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See detailAN IMPROVED ONE-POINT INTEGRATION METHOD FOR LARGE-STRAIN ELASTOPLASTIC ANALYSIS
Stainier, Laurent ULg; Ponthot, Jean-Philippe ULg

in Computer Methods in Applied Mechanics & Engineering (1994), 118(1-2), 163-177

In this paper, we present a new one-point integration method generalizing Flanagan and Belytschko's method (Internat. J. Numer. Methods Engrg. 17 (1981) 679-706) and a modification of Belytschko and ... [more ▼]

In this paper, we present a new one-point integration method generalizing Flanagan and Belytschko's method (Internat. J. Numer. Methods Engrg. 17 (1981) 679-706) and a modification of Belytschko and Bindeman's method (Comput. Methods Appl. Mech. Engrg. 88 (1991) 311-340), both in the frame of large deformation elastoplastic analysis. These stabilization methods are combined with the radial return method used to integrate the constitutive law. Plane strain problems are first considered, and the method is then generalized to axisymmetrical situations. The explicit time integration scheme with its critical timestep is also considered. A few examples are presented that show the great time savings that can be obtained with reduced integration without any loss of accuracy, and even with a gain in the solution quality, since the underintegrated elements prove to be 'flexurally superconvergent'. [less ▲]

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See detailImproved operational model for real-time reconstruction of the electron density profile at a single ionosonde location
Stankov, Stanimir; Warnant, René ULg; Jodogne, Jean-Claude

in Proceedings of the COST271 2002 workshop (2002, October)

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See detailImproved Outcome Prediction Based on Csf Extrapolated Creatine Kinase Bb Isoenzyme Activity and Other Risk Factors in Severe Head Injury
Hans, Pol ULg; Albert, Adelin ULg; FRANSSEN, Colette ULg et al

in Journal of Neurosurgery (1989), 71(1), 54-8

The present study of 43 patients with severe head injury shows that outcome prediction can be markedly improved by combining an appropriate marker of the degree of initial brain damage and other risk ... [more ▼]

The present study of 43 patients with severe head injury shows that outcome prediction can be markedly improved by combining an appropriate marker of the degree of initial brain damage and other risk factors. The patients were classified into three groups according to their actual outcome after 6 months: death (22 patients); persistent vegetative state or severe disability (eight patients); and moderate disability or good recovery (13 patients). By applying stepwise logistic discriminant analysis to the patients' data, five significant risk factors were selected: degree of neurological damage assessed by cerebrospinal fluid (CSF) extrapolated creatine kinase BB isoenzyme activity, Glasgow-Liege Coma Scale score, age, incidence of thoracic injury, and intracranial pressure (ICP). Extrapolated creatine kinase BB activity had the highest prognostic ability (67%). Uncontrollable elevated ICP proved to be systematically associated with death, whereas its absence was not necessarily indicative of a favorable outcome. The combination of the five variables yielded a total prognostic efficiency of 91%. The percentages of correctly predicted patients for the three outcome groups were, respectively, 100%, 50%, and 100%. Thus, half of the persistently vegetative and severely disabled patients were identified by the selected factors. [less ▲]

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See detailImproved pancreatic K-ATP channel openers belonging to the pyridothiadiazine chemical class
Pirotte, Bernard ULg; De Tullio, Pascal ULg; Lebrun, P. et al

in Journal de Pharmacie de Belgique (1993), 48

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See detailImproved parallelism and scheduling in multi-core software routers
Egi, Norbert; Iannaccone, Gianluca; Manesh, Maziar et al

in Journal of Supercomputing (2011)

Recent technological advances in commodity server architectures, with multiple multi-core CPUs, integrated memory controllers, high-speed interconnects, and enhanced network interface cards, provide ... [more ▼]

