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See detailFurther Purification and Characterization of the DNA 3'-Phosphatase from Rat-Liver Chromatin Which Is Also a Polynucleotide 5'-Hydroxyl Kinase
Habraken, Yvette ULg; Verly, W. G.

in European Journal of Biochemistry (1988), 171(1-2), 59-66

The DNA 3'-phosphatase activity of rat-liver chromatin has been purified. A DNA 5'-hydroxyl kinase activity comigrates at each step of purification. Both enzymes have the same molecular mass (79 kDa) and ... [more ▼]

The DNA 3'-phosphatase activity of rat-liver chromatin has been purified. A DNA 5'-hydroxyl kinase activity comigrates at each step of purification. Both enzymes have the same molecular mass (79 kDa) and the same isoelectric point (8.6). It thus seems that the two activities are born by the same protein just as with the phage T4 enzyme which is, at the same time, a 5'-hydroxyl kinase and a 3'-phosphatase. An additional argument is that ATP, which does not influence the rate of the 3'-phosphatase reaction but which is a cosubstrate of the 5'-hydroxyl kinase, protects the 3'-phosphatase activity against thermal denaturation and trypsin digestion. The two active sites must, however, be largely independent within a common support: the thermal denaturation and trypsin inactivation rates are very different for the two activities; increasing the ionic strength activates the kinase and inhibits the phosphatase; polyvalent anions inhibit the phosphatase and have little effect on the kinase. The two active sites might belong to different domains of the protein; they could not however be separated by a partial trypsin digestion. The rates of 3'-dephosphorylation and 5'-phosphorylation by the chromatin enzyme are the same in native and denatured DNA. The 3'-phosphatase has no action on 3'-monodeoxynucleotide, but it hydrolyzes the 3'-phosphate in dinucleotides. The Km of the 3'-phosphatase is 0.548 microM. The Km (5'-OH) and Km (ATP) of the 5'-hydroxyl kinase are about 3.9 microM and 0.69 microM respectively. The chromatin enzyme is unable to hydrolyze 3'-phosphoglycolate ends in DNA. [less ▲]

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See detailFurther reduction in nonvertebral fracture rate is observed following 3 years of denosumab treatment: results with up to 7 years in the freedom extension
Ferrari, S; Adachi, JD; Lippuner, K et al

in Osteoporosis International (2014), 25(2), 56

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See detailFurther reductions in nonvertebral fracture rate with long-term denosumab treatment in the FREEDOM open-label extension and influence of hip bone mineral density after 3 years.
FERRARI, S.; ADACHI, J.D.; LUPPUNER, K. et al

in Osteoporosis International (2015), 26

Limited data exist on the efficacy of long-term therapies for osteoporosis. In osteoporotic postmenopausal women receiving denosumab for 7 years, nonvertebral fracture rates significantly decreased in ... [more ▼]

Limited data exist on the efficacy of long-term therapies for osteoporosis. In osteoporotic postmenopausal women receiving denosumab for 7 years, nonvertebral fracture rates significantly decreased in years 4–7 versus years 1–3. This is the first demonstration of a further benefit on fracture outcomes with long-term therapy for osteoporosis. Introduction This study aimed to evaluate whether denosumab treatment continued beyond 3 years is associated with a further reduction in nonvertebral fracture rates. Methods Participants who completed the 3-year placebocontrolled Fracture REduction Evaluation of Denosumab in Osteoporosis every 6 Months (FREEDOM) study were invited to participate in an open-label extension. The present analysis includes 4,074 postmenopausal women with osteoporosis (n=2,343 long-term; n=1,731 cross-over) who enrolled in the extension, missed ≤1 dose during their first 3 years of denosumab treatment, and continued into the fourth year of treatment. Comparison of nonvertebral fracture rates during years 1–3 of denosumab with that of the fourth year and with the rate during years 4–7 was evaluated. Results For the combined group, the nonvertebral fracture rate per 100 participant-years was 2.15 for the first 3 years of denosumab treatment (referent) and 1.36 in the fourth year (rate ratio [RR]=0.64; 95 % confidence interval (CI)=0.48 to 0.85, p=0.003). Comparable findings were observed in the groups separately and when nonvertebral fracture rates during years 1–3 were compared to years 4–7 in the longterm group (RR=0.79; 95 % CI=0.62 to 1.00, p=0.046). Fracture rate reductions in year 4 were most prominent in subjects with persisting low hip bone mineral density (BMD). Conclusions Denosumab treatment beyond 3 years was associated with a further reduction in nonvertebral fracture rate that persisted through 7 years of continuous denosumab administration. The degree to which denosumab further reduces nonvertebral fracture risk appears influenced by the hip bone density achieved with initial therapy [less ▲]

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See detailFurther results on the line-profile variability of WR 134
Gosset, Eric ULg; Vreux, Jean-Marie ULg; Andrillat, Y.

in Astrophysics & Space Science (1994, November 01), 221

We discuss a few conclusions previously derived from the analysis of the line-profile variability of the Wolf-Rayet star WR 134, some details are made more explicit. In addition, we present a new set of ... [more ▼]

