Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailInsulin-stimulated glucose disposal is not increased in anorexia nervosa.
Castillo, M.; Scheen, André ULg; Lefebvre, Pierre ULg et al

in Journal of Clinical Endocrinology and Metabolism (1985), 60(2), 311-4

Insulin-stimulated glucose disposal was investigated using the euglycemic hyperinsulinemic glucose clamp technique in six women with anorexia nervosa (27.3 +/- 4.9 yr old; weight, 38.8 +/- 6.6 kg) and ... [more ▼]

Insulin-stimulated glucose disposal was investigated using the euglycemic hyperinsulinemic glucose clamp technique in six women with anorexia nervosa (27.3 +/- 4.9 yr old; weight, 38.8 +/- 6.6 kg) and compared to results obtained in six normal women (22.6 +/- 1.2 yr old; weight, 58 +/- 2.5 kg) and seven obese women (26.8 +/- 7.7 yr old; weight, 92.5 +/- 13.8 kg). The glucose clamp was performed for 2 h using the Biostator and a continuous insulin infusion of 100 mU kg-1 h-1. Plasma levels of insulin were determined at 30-min intervals. Plasma levels of glucagon, FFA, glycerol, 3-hydroxy-butyrate, and alanine were measured basally. Blood glucose levels were similar in normal subjects and anorectic patients; they were slightly but significantly higher in the obese patients. The indices of insulin sensitivity measured were the MCR of glucose and the ratio of glucose infused to insulin infused (G/I). They were very similar in anorectic subjects [MCR, 13.5 +/- 2.4 (+/- SEM) ml kg-1 min-1; G/I, 5.2 +/- 0.9 mg/mU) and normal subjects (MCR, 13.5 +/- 1.7 ml kg-1 min-1; G/I, 5.2 +/- 0.4 mg/mU), but were significantly reduced in obese patients (MCR, 5.1 +/- 0.8 ml kg-1 min-1; G/I, 2.6 +/- 0.3 mg/mU; P less than 0.0025). Differences in plasma insulin among the three groups were not statistically significant. Plasma alanine levels were higher in anorectic than in normal or obese subjects, suggesting defective gluconeogenesis. Thus, insulin-stimulated glucose disposal is normal in patients with anorexia nervosa, a finding that contrasts with the previously reported increase in erythrocyte insulin receptors in this disease. [less ▲]

Detailed reference viewed: 19 (0 ULg)
Full Text
Peer Reviewed
See detailInsuline detemir (Levemir) dans l'etude predictive: resultats obtenus chez les patients diabetiques de type 1 de la cohorte belge.
Philips, Jean-Christophe ULg; Scheen, André ULg

in Revue Médicale de Liège (2009), 64(3), 124-30

Insulin detemir (Levemir) is a soluble human insulin analogue acylated with a 14-carbon fatty acid, which reversibly binds to albumin, thereby providing a more prolonged metabolic effect with lower ... [more ▼]

Insulin detemir (Levemir) is a soluble human insulin analogue acylated with a 14-carbon fatty acid, which reversibly binds to albumin, thereby providing a more prolonged metabolic effect with lower variability as compared to NPH insulin taken as reference. Thanks to this pharmacokinetic and pharmacodynamic profile, insulin detemir is essentially used within a basal-bolus regimen. We report the results obtained in 232 type 1 diabetic patients recruited in Belgium in the frame of the international observational, open, prospective PREDICTIVE study. In patients initially treated with either NPH insulin or glargine, followed for 26 weeks, the shift to insulin detemir did not change HbA1c levels, but significantly reduced both the mean and the variability of fasting blood glucose levels while diminishing the risk of hypoglycaemic episodes, especially at night. Therefore, insulin detemir was associated with significantly improved quality of life. These changes were obtained with a slight increase in daily insulin doses but without weight gain. [less ▲]

Detailed reference viewed: 92 (0 ULg)
Full Text
Peer Reviewed
See detailInsuline glargine et cancer: une tempete dans un verre d'eau?
Scheen, André ULg; Lefebvre, Pierre ULg

in Revue Médicale de Liège (2009), 64(9), 440-5

Insulin glargine is widely used as basal insulin in the treatment of type 1 and type 2 diabetes mellitus. However, this insulin analogue has been recently suspected to be associated with an increased risk ... [more ▼]

