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See detailImpact of chronic cadmium exposure at environmental dose on escape behaviour in sea bass (Dicentrarchus labrax L.; Teleostei, Moronidae).
Faucher, Karine ULg; Fichet, Denis; Miramand, Pierre et al

in Environmental Pollution (2008), 151(1), 148-57

The effect of chronic exposure to a low concentration (0.5 microg l(-1)) of cadmium ions was investigated on escape behaviour of sea bass, Dicentrarchus labrax, using video analysis. Observations were ... [more ▼]

The effect of chronic exposure to a low concentration (0.5 microg l(-1)) of cadmium ions was investigated on escape behaviour of sea bass, Dicentrarchus labrax, using video analysis. Observations were also performed on the microanatomy of lateral system neuromasts. When fish were exposed for 4h per day over 8 days to the cadmium ions, most of both types of neuromasts observed remained intact. However, some of them presented damaged sensory maculae. Whereas before cadmium exposure, fish responded positively to nearly all the lateral system stimulations, after exposure they decreased by about 10% their positive responses to stimulations. From the 15th day after the beginning of cadmium exposure, neuromasts presented progressively less damage, cadmium accumulation in gills and scales decreased significantly and fish escape behaviour had recovered. This study presents a new concept in ecotoxicology: using behavioural change to reveal the effects of pollution levels, scarcely detectable by currently used techniques (physiological responses). [less ▲]

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See detailImpact of chronic graft-versus-host disease (GVHD) after reduced intensity conditioning (RIC) allogeneic stem cell transplantation (allo-SCT) as treatment for acute myeloid leukemia (AML) : a survey from the Acute Leukemia Working Party of the EBMT
Baron, Frédéric ULg; Labopin, Myriam; Niederwieser, Dietger et al

in Blood (2011), 118

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients ... [more ▼]

The goal of RIC allo-SCT is to harness the graft-versus-leukemia (GVL) effect, while minimizing toxicities and the risk of GVHD. However, prior studies have shown a lower risk of relapse in AML patients (pts) who experienced chronic GVHD after RIC allo-SCT versus in those who did not. Here, we investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in first (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affiliated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). Median pt age at transplantation was 56 y (range, 18–77). 338 male pts were given grafts from female donors. RIC was based on low-dose TBI in 520 (28%) pts, while the remaining pts received chemotherapy-based RIC. ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD on relapse risk, non-relapse mortality (NRM), leukemia-free survival (LFS), and overall survival (OS) was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. Three-year incidences of relapse, NRM, LFS and OS were 34±1%, 15±1%, 51±2% and 60±2% in MRD recipients, respectively, and 34±2% (p=NS), 24±2% (P<0.001), 42±2% (P=0.001) and 47±2% (P=0.001) in MUD recipients, respectively. Grade II, III and IV acute GVHD were observed in 133 (11%), 61 (5%) and 30 (2%) MRD recipients and in 119 (18%), 41 (6%) and 24 (4%) MUD recipients, respectively. The 3-y cumulative incidence of chronic GVHD was 47%. Fifty-three percent of patients with chronic GVHD had extensive chronic GVHD, while the remaining 47% had limited chronic GVHD. In multivariate analyses, occurrence of grade II-IV acute GVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited chronic GVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive chronic GVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). The median interval from transplantation to occurrence of chronic GVHD was 163 (range, 100–1545) days. To further assess the graft-versus-leukemia effect of chronic GVHD, we performed a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776). Median follow-up from this landmark time-point was 24 (range, 0.1–112) months. Two-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without chronic GVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with chronic GVHD before the landmark time-point.In conclusion, in this cohort of AML patients transplanted in remission, occurrence of chronic GVHD was associated with a lower risk of relapse that translated to better OS in patients with limited chronic GVHD but not in those with extensive chronic GVHD who experienced higher long term NRM, highlighting the need for long term prospective assessment of long term effects and quality of life in patients receiving RIC allo-SCT. [less ▲]

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See detailImpact of chronic graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukaemia: A report from the Acute Leukaemia Working Party of the European Group for Blood and Marrow Transplantation
Baron, Frédéric ULg; Labopin, M.; Niederwieser, D. et al

Conference (2012)

We investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in fi rst (n=1439) or second ... [more ▼]

