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See detailImpact of M. fijiensis metabolites on banana antioxidant systems
Busogoro, J. P.; Lepoivre, Philippe ULg; Etame, J. J. et al

Conference (2004)

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See detailImpact of medical specialist' locus of control on communication skills in oncological interviews
Libert, Y.; Janne, P.; Razavi, D. et al

in British Journal of Cancer (2003), 88

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See detailImpact of medical therapies on inflammatory bowel disease complication rate.
REENAERS, Catherine ULg; Belaiche, Jacques ULg; Louis, Edouard ULg

in World Journal of Gastroenterology (2012), 18(29), 3823-7

Crohn's disease and ulcerative colitis are progressive diseases associated with a high risk of complications over time including strictures, fistulae, perianal complications, surgery, and colorectal ... [more ▼]

Crohn's disease and ulcerative colitis are progressive diseases associated with a high risk of complications over time including strictures, fistulae, perianal complications, surgery, and colorectal cancer. Changing the natural history and avoiding evolution to a disabling disease should be the main goal of treatment. In recent studies, mucosal healing has been associated with longer-term remission and fewer complications. Conventional therapies with immunosuppressive drugs are able to induce mucosal healing in a minority of cases but their impact on disease progression appears modest. Higher rates of mucosal healing can be achieved with anti-tumor necrosis factor therapies that reduce the risk of relapse, surgery and hospitalization, and are associated with perianal fistulae closure. These drugs might be able to change the natural history of the disease mainly when introduced early in the course of the disease. Treatment strategy in inflammatory bowel diseases should thus be tailored according to the risk that each patient could develop disabling disease. [less ▲]

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See detailImpact of medication non-compliance and non-persistence on pharmacoeconomic evaluations in osteoporosis
Hiligsmann, Mickaël ULg; Rabenda, Véronique ULg; Gathon, Henry-Jean ULg et al

in Osteoporosis International (2008, December), 19(S2), 282

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See detailImpact of metallurgical size effects on plasticity of thin mettallic materials
Hug, Eric; keller, clement; Habraken, Anne ULg

in Materials Science Forum (2014), 783-786

Three examples involving size effects are presented witj implications concerning the formability: small Ni-20wt.%Cr resistive bridges, magnetic micro-sensors performed with (Ni,Co,Fe)based alloys and ... [more ▼]

Three examples involving size effects are presented witj implications concerning the formability: small Ni-20wt.%Cr resistive bridges, magnetic micro-sensors performed with (Ni,Co,Fe)based alloys and copper clad aluminum thin wires. The mechanical properties are directly linked to the ratio thickness over grain size (t/d ratio) of the parts.These metallurgical considerations must be taken into account when we are concerned by numerical simulation of the process of such components. It is shown that the simulations can correctly reproduce the softening effect linked to a decrease in thickness and in number of grains across the thickness. Finally the effect of a moderate increase in temperature on these results will be briefly reported. [less ▲]

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See detailImpact of micro-physics and macro-physics on the seismic properties of main-sequence B-type stars
Salmon, Sébastien ULg

Doctoral thesis (2014)

L’étude des pulsations stellaires, tout comme les ondes sismiques sur Terre, nous donne une méthode puissante afin de découvrir l’intérieur des étoiles. Cette discipline scientifique est aussi connue sous ... [more ▼]

L’étude des pulsations stellaires, tout comme les ondes sismiques sur Terre, nous donne une méthode puissante afin de découvrir l’intérieur des étoiles. Cette discipline scientifique est aussi connue sous le nom d’astérosismologie. Grâce aux missions spatiales CoRoT et Kepler, l’astérosismologie est entrée depuis dans une période faste. Par ailleurs, une frac- tion significative des étoiles présente des pulsations, ce qui nous permet de sonder leur intérieur pour la plupart de leurs stades d’évolution. Cette thèse se concentre sur les étoiles de type B de la séquence principale. Via l’inter- action de leurs vents stellaires avec leur milieu environnant et la production de nouveaux éléments chimiques en leurs intérieurs, elles contribuent aux processus dynamiques et d’enrichissement chimique du milieu interstellaire. Heureusement, deux types de pulsa- tion stellaire affectent ces étoiles: d’une part les pulsations dites de type β Cephei et d’autre part celles de type SPB. La nature de ces pulsations est sensible aux processus physiques internes de ces étoiles. Ainsi, l’observation de ces pulsations nous offre de sonder ces différents processus. Dans cette thèse, nous étudions tout particulièrement la sensibilité de ces étoiles aux opacités ra- diatives, et nous appuyant sur ces résultats, contraignons l’opacité radiative des éléments du groupe du fer à l’aide des étoiles pulsantes repérées dans les Nuages de Magellan. Dans une seconde étape, nous évaluons la possibilité de contraindre la nature du mélan- ge (diffusif ou overshooting instantané) à l’aide de la modélisation des β Cephei par l’ap- proche directe. Nous testons également les facteurs influençant la détermination de l’exten- sion de la zone mélangée. Enfin, nous proposons un scénario explicatif de la récente découverte d’une nouvelle classe d’étoiles variables dans un amas stellaire connu pour comporter de nombreuses étoiles en rotation rapide. [less ▲]

