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See detailHORIZONTAL EVALUATION METHOD FOR THE IMPLEMENTATION OF THE CONSTRUCTION PRODUCTS DIRECTIVE HEMICPD
Lor, Marc; Vause, Kevin; Dinne, Karla et al

Report (2010)

A. Context One of the objectives of the European Construction Products Directive (CPD) is to harmonize the technical specifications with regard to dangerous substances and construction materials ... [more ▼]

A. Context One of the objectives of the European Construction Products Directive (CPD) is to harmonize the technical specifications with regard to dangerous substances and construction materials. Construction products could emit or contain dangerous substances that have been defined as dangerous substances under Commission directives and national regulations. In the future construction products may only be placed on the market in the European Union if they accord with the (second generation) harmonized technical specifications including health aspects and bear the CE mark. B. Objectives The goal of this research project is to improve the flow of knowledge and information vis-à-vis normalisation activities in the domain of indoor air measurements, indoor product emission testing, labeling and certification by proposing an evaluation method and standardized assessment methods for a harmonized approach relating to emissions from building materials into indoor air for implementation in Belgium. This approach will comply with current European harmonizing efforts ongoing on European level. C. Conclusions  International tendencies as well as national developments indicate the growing importance of building material emission testing  Harmonisation of governmental schemes to assess volatile organic emissions in the context of the CPD is necessary to obtain transparency  The topic of different limit values in different countries is a difficult problem to solve  It was demonstrated that it is possible with alternative methods (µ-chamber and FLEC) to achieve a qualitative and quantitative correlation with the reference method. However there is a need to extend this comparative study to more materials  The important influence of the quantification procedure on the emission results was demonstrated  The possiblity to investigate microbial resistance of building materials with the so called µ-chamber technique was demonstrated  A twofold methodology for the odour determination of building materials was developed: a quantitative method based on intensity and a qualitative method based on hedonic scale. Furthermore the basis for the development of an electronic nose specific for evaluation of building materials was laid down  A possible evaluation scheme for Belgium on the basis of AFSSET/AgBB/prEN15052 was proposed with two modifications: - Time path modification (7 or 10 days) - Prescreening with alternative method (< 20 L) D. Contribution of the project in a context of scientific support to transfer of knowledge and innovation This research project for implementation of the essential requirement “Hygiene, health and the environment” of the Construction Products Directive has besides its informative and sensitizing role also performed a supporting role in the development of new innovative low emission construction products. The research project has also ensured a Belgian input in the validation work of the draft standard "Emissions into indoor air" - WI 351009 - Construction products - Assessment of emissions of regulated dangerous substances from construction products - Determination of emissions into indoor air” in development in working group 2 of CEN/TC 351. Furthermore this research project has lead to the development of new innovative test methods tailored to the specific needs of construction products. [less ▲]

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See detailHorizontal Evaluation Method for the Implementation of the Construction Products Directive (HEMICPD)
Lor, Marc; Vause, Kevin; Dinne, Karla et al

Poster (2007)

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See detailHorizontal evaluation method for the implementation of the construction products directive - emissions from construction products into indoor air
Lor, Marc; Vause, Kevin; Dinne, Karla et al

in 9th International Conference and Exhibition on Healthy Buildings 2009 (2009, September)

Worldwide different (mostly voluntary) approaches exist to evaluate emissions from construction products. The importance of the relation between construction products and health & environment is ... [more ▼]

Worldwide different (mostly voluntary) approaches exist to evaluate emissions from construction products. The importance of the relation between construction products and health & environment is highlighted in the mandatory European Construction Products Directive (CPD). One of the objectives of the European Construction Products Directive (CPD) is to harmonize the technical specifications with regard to dangerous substances and construction materials as stated in the Essential Requirement N°3 “Hygiene, health and the environment” (ER3). The Belgian Building Research Institute (BBRI) is involved in the implementation of ER3 by participation in standardisation work on CEN (CEN/TC 351) and EOTA (EOTA PT9) level. This paper presents first results of ongoing BBRI research activities in collaboration with VITO (Flemish Institute for Technological Research) and ULg (Université de Liège) concerning “horizontal evaluation method for implementation of the CPD (HEMICPD)”: http://www.bbri.be/go/hemicpd. [less ▲]

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See detailHorizontal gene transfer from Eukarya to Bacteria and domain shuffling: the alpha-amylase model
Da Lage, J. L.; Feller, Georges ULg; Janecek, S.

