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See detailIntense physical exercise related to the emergent generation of cardiovascular risk markers: review
LE GOFF, Caroline ULg; LAURENT, Terry ULg; Kaux, Jean-François ULg et al

in Biology of Sport (2012), 29(1), 11-16

Objective: The present review was performed in order to bring together the current knowledge about the impact of intense physical exercise on cardiovascular function, especially on plasma levels of ... [more ▼]

Objective: The present review was performed in order to bring together the current knowledge about the impact of intense physical exercise on cardiovascular function, especially on plasma levels of cardiovascular risk markers such as cardiac troponin T (cTnT), myeloperoxidase (MPO), amino-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP) and oxidized low-density lipoprotein (oxLDL). Methods: Data were collected using the PubMed database. The articles were chosen for their relevance and importance in the area of interest. Results: The literature describes numerous examples where physical exercise induces plasma variation for the markers studied. Intense physical effort increases the levels of cTnT, MPO and NTproBNP, whereas CRP and oxLDL levels tend to be decreased with regular sport activities. Conclusions: The present literature investigation confirms the fact that intense physical exercise has an impact on the plasma variations of the five cardiovascular risk markers studied. However, practising regular exercise remains one of the first strategies for the prevention of cardiovascular disorders. [less ▲]

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See detailIntense pulsed light treatment of persistent facial hypermelanosis following drug-induced toxic epidermal necrolysis.
Paquet, Philippe ULg; Pierard, Gérald ULg

in Dermatologic Surgery (2004), 30(12 Pt 2), 1522-5

BACKGROUND: Cutaneous hyperpigmentation is one of the most cosmetically disturbing sequel of drug-induced toxic epidermal necrolysis. Intense pulsed light is a promising tool for treating some melanocytic ... [more ▼]

BACKGROUND: Cutaneous hyperpigmentation is one of the most cosmetically disturbing sequel of drug-induced toxic epidermal necrolysis. Intense pulsed light is a promising tool for treating some melanocytic lesions. OBJECTIVE: The objective was to assess the effect of intense pulsed light in treating post-toxic epidermal necrolysis facial hypermelanosis. METHODS: Two Caucasian men aged 35 and 50 years presented with long-standing (32 and 39 years) severe hypermelanosis of the face after sulfonamide-induced toxic epidermal necrolysis. They were treated by intense pulsed light. Cutoff filters of 550, 590, and 615 nm were employed for five intense pulsed light sessions at 4-week intervals. The treatment was characterized by energy fluence of 25 to 32 J/cm2, pulse width of 2.2 to 3.2 ms, and double- to triple-pulse mode respecting a 30-ms delay. Before intense pulsed light treatment, and 2 months after the fifth intense pulsed light session, clinical photographs and skin biopsies were performed in combination with quantitative narrow-band remittance spectrophotometry of melanin pigmentation. Patients were clinically followed-up for 8 months after the end of the treatment. RESULTS: In both patients, clinical, histologic, and spectrophotometric assessments showed an average of 80% decrease in the hypermelanosis. No clinical recurrence of the hypermelanosis developed during the 8-month follow-up after intense pulsed light treatment. No major persistent side effects were experienced, especially hypopigmentation. CONCLUSION: Intense pulsed light appears to be effective and safe for treating post-toxic epidermal necrolysis hypermelanosis in Caucasian patients. [less ▲]

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See detailIntense pulsed-light therapy for proliferative superficial strawberry haemangiomas of infancy.
CAUCANAS, Marie ULg; PAQUET, Philippe ULg; HENRY, Frédérique ULg et al

in Case Reports in Dermatological Medicine (2011), 2011(art.253607), 1-5

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See detailIntensification agricole et qualité des sols et des eaux
Soudi, B.; Chiang, C.; Badraoui, M. et al

Book published by IAV Hassan II - Actes du séminaire de Rabat (2002)

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See detailL'intensification de la culture de céréales
Falisse, André; Poelaert, Jean; Bodson, Bernard ULg

in Fumure et protection phytosanitaire des céréales (1983, February 24)

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See detailL'intensification de la culture de céréales: 1. Le froment d'hiver
Rixhon, L.; Crohain, A.; Guiot, Joseph et al

in Fumure et protection phytosanitaire des céréales (1983, February 24)

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See detailL'intensification de la culture de céréales: l'avoine de printemps
Poelaert, Jean; Bodson, Bernard ULg; Nyst, Pierre et al

in Fumure et protection phytosanitaire des céréales (1983, February 24)

