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See detailFolate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits
RAMAEKERS, Vincent ULg; Blau, N.; Sequeira, J. M. et al

in Neuropediatrics (2007), 38(6), 276-281

Reduced folate transport to the CNS was identified in two autism spectrum disorders, i.e., Rett syndrome and infantile low-functioning autism with neurological abnormalities. Twenty-five patients with ... [more ▼]

Reduced folate transport to the CNS was identified in two autism spectrum disorders, i.e., Rett syndrome and infantile low-functioning autism with neurological abnormalities. Twenty-five patients with early-onset low-functioning autism with or without neurological deficits, were evaluated for serum folate, cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), and serum FR autoantibodies of the blocking type to determine the significance of folate receptor (FR) autoantibodies with respect to folate transport across the blood-CSF barrier. In spite of normal serum folate, CSF 5MTHF was low in 23 of 25 patients. The reduced CSF folate in 19 of these 23 patients could be explained by serum FR autoantibodies blocking the folate binding site of the membrane-attached FR on the choroid epithelial cells. Oral folinic acid supplements led to normal CSF 5MTHF and partial or complete clinical recovery after 12 months. Serum FR autoimmunity appears to represent an important factor in the pathogenesis of reduced folate transport to the nervous system among children with early-onset low-functioning autism associated with or without neurological deficits. Early detection of FR autoantibodies may be a key factor in the prevention and therapeutic intervention among this subgroup of patients with autism. © Georg Thieme Verlag KG Stuttgart. [less ▲]

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See detail« Folded time » : le temps en héritage dans l’œuvre de Gail Jones
Belleflamme, Valérie-Anne ULg

Conference (2015, July 04)

« Folded time » : le temps en héritage dans l’œuvre de Gail Jones The photograph of someone one loves, as a child: folded time. The present is given adorable density; in the face of the beloved rests an ... [more ▼]

« Folded time » : le temps en héritage dans l’œuvre de Gail Jones The photograph of someone one loves, as a child: folded time. The present is given adorable density; in the face of the beloved rests an earlier face. (Gail Jones, Dreams of Speaking, p. 37) Le temps pour Gail Jones n’est ni chronologique, ni linéaire, ni cyclique : telles des couches mémorielles se superposant les unes par rapport aux autres sans pour autant s’additionner, le temps, selon Jones, est « folded » (plissé, replié) et le moment présent n’est que le résultat d’un long processus de soustractions. Romancière, nouvelliste et essayiste australienne, Gail Jones est aussi une contemporaine de la fameuse « réconciliation australienne ». Du fait de son identité « blanche » et ses origines « européennes », Jones s’inscrit ainsi dans une lignée d’écrivains confrontés aux dangers liés à la victimisation symptomatique des cultures colonisatrices à l’époque postcoloniale. Afin d’aborder la question de la légitimité de l’héritage culturel, linguistique, littéraire et historique dans les récits traumatiques, sans pour autant assimiler le rôle réparateur des témoignages des victimes au rôle rédempteur des récits traumatiques des exterminateurs, Jones joue avec la notion de temporalité. C’est en effet au travers de son œuvre romanesque que Jones montre comment l’émergence d’événements du passé met en lumière un pan de l’histoire de l’Australie qui, jusqu’ici, fut passé sous silence. De même, dans une interview, Jones a exprimé son envie d’écrire sur l’amnésie historique, sur ce que c’est que d’oublier, d’avoir une histoire lacunaire (voir Block 2). Son but, je pense, n’est pas tant de combler le vide au centre de l’Histoire de l’Australie que d’écrire sur ce phénomène typiquement (post)colonial. Mon exposé s’attachera donc à montrer par quels moyens techniques et littéraires Jones tente de faire résonner les dangers récurrents liés à l’écriture et à la transmission orale de l’indicible dans la littérature contemporaine de l’Australie colonisatrice. Jones, je soutiens, fait preuve de grande subtilité à l’égard des sujets souvent très délicats que sont l’indigénéité, la marginalité, le racisme, le trauma, la victimisation et la violence, pour n’en citer que quelques uns, en ayant recours à des techniques d’écriture originales et contre-discursives, dont l’allégorie et l’intertextualité. Par ailleurs, son approche de la temporalité, tant au niveau de la forme (fragments, flashbacks, points de vue) que du contenu (troubles de la mémoire, héritage) et sa conception soustractive de l’histoire contribuent au caractère unique de sa vision du monde et de son écriture. [less ▲]

