Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailHyper-replicative bovine leukemia virus by mutation of an envelope N-linked glycosylation site
De Brogniez, Alix ULg; Bouzar, Amel-Baya; Jacques, Jean-Rock ULg et al

in Retrovirology (2014), 11(1), 141

Reverse genetics can be used in the bovine leukemia virus (BLV) system to characterize mechanisms of viral persistence and pathogenesis. The question addressed here pertains to the role of glycans bound ... [more ▼]

Reverse genetics can be used in the bovine leukemia virus (BLV) system to characterize mechanisms of viral persistence and pathogenesis. The question addressed here pertains to the role of glycans bound to the BLV envelope glycoprotein (SU). A commonly accepted hypothesis is that addition of carbohydrates to the SU protein potentially creates a structure called « glycan shield » that confers resistance to the virus against the host immune response. On the other hand, glycosylation can also modulate attachment of the virus to the cell membrane. To unravel the role of SU glycosylation, three complementary strategies were developed: pharmacological inhibition of different glycosylation pathways, interference with glycan attachment and site-directed mutagenesis of N-glycosylation sites in an infectious BLV provirus. The different approaches show that glycosylation is required for cell fusion, as expected. Simultaneous mutation of all 8 potential N-glycosylation sites destroys infectivity. Surprisingly, mutation of the asparagine residue at position 230 creates a virus having an increased capacity to form syncytia in vitro. Compared to wild-type BLV, mutant N230 also replicates at accelerated rates in vivo. Collectively, this data thus illustrates an example of a N-glycosylation site that restricts viral replication, contrasting with the hypothesis supported by glycan shield model. [less ▲]

Detailed reference viewed: 36 (22 ULg)
Full Text
See detailHyper-volatiles in Comet C/2010 G2 (Hill)
Kawakita, Hideyo; Dello Russo, N.; Vervack, R. J. J. et al

in Bulletin of the American Astronomical Society (2013, October 01), 45

We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ~ 2.5x10^4) at the Keck II telescope on UT 2012 Jan 9 and 10. The ... [more ▼]

We performed high-dispersion near-infrared spectroscopic observations of comet C/2010 G2 (Hill) at 2.5 AU from the Sun using NIRSPEC (R ~ 2.5x10^4) at the Keck II telescope on UT 2012 Jan 9 and 10. The comet had been in outburst. Over the two nights of our observations, prominent emission lines of CH4 and C2H6 along with weaker emission lines of H2O, HCN, CH3OH and CO were detected. The gas production rate of CO was comparable to that of H2O. The mixing ratios of CO, HCN, CH4, C2H6, and CH3OH with respect to H2O are higher than those for normal comets by a factor of five or more. Hyper-volatile species such as CO and CH4 were enriched in the coma of comet Hill suggesting that the sublimation of these hyper-volatiles could sustain the outburst of the comet. Based on a comparison with optical observations, some fraction of water in the inner coma existed as icy grains. Those icy ice grains were likely ejected from nucleus by the sublimation of hyper-volatiles. [less ▲]

Detailed reference viewed: 12 (1 ULg)
Full Text
Peer Reviewed
See detailHyperactivity in the low sternal region with Tc-99m sestamibi: possible cardiac origin
Servais, Fabienne; Seret, Alain ULg; Blocklet, Didier et al

in Clinical Nuclear Medicine (1998), 23(7), 461-462

Scintimammography performed with Tc-99m sestamibi in a 63-year-old woman with a history of mitral valve replacement and pulmonary hypertension demonstrated that the frequently observed sternal ... [more ▼]

Scintimammography performed with Tc-99m sestamibi in a 63-year-old woman with a history of mitral valve replacement and pulmonary hypertension demonstrated that the frequently observed sternal hyperactivity on anterior views could arise from the myocardium. Caution therefore should be taken before the diagnosing of any hyperactivity in the lower sternal region as a neoplastic involvement. [less ▲]

