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See detailImplementation of a Design Space Approach for Enantiomeric Separations in Polar Organic Solvent Chromatography
Nistor, Iolanda; Lebrun, Pierre ULg; Ceccato, Attilio ULg et al

in Journal of Pharmaceutical & Biomedical Analysis (2013), 74

This paper focuses on implementing a Design Space approach and on the critical process parameters (CPPs) to consider when applying the Quality by Design (QbD) concepts outlined in ICH Q8(R2), Q9 and Q10 ... [more ▼]

This paper focuses on implementing a Design Space approach and on the critical process parameters (CPPs) to consider when applying the Quality by Design (QbD) concepts outlined in ICH Q8(R2), Q9 and Q10 to analytical method development and optimization for three chiral compounds developed as modulators of small conductance calcium-activated potassium (SK) channels. In this sense, an HPLC method using a polysaccharide-based stationary phase containing a cellulose tris (4-chloro-3-methylphenylcarbamate) chiral selector in polar organic solvent chromatography mode was considered. The effects of trifluoroacetic acid (TFA) and n-hexane concentration in an acetonitrile (MeCN) mobile phase were investigated under a wide range of column temperatures. Good correlations were found between the observed data obtained after using a central composite design and the expected chromatographic behaviours predicted by applying the design of experiments-design space (DoE-DS) methodology. The critical quality attribute represented here by the separation criterion (Scrit) allowed assessing the quality of the enantioseparation. Baseline separation for the compounds of interest in an analysis time of less than 20 minutes was possible due to the original and powerful tools applied which facilitated an enhanced method comprehension. Finally, the advantage of the DoE-DS approach resides in granting the possibility to concurrently assess robustness and identify the optimal conditions which are compound dependent. [less ▲]

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See detailIMPLEMENTATION OF A METAL STRUCTURED PACKING IN A FUNGAL BIOFILM REACTOR FOR THE PRODUCTION OF A RECOMBINANT PROTEIN BY ASPERGILLUS ORYZAE
Zune, Quentin ULg; Delepierre, Anissa; Toye, Dominique ULg et al

in Communications in Agricultural and Applied Biological Sciences (2014, February 07)

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See detailImplementation of a non-orthogonal constitutive model for the finite element simulation of textile composite draping
Pierce, Robert S; Falzon, Brian G; Thompson, Mark C et al

in Applied Mechanics and Materials (2014), 553

In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This ... [more ▼]

In the pursuit of producing high quality composite aircraft structures at a low cost, out-of-autoclave manufacturing processes for textile reinforcements are being simulated with increasing accuracy. This paper focuses on the continuum-based, finite element modelling of textile composites as they deform during the draping process. A non-orthogonal constitutive model tracks yarn orientations within a material subroutine developed for Abaqus/Explicit, resulting in the realistic determination of fabric shearing and material draw-in. Supplementary material characterisation was experimentally performed in order to define the tensile and non-linear shear behaviour accurately. The validity of the finite element model has been studied through comparison with similar research in the field and the experimental lay-up of carbon fibre textile reinforcement over a tool with double curvature geometry, showing good agreement. [less ▲]

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See detailImplementation of a RTW program for low back pain workers in Belgium : Assessment of the workplace intervention component
Mairiaux, Philippe ULg; Schrijvers, G.; Delaruelle, D. et al

in WDPI 2010, Book of abstracts (2010)

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See detailImplementation of a texture based interpolated yield locus in a FEM code
Duchene, Laurent ULg; Habraken, Anne ULg; Godinas, A.

in Balkema (Ed.) Proceedings of NUMIFORM 2001 (Simulation of Materials Processing: Theory, Methods and Applications) (2001)

This paper presents a constitutive law based on Taylor's model implemented in our non linear finite element code LAGAMINE. The yield locus is only described and a particular interpolation method has been ... [more ▼]

This paper presents a constitutive law based on Taylor's model implemented in our non linear finite element code LAGAMINE. The yield locus is only described and a particular interpolation method has been developed. This local yield locus model uses a discrete representation of the material's texture. The interpolation method is presented and a deep-drawing application is simulated in order to show up the influence of the texture evolution during forming processes. [less ▲]

