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See detailHjelmslev
Badir, Sémir ULg

Book published by Taishukan (2007)

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See detailHjelmslev's notion of "Participation"
Cigana, Lorenzo ULg

Conference (2012, September 29)

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See detailThe HLA dermatosis connection
Nikkels, Arjen ULg; Tassoudji, Nazli ULg; Pierard, Gérald ULg

in Journal of the European Academy of Dermatology & Venereology (1992), 1

A number of dermatological diseases are associated with distinct HLA types. These associations vary in different populations and ethnic groups. HLA determination can be related to different diseases ... [more ▼]

A number of dermatological diseases are associated with distinct HLA types. These associations vary in different populations and ethnic groups. HLA determination can be related to different diseases courses, various anatomical predilection sites and can be used as a diagnostic tool. However, the pathogenic role of HLA in susceptibility to specific dermatological diseases often remains unclear. [less ▲]

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See detailHLA genetics in 'latent' autoimmune diabetes of adults (LADA)
Geenen, Vincent ULg

in International Diabetes Monitor (2008), 20

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See detailHLA-DQA is associated with abdominal aortic aneurysms in the Belgian population
Tromp, Gerard; Ogata, Toru; Grégoire, Lucie et al

in Annals of the New York Academy of Sciences (2006), 1085

Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs ... [more ▼]

Chronic inflammation and autoimmunity likely contribute to the pathogenesis of abdominal aortic aneurysms (AAAs). The aim of this study was to investigate the role of autoimmunity in the etiology of AAAs using a genetic association study approach with human leukocyte antigen (HLA) polymorphisms (HLA-DQA1, -DQB1, -DRB1 and -DRB3-5 alleles) in 387 AAA cases and 426 controls. We observed an association with the HLA-DQA1 locus among Belgian males, and found a significant difference in the HLA-DQA1 *0102 allele frequencies between AAA cases and controls. In conclusion, this study showed potential evidence that the HLA-DQA1 locus harbors a genetic risk factor for AAAs suggesting that autoimmunity plays a role in the pathogenesis of AAAs. [less ▲]

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See detailHLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populations.
Dilernia, Dario Alberto; Jones, Leandro; Rodriguez, Sabrina ULg et al

in PLoS ONE (2008), 3(10), 3429

BACKGROUND: Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these escape mutations at a ... [more ▼]

BACKGROUND: Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these escape mutations at a population-level would help to understand how HLA-mediated selection drives the evolution of HIV-1. METHODOLOGY/PRINCIPAL FINDINGS: We undertook a study of the dynamics of HIV-1 CTL-escape mutations by analyzing through statistical approaches and phylogenetic methods the viral gene gag sequenced in plasma samples collected between the years 1987 and 2006 from 302 drug-naive HIV-positive patients. By applying logistic regression models and after performing correction for multiple test, we identified 22 potential CTL-escape mutations (p-value<0.05; q-value<0.2); 10 of these associations were confirmed in samples biologically independent by a Bayesian Markov Chain Monte-Carlo method. Analyzing their prevalence back in time we found that escape mutations that are the consensus residue in samples collected after 2003 have actually significantly increased in time in one of either B or F subtype until becoming the most frequent residue, while dominating the other viral subtype. Their estimated prevalence in the viral subtype they did not dominate was lower than 30% for the majority of samples collected at the end of the 80's. In addition, when screening the entire viral region, we found that the 75% of positions significantly changing in time (p<0.05) were located within known CTL epitopes. CONCLUSIONS: Across HIV Gag protein, the rise of polymorphisms from independent origin during the last twenty years of epidemic in our setting was related to an association with an HLA allele. The fact that these mutations accumulated in one of either B or F subtypes have also dominated the other subtype shows how this selection might be causing a convergence of viral subtypes to variants which are more likely to evade the immune response of the population where they circulate. [less ▲]

