresne, Marie-Paule ULg; Greimers, Roland ULg et al

in Cellular Immunology (1991), 136(1), 113-21

The thymic stroma plays a critical role in the generation of T lymphocytes by direct cell-to-cell contacts as well as by secreting growth factors or hormones. The thymic epithelial cells, responsible for ... [more ▼]

The thymic stroma plays a critical role in the generation of T lymphocytes by direct cell-to-cell contacts as well as by secreting growth factors or hormones. The thymic epithelial cells, responsible for thymic hormone secretion, include morphologically and antigenically distinct subpopulations that may exert different roles in thymocyte maturation. The recent development of thymic epithelial cell lines provided an interesting model for studying thymic epithelial influences on T cell differentiation. Treating mouse thymocytes by supernatants from one of TEC line (IT-76M1), we observed an induction of thymocyte proliferation and an increase in the percentages of CD4-/CD8- thymocytes. This proliferation was largely inhibited when thymocytes were incubated with IT-76M1 supernatants together with an anti-thymulin monoclonal antibody, but could be enhanced by pretreating growing epithelial cells by triiodothyronine. We suggest that among the target cells for thymulin within the thymus, some putative precursors of early phenotype might be included. [less ▲]

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See detailInduction of tissue resorption in echinoderms
Dubois, P.; Bureau, Fabrice ULg; Gyoot, M.

Poster (1993)

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See detailInduction of tissue resorption in globiferous pedicellariae of the echinoid Sphaerechinus granularis
Dubois, P.; Ghyoot, M.; Bureau, Fabrice ULg

in David, B.; Guille, A.; Féral, J.-P. (Eds.) et al Echinoderms Through Time (1994)

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See detailInduction-Déduction en anthropologie
Strivay, Lucienne ULg; Genard, Jean-Louis

Conference (2008, May 16)

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See detailAn inductive and opportunistic detection of a pedagogical pattern in a 17 online course sample
Verpoorten, Dominique ULg; Poumay, Marianne ULg; Delcomminette, Séverine ULg et al

in Proceedings of the European Distance Education Network (2006)

LabSET (Support Lab for Telematic Learning – University of Liège, Belgium) applied a pedagogical pattern detection process on 17 online courses designed by faculty. The analysis unearths 11 instances of ... [more ▼]

LabSET (Support Lab for Telematic Learning – University of Liège, Belgium) applied a pedagogical pattern detection process on 17 online courses designed by faculty. The analysis unearths 11 instances of an activity structure named here RQAT (Reading-Questions/Answers-Test) which offers an alternative (among others) to the conventional lecturing, still extensively practiced in higher education. The recurrence and the relative invariance of the RQAT learning design legitimated an attempt to format it as a pedagogical pattern, used within LabSET's missions of teacher professional development. The conceptual documentation of RQAT suggests also an "illustration" of the pattern and its linkage to a taxonomy of skills. [less ▲]

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See detailInductively coupled plasma-mass spectrometric (ICP-MS) analysis of silicate rocks and minerals
Vander Auwera, Jacqueline ULg; Bologne, Guy; Roelandts, Iwan et al

in Geologica Belgica (1998), 1

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See detailInduire des changements de comportements
Partoune, Christine ULg

in Tableau de bord "Participation et espaces publics" - Pour un développement et une gestion concertée des espaces publics (2010)

Plus précisément, le titre de cette fiche devrait être "Induire des changements communs de comportements dans les processus de participation des citoyennes et des citoyens au développement et à la gestion ... [more ▼]

Plus précisément, le titre de cette fiche devrait être "Induire des changements communs de comportements dans les processus de participation des citoyennes et des citoyens au développement et à la gestion des espaces publiques". Partant d’une réflexion sur le sens des mots et des concepts ici-présents, ce document devrait aider l’animateur territorial à définir et emprunter la posture la plus adéquate, au moment d’accompagner un groupe dans de tels processus de participation. [less ▲]

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See detailIndustrial applications of extended output-only Blind Source Separation techniques
Rutten, Christophe ULg; Nguyen, Viet Ha; Golinval, Jean-Claude ULg

in Vibration Problems Icovp 2011: The 10th International Conference on Vibration Problems (2011)

In the field of structural health monitoring or machine condition moni-toring, most vibration based methods reported in the literature require to measure responses at several locations on the structure ... [more ▼]

In the field of structural health monitoring or machine condition moni-toring, most vibration based methods reported in the literature require to measure responses at several locations on the structure. In machine condition monitoring, the number of available vibration sensors is often small and it is not unusual that only one single sensor is used to monitor a machine. This paper presents industrial applications of two possible extensions of output-only Blind Source Separation (BSS) techniques, namely Principal Component Analysis (PCA) and Second Order Blind Identification (SOBI). Through the use of block Hankel matrices, these methods may be used when a reduced set of sensors or even one single sensor is available. The objective is to address the problem of fault detection in mechanical systems using subspace-based methods. The detection is achieved by comparing the subspace features between the reference and a current state using the concept of angular coherence between subspaces. [less ▲]

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