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See detailFolder STARESO Station de Recherches Sous-Marines et Océanographiques
Lejeune, Pierre; Pelaprat, Corinne; Gobert, Sylvie ULg

Learning material (2014)

STARESO (8 ̊45′ E, 42 ̊35′ N) (University of Liège, Belgium) is also a Technical Office toward communities and private customers in the field of marine environmental impact studies. STARESO is located in ... [more ▼]

STARESO (8 ̊45′ E, 42 ̊35′ N) (University of Liège, Belgium) is also a Technical Office toward communities and private customers in the field of marine environmental impact studies. STARESO is located in the Calvi Bay on the northwest coast of Corsica in the Mediterranean Sea. This oligotrophic area is classified as a “pristine site” where environmental disturbances caused by anthropogenic pressure are exceptionally low. The study site includes representatives of most major coastal ecosystems of the Mediterranean. The Calvi Bay is characterized by healthy benthic and pelagic ecosystems associated with a high biodiversity close the Liguro–Provençal current The marine lab offers direct access to the sea, and facilitates investigations using diving, boats, and laboratories. Since 1970, time series of physical, chemical, and biological data (sampling at sea with automated systems and sensors deployed in the Bay, as well as in situ experiments) have been recorded. In front of the lab, P. oceanica (L.) Delile is the dominant ecosystem going from the surface to a lower limit that reaches 37 m. The direct proximity of underwater in situ field analysis and the wet and dry lab allowed very easy sampling of biological material and fast processing of tissues. Finally, in the same way as an oceanographic ship, the marine lab offers full logistic capabilities (meeting rooms, efficient inter- net connection, meals, and lodging accommodations) that enabled scientific work day and night without interruption. [less ▲]

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See detailFolding and Stability of Class A beta-Lactamases
Matagne, André ULg; Pain, Roger

in Frère, Jean-Marie (Ed.) Beta-Lactamases (2012)

Class A β-lactamases have proved useful as model proteins in studying a wide variety of aspects of protein folding. We review those features that have shed light on kinetic intermediates that take part in ... [more ▼]

Class A β-lactamases have proved useful as model proteins in studying a wide variety of aspects of protein folding. We review those features that have shed light on kinetic intermediates that take part in folding, including some insight into the molecular basis of the kinetic and stable molten-globule states that have been identified. The contrast between the folding behaviour of PC1 and the two lactamase mutants, P54 and P2, can be attributed in some detail to changes in molecular conformation. The early, very rapid stages of folding of β-lactamases have been shown to be multiphasic, and an interesting intermediate is described that has non-native contacts involving burial of the C-terminal tryptophan. A further feature is that the region around the disulphide bond in the TEM enzymes is formed very early in the foldingreaction. The unusual feature of class A β-lactamases, i.e. a cispeptide bond critical in the stereochemistry of the active site that usually, but not always, involves a proline residue, has been shown to be important in accounting for the slow folding reactions. The effect of substrates on the stabilization of the enzymes and on their reversible deactivation is also reviewed. [less ▲]

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See detailFolding of class A beta-lactamases is rate-limited by peptide bond isomerization and occurs via parallel pathways.
Vandenameele, Julie ULg; Lejeune, Annabelle ULg; Di Paolo, Alexandre ULg et al

in Biochemistry (2010), 49(19), 4264-75

Class A beta-lactamases (M(r) approximately 29000) provide good models for studying the folding mechanism of large monomeric proteins. In particular, the highly conserved cis peptide bond between residues ... [more ▼]

