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See detailThe importance of carbonic anhydrase II in red blood cells during exposure of chicken embryos to CO2.
Everaert, Nadia ULg; Willemsen, H.; Hulikova, A. et al

in Respiratory physiology & neurobiology (2010), 172(3), 154-61

The importance of carbonic anhydrase (CA) during exposure of chicken embryos to CO(2) during the second half of incubation was investigated. The protein abundance and activity of CAII in erythrocytes was ... [more ▼]

The importance of carbonic anhydrase (CA) during exposure of chicken embryos to CO(2) during the second half of incubation was investigated. The protein abundance and activity of CAII in erythrocytes was significantly higher in CO(2)-exposed embryos compared to normal conditions. Daily injections of acetazolamide (ATZ), an inhibitor of CA, increased blood P(CO2) and decreased blood pH in both control and CO(2)-incubated embryos. ATZ increased blood bicarbonate concentration in embryos exposed to normal atmosphere and in day-12 embryos exposed to high CO(2). The tendency of an increased blood potassium concentration in ATZ-injected embryos under standard atmospheric conditions might indicate that protons were exchanged with intracellular potassium. However, there was no evidence for such an exchange in CO(2)-incubated ATZ-treated embryos. This study shows for the first time that chicken embryos adapt to CO(2) during the second half of incubation by increasing CAII protein expression and function in red blood cells. This response may serve to "buffer" elevated CO(2) levels. [less ▲]

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See detailImportance of Cell Kinetics Rhythmicity for the Control of Cell Proliferation and Carcinogenesis in Rat Liver (Review)
Barbason, Hervé ULg; Herens, Christian ULg; Robaye, B. et al

in In Vivo (Athens, Greece) (1995), 9(6, Nov-Dec), 539-48

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle ... [more ▼]

The circadian control of cell Proliferation and Differentiation has been studied principally in rat liver. The comparison between the differentiation by hepatic enzymes and the division by the cell cycle under various experimental conditions (postnatal maturation, regeneration after partial hepatectomy, adrenalectomy, corticosterone treatments etc.) leads to the following conclusions: Under physiological conditions, proliferation and differentiation activities present a mutually exclusive relationship with a specific circadian rhythm. For both functions, the circadian variation of corticosterone plays the role of synchronizer, each evening (peak) it induces the synthesis of tissue specific enzymes in G0 cells and simultaneously inhibits the DNA synthesis in cycling cells. The same parameters have been studied during the different stages of hepatocarcinogenesis induced by Diethylnitrosamine (DEN). After initiation alone, (DEN for 2 weeks) circadian control is unchanged and precancerous cells are not able to reach malignancy. Promotion (DEN for 6 weeks) consists of disturbing the circadian synchronization to liberate the selective growth of initiated precancerous cells. This proliferation advantage favours the accumulation of chromosomal aberrations including those implicated in malignant transformation: i.e. activation of oncogenes or inhibition of antioncogenes. [less ▲]

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See detailImportance of clean-up for comparison of TEQ-values obtained by CALUX and chemo-analysis
Van Wouwe, N.; Windal, I.; Vanderperren, H. et al

in Talanta (2004), 63(5), 1269-1272

This paper presents Chemically Activated LUciferine gene eXpression (CALUX) TEQ-values obtained for nine plasma samples following two different purification procedures, one of them involving fractionation ... [more ▼]

This paper presents Chemically Activated LUciferine gene eXpression (CALUX) TEQ-values obtained for nine plasma samples following two different purification procedures, one of them involving fractionation. CALUX results obtained for the dioxin (DX) and dioxin + PCB (DX + PCB) fractions were then compared to the GC-HRMS TEQ-values calculated for the 17 polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (17 PCDD/F) and 17 PCDD/F + 4 cPCB congeners, respectively. The overestimation of the CALUX (DX fraction) TEQ-values in comparison with the chemo-analyses of the 17 PCDD/F is mainly explained by the presence of other AhR agonists, like brominated compounds. Otherwise, the constancy of the CALUX (DX + PCB fraction) TEQ-value which compares to increasing the GC-HRMS (17 PCDD/F + 4 cPCB) TEQ results raises questions concerning (1) the significance of CALUX results obtained without fractionation as well as (2) the toxicological effect of a cocktail of contaminants on the human health. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailImportance of concomitant local and systemic eosinophilia in uncontrolled asthma.
SCHLEICH, FLorence ULg; Chevremont, Anne; Paulus, Virginie et al

in The European respiratory journal (2014), 44

Systemic and airway eosinophilia are recognised features of asthma. There are, however, patients who exhibit discordance between local and systemic eosinophilia. In this study, we sought to determine the ... [more ▼]

