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See detailEvidence of food quality limitation in benthic river insects
Darchambeau, François ULg; Glémet, Hélène; Bélanger, Tommy et al

Conference (2007, July 12)

Detailed reference viewed: 8 (2 ULg)
See detailEvidence of food quality limitation in benthic river insects
Darchambeau, François ULg; Glémet, Hélène; Bélanger, Tommy et al

Conference (2007, August 16)

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See detailEvidence of health benefits of of polyphenols enriched foods : from In Vitro studies to clinical trials performed at university - CHU of Liège, Belgium
PINCEMAIL, Joël ULg; Kevers, Claire ULg; Tabart, Jessica ULg et al

in University of Ferrara (Ed.) Second Internaional conference on environmental stressors in biology and medicine (2011, October)

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See detailEvidence of HLA-mediated immune response driving the maintenance of CTL-escape variants in patients with undetectable viral load
Dilernia, D.; Lourtau, L.; Jones, L.R. et al

in AIDS Research and Human Retroviruses (2008, October 13), 4(1), 79

Evidence of HLA-mediated immune response driving the maintenance of CTL-escape variants in patients with undetectable viral load. Dario A Dilernia, L Lourtau, L Jones, S Rodriguez, C Bautista, M Gomez ... [more ▼]

Evidence of HLA-mediated immune response driving the maintenance of CTL-escape variants in patients with undetectable viral load. Dario A Dilernia, L Lourtau, L Jones, S Rodriguez, C Bautista, M Gomez-Carrillo, M Losso, and H Salomon. Immune response drives the selection of CTL-escape mutations during the course of HIV infection. After initiation of HAART, antiviral drugs exert a stronger selective force leading to a higher limitation of viral replication. Our objective was to evaluate the effectiveness of immune response as a selective force in a context of extremely reduced viral population size. Gag gene was sequenced and HLA-A and B genotyped over 108 samples from drug-naïve HIV-1 positive individuals. Associations between HLA alleles and viral polymorphisms were assessed by logistic regression. Multiple comparison corrections were addressed by the BH method (q-values). Phylogeny correction was performed by a Bayesian Markov-Chain Monte-Carlo method. Analysis of site-specific synonymous and non-synonymous substitution rate was assessed through the codon-based ML IFEL method. For four patients with viral load < 50 copies/ml (identified according to their HLA profile), RNA extraction was performed from 7 ml of plasma through an ultracentrifugation-based method and gag gene amplified through a Hi-Fi PCR. 20-40 clones were sequenced in samples obtained previously and during HAART. We found that HLA-B57 and A03 were the most efficient alleles in forcing CTL-escape, targeting mainly the previously characterized epitopes TSTLQEQIGW(p=0.0002) and RLRPGGKKK(p<10E-7), respectively. Sites under significant positive selection (p<0.05) during HAART were position 20 (within A03-restricted RLRPGGKK) for patient A02A3B35B39, position 385 (within A3-restricted RGNFRNQRK) for patient A3A31B7B45 and position 84 (within A2-restricted SLYNTVATL) for patient A2A3B39B57. Epitopes sequences of RLRPGGKKK and TSTLQEQIGWF were in the escape state for patients harboring the selective alleles. In spite of the low viral diversity achieved during HAART, we detected sites under positive selection. Our results show that during successful HAART, targeted CTL-epitopes are still forced to evolve adaptively, suggesting that CTL-mediated immune response would be able to keep driving the evolution of HIV variants even in viral population with a remarkable low replication rate. [less ▲]

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See detailEvidence of involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair
Johnson, Robert; Kovvali, G.; Guzder, Sami et al

in Journal of Biological Chemistry (1996), 271(45), 27897-90

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See detailEvidence of magnetic field decay in massive main-sequence stars
Fossati, L.; Schneider, F. R. N.; Castro, N. et al

in Astronomy and Astrophysics (2016), 592

A significant fraction of massive main-sequence stars show strong, large-scale magnetic fields. The origin of these fields, their lifetimes, and their role in shaping the characteristics and evolution of ... [more ▼]

