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See detailInteraction of androgens and estrogens in the control of sexual behavior in male Japanese quail.
Balthazart, Jacques ULg; Schumacher, M.; Malacarne, G.

in Physiology & Behavior (1985), 35(2), 157-66

A series of 4 experiments was performed to study the relative contribution of androgens and estrogens in the activation of sexual behavior in castrated male quail. The synthetic androgen methyltrienolone ... [more ▼]

A series of 4 experiments was performed to study the relative contribution of androgens and estrogens in the activation of sexual behavior in castrated male quail. The synthetic androgen methyltrienolone (R 1881) which is not metabolized in androgen target tissues activated sexual behavior in castrated birds and at the dose level of 0.5-1 mg/day/animal had the same potency as testosterone (T). However R 1881 was much more active than T in the induction of cloacal gland growth and activation of crowing, two typically androgen-dependent responses. This suggests that sexual behavior is not controlled by exactly the same mechanism as crowing or cloacal gland growth. In another experiment, estradiol (E2) alone activated sexual behavior but it is only at very high doses which had clear toxic effects that a significant behavioral activation could be observed. This questions the role of E2 as the physiological agent stimulating copulation in intact birds unless it is assumed that centrally administered E2 would be much more active compared to peripheral E2 which is exposed to a very intense peripheral catabolism. In the last two experiments, a clear synergism could be detected between 5 alpha-dihydrotestosterone (5 alpha-DHT) and E2 in the activation of sexual activity and doses of hormones could be defined which had almost no activity by themselves but significantly stimulated sexual behavior when given simultaneously. It was however impossible to define a hormonal treatment with T metabolites which restored behavior to its precastration level, a result very easily achieved with T treatments. Taken together, these data suggest that activation of sexual behavior in quail does not depend only on E2, nor 5 alpha-DHT nor even on their combined action. Considering that specific T receptors which probably do not bind 5 alpha-DHT are present in the brain, it would seem justified to reconsider the possible role played by T itself in the activation of behavior. [less ▲]

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See detailInteraction of antimicrobial lipopeptides from Bacillus subtilis with lipid membranes
Deleu, Magali ULg; Paquot, Michel ULg; Olofsson, Gerd et al

Poster (2004)

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See detailInteraction of ceftobiprole with the low-affinity PBP 5 of Enterococcus faecium
Henry, X.; Amoroso, Ana Maria ULg; Coyette, Jacques ULg et al

in Antimicrobial Agents and Chemotherapy (2010), 54

Detailed reference viewed: 17 (3 ULg)
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See detailInteraction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study
Dilly, Sébastien ULg; Liégeois, Jean-François ULg

in Journal of Computer-Aided Molecular Design (2011), 25(2), 163-169

The interaction of diazepine analogues like clozapine or olanzapine with D2 receptor was greatly affected by a mixture of HRP/H2O2 known to induce the formation of nitrenium ion. Unlike diazepine ... [more ▼]

The interaction of diazepine analogues like clozapine or olanzapine with D2 receptor was greatly affected by a mixture of HRP/H2O2 known to induce the formation of nitrenium ion. Unlike diazepine derivatives, the oxidative mixture had low impact on the affinity of oxa- and thiazepine derivatives such as loxapine, clothiapine or JL13 for the D2 receptor. Molecular docking simulations revealed a huge difference between the mode of interaction of clozapine nitrenium ion and the parent drug. Electronic and geometric changes of the tricyclic ring system caused by the oxidation appeared to prevent the compound finding the correct binding mode and could therefore explain the difference observed in binding affinities. [less ▲]

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See detailInteraction of Defined Benefit Pension Plans and Social Security
Possen, Uri M.; Pestieau, Pierre ULg

in Pensions : An International Journal (2008)

This paper explores the shift from defi ned benefi t to defi ned contribution pension plans when the payout rate from social security is set optimally. This paper shows that when employees are receiving ... [more ▼]

This paper explores the shift from defi ned benefi t to defi ned contribution pension plans when the payout rate from social security is set optimally. This paper shows that when employees are receiving more of their private pensions from defi ned contribution plans one should be raising the payout rate from traditional social security rather than trying to privatise part of it. [less ▲]

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See detailInteraction of fengycin with stratum corneum mimicking model membranes: a calorimetry study
Nasir, Mehmet Nail ULg; Eeman, Marc; Olofsson, Gerd et al

in European Biophysics Journal [=EBJ] (2013), 42(S1), 168

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See detailInteraction of global and local buckling in welded RHS compression members
Degée, Hervé ULg; Detzel, Annette; Kuhlmann, Ulrike

in Journal Of Constructional Steel Research (2008), 64(7-8), 755-765

This paper presents the results of a research project analysing some aspects of the stability failure of thin-walled compression members that are likely to exhibit combined global and local buckling. In ... [more ▼]