Recent technological advances in commodity server architectures, with multiple multi-core CPUs, integrated memory controllers, high-speed interconnects, and enhanced network interface cards, provide substantial computational capacity, and thus an attractive platform for packet forwarding. However, to exploit this available capacity, we need a suitable software platform that allows effective parallel packet processing and resource management. In this paper, we at first introduce an improved forwarding architecture for software routers that enhances parallelism by exploiting hardware classification and multi-queue support, already available in recent commodity network interface cards. After evaluating the original scheduling algorithm of the widely-used Click modular router, we propose solutions for extending this scheduler for improved fairness, throughput, and more precise resource management. To illustrate the potential benefits of our proposal, we implement and evaluate a few key elements of our overall design. Finally, we discuss how our improved forwarding architecture and resource management might be applied in virtualized software routers. [less ▲]

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See detailImproved parameters for the transiting hot Jupiters WASP-4b and WASP-5b
Gillon, Michaël ULg; Smalley, B.; Hebb, L. et al

in Astronomy and Astrophysics (2009), 496

The gaseous giant planets WASP-4b and WASP-5b are transiting 12-magnitude solar-type stars in the Southern hemisphere. The aim of the present work is to refine the parameters of these systems using high ... [more ▼]

The gaseous giant planets WASP-4b and WASP-5b are transiting 12-magnitude solar-type stars in the Southern hemisphere. The aim of the present work is to refine the parameters of these systems using high cadence VLT/FORS2 z-band transit photometry and high-resolution VLT/UVES spectroscopy. For WASP-4, the new estimates for the planet radius and mass from a combined analysis of our VLT data with previously published transit photometry and radial velocities are R[SUB]p[/SUB] = 1.30[SUP]+0.05[/SUP][SUB]-0.04[/SUB] R[SUB]J[/SUB] and M[SUB]p[/SUB] = 1.21[SUP]+0.13[/SUP][SUB]-0.08[/SUB] M_J, resulting in a density rho[SUB]p[/SUB] = 0.55[SUP]+0.04[/SUP][SUB]-0.02[/SUB] rho_J. The radius and mass for the host star are R_* = 0.87[SUP]+0.04[/SUP][SUB]-0.03[/SUB] R_o and M_* = 0.85[SUP]+0.11[/SUP][SUB]-0.07[/SUB] M_o. Our ground-based photometry reaches 550 ppm at time sampling of ~50 s. Nevertheless, we also report the presence of an instrumental effect on the VLT that degraded our photometry for the WASP-5 observations. This effect could be a major problem for similar programs. Our new estimates for the parameters of the WASP-5 system are R[SUB]p[/SUB] = 1.09 ± 0.07 R_J, M[SUB]p[/SUB] = 1.58[SUP]+0.13[/SUP][SUB]-0.10[/SUB] M_J, rho[SUB]p[/SUB] = 1.23 [SUP]+0.26[/SUP][SUB]-0.16[/SUB] rho_J, R_* = 1.03[SUP]+0.06[/SUP][SUB]-0.07[/SUB] R_o, and M_* = 0.96[SUP]+0.13[/SUP][SUB]-0.09[/SUB] M_o. The measured size of WASP-5b agrees well with the basic models of irradiated planets, while WASP-4b is clearly an ``anomalously'' large planet. Based on data collected with the FORS2 imager at the VLT-UT4 telescope and with the UVES spectrograph at the VLT-UT2 telescope (Paranal Observatory, ESO, Chile) in the programme 280.C-5003. [less ▲]

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See detailImproved parameters for the transiting planet HD 17156b: a high-density giant planet with a very eccentric orbit
Gillon, Michaël ULg; Triaud, A H M J; Mayor, M. et al

in Astronomy and Astrophysics (2008), 485

We report high-precision transit photometry for the recently detected planet HD 17156b. Using these new data with previously published transit photometry and radial velocity measurements, we perform a ... [more ▼]