in Cellular and Molecular Life Sciences : CMLS (2004), 61(1), 97-109

alpha-Amylases are present in all kingdoms of the living world. Despite strong conservation of the tertiary structure, only a few amino acids are conserved in interkingdom comparisons. Animal alpha ... [more ▼]

alpha-Amylases are present in all kingdoms of the living world. Despite strong conservation of the tertiary structure, only a few amino acids are conserved in interkingdom comparisons. Animal alpha-amylases are characterized by several typical motifs and biochemical properties. A few cases of such alpha-amylases have been previously reported in some eubacterial species. We screened the bacterial genomes available in the sequence databases for new occurrences of animal-like alpha-amylases. Three novel cases were found, which belong to unrelated bacterial phyla: Chloroflexus aurantiacus, Microbulbifer degradans, and Thermobifida fusca. All the animal-like alpha-amylases in Bacteria probably result from repeated horizontal gene transfer from animals. The M. degradans genome also contains bacterial-type and plant-type alpha-amylases in addition to the animal-type one. Thus, this species exhibits alpha-amylases of animal, plant, and bacterial origins. Moreover, the similarities in the extra C-terminal domains (different from both the alpha-amylase domain C and the starch-binding domain), when present, also suggest interkingdom as well as intragenomic shuffling. [less ▲]

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See detailHorizontal gene transfer from human host to HIV-1 reverse transcriptase confers drug resistance and partly compensates for replication deficits.
Megens, Sarah; Vaira, Dolores; De Baets, Greet et al

in Virology (2014), 456-457

We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI ... [more ▼]

We investigated the origin and the effect of insertion D67D-THGERDLGPA within HIV-1 RT from a patient failing antiviral therapy. The insertion developed within the context of pre-existing NRTI and NNRTI mutations (M41L, L210W, T215Y and N348I). Concurrently, the NRTI mutations T69I and V118I and the NNRTI mutations K103N and Y181C were detected for the first time. High-level drug resistance (fold-changes>/=50) and a good replication capacity (87% of wild-type) were observed, significantly higher than for the previous virus without insertion. The insertion was very similar to a region within human chromosome 17 (31/34 nucleotide identity), and had already been detected independently in a Japanese HIV-1 isolate. These results suggest that a particular sequence within human chromosome 17 is prone to horizontal gene transfer into the HIV-1 RT finger subdomain. This insertion confers selective advantage to HIV-1 by its contribution to multi-drug resistance and restoration of impaired replication capacity. [less ▲]

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See detailHorloge interne et adaptations comportementales chez l'animal
Richelle, Marc ULg

in Oleron, G. (Ed.) Psychologie expérimentale et comparée (1977)

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See detailLes Horloges Atomiques
Bastin, Thierry ULg

in Bulletin de la Société Royale des Sciences de Liège (2005), 74

In this paper, a short review of the basic physical mechanisms underlying the atomic clocks is given. We cover the standard cesium atomic clocks along with the new generation of cold atom clocks.

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See detailHormonal and biochemical normalization and tumor shrinkage induced by anti-parathyroid hormone immunotherapy in a patient with metastatic parathyroid carcinoma
Betea, Daniela ULg; Bradwell, A. R.; Harvey, T. C. et al

in ENEA congress : Napoli, April 2004 (2004, April)

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See detailHormonal and biochemical normalization and tumor shrinkage induced by anti-parathyroid hormone immunotherapy in a patient with metastatic parathyroid carcinoma.
Betea, Daniela ULg; Bradwell, A. R.; Harvey, T. C. et al

in Journal of Clinical Endocrinology and Metabolism (2004), 89(7), 3413-20

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism, and the efficacy of medical therapy and chemo- and radiotherapy is poor in recurrent or metastatic disease. We report the first case ... [more ▼]

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism, and the efficacy of medical therapy and chemo- and radiotherapy is poor in recurrent or metastatic disease. We report the first case of PTH immunization in which tumor shrinkage accompanied hormonal, biochemical, and clinical improvements in a patient with metastatic parathyroid carcinoma.A 50-yr-old woman with refractory parathyroid carcinoma and pulmonary metastases was immunized eight times between February 2001 and December 2003 with bovine and modified human PTH fragments and intact human PTH, mixed with Freund's adjuvant. Total and ionized calcium and PTH levels were assayed weekly for 6 months and regularly thereafter. Thoracic computed tomography scans were performed regularly.Antibodies to all PTH fragments were detected after two immunizations. Baseline PTH and total calcium were 213.0 ng/liter and 13.96 mg/dl, respectively, and remained elevated during the first three immunizations. From the fourth immunization onward, PTH and calcium decreased, and the patient's clinical condition improved markedly. PTH and calcium levels have remained controlled for more than 24 months, and the sizes (surface area) of pulmonary metastases decreased from baseline by 39-71%.This is the first evidence that PTH immunization not only can improve clinical, hormonal, and biochemical measures in parathyroid carcinoma but also has an antitumor effect. [less ▲]

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See detailHormonal and metabolic adaptation to protein-supplemented fasting in obese subjects.
Scheen, André ULg; Luyckx, A. S.; Scheen, Myriam ULg et al

in International Journal of Obesity & Related Metabolic Disorders (1982), 6(2), 165-74