Systemic and airway eosinophilia are recognised features of asthma. There are, however, patients who exhibit discordance between local and systemic eosinophilia. In this study, we sought to determine the prevalence and characteristics of patients with concordant and discordant systemic and bronchial eosinophilia.We conducted a retrospective study on 508 asthmatics with successful sputum induction. We assessed the relationship between blood and sputum eosinophils by breaking down the population into four groups according to blood (>/=400 cells per mm3) and sputum (>/=3%) eosinophils. Then, we prospectively reassessed the link between eosinophils and asthma control (Asthma Control Questionnaire (ACQ)) and exacerbation rate in a new cohort of 250 matched asthmatics.In our retrospective cohort, asthmatics without eosinophilic inflammation were the largest group (49%). The group with isolated sputum eosinophilia (25%) was, compared with noneosinophilic asthma, associated with lower forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity ratio and higher bronchial hyperresponsiveness and exhaled nitric oxide fraction (FeNO). Asthmatics exhibiting isolated systemic eosinophilia (7%) had similar characteristics as noneosinophilic asthmatics. The group with concordant systemic and airway eosinophilia (19%) showed remarkable male predominance, and had the lowest airway calibre, ACQ score and quality of life, and the highest bronchial hyperresponsiveness, FeNO and exacerbation rate. The prospective cohort confirmed the different subgroup proportions and the higher ACQ and exacerbation rates in cases of diffuse eosinophilia compared with noneosinophilic asthmatics.Concomitant systemic and bronchial eosinophilic inflammation contribute to poor asthma control. [less ▲]

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See detailImportance of copepod carcasses versus faecal pellets in the upper water column of an oligotrophic area
Frangoulis, Constantin; Skliris, Nikolaos; Lepoint, Gilles ULg et al

in Estuarine Coastal & Shelf Science (2011), 92

Downward flux of zooplankton faecal pellets and carcasses was studied during and after the spring bloom in an oligotrophic coastal area of the Western Mediterranean using a « swimmer-excluding » sediment ... [more ▼]

Downward flux of zooplankton faecal pellets and carcasses was studied during and after the spring bloom in an oligotrophic coastal area of the Western Mediterranean using a « swimmer-excluding » sediment trap. Zooplankton detritus retrieved in the trap were comprised of cylindrical faecal pellets (from meso- and macrozooplankton) and copepod carcasses with a respective carbon flux of 0.05 - 2.69 mg m-2 d-1 and 0.42 - 4.37 mg m-2 d-1. Carbon and nitrogen flux of carcasses always exceeded that of faecal pellets, except at the beginning of the bloom due to a higher contribution of macrozooplankton faecal material. During the peak of phytoplankton biomass, total faecal flux essentially comprised of copepod faecal pellets (68 - 86% of the total faecal carbon), whereas before and after this period, macrozooplankton faecal material dominated (88 - 91% of total faecal carbon flux). Copepod faecal flux was positively correlated with phytoplankton biomass. Estimates of non-predatory biomass mortality rates (from < 0.01 to 0.05 d-1) were negatively correlated with chl a with a time lag of 12 days and were lower than predatory mortality values reported in the same area. The paper discusses the relative importance of carcasses versus faecal pellet flux and of non-predatory versus predatory mortality, as well as the potential role of these zooplankton detritus in supporting the production of benthos in oligotrophic areas. [less ▲]

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See detailThe importance of distinguishing item and order memory for understanding short-term memory deficits in brain-damaged patients
Attout, Lucie ULg; VAN DER KAA, Marie-Anne ULg; GEORGE, Mercédès ULg et al

Poster (2011, October 18)

Selective verbal short-term memory (STM) deficits are rare and are often associated with a history of aphasia, raising doubts about the selectivity of these deficits. We explore here the distinction ... [more ▼]