We report high-precision transit photometry for the recently detected planet HD 17156b. Using these new data with previously published transit photometry and radial velocity measurements, we perform a combined analysis based on a Markov Chain Monte Carlo approach. The resulting mass M[SUB]p[/SUB] = 3.09[SUP]+0.22[/SUP][SUB]-0.17[/SUB]~M_Jup and radius R[SUB]p[/SUB] = 1.23[SUP]+0.17[/SUP][SUB]-0.20[/SUB] R_Jup for the planet places it at the outer edge of the density distribution of known transiting planets with rho[SUB]p[/SUB] = 1.66[SUP]+1.37[/SUP][SUB]-0.60[/SUB] rho_Jup. The obtained transit ephemeris is T_Tr = 2 454 438.48271[SUP]+0.00077[/SUP][SUB]-0.00057[/SUB] + N × 21.21747[SUP]+0.00070[/SUP][SUB]-0.00067[/SUB] BJD. The derived plausible tidal circularization time scales for HD 17156b are larger than the age of the host star. The measured high orbital eccentricity e = 0.6719[SUP]+0.0052[/SUP][SUB]-0.0063[/SUB] can thus not be interpreted as the clear sign of the presence of another body in the system. Based on observations made with the Mercator Telescope, operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. Photometric measurements are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/485/871 [less ▲]

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See detailImproved performances of intraocular lenses by poly(ethylene glycol) chemical coatings
Bozukova, Dimitriya ULg; Pagnoulle, Christophe; Gillet, Marie-Claire ULg et al

in Biomacromolecules (2007), 8(8), 2379-2387

Cataract surgery is a routine ophthalmologic intervention resulting in replacement of the opacified natural lens by a polymeric intraocular lens (IOL). A main postoperative complication, as a result of ... [more ▼]

Cataract surgery is a routine ophthalmologic intervention resulting in replacement of the opacified natural lens by a polymeric intraocular lens (IOL). A main postoperative complication, as a result of protein adsorption and lens epithelial cell (LEC) adhesion, growth, and proliferation, is the secondary cataract, referred to as posterior capsular opacification (PCO). To avoid PCO formation, a poly(ethylene glycol) (PEG) chemical coating was created on the surface of hydrogel IOLs. Attenuated total reflectance Fourier transform infrared spectroscopy, “captive bubble” and “water droplet” contact angle measurements, and atomic force microscopy analyses proved the covalent grafting of the PEG chains on the IOL surface while keeping unchanged the optical properties of the initial material. A strong decrease of protein adsorption and cell adhesion depending on the molar mass of the grafted PEG (1100, 2000, and 5000 g/mol) was observed by performing the relevant in vitro tests with green fluorescent protein and LECs, respectively. Thus, the study provides a facile method for developing materials with nonfouling properties, particularly IOLs. [less ▲]

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See detailImproved phase segmentation using RGB imaging
Tarquini, Simone; Pirard, Eric ULg

(1996)

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See detailImproved Policy Support Through Segmentation Based on Social Acceptance
Cools, Mario ULg; Brijs, Kris; Tormans, Hans et al

in Proceedings of the 90th Annual Meeting of the Transportation Research Board (DVD-ROM) (2011)

This paper proposes Q-methodology as a technique for the identification of more homogeneous subgroups or ‘segments’ within a rather heterogeneous overall population when it comes to social acceptance of ... [more ▼]

This paper proposes Q-methodology as a technique for the identification of more homogeneous subgroups or ‘segments’ within a rather heterogeneous overall population when it comes to social acceptance of demand restricting policy measures. Identification of such segments would allow policy makers to better tailor their future actions and thereby increase the chance for a successful implementation of the measures they propose. A set of 33 persons, selected in function of age, gender and car ownership evaluated the acceptability of a total number of 42 demand restricting policy measures. Special care was taken that the final set of statements covered the four classically distinguished demand restricting strategies, i.e., improved transport options, incentives for the use of alternative transport modes, parking and land-use management, and institutional policy revision. In addition, a balance between both ‘hard’ and ‘soft’ and ‘push’ and ‘pull’ measures was strived for. The results indicate that four different segments in terms of social acceptance of demand restricting policy measures, can be distinguished, i.e., travelers in favor of traffic calming, travelers against hard push measures, travelers in favor of demand restriction, and travelers against policy innovations. Besides the differences and similarities between these segments, the practical implications for policy makers are discussed, together with a series of specific recommendations and suggestions for future research. [less ▲]