Detailed reference viewed: 37 (1 ULg)
Full Text
Peer Reviewed
See detailHyperacute graft rejection during heart transplantation for giant cell myocarditis: A case report.
Mutijima, E.; Delbecque, Katty ULg; Defraigne, Jean-Olivier ULg et al

in Pathology - Research & Practice (2010), 15(206), 411-4

We report the case of a patient with giant cell myocarditis who was bridged to transplantation with mechanical circulatory support and developed a fatal perioperative hyperacute rejection. The patient had ... [more ▼]

We report the case of a patient with giant cell myocarditis who was bridged to transplantation with mechanical circulatory support and developed a fatal perioperative hyperacute rejection. The patient had received abundant transfusions that had raised her anti-HLA antibody titers. The cross-match test was positive. No pre-transplantation immunosuppressive therapy had been administered given concomitant infection. The severity and acuteness of the rejection in this case likely reflect the combined effect of preformed anti-HLA antibodies in the context of an active organ-specific immune process at the time of transplantation. This case raises the questions of the need for intensive immunosuppressive therapy before transplantation in giant cell myocarditis and of the management of patients with positive cross-match in the context of a giant cell myocarditis. [less ▲]

Detailed reference viewed: 31 (8 ULg)
See detailL'hyperaldostéronisme primaire
Beckers, Albert ULg

Scientific conference (1994, April 30)

Detailed reference viewed: 7 (0 ULg)
Full Text
Peer Reviewed
See detailL'hyperaldostéronisme primaire. Mise au point et traitement raisonnés.
Baudoin, Béatrice ULg; Hamoir, Etienne ULg; Defechereux, Thierry et al

in Revue Française d'Endocrinologie Clinique, Nutrition, et Métabolisme (La) (1997), 38(6), 555-568

Depuis la découverte par Jérôme Conn, en 1954, de l'adénome sécréteur d'aldostérone (ou aldostéronome), neuf variétés ou associations particulières d'hyperaldostéronisme primaire ont été décrites. La ... [more ▼]

Depuis la découverte par Jérôme Conn, en 1954, de l'adénome sécréteur d'aldostérone (ou aldostéronome), neuf variétés ou associations particulières d'hyperaldostéronisme primaire ont été décrites. La manifestation principale de ce désordre endocrinien est l'hypertension artérielle, réfractaire aux thérapeutiques habituelles. Cependant, certains types d'hyperaldostéronisme sont sensibles à la chirurgie qui éradique cette hypertension et ses conséquences. Il importe donc de distinguer ces différentes variétés grâce aux moyens d'investigations actuellement à notre disposition afin d'appliquer le traitement le plus judicieux dans chaque cas. [less ▲]

Detailed reference viewed: 123 (2 ULg)
See detailLes hyperaldostéronismes primaires
Beckers, Albert ULg

Scientific conference (2010, December 17)

Detailed reference viewed: 11 (1 ULg)
Full Text
Peer Reviewed
See detailHyperammonemia after high-dose chemotherapy and stem cell transplantation.
Frere, Pascale ULg; Canivet, Jean-Luc ULg; Gennigens, Christine ULg et al

in Bone Marrow Transplantation (2000), 26(3), 343-5

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the ... [more ▼]

We report a patient with multiple myeloma who suffered from hyperammonemia after a second stem cell autograft. This syndrome is not well known but is associated with a high mortality rate. Considering the possibility of this diagnosis in patients developing confusion and neurological degradation with respiratory alkalosis after intensive chemotherapy, could allow earlier treatment and perhaps improved survival. Possible mechanisms and potential therapies are discussed. With rapid recognition and treatment of the syndrome, the patient fully recovered. One and a half years later, she is still alive and well, on interferon for persisting myeloma. [less ▲]

Detailed reference viewed: 74 (1 ULg)
Peer Reviewed
See detailHyperandrogénie: sémiologie, exploration et traitement
Beckers, Albert ULg; Parotte, M. C.; Gaspard, Ulysse ULg et al

in Revue Médicale de Liège (1999), 54(4), 274-282

Androgen excess (AE) is one of the most common endocrine disorders, affecting 10% of adult women before the menopause. The clinical picture varies widely depending on the etiology of AE. Most of these ... [more ▼]

