Improvement of insulin-induced glucose disposal in obese patients with NIDDM after 1-wk treatment with d-fenfluramine.
Scheen, André ; ; et al
in Diabetes Care (1991), 14(4), 325-32
OBJECTIVE: To study the short-term effects of the serotoninergic anorectic drug d-fenfluramine on insulin-induced glucose disposal. RESEARCH DESIGN AND METHODS: A randomized double-blind placebo ... [more ▼]
OBJECTIVE: To study the short-term effects of the serotoninergic anorectic drug d-fenfluramine on insulin-induced glucose disposal. RESEARCH DESIGN AND METHODS: A randomized double-blind placebo-controlled crossover trial with 1-wk treatment periods (2 x 15 mg/day d-fenfluramine) was conducted. Twenty obese subjects, 10 with normal oral glucose tolerance and 10 with non-insulin-dependent diabetes mellitus (NIDDM), were all treated with a weight-maintaining diet. Euglycemic-hyperinsulinemic glucose clamps with measurement of glucose kinetics with D-[3-3H]glucose were performed at either two (patients without NIDDM, 0.05 and 0.10 U.kg-1.h-1) or three (patients with NIDDM, 0.05, 0.10, and 0.50 U.kg-1.h-1) insulin delivery rates. RESULTS: In the nondiabetic subjects, no significant changes in any metabolic or hormonal parameter were measured in the basal state or during the clamp despite a slight reduction in body weight (-1.2 +/- 0.5 kg, P less than 0.05). In the diabetic patients, no significant changes in body weight or basal plasma insulin levels were observed, but fasting blood glucose levels (8.0 +/- 0.8 vs. 9.4 +/- 1.1 mM, P less than 0.005) and plasma free fatty acid concentrations (1150 +/- 227 vs. 1640 +/- 184 microM, P less than 0.05) were significantly reduced after d-fenfluramine compared with placebo. During the clamp, insulin metabolic clearance rate (MCR) was similar after both placebo and d-fenfluramine; endogenous (hepatic) glucose production was similarly and almost completely suppressed, whereas glucose disposal was remarkably enhanced after d-fenfluramine (average increase of glucose MCR 35 +/- 12%, P less than 0.02). CONCLUSIONS: Whatever the mechanism(s) involved, a 1-wk treatment with d-fenfluramine induces better blood glucose control and improves insulin sensitivity in obese patients with NIDDM independent of significant weight reduction; this last effect is not present in obese subjects with normal oral glucose tolerance. [less ▲]Detailed reference viewed: 8 (1 ULg)
Improvement Of Inulin Hydrolysis Yeast-Cell Reactor By Mutants Selection
Thonart, Philippe ; Weber, Dominique ;
in Applied Biochemistry and Biotechnology (1988), 17Detailed reference viewed: 3 (0 ULg)
Improvement Of Lactic Cell Production
; ; et al
in Applied Biochemistry and Biotechnology (1998), 70-2Detailed reference viewed: 12 (2 ULg)
Improvement of lactic cell production.
; ; et al
Poster (1997, May)Detailed reference viewed: 3 (0 ULg)
Improvement of lipase production by the yeast Yarrowia lipolytica
; Destain, Jacqueline ; Thonart, Philippe
Poster (2000, March 31)Detailed reference viewed: 13 (1 ULg)
Improvement Of Lipase Production From Yarrowia Lipolytica
Destain, Jacqueline ; ; Thonart, Philippe
in Biotechnology Letters (1997), 19(2),Detailed reference viewed: 10 (0 ULg)
Improvement of lupin seed valorisation by the pig with the addition of alpha-galactosidase in the feed and the choice of a suited variety.