Insulin glargine is widely used as basal insulin in the treatment of type 1 and type 2 diabetes mellitus. However, this insulin analogue has been recently suspected to be associated with an increased risk of cancer, especially breast cancer, in patients with type 2 diabetes. The present article aims at briefly presenting the state of the art based upon currently available data. We will first summarize the observations reported in recent publications, then we will present a critical analysis of these in fact non-conclusive findings, and finally we will conclude with some practical recommendations. [less ▲]

Detailed reference viewed: 47 (1 ULg)
Full Text
Peer Reviewed
See detailLes insulinosensibilisateurs.
Scheen, André ULg; Paquot, Nicolas ULg

in Revue Médicale de Liège (2005), 60(5-6), 409-13

Insulin resistance has a genetic background and its phenotypic expression is triggered by fat diet, lack of physical activity and obesity. It provokes a stress on B cells, tends to increase blood glucose ... [more ▼]

Insulin resistance has a genetic background and its phenotypic expression is triggered by fat diet, lack of physical activity and obesity. It provokes a stress on B cells, tends to increase blood glucose levels, is intimately associated with the metabolic syndrome and represents a major cardiovascular risk factor. Insulin resistance may be favourably influenced by simple life-style changes. If necessary, drugs may be prescribed, such as metformin, the first choice antidiabetic oral agent in overweight individuals, or thiazolidinediones (glitazones), new insulin sensitizers with promising effects. New molecules are currently developed, especially PPAR alpha/gamma or pan-agonists. Targeting insulin resistance has several objectives: reducing hyperglycaemia in type 2 diabetic patients, protecting B cells in order to prevent type 2 diabetes in at risk individuals and limiting the progressive metabolic deterioration in diabetic patients, finally, and perhaps most importantly, ameliorating the global cardiovascular prognosis. [less ▲]

Detailed reference viewed: 109 (1 ULg)
Full Text
Peer Reviewed
See detailL'insulinotherapie dans le diabete de type 2.
Philips, Jean-Christophe ULg; Scheen, André ULg

in Revue Médicale de Liège (2005), 60(5-6), 419-23

As compared to type 1 diabetes, type 2 diabetes usually requires insulin at a late stage, after secondary failure to oral antidiabetic drugs. However, it should be pointed out that insulin therapy should ... [more ▼]

As compared to type 1 diabetes, type 2 diabetes usually requires insulin at a late stage, after secondary failure to oral antidiabetic drugs. However, it should be pointed out that insulin therapy should not be delayed in patients not well controlled on oral agents. Type 2 diabetic patients failing to oral antidiabetic medications need insulin. Nevertheless, insulin therapy in type 2 diabetic patients is less standardized than in those with type 1 diabetes. Several clinical trials tried to investigate what is the most appropriate initial insulin therapy in type 2 diabetic patients, with the main objectives of reaching almost normoglycaemia without increased risk of frequent or severe hypoglycaemic episodes. However, there is no agreement upon optimal mode of initiating insulin. The most important factors leading to adequate metabolic control are a global educational approach together with a intensified follow up, independently of the insulin regimen. [less ▲]

Detailed reference viewed: 195 (0 ULg)
Full Text
Peer Reviewed
See detailL'insulinotherapie par pompe externe a perfusion continue d'insuline.
Radermecker, Régis ULg; Hermans, M. P.; Legrand, Delphine ULg et al

in Revue Médicale de Liège (2005), 60(5-6), 329-34

Type I diabetes mellitus requires an exogenous supply of insulin that ideally mimics physiological insulin secretion. The treatment goal is to achieve normoglycaemia in order to prevent or delay chronic ... [more ▼]

Type I diabetes mellitus requires an exogenous supply of insulin that ideally mimics physiological insulin secretion. The treatment goal is to achieve normoglycaemia in order to prevent or delay chronic complications, while limiting the risk of hypoglycaemia. Numerous advances have been performed in the last 10 years, as far as nature of insulin formulations, home blood glucose monitoring devices and modes of insulin delivery. Among the latter, continuous subcutaneous insulin infusion (CSII) using portable pumps represents the most sophisticated treatment capable of best mimicking normal insulin secretion. Such treatment provides better glucose control and glucose stability as compared to conventional multiple injection insulin therapy. However, it is essential to respect well defined indications and to organize a structured management by a multidisciplinary team in order to get the best metabolic results. The present paper describes recommendations, advantages and limits as well as cost of CSII with portable pumps in type 1 diabetic patients. [less ▲]