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See detailImpact of microbial activities on the mineralogy and performance of column-scale permeable reactive iron barriers operated under two different redox conditions
Van Nooten, Thomas; Lieben, François; Dries, Jan et al

in Environmental Science & Technology (2007), 41(16), 5724-5730

The present study focuses on the impact of microbial activities on the performance of various long-term operated laboratory-scale permeable reactive barriers. The barriers contained both aquifer and Fe-0 ... [more ▼]

The present study focuses on the impact of microbial activities on the performance of various long-term operated laboratory-scale permeable reactive barriers. The barriers contained both aquifer and Fe-0 compartments and had received either sulfate or iron(Ill)-EDTAto promote sulfatereducing and iron(Ill)-reducing bacteria, respectively. After dismantlement of the compartments after almost 3 years of operation, DNA-based PCR-DGGE analysis revealed the presence of methanogenic, sulfate-reducing, metalreducing, and denitrifying bacteria within as well as up- and downgradient of the Fe-0 matrix. Under all imposed conditions, the main secondary phases were vivianite, siderite, ferrous hydroxy carbonate, and carbonate green rust as found by scanning electron microscopy (SEM) combined with energy dispersive X-ray analysis (EDX), and X-ray diffraction (XRD). Under sulfate-reduction promoting conditions, iron sulfides were formed in addition, resulting in 7 and 10 times higher degradation rates for PCE and TICE, respectively, compared to unreacted iron. These results indicate that the presence of sulfate-reducing bacteria in or around iron barriers and the subsequent formation of iron sulfides might increase the barrier reactivity. [less ▲]

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See detailImpact of microbiological processes on the cycling of Fe in Antarctic sea-ice during Spring
Schoemann, Véronique; Lannuzel, Delphine; Becquevort, Sylvie et al

Poster (2006, February)

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See detailImpact of Missing Data on Phylogenies Inferred from Empirical Phylogenomic Data Sets
Roure, Béatrice; Baurain, Denis ULg; Philippe, Hervé

in Molecular Biology and Evolution (2013), 30(1), 197-214

Progress in sequencing technology allows researchers to assemble ever-larger supermatrices for phylogenomic inference. However, current phylogenomic studies often rest on patchy data sets, with some ... [more ▼]

Progress in sequencing technology allows researchers to assemble ever-larger supermatrices for phylogenomic inference. However, current phylogenomic studies often rest on patchy data sets, with some having 80% missing (or ambiguous) data or more. Though early simulations had suggested that missing data per se do not harm phylogenetic inference when using sufficiently large data sets, Lemmon et al. (Lemmon AR, Brown JM, Stanger-Hall K, Lemmon EM. 2009. The effect of ambiguous data on phylogenetic estimates obtained by maximum likelihood and Bayesian inference. Syst Biol. 58:130-145.) have recently cast doubt on this consensus in a study based on the introduction of parsimony-uninformative incomplete characters. In this work, we empirically reassess the issue of missing data in phylogenomics while exploring possible interactions with the model of sequence evolution. First, we note that parsimony-uninformative incomplete characters are actually informative in a probabilistic framework. A reanalysis of Lemmon's data set with this in mind gives a very different interpretation of their results and shows that some of their conclusions may be unfounded. Second, we investigate the effect of the progressive introduction of missing data in a complete supermatrix (126 genes × 39 species) capable of resolving animal relationships. These analyses demonstrate that missing data perturb phylogenetic inference slightly beyond the expected decrease in resolving power. In particular, they exacerbate systematic errors by reducing the number of species effectively available for the detection of multiple substitutions. Consequently, large sparse supermatrices are more sensitive to phylogenetic artifacts than smaller but less incomplete data sets, which argue for experimental designs aimed at collecting a modest number (∼50) of highly covered genes. Our results further confirm that including incomplete yet short-branch taxa (i.e., slowly evolving species or close outgroups) can help to eschew artifacts, as predicted by simulations. Finally, it appears that selecting an adequate model of sequence evolution (e.g., the site-heterogeneous CAT model instead of the site-homogeneous WAG model) is more beneficial to phylogenetic accuracy than reducing the level of missing data. [less ▲]