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See detailImproved precision on the radius of the nearby super-Earth 55 Cnc e
Gillon, Michaël ULg; Demory, B.-O.; Benneke, B. et al

in Astronomy and Astrophysics (2012), 539

We report on new transit photometry for the super-Earth 55 Cnc e obtained with Warm Spitzer/IRAC at 4.5 microns. An individual analysis of these new data leads to a planet radius of 2.21-0.16+0.15 Rearth ... [more ▼]

We report on new transit photometry for the super-Earth 55 Cnc e obtained with Warm Spitzer/IRAC at 4.5 microns. An individual analysis of these new data leads to a planet radius of 2.21-0.16+0.15 Rearth, in good agreement with the values previously derived from the MOST and Spitzer transit discovery data. A global analysis of both Spitzer transit time-series improves the precision on the radius of the planet at 4.5 microns to 2.20+-0.12 Rearth. We also performed an independent analysis of the MOST data, paying particular attention to the influence of the systematic effects of instrumental origin on the derived parameters and errors by including them in a global model instead of performing a preliminary detrending-filtering processing. We deduce from this reanalysis of MOST data an optical planet radius of 2.04+-0.15 Rearth that is consistent with our Spitzer infrared radius. Assuming the achromaticity of the transit depth, we performed a global analysis combining Spitzer and MOST data that results in a planet radius of 2.17+-0.10 Rearth (13,820+-620 km). These results confirm that the most probable composition of 55 Cnc e is an envelope of supercritical water above a rocky nucleus. [less ▲]

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See detailAn improved preparation method of benzyl and thenyl triphenylphosphonium salt
Zhang, Jian-Xin; Dubois, Philippe ULg; Jérôme, Robert ULg

in Synthetic Communications (1996), 26(16), 3091-3095

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine ... [more ▼]

New benzyl and thenyl phosphonium salts have been prepared by an improved method in solution from the parent alcohols and triphenylphosphine hydrobromide. Benzyl-type alcohols containing a tertiary amine can also be converted within high yields to phosphonium salts by removing the formed water by azeotropic distillation. Solvent (methylene chloride, chloroform and acetonitrile) and temperature have been chosen in close relation to the alcohol reactivity. Purification is straightforward and yields are relatively high. [less ▲]

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See detailImproved PRESS sequence for lactate detection in the human vitreous body
Balteau, Evelyne ULg; COLLIGNON, Nathalie ULg; Robe, Pierre ULg et al

in Proceedings of the International Society for Magnetic Resonance in Medicine (2006), 14

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See detailAn Improved Protocol for Efficient Engraftment in NOD/ LTSZ-SCIDIL-2RcNULL Mice Allows HIV Replication and Development of Anti-HIV Immune Responses
Singh, Maneesh; Singh; Gaudray et al

in PLoS ONE (2012), 7(6), 38491

Cord blood hematopoietic progenitor cells (CB-HPCs) transplanted immunodeficient NOD/LtsZ-scidIL2Rcnull (NSG) and NOD/SCID/IL2Rcnull (NOG) mice need efficient human cell engraftment for long-term HIV-1 ... [more ▼]

Cord blood hematopoietic progenitor cells (CB-HPCs) transplanted immunodeficient NOD/LtsZ-scidIL2Rcnull (NSG) and NOD/SCID/IL2Rcnull (NOG) mice need efficient human cell engraftment for long-term HIV-1 replication studies. Total body irradiation (TBI) is a classical myeloablation regimen used to improve engraftment levels of human cells in these humanized mice. Some recent reports suggest the use of busulfan as a myeloablation regimen to transplant HPCs in neonatal and adult NSG mice. In the present study, we further ameliorated the busulfan myeloablation regimen with fresh CB-CD34+cell transplantation in 3–4 week old NSG mice. In this CB-CD34+transplanted NSG mice engraftment efficiency of human CD45+cell is over 90% in peripheral blood. Optimal engraftment promoted early and increased CD3+T cell levels, with better lymphoid tissue development and prolonged human cell chimerism over 300 days. These humanized NSG mice have shown long-lasting viremia after HIV-1JRCSF and HIV-1Bal inoculation through intravenous and rectal routes. We also saw a gradual decline of the CD4+T cell count, widespread immune activation, up-regulation of inflammation marker and microbial translocation after HIV-1 infection. Humanized NSG mice reconstituted according to our new protocol produced, moderate cellular and humoral immune responses to HIV-1 postinfection. We believe that NSG mice reconstituted according to our easy to use protocol will provide a better in vivo model for HIV-1 replication and anti-HIV-1 therapy trials. [less ▲]