Thirty hospitalized, severely obese patients (40 +/- 2 yr, 82 +/- 4 percent weight excess) were submitted to a 13-d protein-supplemented fast (PSF) with 70 g milk proteins/d (1.26 MJ or 300 kcal). The ... [more ▼]

Thirty hospitalized, severely obese patients (40 +/- 2 yr, 82 +/- 4 percent weight excess) were submitted to a 13-d protein-supplemented fast (PSF) with 70 g milk proteins/d (1.26 MJ or 300 kcal). The mean weight loss during PSF was 5.4 +/- 0.3 kg corresponding to 422 +/- 39 g/d. Comparison of the urinary nitrogen excretion with daily protein intake revealed that the nitrogen balance was equilibrated during PSF. Blood glucose decreased moderately but significantly during the whole PSF period whereas plasma insulin was only reduced during the first 9 d and tended to rise thereafter. Plasma FFA increased rapidly and remained elevated until the end of the study (+ 60 per cent); serum total cholesterol and plasma triglycerides showed a 26 and a 35 per cent decrease respectively. Basal plasma glucagon was slightly increased. Due to the low sodium intake (42 mmol/d) urinary sodium excretion dropped rapidly. Simultaneously both systolic (-13 mmHg) and diastolic (-7 mmHg) arterial blood pressure decreased significantly. The biological tolerance was good: metabolic acidosis was prevented with sodium bicarbonate, excessive rise in serum uric acid was corrected with allopurinol and a marked decrease in serum potassium was avoided with an appropriate dose of spironolactone. Twenty-six patients could be weighed 6 to 15 months after PSF: 12 showed a further weight reduction (6.6 +/- 1.6 kg) and seven a discrete weight gain (1.0 +/- 0.4 kg). Thus, PSF was well accepted and was profitable in 19 out of our 30 patients. It should be restricted to cases of severe and refractory obesity and performed under careful medical supervision. [less ▲]

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See detailHormonal Control of Female Sexual Behavior in the Japanese Quail
Delville, Y.; Balthazart, Jacques ULg

in Hormones & Behavior (1987), 21(3), 288-309

Four experiments were carried out to study the hormonal control of female receptivity and proceptivity in Japanese quail. Both aspects of reproductive behavior can be activated in a dose-dependent manner ... [more ▼]

Four experiments were carried out to study the hormonal control of female receptivity and proceptivity in Japanese quail. Both aspects of reproductive behavior can be activated in a dose-dependent manner by injections of estradiol benzoate (EB). Progesterone (P) given in addition to suboptimal doses of EB has little additional stimulatory effect. Other aspects of the reproductive physiology such as enlargement of the cloacal diameter and growth of the oviduct also seem to be controlled primarily by estrogens with little or no additive effect of P. These conclusions were confirmed by injecting egg-laying females with an antiestrogen, tamoxifen, or an antiprogestin, RU38486. Only the former had marked effects on sexual receptivity, cloacal diameter, and oviduct weight. The inhibiting effects of tamoxifen could easily be reversed by injecting females with large doses of estrogen, which demonstrates that tamoxifen acts on an estrogen-dependent mechanism and not through nonspecific effects. [less ▲]

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See detailHormonal control of proliferation in meristematic agglomerates of Eucalyptus camaldulensis Dehn
Arezki, Ouoimare; Boxus, Philippe; Kevers, Claire ULg et al

in In Vitro Cellular & Developmental Biology-Plant (2000), 36(5), 398-401

Eucalyptus camaldulensis can he micropropagated through so-called meristematic agglomerates (MAs). MAs (4-6 mm diameter) are dense shoot clusters initiated by the Outgrowth of numerous successive buds ... [more ▼]

Eucalyptus camaldulensis can he micropropagated through so-called meristematic agglomerates (MAs). MAs (4-6 mm diameter) are dense shoot clusters initiated by the Outgrowth of numerous successive buds. Their reddish nature is associated with an increase ill their endogenous cytokinin level during the exponential phase of growth. A simultaneous decrease in the auxin level favors a high cytokinin/auxin ratio. A low level of polyamines occurs at the time of the lowest level of auxins. Slow hormone release by activated charcoal plays a role in this very prolific organogenesis. [less ▲]

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See detailHormonal control of the gonadal regression and recovery observed in short days in male and female doves.
Balthazart, Jacques ULg; Balthazart-Raze, C.; Cheng, M. F.

in Journal of Endocrinology (1981), 89(1), 79-89

Sexually mature ring doves (Streptopelia risoria) maintained from hatch on a photoperiod of 14 h light : 10 h darkness (14L : 10D) and kept in isolation were transferred to 8L : 16D. This treatment ... [more ▼]