This paper presents the results of a research project analysing some aspects of the stability failure of thin-walled compression members that are likely to exhibit combined global and local buckling. In particular, the influence of various imperfections, namely residual stresses due to welding and local as well as global geometrical defects, on the load-carrying capacity was Subjected to detailed experimental and numerical investigations. The insights obtained into the structural behaviour led to a proposal for modification of the non-dimensional slenderness used in the global buckling verification, and to the recommendation of a shift from the Currently applied European buckling curve to a more favourable one in the case of non-stiffened members with welded box sections subjected to pure compression. (C) 2008 Elsevier Ltd. All rights reserved. [less ▲]

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See detailInteraction of global and local buckling of compression members with welded box cross section
Kuhlmann, U.; Degée, Hervé ULg; Detzel, A.

in Camotim, D. (Ed.) Proceedings of the SDSS Conference (STABILITY AND DUCTILITY OF STEEL STRUCTURES) (2006)

This paper summarises a research project that analysed aspects of stability failure of thin-walled compression members that are likely to exhibit combined global and local buckling. In particular the ... [more ▼]

This paper summarises a research project that analysed aspects of stability failure of thin-walled compression members that are likely to exhibit combined global and local buckling. In particular the influence of various imperfections on the load-carrying capacity, namely welding residual stresses and local as well as global geometrical defects was subject of detailed experimental and numerical investigations. The insight into the structural behaviour has led in the case of thin-walled box sections to a proposal for a modification of the non-dimensional slenderness value used in the buckling verification and to the recommendation of a shift of the applied European buckling curve to a more favourable one. [less ▲]

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See detailInteraction of Hexadecylbetainate Chloride with Biological Relevant Lipids
Nsimba Zakanda, Francis; Lins, Laurence ULg; Nott, Katherine ULg et al

in Langmuir (2012), 28(7), 3524-3533

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See detailInteraction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
Barez, Pierre-Yves ULg; Willems, Luc ULg

Poster (2012, June 22)

First human retrovirus discovered, HTLV-1 infects approximately twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most important are the adult T ... [more ▼]

First human retrovirus discovered, HTLV-1 infects approximately twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most important are the adult T-cell leukemia (ATL) and a neurodegenerative disorder called HAM/TSP (Human associated myelopathy/ Tropical spastic paraparesis). We are interested in the mechanisms of transformation by the viral Tax oncoprotein. Recently, we showed that Tax interacts with the minichromosome maintenance MCM2-7 helicase and binds to origins of DNA replication (Boxus et al, 2012 Blood 119:151). Thereby, Tax modulates the spatiotemporal program of origin activation during the S phase of cell cycle. In fact, Tax accelerates S phase progression by inducing early firing of late replication origins. Concomitantly, Tax-MCM2-7 interplay also modulates viral transcription. Together, our data demonstrates that interaction between Tax and MCM2-7 is involved in replication reprogramming and viral transcription. [less ▲]

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See detailInteraction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program
Boxus, Mathieu ULg; Twizere, Jean-Claude ULg; Legros, Sébastien et al

in Blood (2012), 119

The Tax oncoprotein encoded by the Human T-cell leukemia virus type 1 (HTLV-1) plays a pivotal role in viral persistence and pathogenesis. HTLV-1 infected cells proliferate faster than normal lymphocytes ... [more ▼]

The Tax oncoprotein encoded by the Human T-cell leukemia virus type 1 (HTLV-1) plays a pivotal role in viral persistence and pathogenesis. HTLV-1 infected cells proliferate faster than normal lymphocytes, expand through mitotic division and accumulate genomic lesions. Here, we show that Tax associates with the minichromosome maintenance MCM2-7 helicase complex and localizes to origins of replication. Tax modulates the spatiotemporal program of origin activation and fires supplementary origins at the onset of S phase. Thereby, Tax increases the DNA replication rate, accelerates S phase progression but also generates a replicative stress characterized by the presence of genomic lesions. Mechanistically, Tax favors p300 recruitment and histone hyperacetylation at late replication domains advancing their replication timing in early S phase. [less ▲]

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See detailInteraction of HTLV-­1 Tax with minichromosome maintenance proteins accelerates the replication timing program
Carpentier, Alexandre ULg; Barez, Pierre-Yves ULg; Willems, Luc ULg

Conference (2013, January 28)

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the ... [more ▼]