; Wathelet, Bernard ; Beckers, Yves et al
in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2005), 9(4), 225-235
Three experiments were conducted to assess whether an a-galactosidase supplement improved the utilisation of lupin seeds by growing and finishing pigs and to determine the best lupin variety in presence ... [more ▼]
Three experiments were conducted to assess whether an a-galactosidase supplement improved the utilisation of lupin seeds by growing and finishing pigs and to determine the best lupin variety in presence of a-galactosidase. In experiment 1, three iso-nitrogen (iso-N) and iso-net energy (iso-NE) diets containing 15% of soybean meal (SBM diet) or 20% of lupin seeds (Lupinus albus var. Arès), with or without an a-galactosidase supplement (‘lupin’ and ‘lupin + a-gal’ diets, respectively), were ingested by 12 pigs fitted with a caecal canula, following a completely randomized experimental design. The ileal digestibility of a-galactosides tended to increase with the lupin + a-gal diet. Nitrogen retention of pigs eating the SBM diet was similar to that of those fed with the lupin + a-gal diet and higher than that observed for pigs given the lupin diet. The results suggested that a-galactosides are the main anti-nutritional factors in lupin seeds for pigs. The same diets were investigated in a production trial (experiment 2) involving 48 pigs with a live weight of between 30 and 105 kg. The fattening period was similar for the SBM and lupin + a-gal diets (107 d) and longer for the lupin diet (123 d). With the lupin diet there was a lower average daily gain (ADG, -16%) and a higher food conversion ratio (FCR, + 8%) than with the two other diets. The backfat of pigs fed with lupin-based diets contained fewer polyunsaturated fatty acids (PUFA) and had a lower w6/w3 ratio. In experiment 3, three iso-N and iso-NE diets containing different varieties of lupin (Lupinus albus cv Lublanc and Amiga; Lupinus angustifolius cv Boltensia) and an a-galactosidase supplement were investigated in 12 pigs fitted with a caecal canula, as in Exp. 1. The results showed that the digestible protein supply by the Boltensia diet was higher than in the others. However, the Boltensia variety led to a higher urinary N excretion than the Lublanc variety. The results obtained with Amiga were intermediate. Consequently, the utilisation of ingested and digested proteins was relatively high with the Lublanc diet, intermediate with the Amiga diet and low with the Boltensia diet. The results suggested that the Lublanc variety was better adapted for pig feed that contained an a-galactosidase supplement. [less ▲]Detailed reference viewed: 75 (23 ULg)
Improvement of metal dispersion in Pd/SiO2 cogelled xerogel catalysts
Lambert, Stéphanie ; ; et al
Poster (2004)Detailed reference viewed: 6 (3 ULg)
Improvement of metal dispersion in Pd/SiO2 cogelled xerogel catalysts for 1,2-dichloroethane hydrodechlorination
Lambert, Stéphanie ; ; Pirard, Jean-Paul et al
in Applied Catalysis B : Environmental (2004), 50
The study of the influence of synthesis operating variables (nature and concentration of complexing silane, palladium percentage, temperatures of gelling, aging and vacuum drying of xerogels, molar ratio ... [more ▼]
The study of the influence of synthesis operating variables (nature and concentration of complexing silane, palladium percentage, temperatures of gelling, aging and vacuum drying of xerogels, molar ratio between the complexing silane and palladium, molar concentration of ammonia solution, and use of tetramethylammonium hydroxide as base instead of NH3) allows improving metal dispersion in Pd/SiO2 cogelled xerogel catalysts. The use of 3-(2-aminoethylamino)propyltrimethoxysilane (EDAS) or 3-(2-aminoethylamino)propyltriethoxysilane (EDAES) to complex palladium in an ethanolic solution containing tetraethoxy si lane (TEOS) and an ammonia solution of 0.54 mol/l allows obtaining a Pd/SiO2 xerogel catalyst with a mean metal particle diameter of 2.4 nm located inside silica particles. Indeed, complexes Pd(EDA(E)S)(x)(n+) induce a nucleation mechanism because of their higher reactivity compared to the network-reagent (TEOS). Although metal particles are located inside the silica particles, their complete accessibility, via the micropore network, has been shown. 1,2-dichloroethane hydrodechlorination over Pd/SiO2 catalysts mainly produces ethane and the specific hydrodechlorination rate per gram of palladium increases proportionally with palladium dispersion. Hydrodechlorination over Pd/SiO2 cogelled xerogel catalysts is a structure insensitive reaction with regard to the ensemble size concept. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]Detailed reference viewed: 87 (8 ULg)
Improvement of Mucor lipase production by mutant selection.
; Destain, Jacqueline ; Thonart, Philippe
Poster (1988, July)Detailed reference viewed: 6 (0 ULg)
Improvement of Mucor lipase production by mutant selection.
Weber, Dominique ; Destain, Jacqueline ; Thonart, Philippe
in Belgian Journal of Food Chemistry and Biotechnology (1989), 44(3), 79-82Detailed reference viewed: 4 (0 ULg)
Improvement Of Oxygen Transfer Coefficient During Penicillium Canescens Culture - Influence Of Turbine Design, Agitation Speed, And Air Flow Rate On Xylanase Production
; ; Thonart, Philippe
in Applied Biochemistry and Biotechnology (1998), 70-2Detailed reference viewed: 12 (0 ULg)
Improvement of oxygen transfer coefficient during Penicillium canescens culture : influence of turbine design, agitation speed and air flow rate.
; ; et al
Poster (1997, May)Detailed reference viewed: 9 (0 ULg)
Improvement of oxygen transfert during Penicillium canescens cultivation in agitated fermenter.