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See detailIMPLEMENTATION OF A WEAK COUPLING APPROACH BETWEEN A CFD AND AN FE SOFTWARE FOR FIRES IN COMPARTMENT
Tondini, Nicola; Franssen, Jean-Marc ULg

in Idelsohn, S; Papadrakakis, M; Schrefler, B (Eds.) V International Conference on Computational Methods for Coupled Problems in Science and Engineering (2013, June 17)

The paper presents the assumptions and the issues that arise when developing an integrated modelling methodology between a Computational Fluid Dynamics (CFD) software applied to compartment fires and a ... [more ▼]

The paper presents the assumptions and the issues that arise when developing an integrated modelling methodology between a Computational Fluid Dynamics (CFD) software applied to compartment fires and a Finite Element (FE) software applied to structural systems subjected to fire. In particular, a weak coupling approach used to simulate a fire exposed structure by modelling the fire development in the compartment, the heat penetration in the structure and the mechanical response is described. The advantages and the disadvantages of such a technique are highlighted compared to a full coupling that conversely takes into account all mutual interactions. The favourable aspect of computing the thermal response of the structure in the FE model in order to avoid modelling the structure in the CFD model is underlined, namely a sensitive reduction of computational demand. Finally, the study is enriched by an application of this methodology that concerns the simulation of a pool fire in an open compartment the results of which are compared with those obtained by employing the simplified Hasemi model included in the Eurocodes. [less ▲]

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See detailImplementation of a www site presenting Liège viewed from space using satellilte images
Donnay, Jean-Paul ULg

in Earth Observation by Satellite (2002)

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See detailImplementation of a yield locus interpolation method in the finite element code LAGAMINE
Duchene, Laurent ULg

Master of advanced studies dissertation (2000)

Detailed reference viewed: 13 (2 ULg)
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See detailImplementation of an active school project in a rural environment in Wallonia. A collaborative study
Cloes, Marc ULg; Dequenne, Aurélie

Conference (2009, May)

Detailed reference viewed: 37 (4 ULg)
See detailImplementation of Automated Procedures in Routine at CART
Focant, Jean-François ULg

Scientific conference (2010, October)

Detailed reference viewed: 12 (3 ULg)
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See detailImplementation of Density-Functional Perturbation Theory within ABINIT: Proj ector Augmented-Waves and Spin-Orbit
Gonze, X.; Verstraete, Matthieu ULg; Audouze, C. et al

in AIP Conference Proceedings (2012), 1504

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See detailImplementation of discharge management for geriatric patients at risk of readmission or institutionalization
Steeman, E.; Moons, P.; Milisen, K. et al

in International Journal for Quality in Health Care (2006), 18(5), 352-358

Objective. To evaluate whether implementation of discharge management by trained social workers or nurses reduces hospital readmissions and institutionalizations of geriatric patients in a real-world ... [more ▼]

Objective. To evaluate whether implementation of discharge management by trained social workers or nurses reduces hospital readmissions and institutionalizations of geriatric patients in a real-world setting. Design. Quasi-experimental design. Setting. Six general hospitals in Belgium. Participants. A representative sample of 824 patients, 355 of whom were assigned to the experimental group receiving comprehensive discharge management and 469 to the control group receiving usual care. Inclusion criteria were patients admitted to a geriatric, rehabilitation, or internal medicine ward, not residing in a nursing home, and showing risk of readmission or institutionalization on admission in the hospital. Intervention. In-hospital discharge planning according to a case management protocol allowing for adjustment to participating hospitals' case mix and patients' and families' specific needs. Main outcome measures. Hospital readmission within 15 and 90 days post discharge; institutionalization at discharge and within 15 and 90 days post discharge. Results. Discharge management resulted in fewer institutionalizations (n = 53; 14.9%) compared with usual care (n = 130; 23.7%) (adjusted odds ratio = 0.47; CI 95% = 0.31-0.70). Readmission rates between the intervention and usual care group were not significantly different. Conclusions. This implementation project showed that a discharge planning intervention can reduce institutionalization rates of elderly patients in real-life settings. [less ▲]

Detailed reference viewed: 39 (2 ULg)