Detailed reference viewed: 127 (6 ULg)
Full Text
Peer Reviewed
See detailInsulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.
Malaisse, W. J.; Nadi, A. B.; Malaisse-Lagae, F. et al

in General Pharmacology (1995), 26(6), 1319-25

1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial ... [more ▼]

1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells. [less ▲]

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailL’insulte « socialement correcte » ?
Meunier, Deborah ULg

Conference (2008)

Detailed reference viewed: 14 (0 ULg)
See detailLes insultes de la cour de récréation
Meunier, Deborah ULg

Conference (2007, January 12)

Detailed reference viewed: 14 (1 ULg)
Full Text
Peer Reviewed
See detailIntact cross-talk between insulin secretion and insulin action after postgastroplasty recovery of ideal body weight in severely obese patients.
Letiexhe, Michel ULg; Desaive, Claude ULg; Lefebvre, Pierre ULg et al

in International Journal of Obesity & Related Metabolic Disorders (2004), 28(6), 821-3

Most reports investigating the hormonal and metabolic effects of bariatric surgery studied obese subjects after partial weight loss only. Nevertheless, all studies showed significant improvements of ... [more ▼]

Most reports investigating the hormonal and metabolic effects of bariatric surgery studied obese subjects after partial weight loss only. Nevertheless, all studies showed significant improvements of insulin secretion, action, clearance and inhibition of its own secretion, although the parallel kinetics of all these changes remained questionable. Using the intravenous glucose tolerance test, we demonstrated a full normalization of insulin secretion, action on glucose metabolism and clearance in eight obese women who recovered and maintained ideal body weight following gastroplasty. Reciprocal changes were observed between postglucose acute insulin secretion and insulin-mediated glucose disposal so that the so-called disposition index (product of these two variables) remained unchanged after vs before gastroplasty in those individuals with normal glucose tolerance. These favourable results should encourage obtaining a drastic and sustained weight loss in patients with severe obesity at risk of developing type II diabetes. [less ▲]

Detailed reference viewed: 21 (2 ULg)
Peer Reviewed
See detailIntact Implicit learning in Schizophrenia
Danion, Jean-Marie; Meulemans, Thierry ULg; Kauffmann-Muller, F. et al

in American Journal of Psychiatry (The) (2001), 158(6), 944-948

Detailed reference viewed: 18 (1 ULg)
Full Text
Peer Reviewed
See detailIntact procedural motor sequence learning in developmental coordination disorder
Lejeune, Caroline ULg; Catale, Corinne ULg; Willems, Sylvie ULg et al

in Research in Developmental Disabilities (2013), 34(6), 1974-1981

The purpose of the present study was to explore the possibility of a procedural learning deficit among children with developmental coordination disorder (DCD). We tested 34 children aged 6–12 years with ... [more ▼]

The purpose of the present study was to explore the possibility of a procedural learning deficit among children with developmental coordination disorder (DCD). We tested 34 children aged 6–12 years with and without DCD using the serial reaction time task, in which the standard keyboard was replaced by a touch screen in order to minimize the impact of perceptuomotor coordination difficulties that characterize this disorder. The results showed that children with DCD succeed as well as control children at the procedural sequence learning task. These findings challenge the hypothesis that a procedural learning impairment underlies the difficulties of DCD children in acquiring and automatizing daily activities. We suggest that the previously reported impairment of children with DCD on the serial reaction time task is not due to a sequence learning deficit per se, but rather due to methodological factors such as the response mode used in these studies. [less ▲]

Detailed reference viewed: 63 (21 ULg)
Peer Reviewed
See detailIntact transferrin receptors in human plasma and their relation to erythropoiesis.
Huebers, H. A.; Beguin, Yves ULg; Pootrakul, P. et al

in Blood (1990), 75(1), 102-7

Intact transferrin receptor molecules complexed with transferrin were found in human plasma. The concentration of receptors was determined by an enzyme-linked immunosorbent assay that uses polyclonal ... [more ▼]