Selective verbal short-term memory (STM) deficits are rare and are often associated with a history of aphasia, raising doubts about the selectivity of these deficits. We explore here the distinction between STM for item information (the items and their phonological and semantic characteristics) and STM for order information (the order of items within a list) to separate STM and language impairment. Recent models of STM consider that STM for item information depends upon activation of the language system, and hence item STM deficits should be associated with language impairment. By contrast, STM for order information is considered to recruit a specific system, distinct from the language system. Hence, order STM should be impaired in patients with language-independent STM deficits. We applied this rationale to the exploration of STM profiles of two patients with a history of aphasia, MB and CG. At the time of this study, patient MB showed poor digit and word STM spans associated with a mild impairment at the level of phonological input processing. Patient CG showed poor STM spans with no residual language impairment. A first experiment assessed STM for order and item information, using order and item probe recognition tasks. Patient MB showed severely impaired performance in the item condition (Z=-4.71; p<.001) but a milder deficit in the order condition (Z=-2.17; p<.05). CG on the other hand showed perfectly preserved performance for the item condition (Z=-0.43) but significantly slowed response times for the order condition (Z=-2.20; p<.05). In a second experiment determining item and order error proportions in an immediate serial recall task for six-word lists, MB showed a significantly increased proportion of item errors (Z=-3.24 and -2.6 for positions 5 and 6, respectively; p<.05) but not of order errors (Z=-1.47), while CG showed perfectly preserved item recall (Z=0.22) but an increase of order errors especially in final list positions (Z =-2.57 for position 6; p<.05). A third experiment assessed reconstruction of serial order for digit lists showing perfectly preserved performance in patient MB (Z=1.32) but severely impaired performance in patient CG (Z=-3.49; p<.05). A final experiment assessed new word learning performance, given that STM for order has been shown to be a critical determinant of vocabulary acquisition in children and adults. CG showed impaired new word learning performance in a paired associate word-new word learning experiment (Z=-3.29; p<.05) but not in a word-word learning control experiment (Z=0.13), while MB showed a more general verbal learning impairment (word-nonword: Z=-3.09, p<.05; word-word: Z=-4.8, p<.05). This study provides the first demonstration of a dissociation between STM for order and STM for item information in patients with a history of aphasia, and further shows that patients with residual language impairment are more likely to present impaired STM for item information which is considered to depend on the integrity of the language system. Order STM deficits on the other hand may represent what is commonly referred to as selective STM impairment, highlighting the importance of distinguishing between item and order STM processes when exploring STM deficits in aphasic patients. [less ▲]

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See detailImportance of early nutritional support in very low birth weight infants
SENTERRE, Thibault ULg

in 5th International Clinical & Community Nutrition Conference (2013, May)

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See detailimportance of ecotone modeling for landscape fragmentation assessment.
Bogaert, Jan ULg

Conference (1999)

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See detailThe importance of ecotone modelling for landscape fragmentation assessment.
Bogaert, Jan ULg; Salvador-Van Eysenrode, D; Van Hecke, P et al

in Proceedings of the 5th World Congress of the International Association for Landscape Ecology (IALE). (1999)

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See detailThe importance of embryonic glycemia on the posthatch performance and insulin sensitivity of broiler chickens.
Franssens, L.; Lesuisse, J.; Koppenol, A. et al

Conference (2013)

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See detailThe Importance of Encoding-Related Neural Dynamics in the Prediction of Inter-Individual Differences in Verbal Working Memory Performance
Majerus, Steve ULg; Salmon, Eric ULg; Attout, Lucie ULg

in PLoS ONE (2013), 8(7),

Studies of brain-behaviour interactions in the field of working memory (WM) have associated WM success with activation of a fronto-parietal network during the maintenance stage, and this mainly for visuo ... [more ▼]

Studies of brain-behaviour interactions in the field of working memory (WM) have associated WM success with activation of a fronto-parietal network during the maintenance stage, and this mainly for visuo-spatial WM. Using an inter-individual differences approach, we demonstrate here the equal importance of neural dynamics during the encoding stage, and this in the context of verbal WM tasks which are characterized by encoding phases of long duration and sustained attentional demands. Participants encoded and maintained 5-word lists, half of them containing an unexpected word intended to disturb WM encoding and associated task-related attention processes. We observed that inter-individual differences in WM performance for lists containing disturbing stimuli were related to activation levels in a region previously associated with task-related attentional processing, the left intraparietal sulcus (IPS), and this during stimulus encoding but not maintenance; functional connectivity strength between the left IPS and lateral prefrontal cortex (PFC) further predicted WM performance. This study highlights the critical role, during WM encoding, of neural substrates involved in task-related attentional processes for predicting inter-individual differences in verbal WM performance, and, more generally, provides support for attention-based models of WM. © 2013 Majerus et al. [less ▲]

