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Peer Reviewed
See detailImpacts of plant invasions on ecosystem processes in Belgium
Vanderhoeven, Sonia ULg; Chapuis-Lardy, L.; Dassonville, N. et al

Poster (2004)

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See detailImpacts of the carbonyl group location of ester bond on interfacial properties of sugar-based surfactants: experimental and computational evidences
Razafindralambo, Hary ULg; Blecker, Christophe ULg; Mezdour, Samir et al

in Journal of Physical Chemistry B (2009), 113

Interfacial properties of surfactants are dependent on the conformation adopted by the hydrophilic headgroup or/and the hydrophobic tail at the boundary limit of two immiscible phases. Here, we ... [more ▼]

Interfacial properties of surfactants are dependent on the conformation adopted by the hydrophilic headgroup or/and the hydrophobic tail at the boundary limit of two immiscible phases. Here, we demonstrate the impacts of the carbonyl group (-CO-) location of the ester bond of sugar-based surfactants by comparing some properties of two closely related esters, octyl glucuronate and glucose octanoate, at the air-water interface. The carbonyl group location influences the rate and extent of interfacial adsorption and the rheology properties of sugar esters at the air-water interface, which were evaluated by dynamic surface tension and complex surface viscoelastic measurements. Octyl glucuronate adsorbs the fastest at the air-water interface whereas glucose octanoate reduces the dynamic surface tension at the lowest value and exhibits the highest film viscoelasticity. Differences are attributed to molecular conformation constraints inducing relevant changes to the surface coverage kinetic capacity and the interaction strengths of the octyl sugar ester adsorbed films at the air-water interface. All of the results are supported by the minimum cross-sectional area values per molecule determined by both experimental and computational approaches. [less ▲]

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See detailImpacts of vegetation changes on LGM climate
Henrot, Alexandra ULg; François, Louis ULg; Munhoven, Guy ULg

Conference (2007, March 12)

The impacts of vegetation change on the climate at the Last Glacial Maximum are investigated with the Earth System Model of Intermediate Complexity Planet Simulator and the dynamic vegetation model Caraib ... [more ▼]

The impacts of vegetation change on the climate at the Last Glacial Maximum are investigated with the Earth System Model of Intermediate Complexity Planet Simulator and the dynamic vegetation model Caraib (CARbon Assimilation in the Biosphere). [less ▲]

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See detailImpacts of WLG on the regeneration of logged forests: preliminary insights in a Gabonese logging concession
Haurez, Barbara ULg; Petre, Charles-Albert ULg; Doucet, Jean-Louis ULg

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013, September), 84(3-5), 284-285

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See detailImpact of sludge storage duration on its dewatering and drying ability
Pambou, Yvon-Bert; Salmon, Thierry ULg; Fraikin, Laurent ULg et al

Poster (2013, October)

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See detailImpaired LTP induction in dentate gyrus of calretinin-deficient mice
Schurmans, Stéphane ULg; Schiffmann, S. N.; Gurden, H. et al

in Proceedings of the National Academy of Sciences of the United States of America (1997), 94

Calretinin (Cr) is a Ca21 binding protein present in various populations of neurons distributed in the central and peripheral nervous systems. We have generated Cr-deficient (Cr2/2) mice by gene targeting ... [more ▼]

Calretinin (Cr) is a Ca21 binding protein present in various populations of neurons distributed in the central and peripheral nervous systems. We have generated Cr-deficient (Cr2/2) mice by gene targeting and have investigated the associated phenotype. Cr2/2 mice were viable, and a large number of morphological, biochemical, and behavioral parameters were found unaffected. In the normal mouse hippocampus, Cr is expressed in a widely distributed subset of GABAergic interneurons and in hilar mossy cells of the dentate gyrus. Because both types of cells are part of local pathways innervating dentate granule cells andyor pyramidal neurons, we have explored in Cr2/2 mice the synaptic transmission between the perforant pathway and granule cells and at the Schaffer commissural input to CA1 pyramidal neurons. Cr2/2 mice showed no alteration in basal synaptic transmission, but long-term potentiation (LTP) was impaired in the dentate gyrus. Normal LTP could be restored in the presence of the GABAA receptor antagonist bicuculline, suggesting that in Cr2/2 dentate gyrus an excess of g-minobutyric acid (GABA) release interferes with LTP induction. Synaptic transmission and LTP were normal in CA1 area, which contains only few Cr-positive GABAergic interneurons. Cr2/2 mice performed normally in spatial memory task. These results suggest that expression of Cr contributes to the control of synaptic plasticity in mouse dentate gyrus by indirectly regulating the activity of GABAergic interneurons, and that Cr2/2 mice represent a useful tool to understand the role of dentate LTP in learning and memory [less ▲]

