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Peer Reviewed
See detailImmunological detection of beta-galactosidase-expressing cells by flow cytometry
Vanderplasschen, Alain ULg; Goltz, M.; Hanon, E.

in Biochemica (1994), 3

Detailed reference viewed: 9 (0 ULg)
See detailImmunological discrimination between self and non self
Defaweux, Valérie ULg; Heinen, Ernst ULg

in Encyclopedia of Life Sciences (2010)

Detailed reference viewed: 43 (16 ULg)
Peer Reviewed
See detailImmunological effect of a synthetic growth hormone peptide on IGF-I and IGFBPs in growing pigs
Renaville, Robert ULg; Bertozzi, Carlo; Carelli, Claude et al

in 4th Intern. Symp. Insulin-like Growth Factors (1997)

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailAN IMMUNOLOGICAL METHOD TO COMBINE THE MEASUREMENT OF ACTIVE AND TOTAL HUMAN MYELOPEROXIDASE ON THE SAME SAMPLE FROM A COMPLEX MEDIUM
Franck, Thierry ULg; MINGUET, Grégory ULg; Mossay, Pierre et al

Conference (2013, September 12)

Active neutrophil myeloperoxidase (MPO) is a powerful producer of oxidant molecules in acute or chronic inflammation, and it is essential to measure its activity in biological samples. We combined two ... [more ▼]

Active neutrophil myeloperoxidase (MPO) is a powerful producer of oxidant molecules in acute or chronic inflammation, and it is essential to measure its activity in biological samples. We combined two immunological techniques, the SIEFED (specific immunologic extraction followed by enzymatic detection) and an ELISA, to measure the active and total contents of human MPO on the same sample and with the same calibration curve, to define an accurate ratio between the active and total enzyme. After the extraction of MPO from aqueous or biological samples by immobilized anti-MPO antibodies followed by a washing to eliminate unbound material, the active and the total contents of the enzyme were sequentially measured without interferences (patent: EP2017351-B1, 2010). Compared to a classical sandwich ELISA, there is one additional step corresponding to the in situ measurement of MPO activity, but this step does not affect the following measurement of the total MPO content. After validation, the combined technique was applied to a whole blood model of in vitro stimulation with phorbol-myristate-acetate (PMA), cytochalasin B/N-formyl-methionyl-leucyl-phenyl-alanine (CB/fMLP) or lipopolysaccharide/ tumor necrosis factor-alpha (LPS/TNF-α) (n=9). The active/total MPO ratio in whole blood reached 0.267±0.126 for non-stimulated condition and was significantly (p<0.05) higher for PMA (0.360±0.106), CB/fMLP (0.380±0.113) and LPS/TNF-α (0.432±0.124) stimulated conditions. These different ratios highlight the real oxidant potential of MPO, which depends on the stimulating conditions, witness of what could happen in pathological situations with diagnostic purpose. The combined SIEFED/ELISA method also appeared as a powerful tool to screen potential inhibitors that could interact directly with the enzyme, either on its active site or on another key position. [less ▲]

Detailed reference viewed: 70 (10 ULg)
See detailImmunological principles relevant for immune-mediated inflammatory diseases and pregnancy
Geenen, Vincent ULg

Scientific conference (2010, November 23)

Detailed reference viewed: 2 (0 ULg)
Peer Reviewed
See detailImmunological reactivity of the Bovine Leukemia Virus glycoprotein gp51.
Portetelle, Daniel ULg; Bruck, Claudine; Cleuter, Yvette et al

in Straub O.C. (Ed.) Current Topics in Veterinary Medicine and Animal Science (1982)

Detailed reference viewed: 2 (0 ULg)
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See detailImmunological Status of Competitive Football Players During the Training Season
Bury, Thierry ULg; Marechal, R.; Mahieu, P. et al

in International Journal of Sports Medicine (1998), 19(5), 364-8

We investigated possible immunological changes in 15 professional football players before, during and after the sports season. We studied the leucocyte count as well as different functions such as T ... [more ▼]

We investigated possible immunological changes in 15 professional football players before, during and after the sports season. We studied the leucocyte count as well as different functions such as T-lymphocyte proliferation, NK activity, chemotaxis and phagocytosis of neutrophils. Training and competitions did not produce any change in the total number of leucocytes but increased neutrophil counts and decreased T4 lymphocyte counts. We also observed a slight decrease of T-lymphocyte proliferation and a significant decrease of neutrophil functions. On the other hand, training and competitions did not induce significant changes in the number of NK cells nor in the total NK cytotoxic activity. The different change observed tended to normalize after the sports season. Our results suggest a predominant neutrophil function depression in football players during a training season which could partly explain the susceptibility of elite athletes to infections. [less ▲]

