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See detailThe 4m International Liquid Mirror Telescope project
Finet, François ULg

Conference (2012)

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See detail4o Foro de diálogo entre la sociedad civil y las instituciones de Gobierno de la Unión Europea y México. Un diálogo sin verdadero deseo
Mariage, Thibaud ULg

in Cuaderno de Trabajo a propósito de la XI Reunión de la Comisión parlamentaria mixta México-Unión Europea (2011)

El punto de visto de un europeo en el 4o Foro de diálogo entre la sociedad civil y las instituciones de Gobierno de la Unión Europea y México.

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See detailThe 4s-4p Transitions in Neutral Phosphorus
Biémont, Emile ULg; Martin, F.; Quinet, Pascal ULg et al

in Astronomy and Astrophysics (1994), 283

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See detail4th International Symposium on Chemosynthesis-based Ecosystems
Ponsard, J; Cambon-Bonavita, M-A; Lepoint, G et al

Poster (2009)

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See detail4U 1700-37
Surdej, Jean ULg; Kruszewski, A.

in IAU Astronomical Telegram N° 3290 (1978)

IAUC 3290 available at Central Bureau for Astronomical Telegrams.

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See detailLes 5 arbres protégés du Gabon
Moumbogou, Carl; Meunier, Quentin; Ogoula Ikinda, L. B. et al

Learning material (2012)

Ces cinq essences forestières sont réputées pour la qualité de leur bois et ont fait l’objet d’exploitation dans le pays. Elles font également partie intégrante de la vie des communautés rurales du Gabon ... [more ▼]

Ces cinq essences forestières sont réputées pour la qualité de leur bois et ont fait l’objet d’exploitation dans le pays. Elles font également partie intégrante de la vie des communautés rurales du Gabon, tant pour leurs vertus alimentaires et médicinales que pour leur importance dans les rites initiatiques traditionnels. [less ▲]

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See detail5 beta-Dihydrotestosterone is weakly androgenic in the adult Japanese quail (Coturnix coturnix japonica).
Deviche, P.; Bottoni, L.; Balthazart, Jacques ULg

in General and Comparative Endocrinology (1982), 48(4), 421-4

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See detail5 notices: « Chose », « Il y a », « Néo-kantisme », « Ontologie fondamentale », « Vérité »
Dewalque, Arnaud ULg

in Beaulieu, Alain (Ed.) Abécédaire de Martin Heiddegger (2008)

Brève analyse du sens de quelques concepts heideggériens et du contexte dans lequel ils apparaissent.

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See detail5 years of the European Initiative for the Exchange of Young Officers Inspired by Erasmus, Lessons Learnt from the International Military Academies Forum 2013
Paile, Sylvain ULg; Gell, Harald

Book published by Ministry of Defence and Sports of the Federal Republic of Austria (2013)

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See detail5',6'-Dehydroguiachrysine and 5',6'-Dehydroguiaflavine, Two Curarizing Quaternary Indole Alkaloids from the Stem Bark of Strychnos Guianensis
Penelle, J.; Christen, P.; Molgo, J. et al

in Phytochemistry (2001), 58(4), 619-26

Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2) were isolated from Strychnos guianensis stem bark. Their structures were determined by analysis of ... [more ▼]

Two new quaternary indole alkaloids 5',6'-dehydroguiachrysine (1) and 5',6'-dehydroguiaflavine (2) were isolated from Strychnos guianensis stem bark. Their structures were determined by analysis of spectral data. Their inhibitory effects on neuromuscular transmission are also reported and compared to that of other quaternary alkaloids. [less ▲]

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See detailA 5,6-Dihydro-Isopyoverdin From Azomonas Macrocytogenes
Michalke, R.; Taraz, K.; Budzikiewicz, H. et al

in Zeitschrift Fur Naturforschung C-A Journal of Biosciences (1997), 52(11-12),

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See detail5,8 analogies per hour, A designer's view on analogical reasoning.
Leclercq, Pierre ULg; Heyligen, A.

in Proceedings of the 7th International Conference on Artificial Intelligence in Design (2002)

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See detail5-(Diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide : Synthesis and Evaluation of Spin Trapping Properties
Roubaud, Valérie; Mercier, Anne; Olive, Gilles ULg et al

in Journal of the Chemical Society. Perkin Transactions 2 (1997), 9

A new spin trap, the 5-(diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide (3), is prepared through a four-step synthetic route. The in vitro spin trapping properties of 3 have been ... [more ▼]