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See detailL'intensification de la culture de céréales: l'escourgeon
Bodson, Bernard ULg; Falisse, André; Poelaert, Jean et al

in Fumure et protection phytosanitaire des céréales (1983, February 24)

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See detailL'intensification de la culture de céréales: l'orge de printemps
Dohet, Jacques; Poelaert, Jean; Bodson, Bernard ULg et al

in Fumure et protection phytosanitaire des céréales (1983, February 24)

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See detailL'intensification de la culture de céréales: le froment de printemps
Nyst, Pierre; Poelaert, Jean; Bodson, Bernard ULg et al

in Fumure et protection phytosanitaire des céréales (1983, February 24)

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See detailIntensification durable de l’agriculture au Bénin, mythe ou réalité ? Une analyse à partir des systèmes de coton biologique et Cotton made in Africa.
Assogba, Sonagnon Claude-Gervais ULg; Tossou, Cocou Rigobert; Lebailly, Philippe ULg et al

Conference (2013, November)

In agriculture, the concept of sustainable development emergence and its omnipresence in political discourses suggests that farming systems move toward systems considered as more environment-friendly and ... [more ▼]

In agriculture, the concept of sustainable development emergence and its omnipresence in political discourses suggests that farming systems move toward systems considered as more environment-friendly and human health-friendly. In Benin, cotton is one of the most sectors concerned by this transformation. Indeed, in spite of the importance of cotton in the economy of Benin, its sustainable production is nowadays threatened by conventional production approach. Various alternatives of production are developed and considered as more environment-friendly than the conventional production approach. This article analyses the sustainability of the organic and cotton made in Africa (CmiA) farming alternatives from the sustainable agricultural intensification theoretical perspective. Structured and non-structured interviews with individuals and focus groups were used to collect data from 90 organic cotton farmers of the municipality of Kandi, and 100 CmiA farmers of the municipality of Pehunco, one of the largest areas of cotton production in the North of Benin. Data were analyzed with methods of normative and relativist comparison, descriptive statistics and analysis of variance. Kolmogorov-Smirnov (K-S) test was used to verify the normality conditions and in some cases, logarithmic transformation was done to test the variance homogeneity. The comparison of means was done with the test of Least Significant Difference. It appears from the results that in the current condition of implementation, the alternatives system to conventional cotton production approach are not intensively sustainable. Soils fertility and pests’ management face enormous constraints and do not allow improvement of yields, economic performances, and environment protection. So, the sustainability of the alternative systems of cotton production is not guaranteed and can hardly become a reality if additional relevant conditions are not created. [less ▲]

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See detailIntensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial
Récher, Christian; Coiffier, Bertrand; Haioun, Corinne et al

in Lancet (2011), 378(9806)

Background The outcome of diff use large B-cell lymphoma has been substantially improved by the addition of the anti-CD20 monoclonal antibody rituximab to chemotherapy regimens. We aimed to assess, in ... [more ▼]

Background The outcome of diff use large B-cell lymphoma has been substantially improved by the addition of the anti-CD20 monoclonal antibody rituximab to chemotherapy regimens. We aimed to assess, in patients aged 18–59 years, the potential survival benefi t provided by a dose-intensive immunochemotherapy regimen plus rituximab compared with standard treatment plus rituximab. Methods We did an open-label randomised trial comparing dose-intensive rituximab, doxorubicin, cyclo phosphamide, vindesine, bleomycin, and prednisone (R-ACVBP) with subsequent consolidation versus standard rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisone (R-CHOP). Random assignment was done with a computer-assisted randomisation-allocation sequence with a block size of four. Patients were aged 18–59 years with untreated diff use large B-cell lymphoma and an age-adjusted international prognostic index equal to 1. Our primary endpoint was event-free survival. Our analyses of effi cacy and safety were of the intention-to-treat population. This study is registered with ClinicalTrials.gov, number NCT00140595. Findings One patient withdrew consent before treatment and 54 did not complete treatment. After a median follow-up of 44 months, our 3-year estimate of event-free survival was 81% (95% CI 75–86) in the R-ACVBP group and 67% (59–73) in the R-CHOP group (hazard ratio [HR] 0·56, 95% CI 0·38–0·83; p=0·0035). 3-year estimates of progression-free survival (87% [95% CI, 81–91] vs 73% [66–79]; HR 0·48 [0·30–0·76]; p=0·0015) and overall survival (92% [87–95] vs 84% [77–89]; HR 0·44 [0·28–0·81]; p=0·0071) were also increased in the R-ACVBP group. 82 (42%) of 196 patients in the R-ACVBP group experienced a serious adverse event compared with 28 (15%) of 183 in the R-CHOP group. Grade 3–4 haematological toxic eff ects were more common in the R-ACVBP group, with a higher proportion of patients experiencing a febrile neutropenic episode (38% [75 of 196] vs 9% [16 of 183]). Interpretation Compared with standard R-CHOP, inten sifi ed immunochemotherapy with R-ACVBP signifi cantly improves survival of patients aged 18–59 years with diff use large B-cell lymphoma with low-intermediate risk according to the International Prognostic Index. Haematological toxic eff ects of the intensive regimen were raised but manageable. Funding Groupe d’Etudes des Lymphomes de l’Adulte and Amgen. [less ▲]