We discuss a few conclusions previously derived from the analysis of the line-profile variability of the Wolf-Rayet star WR 134, some details are made more explicit. In addition, we present a new set of data and briefly comment on recent results deduced from its analysis. [less ▲]

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See detailFurther spectroscopic observations of 25 quasi-stellar objects
Surdej, Jean ULg; Swings, Jean-Pierre ULg

in Astronomy and Astrophysics. Supplement Series (1981), 46

Spectroscopic observations are reported for 25 quasars suspected of having line profiles which are indicative of mass outflow from the central quasar. The quasars were selected on the basis of optical ... [more ▼]

Spectroscopic observations are reported for 25 quasars suspected of having line profiles which are indicative of mass outflow from the central quasar. The quasars were selected on the basis of optical variability and/or the presence of P Cygni spectral profiles, and large emission redshift, and observed on widened spectrograms obtained at the Cassegrain focus of the ESO 3.6-m telescope at La Silla during December 1977 and July 1978. Observations confirm the previously detected emission and absorption redshifts for most of the quasars, and reveal previously undetected lines and absorption redshifts in a few cases. [less ▲]

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See detailFurther studies on the genetic diversity of lima beans (Phaseolus lunatus L.) using allozymes
Maquet, Alain; Wathelet, Bernard ULg; Baudoin, Jean-Pierre ULg

in Annual Report of the Bean Improvment Cooperative (1993), 36

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See detailFurther Studies on the Mechanism of Radiation Induced Thymic Lymphoma Prevention by Bone Marrow Transplantation in C57bl Mice
Humblet, Chantal ULg; Defresne, Marie-Paule ULg; Greimers, Roland ULg et al

in Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K (1989), 3(11), 813-8

Whole body fractionated irradiation induces thymic lymphomas in C57BL/Ka mice after a latent period during which intrathymic lymphopoiesis is modified; thymocyte numbers are subnormal and the epithelial ... [more ▼]

Whole body fractionated irradiation induces thymic lymphomas in C57BL/Ka mice after a latent period during which intrathymic lymphopoiesis is modified; thymocyte numbers are subnormal and the epithelial component of thymic nurse cells (TNCs) is altered as estimated by the number of TNCs in vivo and by its ability to interact with immature thymocytes in vitro. A graft of normal bone marrow cells immediately after the last irradiation prevents the development of lymphomas; but when such a graft is performed 1 month later, it does not inhibit the emergence of tumors. In both cases the grafted precursors home and repopulate the thymus. However, the delayed graft does not exert any effect upon the altered epithelial component of TNCs, whereas the early one restores the numbers of TNCs and the function of their epithelial component. The results thus demonstrate that lymphoid thymic repopulation by a bone marrow graft is not sufficient to prevent the development of lymphomas and that there is an intimate relationship between tumor development and alterations of nurse cells microenvironment. [less ▲]

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See detailFurther taxonomic rearrangements in the Brachytheciaceae (Bryophyta): Frahmiella, a new genus segregated from Rhynchostegiella
Ignatov, Michael; Aigoin, Delphine ULg; Huttunen, Sanna et al

in Tropical Bryology (2010), 31

The taxonomic position of Rhynchostegiella acicula, a local endemic of Shaanxi Province of China, is investigated by means of cladistic analyses employing nrITS sequences. The analyses show that R ... [more ▼]

The taxonomic position of Rhynchostegiella acicula, a local endemic of Shaanxi Province of China, is investigated by means of cladistic analyses employing nrITS sequences. The analyses show that R. acicula does not belong to Rhynchostegiella s.str. (Helicodontioideae) but is resolved within the Homalothecioideae as sister to Eurhynchiastrum, from which it differs by a soft and slender habit; narrow lanceolate and acuminate leaves; a percurrent costa; and an autoicous condition. It differs from Brachytheciastrum and Brachythecium in a longly rostrate operculum, and from Homalothecium in a small plants that lack thick-walled basal laminal cells characteristic of this genus, as well as in an autoicous inflorescence. As a consequence, R. acicula is transferred into its own, monospecific genus Frahmiella Ignatov, Vanderpoorten & Wang You-fang, gen. nov. [less ▲]

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See detailFusariose disséminée chez un patient immunodéprimé
QUATRESOOZ, Pascale ULg; Meiers, I.; ARRESE ESTRADA, Jorge ULg et al

in Revue de l’Association Belge des Technologues de Laboratoire = Tijdschrift van de Belgische Vereniging van Laboratoriumtechnologen (2001), 28

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See detailFusarioses sur blé d'hiver au Grand-Duché de Luxembourg
Giraud, Frédéric; Pasquali, Matias; Vrancken, Carine et al

in Phytoma - la Défense des Végétaux (2009), 622-623

Au Grand-Duché de Luxembourg, la campagne 2006-2007 a été caractérisée par un hiver relativement doux et un printemps pluvieux. Ces conditions météorologiques ont permis le développement de nombreuses ... [more ▼]

