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Peer Reviewed
See detailIdentification of micrometastasis of breast carcinomas by presence of basement membrane collagen.
Liotta, L. A.; Foidart, Jean-Michel ULg; Gehron Robey, P. et al

in Lancet (1979), 2(8134), 146-7

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See detailIdentification Of Mitochondrial Plasmid Like Dnas In Picea Abies (L.) Karst.
Chandelier, A.; Du Jardin, Patrick ULg; Avril, C. et al

in Plant Cell Reports (1999), 18(10),

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See detailIdentification of multi-degree of freedom non-linear systems using an extended modal space model
Platten, Michael F; Wright, Jan Robert; Dimitriadis, Grigorios ULg et al

in Mechanical Systems & Signal Processing (2009), 23(1), 8-29

The identification of non-linear dynamic systems is an increasingly important area of research, with potential application in many industries. Current non-linear identification methodologies are, in ... [more ▼]

The identification of non-linear dynamic systems is an increasingly important area of research, with potential application in many industries. Current non-linear identification methodologies are, in general, mostly suited to small systems with few degrees of freedom and few non-linearities. In order to develop a practical identification approach for real engineering structures, the capability of such methods must be significantly extended. In this paper, it is shown that such an extension can be achieved using multi-exciter techniques in order to excited specific modes or degrees of freedom of the system under investigation. A novel identification method for large non-linear systems is presented, based on the use of a multi-exciter arrangement using appropriated excitation applied in bursts. This proposed Non-linear Resonant Decay Method is applied to a simulated system with 5 degrees of freedom and an experimental clamped panel structure. The technique is essentially a derivative of the Restoring Force Surface method and involves a non-linear curve fit performed in modal space. The effectiveness of the resulting reduced order model in representing the non-linear characteristics of the system is demonstrated. The potential of the approach for the identification of large continuous non-linear systems is also discussed. [less ▲]

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See detailIdentification of multiple pregnancy-associated glycoproteins (PAGs) purified from the European bison (Eb; Bison bonasus L.) placentas.
Kiewisz, J.; Melo de Sousa, Noelita ULg; Beckers, Jean-François ULg et al

in Animal Reproduction Science (2008), 112

This paper describes the first identified chorionic PAGs in the European bison (Eb), named EbPAGs, predominantly expressed during early and mid-pregnancy (45-120 day post-coitum; dpc). Many EbPAGs were ... [more ▼]

This paper describes the first identified chorionic PAGs in the European bison (Eb), named EbPAGs, predominantly expressed during early and mid-pregnancy (45-120 day post-coitum; dpc). Many EbPAGs were extracted from various cotyledonary tissues, precipitated, chromatographed (DEAE and VVA: Vicia villosa agglutinin), electrophoresed (1D- and 2D-PAGE), analysed by heterologous (cross-species) Western blotting and then micro-sequenced by Edman degradation. Finally, twelve selected VVA-purified isoforms (Ip 3.7-7.4) were entirely characterised. Nine identified NH(2)-terminal micro-sequences were found to be PAGs. On 45dpc, three identified forms were named: EbPAG(67AkDa) (RGSNLTHPLRNIGDLFYVGN), EbPAG(55BkDa) (RGSNLTHPL) and EbPAG(50CkDa) (SQISLRGSNLTI). On 60dpc, the next three forms were named: EbPAG(71DkDa) (RGSNLTIHPLRNIIDLFYVG), EbPAG(55EkDa) (RGSNLTHPLRNI) and EbPAG(50FkDa) (SQISLRGS). On 120dpc, three other forms were named: EbPAG(71GkDa) (RGSNLTHPLRNIRDLFYVG), EbPAG(60HkDa) (RGSNLTTHPLRNIKDLVVYM) and EbPAG(50IkDa) (SGSNLTTV). These EbPAG ((A-I)) sequences are unique, as they are not identical to any other PAGs purified previously in related species of the Bovidae family. However, the EbPAGs (A-I forms) have some sequence resemblance to internal sequences of various full-length polypeptide PAG precursors (in silico translated from cloned cDNAs) identified in domestic cattle. Three other novel native isoforms (J1, J2 and K): EbUPG(45kDa) J1 (SKDNYKNYIPLIVPFAT), EbUPG(45kDa) J2 (SKDNQKNYIPLIVPFAT) and EbUPG(76kDa) K (SPEFTV), were temporarily named 'unknown placental glycoproteins' (UPGs), due to their efficient VVA-purification (specific for glycoproteins only) and a lack of considerable consensus to previously sequenced placental glycoproteins in the Bovidae family. This is the first study identifying NH(2)-terminals of multiple/diverse EbPAGs and some EbUPGs purified from the synepitheliochorial cotyledonary placenta of the endangered Bison bonasus (Red list) [less ▲]

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See detailIdentification of neurotensin-related peptides in human thymic epithelial cell membranes and relationship with MHC class I molecules
Vanneste, Yves; Ntodou-Thomé, Agnès; Vandersmissen, Eric et al

in Journal of Neuroimmunology (1997), 76

This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain ... [more ▼]