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See detailImpact of mitral regurgitation and myocardial viability on left ventricular reverse remodeling after cardiac resynchronization therapy in patients with ischemic cardiomyopathy.
Senechal, Mario; Lancellotti, Patrizio ULg; Magne, Julien ULg et al

in American Journal of Cardiology (2010), 106(1), 31-7

This study investigated the impact of ischemic mitral regurgitation (MR) severity and viability on left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT) in patients with ... [more ▼]

This study investigated the impact of ischemic mitral regurgitation (MR) severity and viability on left ventricular (LV) reverse remodeling after cardiac resynchronization therapy (CRT) in patients with ischemic cardiomyopathy. Severe MR and ischemic cardiomyopathy have been associated with lack of LV reverse remodeling after CRT. Fifty-seven consecutive patients with ischemic MR, LV ejection fraction < or =35%, QRS duration > or =120 ms, and intraventricular dyssynchrony > or =50 ms were prospectively included. Stress echocardiography was performed before CRT implantation. Viability in the region of the LV pacing lead was defined as the presence of viability in 2 contiguous segments. Response to CRT at 6 months was defined by evidence of > or =15% LV decrease in end-systolic volume. Severe MR was defined by an effective regurgitant orifice (ERO) area > or =20 mm(2). Thirty-three patients (58%) were responders at follow-up. Baseline ERO area and prevalence of severe MR were not different between responders and nonresponders (19 +/- 11 vs 21 +/- 13 mm(2), p = 0.67; 52% vs 53%, p = 0.84). In responders, MR was decreased by 58% (ERO 19 +/- 12 to 8 +/- 6 mm(2)). In the presence of viability in the region of the pacing lead, 74% (n = 29 patients) were responders (sensitivity 88%, specificity 58%); in the subgroup of patients with viability in the region of the pacing lead and severe MR, 83% (n = 17 patients) were responders. In conclusion, LV remodeling is frequent and ischemic MR decrease important in patients with viability in the region of the pacing lead without regard to MR severity. [less ▲]

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See detailImpact of mixing imperfections on yeast bioreactor performances: Scale-down reactor concept and related experimental tools
Delvigne, Frank ULg; Blaise, Yannick ULg; Destain, Jacqueline ULg et al

in Cerevisia and Biotechnology (2012), 37

A method combining environmental data extracted from the dissolved oxygen profile of a fed-batch bioreactor and a dynamic discrete Markov chain model has been presented in order to give more insight about ... [more ▼]

A method combining environmental data extracted from the dissolved oxygen profile of a fed-batch bioreactor and a dynamic discrete Markov chain model has been presented in order to give more insight about the glucose and dissolved oxygen fluctuations experienced by the microorganisms during cultivation in heterogeneous bioreactor. The fed-batch cultivation of Saccharomyces cerevisiae has been performed in a well-mixed and a partitioned scale-down reactor (SDR). The analysis of the environmental sequences has shown extended time lengths for the glucose availability and depletion sequences in the case of the SDR under a DO-controlled fed-batch culture. The Markov chain model developed in this work is able to capture the stochastic environmental events, i.e. in our case the environmental states experienced by the microorganisms crossing the tubular part of the SDR. The simulation results show clearly an extension of the starvation periods in the case of the culture performed in the SDR. The simulations have been performed at the single cells level allowing future improvements of our model and notably in the context of the population segregation phenomena occurring in fed-batch cultures. As a perspective, flow cytometry has been presented as a high-throughput analytical tool for the investigation of yeast physiology at the single cell level and in process-related conditions. [less ▲]

