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See detailHow to define responders in osteoarthritis
Cooper, Cyrus; Adachi, Jonathan D; Bardin, Thomas et al

in Current Medical Research & Opinion (2013), 29(6), 719-29

Background: Osteoarthritis is a clinical syndrome of failure of the joint accompanied by varying degrees of joint pain, functional limitation, and reduced quality of life due to deterioration of articular ... [more ▼]

Background: Osteoarthritis is a clinical syndrome of failure of the joint accompanied by varying degrees of joint pain, functional limitation, and reduced quality of life due to deterioration of articular cartilage and involvement of other joint structures. Scope: Regulatory agencies require relevant clinical benefit on symptoms and structure modification for registration of a new therapy as a disease-modifying osteoarthritis drug (DMOAD). An international Working Group of the European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and International Osteoporosis Foundation was convened to explore the current burden of osteoarthritis, review current regulatory guidelines for the conduct of clinical trials, and examine the concept of responder analyses for improving drug evaluation in osteoarthritis. Findings: The ESCEO considers that the major challenges in DMOAD development are the absence of a precise definition of the disease, particularly in the early stages, and the lack of consensus on how to detect structural changes and link them to clinically meaningful endpoints. Responder criteria should help identify progression of disease and be clinically meaningful. The ideal criterion should be sensitive to change over time and should predict disease progression and outcomes such as joint replacement. Conclusion: The ESCEO considers that, for knee osteoarthritis, clinical trial data indicate that radiographic joint space narrowing40.5mm over 2 or 3 years might be a reliable surrogate measure for total joint replacement. On-going research using techniques such as magnetic resonance imaging and biochemical markers may allow the identification of these patients earlier in the disease process [less ▲]

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See detailHow to define responders in osteoarthritis?
Bruyère, Olivier ULg

Conference (2012, March 23)

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See detailHow to diagnose atypical myopathy
Votion, Dominique ULg

in In proceedings: 50th British Equine Veterinary Association (BEVA) Congress (2011, September 08)

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See detailHow to do percutaneous ultrasound-guided liver biopsy in the adult horse
Busoni, Valeria ULg

in XIV SIVE / FEEVA Congress Proceedings (2008)

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See detailHow to enhance the performance of OSH services ?
Mairiaux, Philippe ULg

Conference (2010, November 23)

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See detailHow to face failure to growth in dogs and cats?
Peeters, Dominique ULg

in Proceedings of the first Belgium International Congress for Small Animal Veterinarians (Canifelis 2007) (2007, January)

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See detailHow to generate regularly behaved production data? A Monte Carlo experimentation on DEA scale efficiency measurement
Santin, Daniel; Perelman, Sergio ULg

in European Journal of Operational Research (2009), (199), 303-310

Monte Carlo experimentation is a well-known approach used to test the performance of alternative methodologies under different hypotheses. In the frontier analysis framework, whatever the parametric or ... [more ▼]

Monte Carlo experimentation is a well-known approach used to test the performance of alternative methodologies under different hypotheses. In the frontier analysis framework, whatever the parametric or non-parametric methods tested, experiments to date have been developed assuming single output multi-input production functions. The data generated have mostly assumed a Cobb–Douglas technology. Among other drawbacks, this simple framework does not allow the evaluation of DEA performance on scale efficiency measurement. The aim of this paper is twofold. On the one hand, we show how reliable two-output two-input production data can be generated using a parametric output distance function approach. A variable returns to scale translog technology satisfying regularity conditions is used for this purpose. On the other hand, we evaluate the accuracy of DEA technical and scale efficiency measurement when sample size and output ratios vary. Our Monte Carlo experiment shows that the correlation between true and estimated scale efficiency is dramatically low when DEA analysis is performed with small samples and wide output ratio variations. [less ▲]

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See detailHow to get rid of the two spotted spider mites?
Attia, Sabrine; Grissa, Kaouthar Lebdi; Heuskin, Stéphanie ULg et al

in Revue des Régions Arides (2014), 35(3), 1739-1748

Two essential oils were tested for their toxicity against eggs and adults of Tetranychus urticae Koch as well as adults of Phytoseiulus persimilis Athias-Henriot, by using a filter paper diffusion ... [more ▼]

Two essential oils were tested for their toxicity against eggs and adults of Tetranychus urticae Koch as well as adults of Phytoseiulus persimilis Athias-Henriot, by using a filter paper diffusion bioassay without allowing direct contact. Responses varied according to oil type and dose, and mite species. The chemical analyses with GC-MS and GC-FID revealed that the two oils differed in their most abundant components. The most abundant components in the Citrus oil were linalyl acetate (41.95%), sabinene (18.60%) and linalool (18.14%) whereas pulegone (41.86%) and menthone (28.33%) were most prevalent in the Mentha oil. Mortality and fecundity were measured with 15 oils concentrations ranged from 0.01 to 8μl/l of air. Tetranychid mortality increased with increasing concentrations with LC50 value of 5.39 and 4.09 μl/l for C. aurantium and M. pulegium, respectively. However few mortality was observed in the case of P. persimilis with LC50 value of 0.46 and 0.26 μl/l for C. aurantium and M. pulegium respectively. For both oils a reduction of fecundity was observed at 0.01 μ/l in the case of T. urticae. The essential oils described herein have potential interest as fumigants for the bio-control of T. urticae. [less ▲]

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See detailHow to get the most information out of your necropsy
Jauniaux, Thierry ULg; Coignoul, Freddy ULg

in COST Meeting proceedings (2002)

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See detailHow to improve assessment of tetanus immunity in the Emergency Room: a prospective cost-effectiveness double blind study.
STUBBE, Muriel; SWINNEN, Ronny; DESRUELLES, Didier et al

Poster (2007, May 13)

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See detailHow to Improve Assessment of Tetanus Immunity in the Emergency Room: A Prospective Cost-Effectiveness, Double Blind Study
STUBBE, Muriel; SWINNEN, Ronny; DESRUELLES, Didier et al

in Prehospital & Disaster Medicine (2007), 22(Suppl 1), 86

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See detailHow to improve the ship efficiency
Caprace, Jean-David ULg

Conference (2011, August)

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See detailHow to improve the working conditions with an aerosol delivery equipment suitable for calves ?
Genicot, B.; Peckova, M.; Lamberty, S. et al

in American Journal of Respiratory & Critical Care Medicine (1994), 149

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See detailHow to improve your vocal resonance
Morsomme, Dominique ULg

in Behrman, Alison; Haskell, John (Eds.) Exercises for Voice Therapy (2013)

Now in its second edition, Exercises for Voice Therapy provides speech-language pathologists with step-by-step instruction for developing session materials for clients-both children and adults-with all ... [more ▼]

Now in its second edition, Exercises for Voice Therapy provides speech-language pathologists with step-by-step instruction for developing session materials for clients-both children and adults-with all types of voice disorders. The new edition includes 17 new expert contributors and 24 new exercises, provinding a greater assortment of exercises and targeting a larger variety of voice disorders. The exercises vary in difficulty and all follow the same format for easy integration into speech-language pathologists' therapy sessions.The accompanying CD contains recordings of many of the exercises to provide an aural model for those that may be difficult to interpret from the text alone. [less ▲]

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See detailHow to include equity in indicators focused on economic and social results of education?
Baye, Ariane ULg

Scientific conference (2002, June 04)

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