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See detailAn improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2Rgammanull mice allows HIV replication and development of anti-HIV immune responses.
Singh, Maneesh; Singh, Pratibha; Gaudray, Gilles et al

in PloS one (2012), 7(6), 38491

Cord blood hematopoietic progenitor cells (CB-HPCs) transplanted immunodeficient NOD/LtsZ-scidIL2Rgamma(null) (NSG) and NOD/SCID/IL2Rgamma(null) (NOG) mice need efficient human cell engraftment for long ... [more ▼]

Cord blood hematopoietic progenitor cells (CB-HPCs) transplanted immunodeficient NOD/LtsZ-scidIL2Rgamma(null) (NSG) and NOD/SCID/IL2Rgamma(null) (NOG) mice need efficient human cell engraftment for long-term HIV-1 replication studies. Total body irradiation (TBI) is a classical myeloablation regimen used to improve engraftment levels of human cells in these humanized mice. Some recent reports suggest the use of busulfan as a myeloablation regimen to transplant HPCs in neonatal and adult NSG mice. In the present study, we further ameliorated the busulfan myeloablation regimen with fresh CB-CD34+cell transplantation in 3-4 week old NSG mice. In this CB-CD34+transplanted NSG mice engraftment efficiency of human CD45+cell is over 90% in peripheral blood. Optimal engraftment promoted early and increased CD3+T cell levels, with better lymphoid tissue development and prolonged human cell chimerism over 300 days. These humanized NSG mice have shown long-lasting viremia after HIV-1JRCSF and HIV-1Bal inoculation through intravenous and rectal routes. We also saw a gradual decline of the CD4+T cell count, widespread immune activation, up-regulation of inflammation marker and microbial translocation after HIV-1 infection. Humanized NSG mice reconstituted according to our new protocol produced, moderate cellular and humoral immune responses to HIV-1 postinfection. We believe that NSG mice reconstituted according to our easy to use protocol will provide a better in vivo model for HIV-1 replication and anti-HIV-1 therapy trials. [less ▲]

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See detailImproved pulmonary adaptation in newborn calves with postnatal acidosis
Varga, J.; Mester, L.; Borzsonyi, L. et al

in Veterinary Journal (2001), 162

The adaptation of newborn calves to extra-uterine life was evaluated by measuring arterial blood gases, acidÐbase values, blood ions and lung mechanical function parameters in normal and acidotic calves ... [more ▼]

The adaptation of newborn calves to extra-uterine life was evaluated by measuring arterial blood gases, acidÐbase values, blood ions and lung mechanical function parameters in normal and acidotic calves during the first 24 h. Twenty-seven Holstein Friesian newborn calves were divided into two groups according to their immediate post partum arterial blood pH values (Group A blood pH ≥ 7.2: normal group; Group B blood pH between 7.2 and 7.0: acidotic group). Pulmonary function parameters were measured and arterial blood samples were analysed for blood gases, acidÐbase variables and ion content immediately post partum (within 2 min) and then 6 and 24 h after calving. Lung resistance and maximal difference between pressure maximum and pressure minimum (maxδPpl) decreased, while dynamic lung compliance increased significantly in both groups. Immediately post partum the lung resistance and maxδPpl were significantly higher in the acidotic group than in the normal group. The arterial blood pH progressively compensated with time in both groups during the first 24 h and there was no difference in arterial blood pH values between the two groups 6 h after birth. These results showed that the compensation of acidosis was associated with the improvement in lung mechanics and these changes occurred mainly during the first 6 h of life. Moderate to pronounced acidosis did not affect the pulmonary adaptation negatively, although some respiratory mechanics parameters (maxδPpl), blood pH and Ca2+ion concentrations remained significantly different between the normal and acidotic groups at 24 h. This might be the result of overcompensation of acidosis and the interdependence between blood pH and Ca2+concentrations. [less ▲]