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See detailImpact of model resolution on simulated wind, drifting snow and surface mass balance in Terre Adelie, East Antarctica
Lenaerts, J. T. M.; van den Broeke, Michiel R.; Scarchilli, Claudio et al

in Journal of Glaciology (2012), 58(211), 821

This paper presents the impact of model resolution on the simulated wind speed, drifting snow climate and surface mass balance (SMB) of Terre Ade ́lie and its surroundings, East Antarctica. We compare ... [more ▼]

This paper presents the impact of model resolution on the simulated wind speed, drifting snow climate and surface mass balance (SMB) of Terre Ade ́lie and its surroundings, East Antarctica. We compare regional climate model simulations at 27 and 5.5 km resolution for the year 2009. The wind speed maxima in Terre Ade ́lie and the narrow glacial valleys of Victoria Land are better represented at 5.5 km resolution, because the topography is better resolved. Drifting snow sublimation is >100 mm a−1 in regions with high wind speeds. Our results indicate a strong feedback between topography, wind gradients and drifting snow erosion. As a result, SMB shows much more local spatial variability at 5.5 km resolution that is controlled by drifting snow erosion, whereas the large-scale SMB gradient is largely determined by precipitation. Drifting snow processes lead to ablation in the narrow glacial valleys of Victoria Land. The integrated SMB equals 86 Gt. Although wind climate, drifting snow processes and SMB variability are better represented at 5.5 km, the area-integrated SMB is not significantly different between the simulations at 27 and 5.5 km. A horizontal resolution of 27 km is sufficient to realistically simulate ice-sheet wide SMB. [less ▲]

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See detailThe impact of model-based therapeutics on glucose control in an intensive care unit
Chase, JG; Hann, CE; Desaive, Thomas ULg et al

in Proceedings of the 4th European Congress for Medical and Biomedical Engineering (eMBEC 2008) (2008)

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See detailThe impact of model-based therapeutics on glucose control in an intensive care unit
Hann, C. E.; Chase, J. G.; Desaive, Thomas ULg et al

in IFMBE Proceedings (2008), 22

This paper investigates the impact of fast parameter identification methods, which do not require any forward simulations, on model-based glucose control, using retrospective data in the Christchurch ... [more ▼]

This paper investigates the impact of fast parameter identification methods, which do not require any forward simulations, on model-based glucose control, using retrospective data in the Christchurch Hospital Intensive Care Unit. The integral-based identification method has been previously clinically validated and extensively applied in a number of biomedical applications; and is a crucial element in the presented model-based therapeutics approach. Common non-linear regression and gradient descent approaches are too computationally intense and not suitable for the glucose control applications presented. The main focus in this paper is on better characterizing and understanding the importance of the integral in the formulation and the effect it has on model-based drug therapy control. As a comparison, a potentially more natural derivative formulation which has the same computation speed advantages is investigated, and is shown to go unstable with respect to modelling error which is always present clinically. The integral method remains robust. © 2009 Springer Berlin Heidelberg. [less ▲]

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See detailImpact of morphosyntactic complexity in sentence comprehension in children with SLI
Leclercq, Anne-Lise ULg; Majerus, Steve ULg; Jacob, Laura et al

Poster (2010, June)

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See detailImpact of mutations affecting ND mitochondria-encoded Subunits on the activity and assembly of complex I in chlamydomonas. Implication for the structural organization of the enzyme
Cardol, Pierre ULg; Matagne, René-Fernand ULg; Remacle, Claire ULg

in Journal of Molecular Biology (2002), 319(5), 1211-1221

The mitochondrial rotenone-sensitive NADH:ubiquinone oxidoreductase (complex 1) comprises more than 35 subunits, the majority of which are encoded by the nucleus. In Chlamydomonas reinhardtii, only five ... [more ▼]

The mitochondrial rotenone-sensitive NADH:ubiquinone oxidoreductase (complex 1) comprises more than 35 subunits, the majority of which are encoded by the nucleus. In Chlamydomonas reinhardtii, only five components (ND1, ND2, ND4, ND5 and ND6) are coded for by the mitochondrial genome. Here, we characterize two mitochondrial mutants (dum5 and dum17) showing strong reduction or inactivation of complex I activity: dum5 is a IT deletion in the 3' UTR of nd5 whereas dum17 is a IT deletion in the coding sequence of nd6. The impact of these mutations and of mutations affecting nd1, nd4 and nd4/nd5 genes on the assembly of complex I is investigated. After separation of the respiratory complexes by blue native (BN)-PAGE or sucrose gradient centrifugation, we demonstrate that the absence of intact ND1 or ND6 subunit prevents the assembly of the 850 kDa whole complex, whereas the loss of ND4 or ND4/ND5 leads to the formation of a subcomplex of 650 kDa present in reduced amount. The implications of our findings for the possible role of these ND subunits on the activity of complex I and for the structural organization of the membrane arm of the enzyme are discussed. In mitochondria from all the strains analyzed, we moreover detected a 160210 kDa fragment comprising the hydrophilic 49 kDa and 76 kDa subunits of the complex I peripheral arm and showing NADH dehydrogenase activity. (C) 2002 Elsevier Science Ltd. All rights reserved. [less ▲]

