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See detailThe immune recognition of hypothalamic magnocellular functions
Geenen, Vincent ULg

Conference given outside the academic context (1991)

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See detailImmune Reconstitution After Alternative Hematopoietic Stem Cell Transplantation: Comparison of Unrelated Cord Blood and Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation
Servais, Sophie ULg; Lenglinne, Etienne; Porcher, Raphael et al

in Bone Marrow Transplantation (2013, April 08), 48(S2), 132

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See detailImmune Reconstitution Inflammatory Syndrome in Natalizumab-Associated PML
Phan-Ba, Rémy ULg; LOMMERS, Emilie ULg; Moonen, Gustave ULg et al

in Neurology (2012), 78(1), 73

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See detailImmune response and antigen recognition in non-pregnant ewes experimentally infected with Neospora caninum tachyzoites.
Rettigner, Chantal; Lasri, Saadia; De Meerschman, Francois et al

in Veterinary Parasitology (2004), 122(4), 261-71

The cellular and humoral responses as well as the antigen recognition during the acute stage of a Neospora caninum (NC) infection were investigated in non-pregnant ewes. The experimentally infected ewes ... [more ▼]

The cellular and humoral responses as well as the antigen recognition during the acute stage of a Neospora caninum (NC) infection were investigated in non-pregnant ewes. The experimentally infected ewes developed specific lymphoproliferative and humoral responses within 2 weeks post-infection (PI). The magnitude of the cellular response showed large variations between animals. A significant decrease in the proliferative response to Con A mitogen and N. caninum, Toxoplasma gondii (TG) antigens was recorded on day 21 post-infection (PI). The humoral response and the pattern of antigen recognition were similar among infected ewes. Proteins of 44, 42, 40, 39 and 28 kDa were intensively recognized by the infected animals during the experiment. The 42 and 28 kDa antigens should be considered as useful for the diagnostic of N. caninum infection, as the intensity of recognition infection of the other antigens had decreased markedly 8 weeks post-infection. For some antigens a sequential recognition was recorded. The 59, 54 and 38-37 kDa proteins were frequently recognized by infected sera during the first weeks of the infection, but recognition of these antigens was absent or rare at the end of the experiment. These antigens could be related to the acute stage of the infection. [less ▲]

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See detailImmune suppression in head and neck cancers: a review.
Duray, Annaëlle; Demoulin, Stéphanie ULg; Hubert, Pascale ULg et al

in Clinical & Developmental Immunology (2010), 2010

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant ... [more ▼]

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common cancer in the world. Despite significant advances in the treatment modalities involving surgery, radiotherapy, and concomitant chemoradiotherapy, the 5-year survival rate remained below 50% for the past 30 years. The worse prognosis of these cancers must certainly be link to the fact that HNSCCs strongly influence the host immune system. We present a critical review of our understanding of the HNSCC escape to the antitumor immune response such as a downregulation of HLA class I and/or components of APM. Antitumor responses of HNSCC patients are compromised in the presence of functional defects or apoptosis of T-cells, both circulating and tumor-infiltrating. Langerhans cells are increased in the first steps of the carcinogenesis but decreased in invasive carcinomas. The accumulation of macrophages in the peritumoral areas seems to play a protumoral role by secreting VEGF and stimulating the neoangiogenesis. [less ▲]

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See detailThe immune system as a foundation for immunologic therapy and hematologic malignancies: a historical perspective.
Baron, Frédéric ULg; Storb, Rainer

in Bailliere's Best Practice & Research. Clinical Haematology = Best Practice & Research. Clinical Haematology (2006), 19(4), 637-53

In this review we aim to provide a historical overview of the immunotherapeutic approaches which have been developed for the treatment of hematological malignancies. After briefly summarizing the ... [more ▼]

In this review we aim to provide a historical overview of the immunotherapeutic approaches which have been developed for the treatment of hematological malignancies. After briefly summarizing the development of the theory of cancer immune surveillance, we describe how initial studies discovering the efficacy of the immune-mediated graft-versus-tumor effects after allogeneic hematopoietic cell transplantation led to new transplantation approaches (termed non-myeloablative transplantation) relying almost exclusively on graft-versus-tumor effects for tumor eradication. We then summarize important steps in the development of tumor vaccines and autologous adoptive immunotherapy in patients with hematological malignancies. Finally, we describe historical discoveries leading to the recent success with monoclonal antibodies as treatment for lymphomas, chronic lymphocytic leukemia, and acute myeloid leukemia. [less ▲]

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See detailImmune-mediated respiratory and cardiac disease
Clercx, Cécile ULg

in Day, M. J. (Ed.) Clinical Immunology of the Dog and Cat”, 1st edition (2006)

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See detailImmune-mediated respiratory and cardiac disease
Clercx, Cécile ULg; Day, M. J.

in Clinical Immunology of the Dog and Cat (2006)

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See detailImmune-mediated respiratory and cardiac disease
Clercx, Cécile ULg

in Clinical Immunology of the Dog and Cat”, 2d edition (2008)

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See detailImmunisation against East Coast fever by the infection and treatment method: evaluation of the use of ice baths for field delivery and appraisal of an acid formulation of long-acting tetracycline.
Marcotty, T.; Billiouw, M.; Chaka, G. et al

in Veterinary Parasitology (2001), 99(3), 175-87

Immunisation by the infection and treatment method using the Katete strain is currently the most efficient prophylactic technique to control East Coast fever (ECF) in the endemic areas of the Eastern ... [more ▼]