A significant fraction of massive main-sequence stars show strong, large-scale magnetic fields. The origin of these fields, their lifetimes, and their role in shaping the characteristics and evolution of massive stars are currently not well understood. We compile a catalogue of 389 massive main-sequence stars, 61 of which are magnetic, and derive their fundamental parameters and ages. The two samples contain stars brighter than magnitude 9 in the V-band and range in mass between 5 and 100 M[SUB]⊙[/SUB]. We find that the fractional main-sequence age distribution of all considered stars follows what is expected for a magnitude limited sample, while that of magnetic stars shows a clear decrease towards the end of the main sequence. This dearth of old magnetic stars is independent of the choice of adopted stellar evolution tracks, and appears to become more prominent when considering only the most massive stars. We show that the decreasing trend in the distribution is significantly stronger than expected from magnetic flux conservation. We also find that binary rejuvenation and magnetic suppression of core convection are unlikely to be responsible for the observed lack of older magnetic massive stars, and conclude that its most probable cause is the decay of the magnetic field, over a time span longer than the stellar lifetime for the lowest considered masses, and shorter for the highest masses. We then investigate the spin-down ages of the slowly rotating magnetic massive stars and find them to exceed the stellar ages by far in many cases. The high fraction of very slowly rotating magnetic stars thus provides an independent argument for a decay of the magnetic fields. [less ▲]

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See detailEvidence of marine food chains by means of stable natural carbon isotopes
Dauby, Patrick ULg; Mosora, Florentina

Conference (1987, September)

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See detailEvidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease
Louis, Renaud ULg; Cataldo, Didier ULg; Buckley, M. G. et al

in European Respiratory Journal (2002), 20(2), 325-331

Although asthma has been viewed mainly, as an eosinophilic disease, and chronic obstructive pulmonary disease (COPD) as a neutrophilic disease, recent studies have shown increased neutrophil counts in ... [more ▼]

Although asthma has been viewed mainly, as an eosinophilic disease, and chronic obstructive pulmonary disease (COPD) as a neutrophilic disease, recent studies have shown increased neutrophil counts in severe asthma and sputum eosinophilia in sonic COPD patients. In an attempt to further characterise these two syndromes according to pathology, the current authors have conducted a study of induced sputum in 15 subjects with COPD, 17 asthmatics, and 17 nonatopic healthy individuals. Sputum was analysed for cytology and levels of eosinophil cationic protein (ECP), albumin, tryptase and soluble intercellular adhesion molecule-1. The COPD subjects differed from the asthmatics as they had higher sputum neutrophil and lower columnar epithelial cell counts, but there were no differences in any soluble marker studied. When compared to control subjects, both the asthmatic and COPD subjects had raised eosinophil counts and ECP levels. In a subset of COPD subjects with Sputum eosinophilia (>3% of total cells), significantly increased levels of tryptase were detected. In conclusion, although chronic obstructive pulmonary disease is a more neutrophilic disease than asthma, the two diseases are difficult to distinguish on the basis of sputum levels of the soluble markers traditionally associated with asthma. However, a subset of patients with chronic obstructive pulmonary disease with airway eosinophilia and mast-cell activation might represent a distinct pathological phenotype. [less ▲]

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See detailEvidence of microbial sulfate reduction in nanopyrites enclosed in 2.7 billions year old stromatolitic organic remains
Marin-Carbonne, Johanna; Remusat, Laurent; Sforna, Marie-Catherine ULg et al

Conference (2015)

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See detailEvidence of nutriceutical effectiveness in the treatment of osteoarthritis
Reginster, Jean-Yves ULg; Gillot, Vincent; Bruyère, Olivier ULg et al

in Current Rheumatology Reports (2000), 2(6), 472-477

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See detailEvidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury
Quoilin, Caroline ULg; Mouithys-Mickalad, Ange ULg; Lécart, Sandrine et al

in Biochimica et Biophysica Acta-Bioenergetics (2014), 1837(10), 1790-1800

To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model using proximal ... [more ▼]