Sexually mature ring doves (Streptopelia risoria) maintained from hatch on a photoperiod of 14 h light : 10 h darkness (14L : 10D) and kept in isolation were transferred to 8L : 16D. This treatment resulted in a partial regression of the ovaries and testes and a fall in the concentration of plasma LH but not of plasma FSH. After 2--3 months exposure to 8L : 16D, the gonads regrew to their original size: this regrowth was accompanied by a parallel increase in the concentration of plasma LH. The responsiveness of the pituitary gland to LH releasing hormone in both sexes after 5 weeks of exposure to 8L : 16D (when the gonads were partially regressed) was similar to the response observed after 15 weeks exposure to this lighting schedule (when the gonads had regrown). It was concluded that the spontaneous recovery of gonadal size in ring doves exposed to 8L : 16D is controlled by the hypothalamus and does not involve changes in the functional capacity of the pituitary gland or of the gonads. [less ▲]

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See detailHormonal correlates of gonadal regression and spontaneous recovery in Japanese quail exposed to short day-lengths.
Delville, Y.; Sulon, J.; Balthazart, Jacques ULg

in Archives Internationales de Physiologie et de Biochimie (1985), 93(2), 123-33

Adult male Japanese quail were transferred from long to short days. Plasma testosterone and dihydrotestosterone quickly decreased and this endocrine response was followed by a regression of the cloacal ... [more ▼]

Adult male Japanese quail were transferred from long to short days. Plasma testosterone and dihydrotestosterone quickly decreased and this endocrine response was followed by a regression of the cloacal gland, an androgen-target organ. After about a month, a spontaneous recovery of gonadal activity was observed in some but not all birds. It was not associated with obvious shifts in the circadian system. The physiological bases of this spontaneous recovery are discussed as well as the detailed relationships between plasma testosterone and cloacal gland size. [less ▲]

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See detailHormonal investigation in osteoporosis
Franchimont, P; Fontaine, MA; Reginster, Jean-Yves ULg

in Acta Clinica Belgica (1988), 43(S1), 12-13

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See detailHormonal measurements in late pregnancy and parturition in dairy cows - possible tools to monitor foetal well being
Kornmatitsuk, B.; Veronesi, M. C.; Madej, A. et al

in Animal Reproduction Science (2002), 72(3-4), 153-164

Three dairy heifers (A, B and C) were induced to parturition with two prostaglandin (PG) F-2alpha injections on day 268 and 269 of pregnancy. Signs of approaching parturition were carefully observed. The ... [more ▼]

Three dairy heifers (A, B and C) were induced to parturition with two prostaglandin (PG) F-2alpha injections on day 268 and 269 of pregnancy. Signs of approaching parturition were carefully observed. The following parameters were registered: degrees of calving difficulty, date and time of parturition, calf's birth weight and calf's sex. Body temperature was measured and blood samples were taken every 3 h 3 days before the first PGF(2alpha) injection until 3 days after parturition. The plasma concentrations of the PGF2a metabolite, progesterone, cortisol, oestrone sulphate and pregnancy associated glycoproteins (PAGs) were analysed. Heifers A, B and C delivered 48, 51 and 57 h after the first PGF(2alpha) injection, respectively. Heifer A delivered without any signs of calving difficulty, whereas, the parturition was considered to be slight and moderate difficulty occurred in the delivery of heifers B and C, respectively. The calf of heifer C, without any abnormal gross-evidences, was stillborn. All animals had retained foetal membranes. A slight increase of the PGF(2alpha) metabolite at the time of parturition was found only in heifer C, whereas the levels dramatically increased in all animals 15-24 h after parturition. At the same time, progesterone levels decreased within 3 h after the first PGF(2alpha) injection (P < 0.05) and reached 0.8, 2.7 and 12.4 nmol/l at the time of parturition in heifers A, B and C, respectively. High release of cortisol at the time of parturition was seen in heifer C. Rising levels of oestrone sulphate around the time of parturition were recorded in all heifers, whereas, increasing levels of PAGs were recorded only in heifer A. In conclusion, the patterns of the PGF(2alpha) metabolite, cortisol, progesterone and PAGs were changed in the cases of calving difficulty and stillbirth after PGF(2alpha)-induction of parturition. However, the relationship between oestrone sulphate and PAGs and the status of foetal well being prior to parturition require further elucidation. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailHormonal profile associated with social behavior in Oreochromis aureus.
Skoufas, G.; Poncin, Pascal ULg; Byamungu, N. et al

Poster (1993)

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See detailHormonal profile of growing male and female diploïds and triploïds of the blue tilapia, Oreochromis aureus, reared in intensive culture
Mol, K.; Byamungu, N.; Cuisset, B. et al

in Fish Physiology and Biochemistry (1994), 13

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