Class A beta-lactamases (M(r) approximately 29000) provide good models for studying the folding mechanism of large monomeric proteins. In particular, the highly conserved cis peptide bond between residues 166 and 167 at the active site of these enzymes controls important steps in their refolding reaction. In this work, we analyzed how conformational folding, reactivation, and cis/trans peptide bond isomerizations are interrelated in the folding kinetics of beta-lactamases that differ in the nature of the cis peptide bond, which involves a Pro167 in the BS3 and TEM-1 enzyme, a Leu167 in the NMCA enzyme, and which is missing in the PER-1 enzyme. The analysis of folding by spectroscopic probes and by the regain of enzymatic activity in combination with double-mixing procedures indicates that conformational folding can proceed when the 166-167 bond is still in the incorrect trans form. The very slow trans --> cis isomerization of the Glu166-Xaa167 peptide bond, however, controls the final step of folding and is required for the regain of the enzymatic activity. This very slow phase is absent in the refolding of PER-1, in which the Glu166-Ala167 peptide bond is trans. The double-mixing experiments revealed that a second slow kinetic phase is caused by the cis/trans isomerization of prolines that are trans in the folded proteins. The folding of beta-lactamases is best described by a model that involves parallel pathways. It highlights the role of peptide bond cis/trans isomerization as a kinetic determinant of folding. [less ▲]

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See detailThe Folding Process of Hen Lysozyme: A Perspective from the 'New View'
Matagne, André ULg; Dobson, Christopher M.

in Cellular and Molecular Life Sciences : CMLS (1998), 54(4), 363-71

How a conformationally disordered polypeptide chain rapidly and efficiently achieves its well-defined native structure is still a major question in modern structural biology. Although much progress has ... [more ▼]

How a conformationally disordered polypeptide chain rapidly and efficiently achieves its well-defined native structure is still a major question in modern structural biology. Although much progress has been made towards rationalizing the principles of protein structure and dynamics, the mechanism of the folding process and the determinants of the final fold are not yet known in any detail. One protein for which folding has been studied in great detail by a combination of diverse techniques is hen lysozyme. In this article we review the present state of our knowledge of the folding process of this enzyme and focus in particular on recent experiments to probe some of its specific features. These results are then discussed in the context of the 'new view' of protein folding based on energy surfaces and landscapes. It is shown that a schematic energy surface for lysozyme folding, which is broadly consistent with our experimental data, begins to provide a unified model for protein folding through which experimental and theoretical ideas can be brought together. [less ▲]

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See detailFolie et divinité dans le monde gréco-romain
Macedo, Gabriel ULg

Article for general public (2012)

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See detail"La folie heureuse" : à propos d'un passage d'Horace (Épîtres II, 2, v. 128-140)
Ricciardetto, Antonio ULg

in Filiber, Carine (Ed.) Vertiges de la folie. Catalogue de l'exposition (Musée de la Vie Wallonne, Liège, 30/03-19/08/2012) (2012)

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See detailLa Folie Mallarmé
Durand, Pascal ULg

in Courrier du Centre International d'Etudes Poétiques (2000), 225

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See detailFoliicolous lichens from Southeastern United States
Sérusiaux, Emmanuël ULg

in Bryologist (1979), 82

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See detailFoliicolous lichens from Zimbabwe
Sérusiaux, Emmanuël ULg

in Lichenologist (1983), 15

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See detailFoliicolous lichens: ecological and chorological data
Sérusiaux, Emmanuël ULg

in Botanical Journal of the Linnean Society (1986), 100

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See detailFolinic acid treatment for schizophrenia associated with folate receptor autoantibodies.
RAMAEKERS, Vincent ULg; Thony, B.; Sequeira, J. M. et al

in Molecular genetics and metabolism (2014), 113(4), 307-14

BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia ... [more ▼]

BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia. Acoustic hallucinations disappeared following folinic acid treatment. Folate transport to the CNS prevents homocysteine accumulation and delivers one-carbon units for methyl-transfer reactions and synthesis of purines. The guanosine derivative tetrahydrobiopterin acts as common co-factor for the enzymes producing dopamine, serotonin and nitric oxide. METHODS: Our study selected patients with schizophrenia unresponsive to conventional treatment. Serum from these patients with normal plasma homocysteine, folate and vitamin B12 was tested for FR autoantibodies of the blocking type on serial samples each week. Spinal fluid was analyzed for MTHF and the metabolites of pterins, dopamine and serotonin. The clinical response to folinic acid treatment was evaluated. RESULTS: Fifteen of 18 patients (83.3%) had positive serum FR auto-antibodies compared to only 1 in 30 controls (3.3%) (chi(2)=21.6; p<0.0001). FRalpha antibody titers in patients fluctuated over time varying between negative and high titers, modulating folate flux to the CNS, which explained low CSF folate values in 6 and normal values in 7 patients. The mean+/-SD for CSF MTHF was diminished compared to previously established controls (t-test: 3.90; p=0.0002). A positive linear correlation existed between CSF MTHF and biopterin levels. CSF dopamine and serotonin metabolites were low or in the lower normal range. Administration of folinic acid (0.3-1mg/kg/day) to 7 participating patients during at least six months resulted in clinical improvement. CONCLUSION: Assessment of FR auto-antibodies in serum is recommended for schizophrenic patients. Clinical negative or positive symptoms are speculated to be influenced by the level and evolution of FRalpha antibody titers which determine folate flux to the brain with up- or down-regulation of brain folate intermediates linked to metabolic processes affecting homocysteine levels, synthesis of tetrahydrobiopterin and neurotransmitters. Folinic acid intervention appears to stabilize the disease process. [less ▲]

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See detailFolipidine, a new type quinoline alkaloid from plants of the Haplophyllum genus
Akhmedzhanova, V. I.; Rasulova, K. A.; Bessonova, I. A. et al

in Chemistry of Natural Compounds (2005), 41(1, JAN-FEB), 60-64

The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC ... [more ▼]

The new quinoline alkaloid folipidine, the structure of which was established by chemical transformations and spectral data (UV, IR, mass, NMR) using APT 2D H-1-H-1 COSY, NOESY, and H-1-(13)CHSQC, HMBC, was isolated from two plants of the Haplophyllum mints. Folipidine is the first representative of a new type of quinoline alkaloids that contain a heteroaromatic skeleton of [3,4-b]conjugated pyrrole and quinoline fragments. The total alkaloids of these plants exhibit antitumor activity. Folipidine does not possess such activity. [less ▲]

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See detailLe folk-lore [sic] et les sociétés historiques
Kurth, Godefroid ULg

in Kurth, Godefroid (Ed.) Le folk-lore [sic] et les sociétés historiques (1888)

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See detailFollicle Stimulating Hormone -Secreting Pituitary adenomas
Beckers, Albert ULg; Stevenaert, Achille ULg; Mashiter, K. et al

in Journal of Clinical Endocrinology and Metabolism (1985), 61(3), 525-528

This retrospective study concerns 40 patients with an apparently nonsecretory pituitary adenoma who were operated on during an 11-yr period from 1971 to 1981. Among them, 6 men had elevated serum FSH ... [more ▼]

This retrospective study concerns 40 patients with an apparently nonsecretory pituitary adenoma who were operated on during an 11-yr period from 1971 to 1981. Among them, 6 men had elevated serum FSH levels. LH levels were normal in 5 and slightly elevated in 1. Testosterone levels were low in 2 patients and within normal limits in 2 others. Sexual impotency had developed from 6 months to 1 yr before surgery in all patients. Primary hypogonadism could be eliminated on clinical grounds (recent onset of hypogonadism, previous fertility of 5 of the 6, and postoperative improvement). After transsphenoidal adenomectomy, FSH levels returned to normal values in all, and clinical recovery occurred in most patients. Tumor tissue obtained at operation stained positively for the gonadotropins, but was negative for other pituitary hormones in all patients. The most probable explanation for these findings was that the tumors were responsible for the elevated FSH secretion. This explanation is supported by the immunocytochemical identification of gonadotropin-containing cells in the tumors. We conclude that these 6 men frm a series of 40 patients who presented with pituitary tumor but no GH, PRL, or ACTH hypersecretion had primary gonadotropinomas. [less ▲]

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See detailA follicle-stimulating-hormone secreting pituitary adenoma treated with long acting repeatable bromocriptine.
Abs, R.; Beckers, Albert ULg; De Longueville, M.

in Journal of Endocrinological Investigation (1990), 13

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See detailFollicular dendritic cells act as accessory cells
Heinen, Ernst ULg; Cormann, N.; Lesage, F. et al

in Progress in Leukocyte Biology (1988), 7

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