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See detailIntensified postgrafting immunosuppression failed to assure long-term engraftment of dog leukocyte antigen-identical canine marrow grafts after 1 gray total body irradiation.
Sorror, Mohamed L; Leisenring, Wendy; Mielcarek, Marco et al

in Transplantation (2008), 85(7), 1023-9

BACKGROUND: Late graft rejection after conditioning with 1 Gy of total body irradiation (TBI) was consistently seen in historical dogs given two postgrafting immunosuppressive drugs. METHODS: Here, 16 ... [more ▼]

BACKGROUND: Late graft rejection after conditioning with 1 Gy of total body irradiation (TBI) was consistently seen in historical dogs given two postgrafting immunosuppressive drugs. METHODS: Here, 16 dogs were given four different three-drug combinations of cyclosporine, mycophenolate mofetil, sirolimus, or methotrexate after 1 Gy TBI and dog leukocyte antigen-identical marrow grafts. In addition, we assessed the effects of TBI doses of 0.5, 1.0, 2.0, or 3.0 Gy, respectively, on immune functions in six dogs not given marrow grafts. RESULTS: All dogs showed initial engraftment, 13 rejected, and three had sustained grafts beyond 26 weeks. The dogs with durable grafts had received greater median numbers of nucleated marrow cells compared with the 13 dogs that rejected their grafts (6.14 vs. 3.6 x 10(8) per kg; P=0.03). In a Cox proportional hazard model, which included data from 16 historical dogs, each increase in transplanted marrow cell numbers by 1 x 10(8) per kg decreased the hazard ratio of rejection by 0.5. Decreasing percents of remaining CD3, CD4, and CD8 cells in peripheral blood and lymph nodes were observed with increasing TBI doses. Further, greater suppressions of B-cell- and T-cell-dependent production of IgM and IgG antibodies in response to sheep red blood cell injections were observed after 2 Gy compared with 1 Gy TBI. CONCLUSION: Overall, triple postgrafting immunosuppression after 1 Gy TBI was well tolerated but failed to prevent graft rejection in this model. In vivo radiation studies have shown higher numbers of remaining host lymphocytes and better T-cell-dependent antibody production after 1 Gy compared with 2 Gy TBI. [less ▲]

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See detailL'intensité des soins en gériatrie : élaboration d'un document de réflexion
Petermans, Jean ULg

in Revue Médicale de Bruxelles (2002), 23

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See detailLes intensités relatives des raies moléculaires d'absorption dans les spectres stellaires
Swings, Polydore ULg; Crespin, D.

in Bulletin de la Société Royale des Sciences de Liège (1938), 7(5), 343-348

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See detailIntensities of the doublet-quadruplet intersystem transitions in C II and N III
Biémont, Emile ULg; Delahaye, F.; Zeippen, C. J.

in Journal of Physics : B Atomic Molecular & Optical Physics (1994), 27

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See detailIntensity dependence of auditory evoked potentials during light interference in migraine.
Ambrosini, Anna; Coppola, Gianluca; Gerardy, Pierre-Yves et al

in Neuroscience letters (2011), 492(2), 80-3

Migraine patients show interictally a strong intensity dependence of auditory evoked cortical potentials (IDAP) and a lack of habituation of evoked potentials. Photic drive on high-frequency flash ... [more ▼]