To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model using proximal tubular epithelial cells exposed to a bacterial endotoxin (lipopolysaccharide, LPS). This investigation has provided key features on the relationship between oxidative stress and mitochondrial respiratory chain activity defects. LPS treatment resulted in an increase in the expression of inducible nitric oxide synthase (iNOS) and NADPH oxidase 4 (NOX-4), suggesting the cytosolic overexpression of nitric oxide and superoxide anion, the primary reactive nitrogen species (RNS) and reactive oxygen species (ROS). This oxidant state seemed to interrupt mitochondrial oxidative phosphorylation by reducing cytochrome c oxidase activity. As a consequence, disruptions in the electron transport and the proton pumping across the mitochondrial inner membrane occurred, leading to a decrease of the mitochondrial membrane potential, a release of apoptotic-inducing factors and a depletion of adenosine triphosphate. Interestingly, after being targeted by RNS and ROS, mitochondria became in turn producer of ROS, thus contributing to increase the mitochondrial dysfunction. The role of oxidants in mitochondrial dysfunction was further confirmed by the use of iNOS inhibitors or antioxidants that preserve cytochrome c oxidase activity and prevent mitochondrial membrane potential dissipation. These results suggest that sepsis-induced AKI should not only be regarded as failure of energy status but also as an integrated response, including transcriptional events, ROS signaling, mitochondrial activity and metabolic orientation such as apoptosis. [less ▲]

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See detailEvidence of pre-prosomatostatin mRNA in human normal and tumoral anterior pituitary gland
Pagesy, P.; Li, J. Y.; Rentier-Delrue, Françoise ULg et al

in Molecular Endocrinology (1989), 3(8), 1289-94

Expression of the SRIH gene was investigated in six human normal anterior pituitaries, six GH-, three PRL-, three mixed GH/PRL-secreting and four nonsecreting adenomas. Total cellular RNA and poly(A ... [more ▼]

Expression of the SRIH gene was investigated in six human normal anterior pituitaries, six GH-, three PRL-, three mixed GH/PRL-secreting and four nonsecreting adenomas. Total cellular RNA and poly(A+) mRNAs were analyzed by dot and Northern blot hybridization to a 3'-end labeled oligonucleotide probe specific for the human pre-proSRIH mRNA. A weak but detectable pre-proSRIH hybridization signal was present in human normal anterior pituitaries and in the four groups of adenomas. The size of this pre-proSRIH mRNA was indistinguishable from that found in our hypothalamic samples and close to that described in the literature. The wide variation of the signal intensity from one case to the other in each group of the different types of normal and tumoral antehypophyseal samples prevented establishment of any correlation between the level of pre-proSRIH mRNA and the nature of the pituitary tissue. The presence of SRIH mRNA in human normal and tumoral anterior pituitary tissues provides a sound basis to substantiate the hypothesis of a SRIH biosynthesis in the human anterior pituitary gland. [less ▲]

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See detailEvidence of Predation and possible competition among three semi aquatic species, the endangered Pyrenean desman (Galemys pyrenaicus), the aquatic shrew (Neomys fodiens) and the European otter (Lutra lutra) using next-generation sequencing methods from faeces
Gillet, François; Mouton, Alice ULg; Vanutryve, Sophie et al

Poster (2016, May)

The Pyrenean desman (Galemys pyrenaicus) is a small-endangered semi-aquatic mammal endemic to the Pyrenean Mountains and to the northern half of the Iberian Peninsula whose ecology and biology are still ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is a small-endangered semi-aquatic mammal endemic to the Pyrenean Mountains and to the northern half of the Iberian Peninsula whose ecology and biology are still poorly known. Its ecological relationships with other semi aquatic mammals like the aquatic shrew (Neomys fodiens) or the European otter (Lutra lutra) are also unknown. The aim of this study was to analyse Pyrenean desman, aquatic shrew and European otter faeces from the same French Pyrenean regions, in order to analyze their respective diets and to detect possible predation or competition patterns among them. To study precisely their diet, we used next-generation sequencing methods (Ion Torrent or Ilumina miseq technologies). We amplified and sequenced a small DNA minibarcode (133bp) of the COI gene in 445 faeces samples from the three species. In the Pyrenean desman faeces, we were able to identify a large set of prey species with a positive match (more than 98% of identity with a reference sequence). These species belonged to four orders and eleven families among which Trichoptera and Hydropsychidae were the most frequent, respectively. The aquatic shrew diet evidenced similar aquatic preys as compared to the Pyrenean Desman. However, it also evidenced an important part of terrestrial invertebrates like woodlouse, ants, coleopters or myriapods. The otter diet was mainly constituted of fishes (eg. Cyprinidae, Salmonidae). However, several faeces samples evidenced Pyrenean Desman DNA, strongly suggesting that otter predate Pyrenean Desman in the studied areas. Future studies will be developed on a better sampling from these three species, in order to gain a better knowledge of their local diets and their ecological relationships. Such information is of great importance to propose the best management measures for the conservation of these protected species. [less ▲]

