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See detailIMPROVE - Design of Innovative Ship Concepts using an Integrated Decision Support System for Ship Production and Operation
Rigo, Philippe ULg

in IMPROVE Workshop (EU Project FP6 n°031382), DUBROVNIK 17-18 Sept. 2009, Croatia, Editor V. Zanic – Univ. of Zagreb (2009, September 17)

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See detailIMPROVE SHIP DESIGN COMPLEXITY (EASYSHIP)
Hage, André ULg; Rigo, Philippe ULg; Caprace, Jean-David ULg

Report (2012)

Nowadays productibility has become a major design attribute for shipbuilding industry. If a ship cannot be manufactured or assembled efficiently, it is not properly designed. To increase the ... [more ▼]

Nowadays productibility has become a major design attribute for shipbuilding industry. If a ship cannot be manufactured or assembled efficiently, it is not properly designed. To increase the productibility of ships, the scientific community and shipyards has developed the concept of Design For Production (DFP) which can be defined as "Design to reduce production costs to a minimum, compatible with the requirements of the vessel to fulfil its operational functions with acceptable safety, reliability and efficiency". DFP optimises all the manufacturing functions (fabrication, assembly, test, procurement, delivery, service, repair, etc.) that reduce the production work content while still meeting the specified design requirements and quality. The goal is to include the impact of design decisions on the production process. Time pressures on commercial ship contracts result in the overlapping of phases of design development, procurement and production. This makes the impact of engineering changes more difficult to manage. There is a need to systematically study the detail design process and its impact on construction with the objective to improve the process and its integration with construction. DFP can significantly reduce the costs, since ships can be quickly assembled from fewer parts. Thus, ships are easier to build and assemble, in less time, with better quality. Designers will save time and money by the reduction of the production complexity. [less ▲]

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See detailImprove the characterization of tropical forests to improve management: policy brief
Gourlet-Fleury, Sylvie; Aleman, Julie; Bayol, Nicolas et al

Report (2014)

CoForChange has shown that management plans based on timber stock recovery are not enough to ensure the sustainability of these production forests. The variability of forest characteristics and their ... [more ▼]

CoForChange has shown that management plans based on timber stock recovery are not enough to ensure the sustainability of these production forests. The variability of forest characteristics and their different responses to disturbance should be considered in management decisions. [less ▲]

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See detailImproved 1.5-sided model for the weakly nonlinear study of Benard-Marangoni instabilities in an evaporating liquid layer.
Margerit, Jonathan; Dondlinger, Mireille; Dauby, Pierre ULg

in Journal of Colloid & Interface Science (2005), 290(1), 220-30

Benard-Marangoni instability, with coupled gravity and surface tension effects, in an evaporating liquid layer surmounted by its vapor and an inert gas is investigated theoretically. We show that this ... [more ▼]

Benard-Marangoni instability, with coupled gravity and surface tension effects, in an evaporating liquid layer surmounted by its vapor and an inert gas is investigated theoretically. We show that this system can be described by a model that consists in the liquid layer equations plus the diffusion equation for the vapor in the gas (the so-called 1.5-sided model) and that this model is equivalent to a one-sided model when the vapor mass fraction field can be considered as quasi-stationary, provided that the equivalent Biot number is a nonlocal function of the interface temperature. A comparison of weakly nonlinear results for the 1.5-sided model with a previous one-sided model [M. Dondlinger, J. Margerit, P.C. Dauby, J. Colloid Interface Sci. 283 (2) (2005) 522-532] that considered a Biot number depending on the wavenumber evaluated at the threshold is performed. Very good agreement is found between both models. For this reason, the present analysis can also be considered as a detailed theoretical justification for the use of a one-sided model in the study of evaporative thermoconvection. [less ▲]

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See detailImproved Aid Effectiveness but Waiting for Results: What are the Missing Links?
Paul, Elisabeth ULg; Dujardin, Bruno; Ireland, Megan et al

Conference (2010)

Objectives: The objective is to analyze the content of the Paris Declaration (PD) on aid effectiveness and Accra Agenda for Action (AAA), and their practical implications for the health sector in aid ... [more ▼]