Androgen excess (AE) is one of the most common endocrine disorders, affecting 10% of adult women before the menopause. The clinical picture varies widely depending on the etiology of AE. Most of these women are suffering from hirsutism, acne, menstrual disturbances, anovulation and obesity. Virilization is unusual, except in patients with ovary or adrenal cancer. Polycystic ovary syndrome (PCOS) and idiopathic hirsutism (IH) are the most frequent causes of androgen excess, accounting for more than 90% of the cases. The pathogenesis of PCOS is still an unresolved problem. A hereditary predisposition has been suggested. Enzymatic deficiency is a less frequent cause of AE, the most common deficiency being the non classic 21-OH deficiency (NCAH). AE has been implicated as a side effect of many drugs. Ovary and adrenal tumours are unusual, however, they must be considered especially in case of severe hirsutism or virilization. Complementary investigations are selected based on the result of clinical examination. Pharmacologic therapy, usually with anti-androgens, is the most widely used treatment for PCOS, IH and NCAH. Surgical therapy should be considered only when there is a particular indication such as Cushing's syndrome, ovary or adrenal tumours. [less ▲]

Detailed reference viewed: 231 (5 ULg)
See detail« Hyperbase-Latin : un instrument au service des études logométriques »
Longrée, Dominique ULg

Scientific conference (2012)

Detailed reference viewed: 12 (0 ULg)
See detailHypercalcaemia of parathyroid carcinoma controlled by immunotherapy
Mead, G. P.; Harvey, T.; Epstein, M. et al

in The Endocrine Society's 84th Annual Meeting - Abstract book (2002)

Detailed reference viewed: 9 (0 ULg)
Full Text
Peer Reviewed
See detailHypercalcemia treated by sunitinib
LOLY, Jean-Philippe ULg; VALDES SOCIN, Hernan Gonzalo ULg; Daly, Adrian ULg et al

in 23rd meeting of the Belgian Endocrine Society - Abstract book (2013, October 19)

Detailed reference viewed: 24 (7 ULg)
Full Text
Peer Reviewed
See detailHypercalcémie réfractaire et sécrétion ectopique de calcitonine dans un cancer neuroendocrine du pancréas : Effets hypocalcémiants du Cinacalcet
VALDES SOCIN, Hernan Gonzalo ULg; LOLY, Jean-Philippe ULg; BETEA, Daniela ULg et al

in Annales d'Endocrinologie (2013, September), 74(4), 235-462

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic ... [more ▼]

Introduction: Paraneoplastic hypercalcemia is a sign of poor prognosis, as it is particularly resistant to the usual hypocalcemic treatments. Observation: In 2009, a well differentiated pancreatic neuroendocrine tumor (Ki-67= 2%) is diagnosed in a 52-year-old diabetic man. The tumor is revealed with a splenic and hepatic carcinomatosis. Plasmatic calcium was: 3.54 mmol/L (2.15 - 2.6). Biology showed hypophosphatemia, PTH < 4 ng/ml, high 1-25 OH VitD, calcitonin: 1016 ng/ml (< 12 ng/ml). He had hypercalciuria and hypophosphaturia. He received for two years several cycles of Streptozotocin-ADRIAMYCIN and FOLFOX, with partial control of the tumor mass and calcium levels. In 2012, calcitonin levels are 29 ng/ml whereas calcemia is 3.17 mmol/L. Hypercalcemia is refractory to hyperhydration, diuretics, corticosteroids, and bisphosphonates therapy. Cinacalcet (Mimpara) is prescribed up to 120 mg/day (PO). Calcemia decreases gradually from 3 to 2.87 and then 2.76 mmol/L. PTH and calcitonin-the tumor mass remain unchanged. After two months of Cinacalcet treatment, Sunitinib (Sutent) 37.5 mg per day was added. During the third month, calcium levels dropped to 2.09 mmol/L and PTH raised to 78 pg/ml, requiring discontinuation of Mimpara. Calcitonin normalized, with a further improvement over pancreatic and metastatic lesions. Conclusion: Cinacalcet is a Calcium Sensing Receptor oral agonist. Cinacalcet hypocalcemic effects have not been previously documented in pancreatic paraneoplastic hypercalcemia. In our patient, Cinacalcet has significantly improved cancer prognosis: this drug could be a new alternative in paraneoplastic hypercalcemia. [less ▲]