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See detailThe importance of exercise echocardiography for clinical decision making in primary mitral regurgitation
Van De Heyning, C. M.; Magne, Julien ULg; Lancellotti, Patrizio ULg et al

in Journal of Cardiovascular Medicine (Hagerstown, Md.) (2012), 13(4), 260-265

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See detailImportance of fat oxidation in starch-based emulsions in the generation of the process contaminant furan.
Owczarek-Fendor, Agnieszka; De Meulenaer, Bruno; Scholl, Georges ULg et al

in Journal of Agricultural and Food Chemistry (2010), 58(17), 9579-86

The formation of the possibly carcinogenic process contaminant furan was studied in starch-based emulsions during heat treatments as applied for sterilization. Fresh and oxidized soybean, sunflower, high ... [more ▼]

The formation of the possibly carcinogenic process contaminant furan was studied in starch-based emulsions during heat treatments as applied for sterilization. Fresh and oxidized soybean, sunflower, high-oleic sunflower, olive, linseed, and rapeseed oils were compared. Results indicated that both the oil type, in particular, the fatty acid composition, and the oxidation degree of the oil determined the susceptibility of the oils to generate furan upon heating. Thus, oils containing the nutritionally relevant omega-3 unsaturated alpha-linolenic acid proved to be able to generate significant amounts of furan if the oils were oxidized. No clear relationship between p-anisidine values of various oils and the amount of generated furan could be observed. However, in the case of soybean oil, significantly more furan was produced upon an increase in oxidation degree. Surprisingly, furan formation in food-relevant systems containing fresh lipids proved to be a minor route (up to 1.5 ppb furan) compared to a previously studied vitamin C containing model system (up to 13 ppb furan). [less ▲]

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See detailImportance of Heat Treating Procedure in the Study and the Characterization of Impurities in high alloyed Steels
Lecomte-Beckers, Jacqueline ULg; Tchuindjang

in Proceedings of The International COST-517 : Workshop on Cleaner Metals for Industrial Exploitation (1999)

This paper deals with the methodology used in a COST 517 research concerning study of inclusions in high alloyed steel for mechanical purpose. In order to establish in a quantitative and statistically ... [more ▼]

This paper deals with the methodology used in a COST 517 research concerning study of inclusions in high alloyed steel for mechanical purpose. In order to establish in a quantitative and statistically justifiable way the relationship between impurities, inclusions and mechanical properties of high alloyed steels, we have to insure that the microstructure on the whole batch of specimens of the same origin is similar. This required appropriated heat treatments before achieving mechanical tests. Otherwise, metallurgical properties of the samples could vary, and the relationship between inclusions and mechanical properties misunderstood. Regardless of the melting or die atmosphere during the melting, inclusions are present in varying amounts in every commercial steel products. Since inclusions significantly influence properties and behavior of materials and at the same time give indications on the quality of the steel, it is quite interesting to precise their nature and their origin. This requires methods of identifying the inclusions and a knowledge of the history during steel making. [less ▲]

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See detailImportance of identification and typing of Brucellae from West African cattle: a review
Sanogo, M; Abatih, E; Thys, E et al

in Veterinary Microbiology (2013)

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See detailImportance of identifying Mycobacterium bovis as a causative agent of human tuberculosis
Allix-Béguec, C.; Fauville-Dufaux, M.; Stoffels, K. et al

in European Respiratory Journal (2010), 35

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See detailImportance of inbterspecific variation for designing conservation strategies in Plants : Centaurea jacea as case study
Vanderhoeven, Sonia ULg; Lefebvre, C.; Hardy, Olivier et al

Poster (2001, December 02)

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See detailThe importance of integrating medication adherence into pharmacoeconomic analyses: the example of osteoporosis.
Hiligsmann, Mickaël ULg; Boonen, Annelies; Rabenda, Véronique ULg et al

in Expert Reviews of Pharmacoeconomics & Outcomes Research (2012), 12(2), 159-66

Adherence to medications is poor and suboptimal in many chronic diseases. Nonadherence can reduce treatment effectiveness and can have an impact on healthcare costs. As a consequence, it may alter the ... [more ▼]

Adherence to medications is poor and suboptimal in many chronic diseases. Nonadherence can reduce treatment effectiveness and can have an impact on healthcare costs. As a consequence, it may alter the cost-effectiveness of drug therapies. This article emphasizes the importance of integrating medication compliance and persistence into pharmacoeconomic evaluations, using osteoporosis as an example. A limited number of studies carried out to date have suggested important economic implications of poor adherence to osteoporosis medications. Therefore, compliance and persistence should be an integral part of clinical studies and pharmacoeconomic analyses in order to estimate the cost-effectiveness of drug therapies in current community practice. Measuring adherence and incorporating it into health economic modeling may, however, pose particular challenges. [less ▲]

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