Human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus that infects about twenty million individuals worldwide. HTLV-1 is the causative agent of different diseases among which the most common are the adult T-cell leukemia (ATL) and a neurodegenerative disorder called HAM/TSP (Human associated myelopathy/ Tropical spastic paraparesis). A key parameter of HTLV-1 pathogenesis is faster replication of provirus-carrying lymphocytes allowing clonal expansion of infected cell populations. The virally-encoded Tax oncoprotein plays an essential role in this process by interacting with DNA replication origins and accelerating S phase progression. By reprogramming the timing of origin firing, Tax also creates a replicative stress leading to DNA double strand breaks. This mechanism further triggers the DNA damage response (DDR) that induces cell cycle arrest and initiates either apoptosis or senescence. However, HTLV-1 infected cells have developed strategies to interfere with the DDR and are adapted to checkpoint control. These cells are thus able to proliferate despite occurrence of DNA damage. Based on these observations, we now propose a novel therapeutic approach based on the principle of synthetic lethality. [less ▲]

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See detailInteraction of hydroxylamine with the S1, S2 and S3 states of the water-oxidizing complex in etiochloroplasts of oat
Franck, Fabrice ULg; Schmid, G. H.

in Biochimica et Biophysica Acta (1989), 977

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See detailInteraction of lipopeptides from Bacillus subtilis with lipid vesicles
Deleu, Magali ULg; Paquot, Michel ULg; Olofsson, Gerd et al

Poster (2004)

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See detailInteraction of nanoparticles for drug delivery with biomimetic model membranes
Frost, Rickard; Cerda, Bernadino; Grandfils, Christian ULg et al

Poster (2009)

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See detailThe interaction of nanoparticles for drug delivery with biomimetic model membranes
Frost, Rickard; Cerda, Bernadino; Grandfils, Christian ULg et al

Poster (2009, February 24)

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See detailInteraction of odorous lactones with phospholipids: Implications in toxicity towards producing yeast cells
Aguedo, Mario ULg; Beney, L.; Waché, Y. et al

in Biotechnology Letters (2002), 24(23), 1975-1979

Some lactonic aroma compounds, that can be produced industrially by microorganisms, become toxic towards the producing cells as these compounds reach high concentrations in the culture medium. To ... [more ▼]

Some lactonic aroma compounds, that can be produced industrially by microorganisms, become toxic towards the producing cells as these compounds reach high concentrations in the culture medium. To determine the manner by which these metabolites may influence yeast physiology, the effects of four lactones (concentration range of 100 to 300 mg l-1) on the growth of Yarrowia lipolytica and on the phase behaviour of deuterated dimyristoylphos-phatidylcholine (DMPC-d27) were studied. The results showed that the hydrophobic lactones decrease the phase transition temperature (Tm) of DMPC-d27 bilayers and that Tm decrease (ΔTm) was related to the inhibitory action of the lactones on yeast growth (evaluated by the lag time). These results suggest that whatever the lactone, a ΔTm of at least 2.5°C resulted in a total growth inhibition: this implicates the lactone-phospholipids interaction in the mechanism of yeast growth inhibition. The test used in the present study may be a predicting method to assess the in vivo action of potential membrane active compounds. [less ▲]

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See detailInteraction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression.
Twizere, Jean-Claude ULg; Kruys, Veronique; Lefebvre, Laurent et al

in Journal of the National Cancer Institute (2003), 95(24), 1846-59

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell ... [more ▼]

BACKGROUND: The Tax oncoproteins are transcriptional regulators of viral expression involved in pathogenesis induced by complex leukemogenic retroviruses (or delta-retroviruses, i.e., primate T-cell leukemia viruses and bovine leukemia virus). To better understand the molecular pathways leading to cell transformation, we aimed to identify cellular proteins interacting with Tax. METHODS: We used a yeast two-hybrid system to identify interacting cellular proteins. Interactions between Tax and candidate interacting cellular proteins were confirmed by glutathione S-transferase (GST) pulldown assays, co-immunoprecipitation, and confocal microscopy. Functional interactions between Tax and one interacting protein, tristetraprolin (TTP), were assessed by analyzing the expression of tumor necrosis factor-alpha (TNF-alpha), which is regulated by TTP, in mammalian cells (HeLa, D17, HEK 293, and RAW 264.7) transiently transfected with combinations of intact and mutant Tax and TTP. RESULTS: We obtained seven interacting cellular proteins, of which one, TTP, was further characterized. Tax and TTP were found to interact specifically through their respective carboxyl-terminal domains. The proteins colocalized in the cytoplasm in a region surrounding the nucleus of HeLa cells. Furthermore, coexpression of Tax was associated with nuclear accumulation of TTP. TTP is an immediate-early protein that inhibits expression of TNF-alpha at the post-transcriptional level. Expression of Tax reverted this inhibition, both in transient transfection experiments and in stably transfected macrophage cell lines. CONCLUSION: Tax, through its interactions with the TTP repressor, indirectly increases TNF-alpha expression. This observation is of importance for the cell transformation process induced by leukemogenic retroviruses, because TNF-alpha overexpression plays a central role in pathogenesis. [less ▲]

Detailed reference viewed: 44 (18 ULg)