Intact transferrin receptor molecules complexed with transferrin were found in human plasma. The concentration of receptors was determined by an enzyme-linked immunosorbent assay that uses polyclonal antibodies. The mean concentration of 8,279 micrograms/L in 56 normal adults appears to be unrelated to age or sex. Additional receptor measurements were performed on plasmas from 260 subjects with erythropoietic disorders. Decreased concentration of plasma receptors was found in patients with erythroid hypoplasia and increased numbers in those with erythroid hyperplasia. Ferrokinetic measurements of erythropoiesis were compared with numbers of receptors in 148 subjects, and a close correlation was found (r = .86). Both sets of values, measured in different conditions and expressed in relation to normal, were consistent with expected values. Receptor values were unproportionally increased only in conditions of iron deficiency. It is concluded that plasma receptors have a constant relationship to tissue receptors, and their number in most instances reflects the rate of erythropoiesis. [less ▲]

Detailed reference viewed: 12 (2 ULg)
Full Text
Peer Reviewed
See detailINTAKE OF DIOXINS AND DIOXIN-LIKE PCBs CONSUMING HOME PRODUCED VERSUS COMMERCIAL EGGS
Sioen, Isabelle; Bilau, Maaike; Van Overmeire, Ilse et al

in Organohalogen Compounds (2008)

Detailed reference viewed: 36 (1 ULg)
See detail«Intavulare». Tables de chansonniers romans. II: Chansonniers français.
Moreno, Paola ULg

Book published by Bibliothèque de la Faculté de Philosophie et Lettres (1999)

Detailed reference viewed: 16 (2 ULg)
Full Text
Peer Reviewed
See detailAn Integer Programming model for air transport of hazardous and special shipments
Kleyntssens, Thomas ULg; Limbourg, Sabine ULg; Schyns, Michael ULg

Conference (2012, February 02)

The aircraft loading problem is a real-world combinatorial optimisation problem highly constrained. This weight must be distributed to keep the centre of gravity within speci ed limits. Moreover, an ... [more ▼]

The aircraft loading problem is a real-world combinatorial optimisation problem highly constrained. This weight must be distributed to keep the centre of gravity within speci ed limits. Moreover, an aircraft has usually several cargo compart- ments with speci c contours and structural limitations such as oor loading, com- bined load limits and cumulative load limitations. Finally, some shipments are par- ticularly restrictive to transport, like dangerous goods, live animals and perishable goods. This paper is concerned with the incorporation of these latter constraints in a mixed integer linear program for the problem of loading a set of Unit Load- ing Devices and bulk into an aircraft. Experimental results show that our method achieves optimal solutions within only few seconds. [less ▲]

Detailed reference viewed: 87 (29 ULg)
Full Text
Peer Reviewed
See detailIntegracion Numerica del Problema Viscoplastico
Andia Fages, Susana; Raichman, Silvia; Mirasso, Anibal et al

(2009)

En este trabajo se discute la integración numérica para el modelo viscoplástico de Perzyna, que conduce a una ecuación de consistencia viscoplástica no lineal, de acuerdo a un trabajo previo de Ponthot ... [more ▼]

En este trabajo se discute la integración numérica para el modelo viscoplástico de Perzyna, que conduce a una ecuación de consistencia viscoplástica no lineal, de acuerdo a un trabajo previo de Ponthot. Esta ecuación no lineal se resuelve mediante elMétodo de Newton Raphson y el algoritmo resultante se implementa en MATLAB. Los resultados obtenidos con el programa desarrollado ajustan muy bien con soluciones cerradas disponibles en la literatura para algunos casos particulares. En este trabajo además se propone una solución cerrada para el caso de sensitividad viscosa lineal (m=1) y exponente de endurecimiento viscoplástico lineal (n=1). Se estudia además la respuesta del algoritmo frente a la variación de diferentes parámetros como el coeficiente de viscosidad. El código obtenido en una etapa posterior del estudio se podrá utilizar para resolver otros problemas de interés y, además, permitirá su implmentación en un código de elementos finitos con capacidades no lineales. [less ▲]

Detailed reference viewed: 30 (2 ULg)
Full Text
See detailIntegral and derivative dispersion relations in the analysis of the data on p p and anti-p p forward scattering
Cudell, Jean-René ULg; Martynov, E.; Selyugin, Oleg V

in Ukrainian Journal of Physics (2003), 48(Nos. 11- 12, 2003),

Detailed reference viewed: 7 (0 ULg)