Objectives: The objective is to analyze the content of the Paris Declaration (PD) on aid effectiveness and Accra Agenda for Action (AAA), and their practical implications for the health sector in aid-recipient countries. Design/methods: The study draws on (i) a critical analysis of the two declarations, (ii) a review of the literature on their implementation and (iii) interviews of people in charge of implementing them – both donors and government representatives. Results: The PD and AAA both have a "missing link" between, on the one hand, international cooperation policies (five pillars of the PD) and national development (health) plans; and, on the other hand, the operational level that is supposed to deliver results. They presume that by changing aid management and respecting a few principles, development results will automatically improve as through a "black box". The influence of international and national policies over health systems, service providers’ behaviour and health impacts is not treated at all by the agenda for aid effectiveness, while it is crucial for its success. Moreover, that agenda is mostly dealt with at a too high level (international forums or at best national sector level), thus deepening the disconnexion from field realities. Conclusions/policy implications: This "missing link" entails the risk that, if the "black box" does not perform as expected – that is, if health systems and health service providers’ behaviour do not evolve in a positive way – and health impacts do not improve, the aid effectiveness agenda may be rejected at all, notwithstanding its (incomplete) added value. Hence the need to closely monitor the processes of national health plans implementation, so in order to better understand how these processes are translated on the field and what could be done to ensure that health service delivery and health results ultimately improve. [less ▲]

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See detailImproved Algorithms for Network Topology Discovery
Donnet, Benoît ULg; Friedman, Timur; Crovella, Mark

in International Workshop on Passive and Active Network Measurement (2005, April)

Topology discovery systems are starting to be introduced in the form of easily and widely deployed software. However, little consideration has been given as to how to perform large-scale topology ... [more ▼]

Topology discovery systems are starting to be introduced in the form of easily and widely deployed software. However, little consideration has been given as to how to perform large-scale topology discovery efficiently and in a network-friendly manner. In prior work, we have described how large numbers of traceroute monitors can coordinate their efforts to map the network while reducing their impact on routers and end-systems. The key is for them to share information regarding the paths they have explored. However, such sharing introduces considerable communication overhead. Here, we show how to improve the communication scaling properties through the use of Bloom filters to encode a probing stop set. Also, any system in which every monitor traces routes towards every destination has inherent scaling problems. We propose capping the number of monitors per destination, and dividing the monitors into clusters, each cluster focusing on a different destination list. [less ▲]

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See detailImproved antigenic methods for differential diagnosis of bovine, caprine, and cervine alphaherpesviruses related to bovine herpesvirus 1
Keuser, V.; Schynts, F.; Detry, Bruno et al

in Journal of Clinical Microbiology (2004), 42(3), 1228-1235

The control of infectious bovine rhinotracheitis induced by bovine herpesvirus 1 (BoHV-1) requires sensitive and specific diagnostic assays. As BoHV-1 is antigenically and genetically related to four ... [more ▼]

The control of infectious bovine rhinotracheitis induced by bovine herpesvirus 1 (BoHV-1) requires sensitive and specific diagnostic assays. As BoHV-1 is antigenically and genetically related to four other alphaherpesviruses of ruminants-namely, BoHV-5, caprine herpesvirus 1 (CpHV-1), cervine herpesvirus 1 (CvHV-1) and CvHV-2-diagnostic tests able to discriminate BoHV-1 from these related viruses are needed to avoid misdiagnosis, especially because some of these viruses are able to cross the species barrier. In this study, murine monoclonal antibodies (MAbs) specific for BoHV-1, BoHV-5, CpHV-1, CvHV-1, and CvHV-2 were produced with the aim of setting up an immunofluorescence assay able to discriminate between these related herpesviruses. Produced MAbs were selected for their viral specificity by enzyme-linked immunosorbent assay and indirect immunofluorescence staining of virus-infected cells. Radioimmunoprecipitation characterization of the selected MAbs revealed that four of them are directed against glycoprotein C (gC) and one of them is directed against gD of these related viruses. The obtained results demonstrate that the antibodies produced allow an unambiguous discrimination of each of the four alphaherpesviruses related to BoHV-1. [less ▲]

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See detailImproved atomic data for iridium atom (Ir I) and ion (Ir II) and the solar content of iridium
Xu, H. L.; Svanberg, S.; Quinet, Pascal ULg et al

in Journal of Quantitative Spectroscopy & Radiative Transfer (2007), 104(1), 52-70

From a combination of radiative lifetime measurements, performed with a time-resolved laser-induced fluorescence technique, for nine odd-parity levels of Ir I and four odd-parity levels of Ir 11 and ... [more ▼]

From a combination of radiative lifetime measurements, performed with a time-resolved laser-induced fluorescence technique, for nine odd-parity levels of Ir I and four odd-parity levels of Ir 11 and branching fraction calculations, extended sets of transition probabilities have been derived for transitions of astrophysical interest. The new results are compared with the few experimental data available in the literature and a good agreement is found. They extend considerably the previous sets of transition probabilities available in the literature. Implications of the new results regarding the solar content of iridium are briefly discussed. (c) 2006 Elsevier Ltd. All rights reserved. [less ▲]

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See detailImproved automatic calibration of groundwater flow models using self-potential measurements
Robert, Tanguy ULg; Therrien, René; Lemieux, Jean-Michel et al