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See detailHLA-matched unrelated donor hematopoietic cell transplantation after nonmyeloablative conditioning for patients with chronic myeloid leukemia
Baron, Frédéric ULg; Maris, M. B.; Storer, B. E. et al

in Biology of Blood and Marrow Transplantation (2005), 11(4), 272-279

We evaluated 10/10 HLA antigen-matched unrelated hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning with fludarabine 3 x 30 mg/m(2) and 2 Gy of total body irradiation as ... [more ▼]

We evaluated 10/10 HLA antigen-matched unrelated hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning with fludarabine 3 x 30 mg/m(2) and 2 Gy of total body irradiation as treatment for patients with chronic myeloid leukemia who were ineligible for conventional HCT. Data from 21 consecutive patients in first chronic phase (CP1; n = 12), accelerated phase (AP; n = 5), second CP (CP2; n = 3), and blast crisis (n = 1) were analyzed. Stem cell sources were bone marrow (n = 4) or granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells (G-PBMCs; n = 17). The patient who underwent transplantation in blast crisis died on day 21 (too early to be evaluated. for engraftment) from progressive disease. Sustained engraftment was achieved in 5 of 12 patients who underwent transplantation in CP1, 4 of 5 patients who underwent transplantation in AP, and 2 of 3 patients who underwent transplantation in CP2, whereas 9 patients rejected their grafts between 28 and 400 days after HCT. Specifically, I of 4 marrow recipients and 10 of 17 G-PBMC recipients achieved sustained engraftment. Graft rejections were nonfatal in all cases and were followed by autologous reconstitution with persistence or recurrence of chronic myeloid leukemia. Seven of 11 patients with sustained engraftment-including all 5 patients in CP 1, 2 of 4 patients in AP, and neither of the 2 patients in CP2-were alive in complete cytogenetic remissions 118 to 1205 days (median, 867 days) after HCT. Two of the remaining 4 patients died of nonrelapse causes in complete (n = 1) or major (n = 1) cytogenetic remissions, and 2 died of progressive disease. Further efforts are directed at reducing the risk of graft rejection by exclusive use of G-PBMC and increasing the degree of pretransplantation immunosuppression. (c) 2005 American Society for Blood and Marrow Transplantation. [less ▲]

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See detailHLPR 2004: Hadronic Physics: Joint meeting Heidelberg- Liege-Paris-Rostock
Lansberg, Jean-Philippe ULg; Cudell, Jean-René ULg; Cugnon, Joseph ULg

Book published by American Institute of Physics - AIP Conference Proceedings (2005)

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See detailHM modelling of in-situ gas injection tests in bentonite and argillite: the PGZ experiment
Gerard, Pierre ULg; Charlier, Robert ULg; Radu, Jean-Pol ULg et al

in Clays in Natural and Engineered Barriers for Radioactive Waste Confinement (2010)

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See detailHMA4 and metal hyperaccumulation in Arabidopsis halleri
Hanikenne, Marc ULg

Conference (2014, July 04)

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See detailThe HMG-Box Transcription Factor Sox4b Is Required for Pituitary Expression of gata2a and Specification of Thyrotrope and Gonadotrope Cells in Zebrafish.
Quiroz O'Donova, Yobhana ULg; Lopez, Mauricio; Mavropoulos, A et al

in Molecular Endocrinology (2012), 26(6), 1014-1027

The pituitary is a complex gland comprising different cell types each secreting specific hormones. The extensive network of signaling molecules and transcription factors required for determination and ... [more ▼]