Migraine patients show interictally a strong intensity dependence of auditory evoked cortical potentials (IDAP) and a lack of habituation of evoked potentials. Photic drive on high-frequency flash stimulation is another well-known interictal feature in migraineurs, associated with alpha-rhythm hyper-synchronisation. We compared therefore the influence of light stimulation on IDAP in healthy volunteers (HV) and migraine patients. A continuous flash stimulation was delivered during the recording of auditory evoked potentials at suprathreshold increasing stimulation intensities. IDAP was measured as the amplitude/stimulus intensity function (ASF) slope. In HV, the ASF slope decreased during flash stimulation, whereas, on average, there was no significant change in migraineurs. A closer analysis of migraineurs disclosed two subgroups of patients with no detectable clinical differences: one, the largest, in which the ASF slope was normal at baseline, but increased during light stimulation, the other with an increased ASF slope at rest and a decrease during light interference. Visual sensory overload is able to increase IDAP in the majority of migraineurs, which contrasts with HV. We hypothesise that this could be due to hyper-synchronisation of the alpha rhythm because of photic drive and possibly thalamo-cortical dysfunction. A minority of migraineurs have, like HV, an IDAP reduction during light interference. They are, however, characterised, unlike most HV, by a high IDAP at baseline. Besides underscoring the pathophysiological heterogeneity of migraine, these results suggest that light interference might improve the phenotyping of migraine patients who have a normal IDAP in the resting condition. [less ▲]

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See detailIntensity Dependence of Auditory Evoked Potentials Is Pronounced in Migraine: An Indication of Cortical Potentiation and Low Serotonergic Neurotransmission?
Wang, W.; Timsit-Berthier, M.; Schoenen, Jean ULg

in Neurology (1996), 46(5), 1404-9

Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between ... [more ▼]

Migraine is associated with stimulus hypersensitivity, increased evoked cortical responses, and abnormal 5-HT levels in peripheral blood. We studied cortical auditory evoked potentials (AEPs) between attacks in 35 patients suffering from migraine without aura (MO, n = 25) or with aura (MA, n = 10) and in 25 healthy volunteers. Binaural tones were delivered at 40, 50, 60, and 70 dB sensation level (SL) in a pseudorandomized order. The intensity dependence of the auditory N1-P2 component was significantly greater in MO (p = 0.003) and MA (p = 0.02) patients than in healthy controls, resulting in a much steeper amplitude/stimulus intensity function slope. When three sequential blocks of 40 averaged responses were analyzed at the 40- and 70-dB SL intensities, N1-P2 amplitude decreased in second and third blocks at both intensities in controls, but increased in migraineurs, a difference that was significant in both blocks for the 70-dB SL stimulus. The strong interictal dependence of AEPs on stimulus intensity may thus be due to potentiation (instead of habituation) of the response during repetition of the high-intensity stimulation. In concordance with previous studies of visual evoked potentials, these results confirm that migraine is characterized between attacks by an abnormality of cortical information processing, which might be a consequence of low 5-HT transmission and favor cortical energy demands. [less ▲]

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See detailIntensity Dependence of the Cortical Auditory Evoked Potentials as a Surrogate Marker of Central Nervous System Serotonin Transmission in Man: Demonstration of a Central Effect for the 5ht1b/1d Agonist Zolmitriptan (311c90, Zomig)
Proietti-Cecchini, A.; Afra, J.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1997), 17(8), 849-54799

As shown in animal studies, 5HT1B/D agonists can inhibit activity in the trigeminal nucleus caudalis, which may be advantageous for their antimigraine effect. To demonstrate a possible central nervous ... [more ▼]

As shown in animal studies, 5HT1B/D agonists can inhibit activity in the trigeminal nucleus caudalis, which may be advantageous for their antimigraine effect. To demonstrate a possible central nervous system (CNS) action of these compounds in man we studied their effect on the intensity dependence of the cortical auditory evoked potentials (IDAPs), thought to be inversely related to central serotonergic transmission. An amplitude/stimulus intensity function (ASF) slope was computed in healthy volunteers and migraine patients between attacks before and 2 h after oral 311C90 (zolmitriptan "Zomig") 10 mg (n=14), 311C90 5 mg (n=7), sumatriptan 100 mg (n=14), dexfenfluramine 15 mg (n=4), lorazepam 1.25 mg (n=4) and placebo (n=14). 311C90 10 mg and, to a lesser degree, 5 mg significantly increased the mean ASF slope (p=0.007 and 0.05 vs placebo). There was a significant positive correlation between plasma levels of 311C90 and ASF slope changes. Sumatriptan and lorazepam had little effect, but dexfenfluramine produced a significant ASF slope decrease. 311C90 is able to modify a CNS activity that is modulated by serotonin, i.e. the IDAP. This effect is probably the consequence of its superior lipophilicity compared to sumatriptan and of activation of prejunctional 5HT1B/D autoreceptors, which lowers central serotonin release and thus the preactivation level of sensory cortices. [less ▲]

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