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See detailImproved Quantification of Angiogenesis in the Rat Aortic Ring Assay
Blacher, Silvia ULg; Devy, L.; Burbridge, M. F. et al

in Angiogenesis (2001), 4(2), 133-42

In vitro angiogenesis assays are essential for the identification of potential angiogenic agents and screening for pharmacological inhibitors. Among these assays, the rat aortic ring model developed by ... [more ▼]

In vitro angiogenesis assays are essential for the identification of potential angiogenic agents and screening for pharmacological inhibitors. Among these assays, the rat aortic ring model developed by Nicosia bridges the gap between in vivo and in vitro models. The quantification of angiogenesis on this system must be applicable to characterise vascular networks of various states of complexity. We present here an improved computer-assisted image analysis which allows: (1) the determination of the aortic ring area and its factor shape; (2) the number of microvessels, the total number of branchings, the maximal microvessel length and the microvessel distribution; (3) the total number of isolated fibroblast-like cells and their distribution. We show that this method is suitable to quantify spontaneous angiogenesis as well as to analyse a complex microvascular network induced by various concentrations of vascular endothelial growth factor (VEGF). In addition, by evaluating a new parameter, the fibroblast-like cell distribution, our results show that: (1) during spontaneous angiogenic response, maximal fibroblast-like cell migration delimits microvascular outgrowth; and (2) the known angiogenic inhibitor Batimastat prevents endothelial cell sprouting without completely blocking fibroblast-like cell migration. Finally, this new method of quantification is of great interest to better understand angiogenesis and to test pro- or anti-angiogenic agents. [less ▲]

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See detailAn improved radioimmunoassay for measurement of pepsinogen in porcine blood samples
Banga-Mboko, Henri; Sulon, Joseph ULg; Lange, J. M. et al

in Veterinary Journal (2003), 165(3), 288-295

The study was conducted to develop a sensitive and specific radioimmunoassay (RIA) for the measurement of pepsinogen in porcine serum, and to use this test for the determination of pepsinogen ... [more ▼]

The study was conducted to develop a sensitive and specific radioimmunoassay (RIA) for the measurement of pepsinogen in porcine serum, and to use this test for the determination of pepsinogen concentrations in serum samples from fetuses and pigs of different ages. Compared to a previously described RIA, major improvements were made concerning the use of specific polyclonal antibodies and the use of an appropriate buffer. The assay was able to detect pepsinogen concentrations of >/=0.2 ng/mL. The recovery of pepsinogen was close to 95%. The intra-assay coefficients of variations ranged between 3.9 and 7.5% whereas the interassay ranged between 8.8 and 11.9%. These percentages correspond to a satisfactory accuracy and reproducibility of the assay. No cross-reactions were observed with the main commercially available products of the aspartic proteases family except porcine pepsin cross-reacted over 62.5 microg/mL. Pepsinogen concentrations increased steadily with increasing age of the fetuses and the pigs (P<0.05). Pepsinogen concentrations (+/-SE) in fetuses of 90-100 (n=24) and 100-110 days of pregnancy (n=36) were 0.5+/-0.1 and 5.3+/-1.3 ng/mL, respectively. In pigs of 21, 98, and 213 days of age, the pepsinogen concentrations were 290.6+/-10.8, 343.1+/-17.9 and 383.5+/-15.3 ng/mL, respectively. The results demonstrate that RIA is accurate and can be used easily to assess pepsinogen concentrations in pig sera. The test may constitute a valuable tool in epidemiological surveys and in studies related to gastric diseases in pigs. [less ▲]

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See detailImproved rank-based dependence measures for categorical data
Vandenhende, François; Lambert, Philippe ULg

in Statistics & Probability Letters (2003), 63

We extend rank-based dependence measures like Spearman's rho to categorical data so that the same ±1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for ... [more ▼]

We extend rank-based dependence measures like Spearman's rho to categorical data so that the same ±1 limits are always reached under complete dependence. A goodness-of-fit procedure is derived for dependence models using copulas. [less ▲]

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