Au Grand-Duché de Luxembourg, la campagne 2006-2007 a été caractérisée par un hiver relativement doux et un printemps pluvieux. Ces conditions météorologiques ont permis le développement de nombreuses maladies cryptogamiques sur le blé d’hiver, dont la fusariose. Cette maladie a été suivie sur 17 sites couvrant le G-D de Luxembourg par des mesures de prévalence (pourcentage moyen d’épis visuellement infectés) et de sévérité (pourcentage moyen d’épillets atteints par épi). Des valeurs moyennes de 8,9± +/- 15,5 % pour la prévalence et de 21,0± +/- 17,8 % pour la sévérité ont été enregistrées avec des différences significatives entre les cantons nord et sud pour la sévérité. Plus de 600 souches isolées des 17 sites ont été identifiées suivant des critères morphologiques et l’emploi d’outils moléculaires. 5 espèces semblent associées à la fusariose : Fusarium graminearum (23,5 %), F. culmorum (12,8 %), F. poae (19,4 %) (3 espèces potentiellement productrices de mycotoxines), F. avenaceum (20 %) et Microdochium nivale (18,7 %). Cette étude est la première du genre à avoir été faite au Grand-Duché de Luxembourg. [less ▲]

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See detailFusarium head blight and associated mycotoxin occurrence on winter wheat in Luxembourg in 2007/2008
Giraud, Frédéric; Pasquali, Matias; El Jarroudi, Moussa ULg et al

in Food Additives & Contaminants (2010), 27

Fusarium head blight (FHB) is among the major causes of reduced quality in winter wheat and its products. In addition, the causal fungi produce a variety of toxins. A relatively high FHB infection rate in ... [more ▼]

Fusarium head blight (FHB) is among the major causes of reduced quality in winter wheat and its products. In addition, the causal fungi produce a variety of toxins. A relatively high FHB infection rate in winter wheat was observed in 2007 and 2008 in Luxembourg. A fusariotoxin survey was carried out in 17 different geographical locations. Three groups of Fusarium mycotoxins (trichothecenes A and B and zearalenone) were analysed by a multi-detection HPLC–MS/MS method. Fusarium strains were also investigated by morphological and molecular methods. In addition, questionnaires relating to cultural practices were sent to the farmers managing the 17 fields investigated. FHB prevalence ranged from 0.3 to 65.8% (mean: 8.5%) in 2007 and from 0 to 24.5% (mean: 8.3%) in 2008. Results of morphological and molecular identification showed that the most common species isolated from diseased wheat spikes was F. graminearum (33.1%), followed by F. avenaceum (20.3%) and F. poae (17.8%). The chemical analysis revealed that 75% of the investigated fields were contaminated by deoxynivalenol (DON, range 0–8111 mg/kg). The preceding crop was highly and significantly correlated to the number of grains infected and had a significant impact on disease prevalence ( p¼0.025 and 0.017, respectively, Fisher’s F-test). A trend was found for maize as the preceding crop ( p¼0.084, Tukey’s test) to predict the amount of DON in the fields. This is the first report on the occurrence of DON and ZON in naturally infected wheat grains sampled from Luxembourg. [less ▲]

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See detailFused Multi-Sensor Image Mining for Feature Foundation Data
Streilein, William; Waxman, Allen M.; Ross et al

Conference (2000)

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See detailFuselage structure optimization
Grihon, Stéphane; Samuelides, Manuel; Merval, Arnaud et al

in Kesseler, Ernst; Guenov, Martin (Eds.) Advances in Collaborative Civil Aeronautical Multidisciplinary Optimization (2010)

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See detailFusion alpha and proton diagnostics by thin layer activation
Chene, Grégoire ULg; Bonheure, George; Delhalle, René ULg et al

Conference (2012, September)

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See detailFusion d’images multi-résolution par égalisation de moyennes et variances locales. Comparaison avec la fusion par la méthode des ondelettes
de Bethune, Stanislas; Donnay, Jean-Paul ULg; Muller, Fabrice

in Actes des journées scientifiques du réseau de télédétection de l’UREF : La réalité de terrain : pratique et méthodes (1998)

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See detailLa fusion des communes : une réforme trentenaire
Lazzari, Mélanie; Verjans, Pierre ULg; Durviaux, Ann-Lawrence ULg

in Territoire(s) Wallon(s) (2008), hors série(Aout 2008), 27-34

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See detailLa fusion froide
Jaminon, Martine ULg

Article for general public (2001)

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See detailFusion Of Bovine Leukemia Virus With Target Cells Monitored By R18 Fluorescence And Pcr Assays
Zarkik, S.; Defrisequertain, F.; Portetelle, Daniel ULg et al

in Journal of Virology (1997), 71(1),

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See detailFusion of Multi- Sensor Passive and Active 3D Imagery
Fay, David A.; Verly, Jacques ULg; Braun, Michael I. et al

Conference (2001, April)

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