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See detailImpaired Accumulation of Granulocytes in the Lung During Ozone Adaptation
Fievez, Laurence ULg; Kirschvink, N.; Dogne, S. et al

in Free Radical Biology & Medicine (2001), 31(5), 633-641

Respiratory alterations induced by an acute exposure to ozone (O(3)) paradoxically resolve during multiday exposure. This adaptation is characteristically accompanied by a gradual attenuation of lung ... [more ▼]

Respiratory alterations induced by an acute exposure to ozone (O(3)) paradoxically resolve during multiday exposure. This adaptation is characteristically accompanied by a gradual attenuation of lung neutrophilia. As maintenance of neutrophilia at the site of inflammation is due to cytokine-mediated delayed neutrophil apoptosis, which is associated with reduced levels of Bax, a proapoptotic protein, we sought to determine whether defects in these mechanisms could account for O(3) adaptation. Lung granulocytes obtained at different time points from calves exposed to 0.75 ppm O(3) for 12 h/d for 7 consecutive days neither showed enhancement of survival nor Bax deficiency, when compared to blood granulocytes. To further investigate the effects of an exogenous oxidative stress on neutrophil survival, human granulocytes were treated with hydrogen peroxide alone, or in combination with granulocyte/macrophage colony-stimulating factor, an antiapoptotic cytokine. Both treatments led to rapid apoptosis associated with downregulation of Bcl-x(L) and Bcl-2, two antiapoptotic proteins. This study shows that O(3) adaptation is associated with a failure in the mechanisms leading to accumulation of neutrophils at the site of inflammation, and suggests that this defect is due to direct proapoptotic effects of exogenous oxidative stress on granulocytes [less ▲]

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See detailImpaired Acquisition Of A Mirror-Reading Skill In Alzheimer’s Disease
Merbah, Sarah ULg; Salmon, Eric ULg; Meulemans, Thierry ULg

in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2011), 47

Several studies using the mirror-reading paradigm have shown that procedural learning and repetition priming may be preserved in the early stages of Alzheimer's disease (AD) (e.g., Deweer et al., 1994 ... [more ▼]

Several studies using the mirror-reading paradigm have shown that procedural learning and repetition priming may be preserved in the early stages of Alzheimer's disease (AD) (e.g., Deweer et al., 1994). According to the classical interpretation, improved reading time for repeated words is sustained by a repetition priming effect, while procedural learning is demonstrated when this improvement is also observed for new words. Following Masson (1986), the hypothesis tested in the present study was that improved reading of new words could also be due to a repetition priming effect rather than to the acquisition of a mirror-reading skill. Indeed, because the same letters are presented throughout the task, a repetition priming effect for the letters could suffice to explain the improvement in performance. To test this hypothesis, we administered to 30 healthy young and elderly subjects and to 30 AD patients a new mirror-reading task in two phases: an acquisition phase comprising pseudo-words constructed with one part of the alphabet, and a test phase in which both pseudo-words constructed with the same part of the alphabet and pseudo-words constructed with another part of the alphabet were presented. If the new pseudo-words composed with repeated letters were read faster, it would reflect a repetition priming effect; if pseudo-words composed of ‘new’ letters were read faster, it would reflect a procedural learning effect. The results show comparable repetition priming effects in AD patients and in healthy elderly subjects, whereas only healthy subjects showed a procedural learning effect. These results suggest, contrary to previous studies, that the learning of a new perceptual skill may not always be preserved in AD. [less ▲]

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See detailImpaired angiogenesis and tumor development by inhibition of the mitotic kinesin Eg5.
Exertier, Prisca; Javerzat, Sophie; Wang, Baigang et al

in Oncotarget (2013), 4(12), 2302-16

Kinesin motor proteins exert essential cellular functions in all eukaryotes. They control mitosis, migration and intracellular transport through interaction with microtubules. Small molecule inhibitors of ... [more ▼]