A new spin trap, the 5-(diethoxyphosphorylmethyl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide (3), is prepared through a four-step synthetic route. The in vitro spin trapping properties of 3 have been investigated and the hydroxyl and superoxide spin adducts characterised. The persistence of the superoxide spin adduct obtained with 3 is compared with those of the analogues obtained with DEPMPO [5-(diethoxyphosphoryl)-5-methyl-4,5-dihydro-3H-pyrrole N-oxide] and DMPO in both phosphate buffer and pyridine. In 0.1 M phosphate buffer at pH 7.0, the HOO-3? adduct is found to be 2.8 times more persistent than HOO-DMPO?, but 5.7 times less than HOO-DEPMPO?. In phosphate buffer, HOO-3? decomposes to give HO-3?. The stereoselectivity of the addition of free radicals on 3 is generally poor, and mixtures of diastereomers have been observed by EPR. The overall spin trapping behaviour of nitrone 3 is more similar to that of DMPO than that of DEPMPO. [less ▲]

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See detail5-ALA-PDT induces RIP3-dependent necrosis in glioblastoma
Coupienne, Isabelle ULg; Fettweis, Grégory ULg; Rubio-Romero, Noemi ULg et al

in Photochemical & Photobiological Sciences (2011)

Glioblastoma constitute the most frequent and deadliest brain tumors of astrocytic origin. They are resistant to all current therapies and are associated with a high rate of recurrence. Glioblastoma were ... [more ▼]

Glioblastoma constitute the most frequent and deadliest brain tumors of astrocytic origin. They are resistant to all current therapies and are associated with a high rate of recurrence. Glioblastoma were previously shown to respond to treatments by 5-aminolevulinic acid (5-ALA)-based photodynamic therapy (PDT) mainly by activating a necrotic type of cell death. The receptor-interacting protein 3 (RIP3) has recently been outlined as a key mediator of this caspase-independent form of programmed cell death. In the present study, we analyzed the necrotic mechanism induced by 5-ALA-PDT in human glioblastoma cells and explored the role of RIP3 in this context. Our results show that PDT-induced necrosis is dependent on RIP3, which forms aggregates and colocalizes with RIP1 following photosensitization. We demonstrate that PDT-mediated singlet oxygen production is the cause of RIP3-dependent necrotic pathway activation. We also prove that PDT induces the formation of a pro-necrotic complex containing RIP3 and RIP1 but lacking caspase-8 and FADD, two proteins usually part of the necrosome when TNF-α is used as a stimulus. Thus, we hypothesize that PDT might lead to the formation of a different necrosome whose components, besides RIP1 and RIP3, are still unknown. In most cases, glioblastoma are characterized by a constitutive activation of NF-κB. This factor is a key regulator of various processes, such as inflammation, immune response, cell growth or apoptosis. Its inhibition was shown to further sensitize glioblastoma cells to PDT-induced necrosis, however, no difference in RIP3 upshift or aggregation could be observed when NF-κB was inhibited. [less ▲]

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See detail5-HT challenge in healthy vigile calves after MDL72222 pretreatment
Linden, Annick ULg; Desmecht, Daniel ULg; Rollin, Frédéric ULg et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

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See detailThe 5-HT1A agonism potential of substituted-piperazine-ethyl-amide derivatives is conserved in the hexyl homologues: molecular modeling and pharmacological evaluation
Dilly, Sébastien ULg; Scuvée-Moreau, Jacqueline ULg; Wouters, Johan et al

in Journal of Chemical Information & Modeling (2011), 51(11), 2961-2966

In a series of carboxamide and sulphonamide alkyl (ethyl to hexyl) piperazine analogues, although the size of the linker is very different, ethyl and hexyl derivatives possess a high affinity for 5-HT1A ... [more ▼]

In a series of carboxamide and sulphonamide alkyl (ethyl to hexyl) piperazine analogues, although the size of the linker is very different, ethyl and hexyl derivatives possess a high affinity for 5-HT1A receptors. Docking studies clearly show that hexyl and ethyl compounds favourably interact with the binding site of the active conformation of 5-HT1A receptors, thus confirming a possible agonist profile. This activity is effectively detected in electrophysiological experiments in which all four compounds inhibit the activity of rat dorsal raphe serotonergic neurons. [less ▲]

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