The pituitary is a complex gland comprising different cell types each secreting specific hormones. The extensive network of signaling molecules and transcription factors required for determination and terminal differentiation of specific cell types is still not fully understood. The SRY-like HMG-box (SOX) transcription factor Sox4 plays important roles in many developmental processes and has two homologs in zebrafish, Sox4a and Sox4b. We show that the sox4b gene is expressed in the pituitary anlagen starting at 24 h after fertilization (hpf) and later in the entire head region including the pituitary. At 48 hpf, sox4b mRNA colocalizes with that for TSH (tshbeta), glycoprotein subunit alpha (gsualpha), and the Zn finger transcription factor Gata2a. Loss of Sox4b function, using morpholino knockdown or expression of a dominant-negative Sox4 mutant, leads to a drastic decrease in tshbeta and gsualpha expression and reduced levels of gh, whereas other anterior pituitary gland markers including prl, slbeta, pomc, and lim3 are not affected. Sox4b is also required for expression of gata2a in the pituitary. Knockdown of gata2a leads to decreased tshbeta and gsualpha expression at 48 hpf, similar to sox4b morphants. Injection of gata2a mRNA into sox4b morphants rescued tshbeta and gsualpha expression in thyrotrope cells. Finally, sox4b or gata2a knockdown causes a significant decrease of gonadotropin expression (lhbeta and fshbeta) at 4 d after fertilization. In summary, our results indicate that Sox4b is expressed in zebrafish during pituitary development and plays a crucial role in the differentiation of thyrotrope and gonadotrope cells through induction of gata2a expression in the developing pituitary. [less ▲]

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See detailHMGB1 secretion during cervical carcinogenesis promotes the acquisition of a tolerogenic functionality by plasmacytoid dendritic cells
Demoulin, Stéphanie ULg; Herfs, Michael ULg; SOMJA, Joan ULg et al

in International Journal of Cancer = Journal International du Cancer (2014)

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See detailHMTY-KM (Black Copper) and the egyptian bronzes collection of the Musee du Louvre
Mathis, François ULg; Delange, Elisabeth; Robcis, Dominique et al

in Journal of Cultural Heritage (2009), 10

At the instigation of the Musée du Louvre’s Department of Egyptian Antiquities, an intensive programme to study black bronze has been carried out at the Centre de Recherche et de Restauration des Muse´es ... [more ▼]

At the instigation of the Musée du Louvre’s Department of Egyptian Antiquities, an intensive programme to study black bronze has been carried out at the Centre de Recherche et de Restauration des Muse´es de France. Systematic research has been undertaken on the museum’s collection to identify objects that might have an intentional black patina. The same experimental protocol has been applied to all the objects, alllowing this study to be one of the most important coherent investigation on this type of bronze decoration. It involves the use of non-invasive analytical methods in order to obtain the maximum amount of information possible about the chemical nature and structure of the surface layer. The protocol makes it possible to compare objects and to propose an interpretation of how this decorative technique evolved during the Egyptian period. Based on previous stylistic investigations (by J. Cooney, 1966) and personal observation, sixteen objects dating from the Middle Kingdom to the Late Period were selected. Thanks to elemental analyses, twelve of them were identified as being intentionally patinated. Only ten of these could be described as hmty-km, because the base patinated alloy contains small amounts of gold and/or silver and the black patina is made up mainly of cuprous oxide Cu2O (cuprite). Among the four other objects, one patina is very close to the black bronze patina, but contains neither gold nor silver. Three other pieces have an unusual patina. A lack of other comparable examples makes it very difficult to determine whether the patinas are of ancient origin. [less ▲]

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See detailHmty-km and the egyptian bronzes polychromy:A study of the Egyptian collection of the Louvre museum
Mathis, François ULg; Delange, Elisabeth; Robcis, Dominique et al

Conference (2007)

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See detailHobbes
Herla, Anne ULg

Conference given outside the academic context (2011)

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See detailHobbes et l'écriture entre les lignes
Herla, Anne ULg

in Cahiers Internationaux de Symbolisme (2011), 128-129-130

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See detailHobbes et l'invention de la langue philosophique moderne
Herla, Anne ULg

in Traductions arabes de la pensée politique moderne (2011)

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See detailHobbes et la civilisation de l'imaginaire : actualité d'un geste critique
Herla, Anne ULg

in Cahiers Internationaux de Symbolisme (2006), 110-111-112

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See detailHobbes et les lumières radicales
Herla, Anne ULg

Scientific conference (2006, November 22)

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