This study shows the expression at the cell surface of human thymic epithelial cells (TEC) of a neurotensin (NT)-like immunoreactivity. NT radio-immunoassay (RIA) revealed that cultured human TEC contain ± 5 ng immunoreactive (ir) NT/106 cells, of which 5% is associated with plasma cell membranes. HPLC analysis of NT-ir present in human TEC showed a major peak of NT-ir corresponding to NT1–13. NT-ir was not detected in the supernatant of human TEC cultures. Using an affinity column prepared with a anti-MHC class I monoclonal antibody, NT-ir-related peptides were retained on the column and eluted together with MHC class I-related proteins. According to the elution time on HPLC of these peptides, they correspond to intact NT1–13, as well as to smaller fragments of NT1–13. [less ▲]

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See detailIdentification of new accessible tumor antigens in human colon cancer by ex vivo protein biotinylation and comparative mass spectrometry analysis.
Conrotto, Paolo; Roesli, Cristof; Rybak, Jascha et al

in International Journal of Cancer = Journal International du Cancer (2008), 123(12), 2856-2864

One of the most promising new strategies for the development of efficacious cancer therapies relies on the targeted delivery of biopharmaceutical to the tumor environment by the use of selective and ... [more ▼]

One of the most promising new strategies for the development of efficacious cancer therapies relies on the targeted delivery of biopharmaceutical to the tumor environment by the use of selective and specific antibodies. The identification of accessible perivascular proteins selectively overexpressed in cancer tissue may facilitate the development of antibody-based biopharmaceutical administration. This approach is potentially highly selective and specific, combining the presence of tumor biomarkers readily accessible from the blood vessels and the high rate of angiogenesis characteristic of cancer tissues. We performed ex vivo perfusions of surgically resected human colon cancer using a reactive ester derivative of biotin, thus achieving a selective covalent modification of accessible proteins in vascular structures and stroma. After extraction and purification, biotinylated proteins were digested and the resulting peptides submitted to a comparative mass spectrometry-based proteomic analysis, revealing quantitative differences between normal and cancer colon. Sixty-seven of the total 367 proteins identified were found to be preferentially expressed at the tumor site. We generated human monoclonal antibodies against 2 potential tumor targets, NGAL and GW112, and we proved their selective expression in cancer colon and not or barely in healthy tissues. This article presents the first proteomic analysis of human colorectal cancer structures readily accessible from the tumor vasculature, revealing the overexpression of novel tumor antigens which may serve as selective targets for antibody-based imaging and therapeutic biomolecular strategies. (c) 2008 Wiley-Liss, Inc. [less ▲]

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See detailIdentification of new microbial enzymes from forest and marine ecosystems by functional metagenomics
Martin, Marjolaine ULg; Biver, Sophie ULg; Barbeyron, Tristan et al

Poster (2012, August 21)

Detailed reference viewed: 90 (36 ULg)
See detailidentification of new parterns of the NOD2 protein
Lecat, Aurore ULg; Di Valentin, Emmanuel ULg; Fillet, Marianne ULg et al

Poster (2011, January 27)

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See detailIdentification of Non-Linear Dynamic Systems using an Expert Approach
Vio, Gareth Arthur; Dimitriadis, Grigorios ULg; Cooper, Jonathan Edward

in Proceedings of the 47th AIAA/ASME/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference (2006, May)

An Expert System approach for the identification of non-linear systems is presented. The Expert System is an attempt to bring order into the non-linear system identification process. The final objective ... [more ▼]

An Expert System approach for the identification of non-linear systems is presented. The Expert System is an attempt to bring order into the non-linear system identification process. The final objective is to deliver a parsimonious mathematical model of the dy- namical system under investigation. It works by defining the key stages of the procedure and iterating between them if necessary. It takes advantage of numerous methodologies to accomplish the tasks in each of the stages and uses the results from many of them. The Expert System applies the excitation forces appropriate to each method and analyses the responses. Each stage ends with a set of recommendations that can be used to begin the next stage. The Expert System is applied to a simple non-linear dynamic system. It is shown that the Expert System procedure can automatically detect, locate and quantify the non- linearity using its array of techniques. Furthermore, it can choose a suitable model struc- ture, select appropriate terms and estimate the model parameters using an extensive set of rules. The resulting identified model is validated and shown to be an accurate represen- tation of the experimental system. [less ▲]

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See detailIdentification of Nonlinear Aeroelastic Systems
Dimitriadis, Grigorios ULg; Cooper, J. E.

in Proceedings of the 1998 International Conference on Noise and Vibration Engineering (1998, September)

The successful identification of nonlinear systems could find uses in many aerospace applications including the validation of finite element models and tracking the stability of aircraft during flight ... [more ▼]

The successful identification of nonlinear systems could find uses in many aerospace applications including the validation of finite element models and tracking the stability of aircraft during flight flutter testing. The effectiveness of existing nonlinear system identification techniques is limited by various factors such as the complexity of the system under investigation and the type of nonlinearities present. In this work, a new approach is introduced that is able to identify multi degree-of-freedom systems featuring any type of nonlinear function, including discontinuous functions. The method is shown to yield accurate identifications of three different simulated aeroelastic systems containing a wide range of structural nonlinearities. [less ▲]