Kinesin motor proteins exert essential cellular functions in all eukaryotes. They control mitosis, migration and intracellular transport through interaction with microtubules. Small molecule inhibitors of the mitotic kinesin KiF11/Eg5 are a promising new class of anti-neoplastic agents currently evaluated in clinical cancer trials for solid tumors and hematological malignancies. Here we report induction of Eg5 and four other mitotic kinesins including KIF20A/Mklp2 upon stimulation of in vivo angiogenesis with vascular endothelial growth factor-A (VEGF-A). Expression analyses indicate up-regulation of several kinesin-encoding genes predominantly in lymphoblasts and endothelial cells. Chemical blockade of Eg5 inhibits endothelial cell proliferation and migration in vitro. Mitosis-independent vascular outgrowth in aortic ring cultures is strongly impaired after Eg5 or Mklp2 protein inhibition. In vivo, interfering with KIF11/Eg5 function causes developmental and vascular defects in zebrafish and chick embryos and potent inhibition of tumor angiogenesis in experimental tumor models. Besides blocking tumor cell proliferation, impairing endothelial function is a novel mechanism of action of kinesin inhibitors. [less ▲]

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See detailImpaired automatic and unconscious motor processes in Parkinson's disease
D'Ostilio, Kevin ULg; CREMERS, Julien ULg; DELVAUX, Valérie ULg et al

in Scientific Reports (2013)

While it is increasingly recognized that voluntary movements are produced by an interaction between conscious and unconscious processes, the role of the latter in Parkinson’s disease has received little ... [more ▼]

While it is increasingly recognized that voluntary movements are produced by an interaction between conscious and unconscious processes, the role of the latter in Parkinson’s disease has received little attention to date. Here, we administered a subliminal masked prime task to 15 Parkinson’s disease patients and 15 age-matched healthy elderly subjects. Compatibility effects were examined by manipulating the direction of the arrows and the interstimuli interval. Analysis of the positive compatibility effect revealed performance differences between the most and the least affected hand in Parkinson’s disease patients. Additionally, patients did not show the same tendency toward a negative compatibility effect as compared to elderly controls. These novel findings provide evidence supporting the role of basal ganglia circuits in controlling the balance between automatic motor response facilitation and inhibition. [less ▲]

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See detailImpaired cerebral connectivity in vegetative state
Laureys, Steven ULg; Faymonville, Marie ULg; Goldman, S. et al

in Physiological imaging of the brain with PET (2000)

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See detailImpaired controlled recollection processes in depression and subjective memory complaints
Jermann, Françoise; Adam, Stéphane ULg; Ceschi, Grazia et al

Poster (2001, July 18)

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See detailImpaired diaphragmatic function in the pneumonic calf
Desmecht, Daniel ULg; Linden, Annick ULg; Amory, Hélène ULg et al

in Proceedings of the 10th Comparative Respiratory Society Meeting (1991)

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See detailImpaired effective cortical connectivity in vegetative state : Preliminary investigation using PET
Laureys, Steven ULg; Goldman, Serge; Phillips, Christophe ULg et al

in Neuroimage (1999), 9(4), 377-382

Vegetative state (VS) is a condition of abolished awareness with persistence of arousal. Awareness is part of consciousness, which itself is thought to represent an emergent property of cerebral neural ... [more ▼]

Vegetative state (VS) is a condition of abolished awareness with persistence of arousal. Awareness is part of consciousness, which itself is thought to represent an emergent property of cerebral neural networks. Our hypothesis was that part of the neural correlate underlying VS is an altered connectivity, especially between the associative cortices. We assessed regional cerebral glucose metabolism (rCMRGlu) and effective cortical connectivity in four patients in VS by means of statistical parametric mapping and [F-18]fluorodeoxyglucose-positron emission tomography. Our data showed a common pattern of impaired rCMRGlu in the prefrontal, premotor, and parietotemporal association areas and posterior cingulate cortex/precuneus in VS. In a next step, we demonstrated that in VS patients various prefrontal and premotor areas have in common that they are less tightly connected with the posterior cingulate cortex than in normal controls. These results provide a strong argument for an alteration of cortical connectivity in VS patients. (C) 1999 Academic Press. [less ▲]

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See detailImpaired emotional facial expression in alcoholism compared with obsessive compulsive disorder and normal controls
Kornreich, C; Blairy, Sylvie ULg; Philippot, P et al

in Psychiatry Research (2001), 102

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See detailImpaired emotional facial expression recognition is associated with interpersonal problems in alcoholism
Kornreich, C; Philippot, P; Foisy, ML et al

in Alcohol & Alcoholism (2002), 37(4), 394-400

Detailed reference viewed: 14 (4 ULg)