Detailed reference viewed: 2 (0 ULg)
Peer Reviewed
See detailImmunological Techniques in Insect Biology (L.I. Gilbert & T.A. Miler, eds.)
Rentier, Bernard ULg

in Biochemical Systematics & Ecology (1989), 17(6), 501-502

Detailed reference viewed: 25 (0 ULg)
See detailImmunologie clinique
Heinen, Ernst ULg

Book published by De Boeck (1993)

Detailed reference viewed: 10 (3 ULg)
See detailImmunology in animal production.
Renaville, Bénédicte; Renaville, Robert ULg

in Rosati, A.; Tewolde, A.; Mosconi, C. (Eds.) Advances in animal science (2007)

Detailed reference viewed: 27 (4 ULg)
Full Text
Peer Reviewed
See detailImmunology in the clinic review series. Focus on type 1 diabetes and virus: enterovirus, thymus and type 1 diabetes pathogenesis
Jaïdane, H.; Sane, F.; Hiar, R. et al

in Clinical & Experimental Immunology (2012), 168

Thymus dysfunction, especially immune suppression, is frequently associated with various virus infections.Whether viruses may disturb the thymus function and play a role in the pathogenesis of autoimmune ... [more ▼]

Thymus dysfunction, especially immune suppression, is frequently associated with various virus infections.Whether viruses may disturb the thymus function and play a role in the pathogenesis of autoimmune diseases is an open issue. Enteroviruses, especially Coxsackievirus B4 (CV-B4), have been largely suggested as potential inducers or aggravating factors of type 1 diabetes (T1D) pathogenesis in genetically predisposed individuals. Several pathogenic mechanisms of enterovirus-induced T1D have been suggested. One of these mechanisms is the impairment of central self-tolerance due to viral infections. Coxsackievirus-B4 is able to infect murine thymus in vitro and in vivo and to infect human thymus in vitro. Thymic epithelial cells and thymocytes are targets of infection with this virus, and several abnormalities, especially disturbance of maturation/differentiation processes, were observed.Altogether, these data suggest that CV-B infection of thymus may be involved in the pathogenesis of T1D. Further investigations are needed to explore this hypothesis. [less ▲]

Detailed reference viewed: 37 (4 ULg)
Peer Reviewed
See detailImmunology of dermatophytosis
Mignon, Bernard ULg; Vermout, S.; Tabart, J. et al

Conference (2004)

Detailed reference viewed: 22 (5 ULg)
Full Text
See detailThe Immunomodulating Peptide Thymosin Alpha 1 Has no Effect on Multiple Myeloma Evolution and on Immune Reconstitution
Binsfeld, Marilène ULg; Otjacques, Eléonore ULg; Hannon, Muriel ULg et al

in Belgian Journal of Hematology (2013), Abstracts book(Supplement of 28th General Meeting of the Belgian Hematological Society), 41

Detailed reference viewed: 25 (15 ULg)
See detailImmunomodulation de la croissance: nouvelles perspectives
Portetelle, Daniel ULg; Massart, Serge; Burny, Arsène et al

in 1° Carrefour des Productions Animales (1995)

Detailed reference viewed: 2 (1 ULg)
See detailImmunomodulation of varicella-zoster virus antigens
Marc, Ph.; Sadzot-Delvaux, Catherine ULg; Merville-Louis, M. P. et al

Poster (1989)

Detailed reference viewed: 11 (2 ULg)
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Peer Reviewed
See detailImmunomodulatory effects of probiotics in the intestinal tract.
Delcenserie, Véronique ULg; Martel, D.; Lamoureux, M. et al

in Current Issues in Molecular Biology (2008), 10(1-2), 37-54

The intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. The interaction between probiotic and enterocytes is the ... [more ▼]

The intestinal microbiota is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human health. The interaction between probiotic and enterocytes is the initiating event in immunomodulation and merits particular attention. The effects of probiotic is strain dependent and for each new probiotic strain, profiles of cytokines secreted by lymphocytes, enterocytes or dendritic cells that come in contact with the strain should be systematically established. To evaluate the effects of probiotics on the immune system, models that mimic the mucosa, and thus the physiological reality, should be preferred whenever it is possible. Then, the in vitro observed effects should be backed up by properly conducted randomized double bind clinical studies. More detailed studies are needed to determine the precise action mode of probiotics on both mucosal and systemic immunity. [less ▲]

Detailed reference viewed: 25 (5 ULg)