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See detailEvidence of rainbow trout prolactin interaction with its receptor through unstable homodimerisation.
Le Rouzic, Philippe; Sandra, Olivier; Grosclaude, Jeanne et al

in Molecular & Cellular Endocrinology (2001), 172(1-2), 105-13

This study aims to characterise Prolactin receptor (PRLR) in rainbow trout for which no information is available despite the availability of Salmonid PRL preparations. By screening a freshwater rainbow ... [more ▼]

This study aims to characterise Prolactin receptor (PRLR) in rainbow trout for which no information is available despite the availability of Salmonid PRL preparations. By screening a freshwater rainbow trout intestine cDNA library with a probe corresponding to the extracellular domain (ECD) of tilapia PRLR, we have cloned a 2.5 kb insert coding for the PRLR. The mature protein of 614 amino acid residues is similar to PRLR isolated in tilapia and also the long form of mammalian PRLR. Analysis of PRLR gene expression in osmoregulatory organs revealed the presence of a unique transcript, thus confirming the involvement of this hormone in the control of osmoregulation in this fish species. By using surface plasmon resonance (SPR) technology, kinetic measurement of interaction between trout PRL and its receptor ECD was studied. This approach allowed us to demonstrate the formation of a transient, unstable homodimeric complex. This unstability could explain the inability to perform binding experiments using homologous PRL. In contrast, heterologous lactogenic ligands were able to interact through a more stable complex. Whether these characteristics of PRL-receptor interaction in rainbow trout are different to what occurs in tilapia where a homologous radioreceptor assay was developed would require further studies. [less ▲]

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See detailEvidence of the Image. A few Suggestions for a Cultural History of Photography
Havelange, Carl ULg

in WIMBÖCK, Gabriele; LEONHARD, Karin; FRIEDRICH, Markus (Eds.) Evidentia. Reichweiten visueller Wahrnehmung in der Frühen Neuzeit (2007)

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See detailEvidence of the impact of visuo-spatial processing on magnitude representation in 22q11.2 microdeletion syndrome.
Attout, Lucie ULg; Noël, Marie-Pascale; Vossius, Line ULg et al

in Neuropsychologia (2017), 99

Detailed reference viewed: 27 (4 ULg)
See detailEvidence of upward filed-aligned currents at the open-closed field line boundary in Saturn's noon magnetosphere: observations and theory
Bunce, E. J.; Cowley, S. W. H.; Talboys, D. L. et al

Conference (2007, June 26)

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See detailEvidence of West European defined miospore zones in the Uppermost Devonian and Lower Carboniferous of the Amazonas Basin (Brazil).
Loboziak, S; Streel, Maurice ULg; Caputo, M.V. et al

in Geobios (1991), 24(1), 5-11

Detailed reference viewed: 11 (3 ULg)
See detailEvidence of wind-induced temperature anomalies in the tropical and subtropical North Atlantic Ocean in winter-spring 2010
Troupin, Charles ULg; Machín, Francis

Poster (2011, April)

During the first months of 2010, the tropical and subtropical North Atlantic displayed anomalously high temperatures, with values seldom observed during the last decades. In situ and remote sensing data ... [more ▼]

During the first months of 2010, the tropical and subtropical North Atlantic displayed anomalously high temperatures, with values seldom observed during the last decades. In situ and remote sensing data are used to evaluate horizontal, vertical and temporal extensions of the anomalies. The repercussions on the seasonal evolution of the mixed layer are examined; in particular, it is shown that the northwest Africa coastal upwelling is significantly weakened in comparison to previous years. The consequences on the biological variables are examined by means of satellite-derived measurements. A simple mechanism related to changes in wind intensity is proposed in order to explain our observations. The wind weakening coincides with a strongly negative value of the North Atlantic Oscillation index. [less ▲]

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