Immunisation by the infection and treatment method using the Katete strain is currently the most efficient prophylactic technique to control East Coast fever (ECF) in the endemic areas of the Eastern Province of Zambia. The maintenance of the cold chain in liquid nitrogen up to the time of inoculation and the cost of the reference long-acting oxytetracycline (Terramycin LA, Pfizer) are the main drawbacks of the method. The work presented in this paper aims at reducing the cost of immunisation against ECF by using an ice bath for the field delivery and a cheaper long-acting oxytetracycline formulation as chemotherapeutic agent. In experimental conditions, the results from 40 calves immunised after various periods of storage on ice ranging from 4 to 32 h indicate that deferred immunisation performed with a stabilate kept on ice for up to 6h after thawing has an efficiency of 90%. Moreover, sporozoites kept on ice were still surviving 32 h after thawing. In a field trial, 91 calves were inoculated with a stabilate kept for 3.5-5.5 h after thawing and dilution whereas 86 calves were immunised using the standard method. Clinical and parasitological reactions to immunisation were monitored as well as the seroconversion. In the field trial, the deferred immunisation was more efficient than the standard method. The acid formulation of oxytetracycline that was tested was found as suitable as the reference alkaline formulation for the chemotherapeutic control of the Katete strain in ECF immunisation. One indoor trial was carried out on 10 animals and a field trial involved 93 calves. [less ▲]

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See detailImmunisation against Theileria parva in eastern Zambia: influence of maternal antibodies and demonstration of the carrier status
Marcotty, T.; Brandt, J.; Billiouw, M. et al

in Veterinary Parasitology (2002), 110(1-2), 45-56

Immunisation of calves by the infection and treatment method (I

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See detailImmunisation passive du poulet de chair vis-à-vis des salmonelles à l'aide d'anticorps du jaune d'oeuf
Marcq, Christopher ULg; Thewis, André ULg; Portetelle, Daniel ULg et al

in Impacts de l'alimentation sur la santé animale : nouveaux développements (2009, October 14)

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See detailL’immunité pénale de certaines personnes morales de droit public et ses incidences sur le délai de prescription de l’action civile née d’une infraction
Michiels, Olivier ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2011), (2011/31), 1542-1550

Le contexte dans lequel s’inscrit la décision commentée est tragique. Elle a pour toile de fond les massacres perpétrés au Rwanda au cours de la guerre civile qui secoua ce pays dans le courant de l’année ... [more ▼]

Le contexte dans lequel s’inscrit la décision commentée est tragique. Elle a pour toile de fond les massacres perpétrés au Rwanda au cours de la guerre civile qui secoua ce pays dans le courant de l’année 1994. Plus précisément, des victimes directes et indirectes de l’attaque du cantonnement basé à l’ETO entendaient engager, entre autre, la responsabilité civile de l’Etat belge en lui reprochant la décision d’évacuation de l’enceinte de l’ETO qui s’est soldée in concreto par l’abandon de deux mille réfugiés rwandais aux mains des miliciens Interahamwe et des gendarmes rwandais. Les faits se déroulèrent le 11 avril 1994. Les actions civiles furent introduites devant le tribunal de première instance de Bruxelles respectivement le 7 avril 2004 et le 4 décembre 2007. Le moyen tiré de la prescription de l’action civile fut, dès lors, l’un des premiers à être soulevé par l’Etat belge. C'est le moyen tiré de la prescription qui est analysé tant sous l'angle pénal que sous l'angle civil. Le commentaire s'attache encore à mettre en lumière les conséquences à tirer lorsque le fait fautif est constitutif d’une infraction imprescriptible et qu’il implique une personne morale de droit public bénéficiant d’une immunité pénale. [less ▲]

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See detailImmunization and dermatophytes
Baldo, Aline ULg; Tabart, J.; Mathy, Anne ULg et al

Conference (2009)

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See detailImmunization and Dermatophytes
Mignon, Bernard ULg; Tabart, Jérémy; Baldo, Aline ULg et al

in Current Opinion in Infectious Diseases (2008), 21(2), 134-140

PURPOSE OF REVIEW: Despite the availability of effective vaccines for certain animal species, vaccination against dermatophytosis requires improvement and further development in both animals and humans ... [more ▼]

PURPOSE OF REVIEW: Despite the availability of effective vaccines for certain animal species, vaccination against dermatophytosis requires improvement and further development in both animals and humans. This review provides an update on the current situation and focuses on recent advances in host-dermatophyte relationships that could have implications for future vaccination against the most prevalent of the fungal diseases. RECENT FINDINGS: Numerous dermatophytic virulence factors have recently been isolated and characterized at the molecular level, notably secreted proteases involved in the invasion of the keratin network. Their precise roles in the different steps of the infectious process and in immunopathogenesis are being studied, while all aspects of the host immune response against dermatophytes, including the innate response, are becoming increasingly documented. In addition, new molecular tools are now available for studying dermatophytes, which will accelerate research on this topic. SUMMARY: The growth of knowledge concerning all aspects of the host-dermatophyte relationship should contribute towards sound strategies for the development of effective and safe vaccines against dermatophytosis. [less ▲]

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See detailImmuno PCR : a new tool for the ultra-sensitive detection of biomolecules
Zorzi, Willy ULg; Elmoualij, Benaïssa ULg

Conference (2008, December 11)

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