; ; et al
Poster (1997, April)Detailed reference viewed: 3 (0 ULg)
Improvement of parathyroid lesion visualization in primary hyperparathyroidism with 99mTc-MIBI pinhole SPECT: comparison with conventional SPECT and planar scintigraphy.
; ; et al
in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(S2), 100Detailed reference viewed: 15 (2 ULg)
Improvement of Physicians’ Patient-Centeredness: An Empirical Evidence of the Benefits of a Communication Skills Training Program
Poster (2010, May 27)
Objectives. No study has yet assessed the benefits of a communication skills training program on patient-centeredness. The purpose of this study is to assess the association between ... [more ▼]
Objectives. No study has yet assessed the benefits of a communication skills training program on patient-centeredness. The purpose of this study is to assess the association between patients’characteristics and physicians’ communication skills before and after a communication skills training program. Methods. Correlations between physicians’ communication skills and patients’ characteristics were categorized as absent or present: the number of present correlations indicates the level of patientcenteredness. Communication skills were assessed during a consultation before and after a communication skills training program. Consultations were audio-recorded and transcripted. Communication skills were rated according to the Cancer Research Campaign Workshop Evaluation Manual. Patients’ characteristics (sociodemographic, physical and psychological) were measured before and after the training program. Results. Sixty-three physicians were included. Before training, physicians’ communication skills were associated with one patients’ sociodemographic characteristic and with one psychological characteristic. After training, physicians’ communication skills were associated with none of the patients’ sociodemographic characteristics and with four psychological characteristics. Conclusions. This study highlights that physicians’ patient-centeredness may be improved through a communication skills training program. After training, physicians are more centered on patients’ psychological characteristics and not on patients’ sociodemographic characteristics anymore. This study underlines the need to design communication skills training which may further improve patient-centeredness. [less ▲]Detailed reference viewed: 40 (10 ULg)
Improvement of physicians' patient-centeredness: an empirical evidence of the benefits of a communication skills training program
Jonius, Bénédicte ; ; Bragard, Isabelle et al
in Psycho-oncology (2010, May), 19(1-313), 254Detailed reference viewed: 16 (4 ULg)
Improvement of pretreatments and technologies for enzymatic hydrolysis of cellulose from industrial and agricultural refuse and comparison with acidic hydrolysis.
Paquot, Michel ; Thonart, Philippe ; et al
Scientific journal (1984)
Chemical and enzymatic hydrolysis of cellulose are compared. Basic research on paper mill celluloses shows that it is mainly the endo- and exocellulase activities which are absorbed on the substrate. In ... [more ▼]
Chemical and enzymatic hydrolysis of cellulose are compared. Basic research on paper mill celluloses shows that it is mainly the endo- and exocellulase activities which are absorbed on the substrate. In the case of the Trichoderma reesei complex with Aspergillus niger beta-glucosidase, the exocellulase activity has proved to be the limiting factor in the design of a reactor which recycles the enzyme complex. Tests were carried out on various pretreatments for substrates of more complex chemical composition, such as straw, maize stalks, beet pulp. The rate and overall degree of hydrolysis, especially for straw, were improved by chemical treatments in combination with mechanical processes. A first pilot plant for straw hydrolysis was set up with the aim of attaining high sugar concn in the fermenter. [less ▲]Detailed reference viewed: 29 (19 ULg)
Improvement of Pull-in Voltage of Electromechanical Microbeams Using Topology Optimization
Lemaire, Etienne ; Duysinx, Pierre ; Rochus, Véronique et al
in 3rd European Conference on Computational Mechanics (ECCM) (2006)
The present work is dedicated to the application of topology optimization in the coupled simulation of multiphysic field problems as in MEMS. Precisely, it describes how it is possible to maximize pull-in ... [more ▼]
The present work is dedicated to the application of topology optimization in the coupled simulation of multiphysic field problems as in MEMS. Precisely, it describes how it is possible to maximize pull-in voltage of an electromechanical microsystem for which the optimization domain is insulated from the electric field. The electromechanical coupling is modeled by the use of a monolithic analysis. The monolithic modeling combined with a Riks-Crisfield algorithm allows computing accurately the pull-in conditions. The optimization task is completed with the help of a sequential convex linear approximation schemes (CONLIN). [less ▲]Detailed reference viewed: 120 (20 ULg)
Improvement of pulmonary function in COPD horses due to environmental management
Vandenput, Sandrina ; Votion, Dominique ; et al
in Pflügers Archiv : European Journal of Physiology (1996), 432(4), 143Detailed reference viewed: 17 (5 ULg)