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See detailImpact of Mycosphaerella fijiensis toxins on banana antioxidant systems.
Busogoro, J. P.; Olivier, T.; Leiva, M. et al

Poster (2006)

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See detailImpact of Myzus persicae infestation on the volatile emission of Arabidopsis thaliana Col-0.
Hien, Truong Thi Dieu ULg; Delaplace, Pierre ULg; Francis, Frédéric ULg et al

Poster (2012, July 22)

Being members of complex communities, plants often emit a wide range of volatile organic compounds to defend themselves against insect invasions. Although many studies exist on insect-induced plant ... [more ▼]

Being members of complex communities, plants often emit a wide range of volatile organic compounds to defend themselves against insect invasions. Although many studies exist on insect-induced plant volatile emission, most of them either compare the influences of various herbivore species on one plant species or the impact of a given herbivore on several host plant species. Moreover, informations related to the influence of insect density as well as the infestation duration are still needed. Here, we showed that a sucking insect – Myzus persicae (green peach aphid) induced the volatile emission from Arabidopsis thaliana Columbia wild-type (A.thaliana Col-0) under laboratory conditions based on results obtained by solid-phase micro-extraction coupled with gas chromatography - mass spectrometry (SPME-GC/MS). The released volatile blend was discussed in relation to related biosynthesis pathways and functions. These included terpenoids, green leaf volatiles, alcohols and isothiocyanate. The qualitative and overall proportion of volatile components differed depended on the number and residence duration of aphids on leaves. By studying the effects of sucking insect stresses to plant, we not only aim to contribute to the fundamental understanding of the emission of volatile components in the interaction between plants and pests, but also to provide standardised and easy to use assays to assess A.thaliana volatile changes according to cross stresses, including both biotic and abiotic ones in ongoing experiments. [less ▲]

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See detailThe impact of naturally-occurring, trans-placental bluetongue virus serotype-8 infection on reproductive performance in sheep.
Saegerman, Claude ULg; Bolkaerts, Benoit; Baricalla, Christine et al

in Veterinary Journal (2011), 187(1), 72-80

Infection with bluetongue virus serotype (BTV)-8 occurred in ruminants in 2006 in Central-Western Europe. The trans-placental passage of this virus has been demonstrated in naturally- and experimentally ... [more ▼]

Infection with bluetongue virus serotype (BTV)-8 occurred in ruminants in 2006 in Central-Western Europe. The trans-placental passage of this virus has been demonstrated in naturally- and experimentally-infected cattle and in experimentally-infected sheep. Trans-placental transmission is potentially important in the 'over-wintering' of this virus and its subsequent impact on reproductive performance. This epidemiological study was carried out on a sheep flock in Belgium that had experienced a severe outbreak of BTV-8 infection, and where the seroprevalence had increased from 1.3% to 88% between January and November 2007. In total, 476 lambs and 26 aborted fetuses from 300 ewes, lambing at four distinct time periods, were investigated between November 2007 and May 2008. The following evidence suggested that BTV-8 infection occurred in utero: (1) positive PCR results from splenic tissue from aborted fetuses (n=4); (2) fetal malformations suggestive of BTV infection (n=10); (3) positive PCR results from red blood cells in-lambs (n=7), and (4) the presence of antibody at birth in viable lambs prior to the intake of colostrum (n=9). The evidence provided by this investigation strongly suggests that trans-placental BTV-8 infection occurs in naturally-infected sheep and the impact of infection on the reproductive performance of such a naive flock was considerable, with up to 25% of ewes aborting and with flock fertility reduced by 50%. The contribution of in utero-infected lambs to the over-wintering of BTV appears limited. [less ▲]

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