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Peer Reviewed
See detailIdentification of nonlinear modal inter. between elastic continua nonlinear attachments
Geogiadis, F.; Tsakirtzis, S.; Panagopoulos, P. et al

in 1st int. Conf. on Computational Dynaics and Earthquake Eng., Rethymno, 2007 (2007)

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See detailIdentification of nonlinear systems using the restoring force Surface method
Kerschen, Gaëtan ULg

in SEM Annual Conference, Cincinnati, 1999 (1999)

The objective of this paper is to demonstrate the performance of the restoring force surface method in the identification of nonlinear systems. The experimental application of the method has been studied ... [more ▼]

The objective of this paper is to demonstrate the performance of the restoring force surface method in the identification of nonlinear systems. The experimental application of the method has been studied and numerical results on a single degree-of-freedom system are described. [less ▲]

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See detailIdentification of novel accessible proteins bearing diagnostic and therapeutic potential in human pancreatic ductal adenocarcinoma
Turtoi, Andrei ULg; Musmeci, Davide; Wang, Yinghong et al

in Journal of Proteome Research (2011), 10(9), 4302-13

Pancreas ductal adenocarcinoma (PDAC) remains a deadly malignancy with poor early diagnostic and no effective therapy. Although several proteomic studies have performed comparative analysis between normal ... [more ▼]

Pancreas ductal adenocarcinoma (PDAC) remains a deadly malignancy with poor early diagnostic and no effective therapy. Although several proteomic studies have performed comparative analysis between normal and malignant tissues, there is a lack of clear characterization of proteins that could be of clinical value. Systemically reachable ("potentially accessible") proteins, suitable for imaging technologies and targeted therapies represent a major group of interest. The current study explores potentially accessible proteins overexpressed in PDAC, employing innovative proteomics technologies. In the discovery phase, potentially accessible proteins from fresh human normal and PDAC tissues were ex vivo biotinylated, isolated and identified using 2D-nano-HPLC-MS/MS method. The analysis revealed 422 up-regulated proteins in the tumor, of which 83 (including protein isoforms) were evaluated as potentially accessible. Eleven selected candidates were further confirmed as up-regulated using Western blot and multiple reaction monitoring protein quantification. Of these, transforming growth factor beta-induced (TGFBI), latent transforming growth factor beta binding 2 (LTBP2), and asporin (ASPN) were further investigated by employing large scale immunohistochemistry-based validations. They were found to be significantly expressed in a large group of clinical PDAC samples compared to corresponding normal and inflammatory tissues. In conclusion, TGFBI, LTBP2, and ASPN are novel, overexpressed, and potentially accessible proteins in human PDAC. They bear the potential to be of clinical value for diagnostic and therapeutic applications and merit further studies using in vivo models. [less ▲]

Detailed reference viewed: 102 (24 ULg)
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See detailIdentification of novel and recurrent glucokinase mutations in Belgian and Luxembourg maturity onset diabetes of the young patients.
Vits, L.; Beckers, D.; Craen, M. et al

in Clinical Genetics (2006), 70(4), 355-9

Detailed reference viewed: 13 (1 ULg)
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See detailIdentification of novel prolactin releasing peptide receptors of Cyprinus carpio and Salmo salar expressed in the pituitary gland
Romero, A. P.; Montefusco, R.; Lopez, Mauricio et al

in Journal of Experimental Zoology. Part A, Comparative Experimental Biology (2006, February 01), 305A(2), 171

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See detailIdentification of novel secreted proteases during extracellular proteolysis by dermatophytes at acidic pH
Sriranganadane, D.; Waridel, P.; Salamin, K. et al

in Proteomics (2011), 11(22), 4422-4433

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See detailIdentification of odour sources in an industrial park from resident diaries statistics
Nicolas, Jacques ULg; Cors, M.; Romain, Anne-Claude ULg et al

in Atmospheric Environment (2010), 44

A methodology based on social participation through the use of resident diaries was applied to evaluate the odour annoyance in the surroundings of an industrial park in Belgium during one year. The ... [more ▼]

A methodology based on social participation through the use of resident diaries was applied to evaluate the odour annoyance in the surroundings of an industrial park in Belgium during one year. The studied area covers about 8 km2 and includes13 potential odour emitting facilities. The network involved 44 residents in the survey, among whom 19 were particularly considered for a detailed analysis. The questionnaire aimed at providing an odour rating twice-daily on a 6-level scale together with an odour type. The fact that the response rate corresponding to “no-odour” was high (79%) is particularly discussed. Some tests are proposed to check the plausibility of the answers, the coherence within clusters of residents and the individual performance of respondents to discriminate among odour ratings. The odour rose is presented as an attractive and visual tool, particularly suited in the case of multi-source areas, to map the different odour emissions, to point out the most worrying ones, to identify others creating less annoyance and possibly new unpredicted ones. The resident diary method has proven to be particularly useful, conjointly to other ones, to the case of multi-sources facilities in large areas, when the purpose is the assessment of the long-term evolution of odour annoyance. [less ▲]

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