Detailed reference viewed: 94 (9 ULg)
Full Text
Peer Reviewed
See detailHypercholesterolaemia in a family of rough collie dogs.
Jeusette, Isabelle; Grauwels, Magda ULg; Cuvelier, Christine ULg et al

in Journal of Small Animal Practice (2004), 45(6), 319-24

A family of five privately owned rough collie dogs was referred for corneal lipidosis and also suffered from hypercholesterolaemia. The hypercholesterolaemia was characterised by an increase in the alpha ... [more ▼]

A family of five privately owned rough collie dogs was referred for corneal lipidosis and also suffered from hypercholesterolaemia. The hypercholesterolaemia was characterised by an increase in the alpha-2 high density lipoprotein-1 band and was due to an increase in the cholesterol content of the very low density lipoprotein, low density lipoprotein and possibly the high density lipoprotein-1 fractions. A low-fat and energy-restricted diet did not reduce either total cholesterol or the corneal lipidosis. Corneal lipidosis regressed with short-chain fructo-oligosaccharide supplementation. However, the effects of short-chain fructo-oligosaccharides on total cholesterol were transient and variable. [less ▲]

Detailed reference viewed: 50 (2 ULg)
Peer Reviewed
See detailHypercholestérolémie modérée et coronaropathies: étude MAAS et étude 4S
Martinez, Christophe ULg; Legrand, Victor ULg; Kulbertus, Henri ULg

in Revue Médicale de Liège (1995), 50(1), 35-40

Detailed reference viewed: 6 (0 ULg)
Full Text
See detailHypercomplex eccentric anomaly in the unified solution to the relative orbital motion
Condurache, D.; Martinusi, Vladimir ULg

in Advances in the Astronautical Sciences (2010), 135

The present work offers an approach to the relative orbital motion by using hypercomplex algebra. An extension to this notion is used for vectors, by introducing the hypercomplex vector in the same way as ... [more ▼]

The present work offers an approach to the relative orbital motion by using hypercomplex algebra. An extension to this notion is used for vectors, by introducing the hypercomplex vector in the same way as hypercomplex numbers are defined. The solution to the relative orbital motion is offered in all possible situations (it stands for any Keplerian reference or targeted trajectories). A unified view on the relative orbital motion is suggested, by generalizing the previous approaches. The solution is offered to the nonlinear model of the relative motion and it is expressed in a coordinate-free hypercomplex vectorial closed form. The key element of this approach is the hypercomplex eccentric anomaly, introduced via a Sundman-like vectorial regularization. [less ▲]

Detailed reference viewed: 3 (0 ULg)
Full Text
Peer Reviewed
See detailLes hyperconflits en organisation
Faulx, Daniel ULg; Delvaux, Sophie

in Actes du 15ème Congrès de Psychologie du Travail et des Organisation de Langue Française. CD-rom. Québec.. (2008)

La description et la compréhension des conflits extrêmes ou « hyperconflits » constituent de nouvelles préoccupations en Psychologie du Travail et des Organisations. A partir de l’analyse des résultats de ... [more ▼]

La description et la compréhension des conflits extrêmes ou « hyperconflits » constituent de nouvelles préoccupations en Psychologie du Travail et des Organisations. A partir de l’analyse des résultats de huit focus groups composés de professionnels du traitement des conflits, nous dégageons 24 indicateurs des hyperconflits. Plus généralement, il ressort de notre étude que ces situations sont liées à une réduction de la complexité du système organisationnel couplée à une généralisation de la dynamique conflictuelle du point de vue de l’espace-temps, des processus et des conséquences. Les implications en termes d’interventions sont également discutées. [less ▲]

Detailed reference viewed: 109 (6 ULg)