Conference (2011, April 11)

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See detailImproved blood pressure control but similar efficacy with lumiracoxib 100 mg OD compared to ibuprofen 600 mg TID in hypertensive patients with osteoarthritis: randomised controlled trial
MacDonald, T.; Littlejohn, T.; Richard, D. et al

in Annals of the Rheumatic Diseases (2007, June), 66(Suppl.II), 502

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See detailImproved blood pressure control with lumiracoxib compared with ibuprofen: a randomized trial in osteoarthritis patients with controlled hypertension
MacDonald, Thomas M; Reginster, Jean-Yves ULg; Littlejohn, Thomas W et al

in Arthritis and Rheumatism (2007, September), 56(number 9 (suppl.)), 659

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See detailImproved Carotid and Mesenteric Blood Flows with the Use of 21% Oxygen During Resuscitation of Newborn Piglets with Severe Asphyxia
Haase, Erika; Stevens, Jonathan; Rigo, Vincent ULg et al

in Pediatric Research (2003, April), 53(4 Part 2/2), 377

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See detailAn improved Clean-up Strategy for Simultaneous Analysis of PCDDs, PCDFs, and PCBs in Biological Samples.
Pirard, C.; Focant, Jean-François ULg; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2001), 50

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See detailAn improved clean-up strategy for simultaneous analysis of polychlorinated dibenzo-p-dioxins (PCDD), polychlorinated dibenzofurans (PCDF), and polychlorinated biphenyls (PCB) in fatty food samples
Pirard, Catherine; Focant, Jean-François ULg; De Pauw, Edwin ULg

in Analytical and Bioanalytical Chemistry (2002), 372(2), 373-381

The study and extension of a simple automated clean-up method for polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) to a broad range of polychlorinated biphenyls (PCB) is ... [more ▼]

The study and extension of a simple automated clean-up method for polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF) to a broad range of polychlorinated biphenyls (PCB) is described. The isolation of seven PCDD, ten PCDF, and three coplanar PCB (cPCB) is extended to eight monoortho substituted PCB and seven so-called "marker PCB" (Aroclor 1260) for fatty food samples. This enables quantification of 35 compounds - including all congeners with a WHO toxic equivalent factor (TEF)--in a single extraction and single purification step. The chromatographic behaviour of mono-ortho PCB and marker PCB on a variety of adsorbents, including basic alumina, has been studied. Partitioning of analytes through multi-column sequences is described and correlated with their structural and electronic properties, by use of molecular modelling calculations. The fractionation process available with the Power-Prep automated clean-up system enables rapid independent analysis of the different groups of compounds. Gas chromatography with high resolution mass spectrometry (GC-HRMS) is used for the PCDD/F and cPCB fraction and quadrupole ion-storage tandem in time mass spectrometry (GC-QISTMS) for analysis of the remaining PCB. A comparison study was performed on quality-control samples and real fatty food samples to evaluate the robustness of the new strategy compared with a reference method. On the basis of this simultaneous clean-up, a rapid simplified strategy for PCDD/F and selected PCB analysis determination is proposed for fatty food samples. [less ▲]

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See detailImproved coloration contrast and electrochromic efficiency of tungsten oxide films thanks to a surfactant-assisted ultrasonic spray pyrolysis process
Denayer, Jessica ULg; Aubry, Philippe; Bister, Geoffroy et al

in Solar Energy Materials & Solar Cells (2014), 130

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See detailImproved computer-assisted analysis of the global lymphatic network in human cervical tissues.
Balsat, Cédric ULg; Signolle, Nicolas; GOFFIN, Frédéric ULg et al

in Modern Pathology : An Official Journal of the United States & Canadian Academy of Pathology, Inc (2013), sous presse

Lymphatic dissemination is a key event in cervical cancer progression and related tumor lymphatic markers are viewed as promising prognostic factor of nodal extension. However, validating such parameters ... [more ▼]

Lymphatic dissemination is a key event in cervical cancer progression and related tumor lymphatic markers are viewed as promising prognostic factor of nodal extension. However, validating such parameters requires an objective characterization of the lymphatic vasculature. Here, we performed a global analysis of the lymphatic network using a new computerized method applied on whole uterine cervical digital images. Sixty-eight cases of cervical neoplasia (12 CIN3, 10 FIGO stage 1A and 46 stage IB1) and 10 cases of normal cervical tissue were reacted with antibodies raised against D2-40, D2-40/p16 and D2-40/Ki67. Immunostained structures were automatically detected on whole slides. The lymphatic vessel density (D2-40), proliferating lymphatic vessel density (D2-40/ki67) and spatial lymphatic distribution in respect to the adjacent epithelium were assessed from normal cervix to early cervical cancer and correlated with lymphovascular space invasion and lymph node status. Prominent lymphatic vessel density and proliferating lymphatic vessel density are detected under the transformation zone of benign cervix and no further increase is noted during cancer progression. Notably, a shift of lymphatic vessel distribution toward the neoplastic edges is detected. In IB1 cervical cancer, although intra- and peritumoral lymphatic vessel density are neither correlated with lymphovascular space invasion nor with lymph node metastasis, a specific spatial distribution with more lymphatic vessels in the vicinity of tumor edges is predictive of lymphatic dissemination. Herein, we provide a new computerized method suitable for an innovative detailed analysis of the lymphatic network. We show that the transformation zone of the benign cervix acts as a baseline lymphangiogenic niche before the initiation of neoplastic process. During cancer progression, this specific microenvironment is maintained with lymphatic vessels even in closer vicinity to tumor cells.Modern Pathology advance online publication, 6 December 2013; doi:10.1038/modpathol.2013.195. [less ▲]

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See detailAn Improved Constitutive Model for the Numerical Simulation of Semi-Solid Thixoforming
Koeune, Roxane ULg; Ponthot, Jean-Philippe ULg

in Proceedings of ACOMEN’2008, Advanced Computational Methods in Engineering (2008)

In order to model thixoforming processes, previous papers presented a thermo-mechanical one-phase modelling. This first version of constitutive model revealed several limitations: the model could not ... [more ▼]

In order to model thixoforming processes, previous papers presented a thermo-mechanical one-phase modelling. This first version of constitutive model revealed several limitations: the model could not degenerate properly to pure solid or liquid behaviour neither to free solid suspensions. The aim of this paper was to propose solutions to overcome these limitations. [less ▲]

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See detailAn improved constitutive model for the numerical simulation of semi-solid thixoforming
Koeune, Roxane ULg; Ponthot, Jean-Philippe ULg

in Journal of Computational & Applied Mathematics (2010), 234

In order to model thixoforming processes, previous papers presented a thermomechanical one-phase modelling. This first version of the constitutive model revealed several limitations: the model could not ... [more ▼]

In order to model thixoforming processes, previous papers presented a thermomechanical one-phase modelling. This first version of the constitutive model revealed several limitations: the model could not degenerate properly to pure solid or liquid behavior nor to free solid suspensions. The aim of this paper was to propose solutions to overcome these limitations. [less ▲]

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See detailImproved detection of chromosomal abnormalities in chronic lymphocytic leukemia by conventional cytogenetics using CpG oligonucleotide and interleukin-2 stimulation: A Belgian multicentric study.
Put, Natalie; Konings, Peter; Rack, Katrina et al

in Genes, Chromosomes & Cancer (2009), 48(10), 843-53

We performed a multicentric study to assess the impact of two different culture procedures on the detection of chromosomal abnormalities in 217 consecutive unselected cases with chronic lymphocytic ... [more ▼]

We performed a multicentric study to assess the impact of two different culture procedures on the detection of chromosomal abnormalities in 217 consecutive unselected cases with chronic lymphocytic leukemia (CLL) referred for routine analysis either at the time of diagnosis (n = 172) or during disease evolution (n = 45). Parallel cultures of peripheral blood or bone marrow were set up with the addition of either the conventional B-cell mitogen 12-O-tetradecanoyl-phorbol-13-acetate (TPA) or a combination of CpG oligonucleotide (CpG) and interleukin-2 (IL-2). Cytogenetic analyses were performed on both cultures. Clonal abnormalities were identified in 116 cases (53%). In 78 cases (36%), the aberrant clone was detected in both cultures. Among these, the percentages of aberrant metaphases were similar in both conditions in 17 cases, higher in the CpG/IL-2 culture in 43 cases, and higher in the TPA culture in 18 cases. Clonal aberrations were detected in only one culture, either in CpG/IL-2 or TPA in 33 (15%) and 5 (2%) cases, respectively. Taken together, abnormal karyotypes were observed in 51% with CpG/IL-2 and 38% with TPA (P < 0.0001). Application of FISH (n = 201) allowed the detection of abnormalities not visible by conventional cytogenetic analysis in 80 cases: del(13q) (n = 71), del(11q) (n = 5), +12 (n = 2), del(14q) (n = 1), and del(17p) (n = 1). In conclusion, our results confirm that CpG/IL-2 stimulation increases the detection rate of chromosomal abnormalities in CLL compared with TPA and that further improvement can be obtained by FISH. However, neither conventional cytogenetics nor FISH detected all aberrations, demonstrating the complementary nature of these techniques. [less ▲]

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