We investigated the impact of occurrence of GVHD on transplantation outcomes in a large cohort of AML pts given allogeneic PBSC after RIC conditioning. Data from 1859 AML pts in fi rst (n=1439) or second (n=420) CR transplanted between 2000 and 2009 following a RIC regimen at EBMT affi liated centres were analyzed. Pts were given PBSC from HLA-identical sibling (MRD, n=1208), or from HLA-matched unrelated donors (MUD, n=651). ATG was given in 269 (22%) MRD and in 267 (41%) MUD recipients, respectively, while 151 (13%) MRD and 165 (25%) MUD recipients received in-vivo T cell depletion with alemtuzumab. The impact of chronic GVHD (cGVHD) on outcomes was assessed using time-dependent multivariate Cox models and in a landmark analysis at 18 months after transplant. The 3-y cumulative incidence of cGVHD was 47%. Fifty-three percent of patients with cGVHD had extensive cGVHD, while the remaining 47% had limited cGVHD. In multivariate analyses, occurrence of grade II-IV aGVHD was associated with a lower risk of relapse (HR=0.8; P=0.04), a higher risk of chronic (HR=2.2; P<0.001) and extensive chronic GVHD (HR=2.8; P<0.001), a higher risk of NRM (HR=2.4 P<0.001), a worsened LFS (HR=1.3; P=0.01), and a worsened OS (HR=1.5; P<0.001). In multivariate time-dependent analyses, occurrence of limited cGVHD was associated with a lower risk of relapse (HR=0.7; P=0.05), comparable NRM (HR=1.4; P=0.16), comparable LFS (HR=0.9; P=0.29) and better OS (HR=0.5; P<0.001), while occurrence of extensive cGVHD was associated with a lower risk of relapse (HR=0.6; P=0.01), higher NRM (HR=3.2; P<0.001), a trend for worsened LFS (HR=1.3; P=0.06) and comparable OS (HR=0.9; P=0.34). In a landmark analysis in patients who were leukemia-free at 18 months after transplantation (n=776), 2-year relapse, NRM, LFS and OS were 16±2%, 2.5±1%, 82±2%, and 89±2%, respectively, in patients without cGVHD before the landmark time-point, versus 9±1% (P=0.001), 8±1% (P<0.001), 83±2% (P=0.65), and 86±2% (P=0.38), respectively, in patients with cGVHD before the landmark time-point. In conclusion, in this cohort of AML patients transplanted in remission, occurrence of cGVHD was associated with a lower risk of relapse that translated to better OS in patients with limited cGVHD but not in those with extensive cGVHD who experienced higher long term NRM. These results highlight the role of the GVT effect in RIC allo-SCT, but also the need for improving the prevention of severe cGVHD in pts receiving RIC allo-SCT. [less ▲]

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See detailImpact of circulation on export production, dissolved organic matter, and dissolved oxygen in the ocean: Results from Phase II of the Ocean Carbon-cycle Model Intercomparison Project (OCMIP-2)
Najjar, R. G.; Jin, X.; Louanchi, F. et al

in Global Biogeochemical Cycles (2007), 21(3),

Results are presented of export production, dissolved organic matter (DOM) and dissolved oxygen simulated by 12 global ocean models participating in the second phase of the Ocean Carbon-cycle Model ... [more ▼]

Results are presented of export production, dissolved organic matter (DOM) and dissolved oxygen simulated by 12 global ocean models participating in the second phase of the Ocean Carbon-cycle Model Intercomparison Project. A common, simple biogeochemical model is utilized in different coarse-resolution ocean circulation models. The model mean (+/- 1 sigma) downward flux of organic matter across 75 m depth is 17 +/- 6 Pg C yr(-1). Model means of globally averaged particle export, the fraction of total export in dissolved form, surface semilabile dissolved organic carbon (DOC), and seasonal net outgassing (SNO) of oxygen are in good agreement with observation-based estimates, but particle export and surface DOC are too high in the tropics. There is a high sensitivity of the results to circulation, as evidenced by (1) the correlation of surface DOC and export with circulation metrics, including chlorofluorocarbon inventory and deep-ocean radiocarbon, (2) very large intermodel differences in Southern Ocean export, and (3) greater export production, fraction of export as DOM, and SNO in models with explicit mixed layer physics. However, deep-ocean oxygen, which varies widely among the models, is poorly correlated with other model indices. Cross-model means of several biogeochemical metrics show better agreement with observation-based estimates when restricted to those models that best simulate deep-ocean radiocarbon. Overall, the results emphasize the importance of physical processes in marine biogeochemical modeling and suggest that the development of circulation models can be accelerated by evaluating them with marine biogeochemical metrics. [less ▲]

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See detailImpact of climate and carbon sensitivities on the North Pacific ventilation in an Earth system model
Mouchet, Anne ULg; Menviel, Laurie; Goosse, Hugues et al

Conference (2011, May)

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See detailImpact of climate change on groundwater reserves
Goderniaux, Pascal ULg

Doctoral thesis (2010)

Estimating the impacts of climate change on groundwater represents one of the most difficult challenges faced by water resources specialists. One difficulty is that simplifying the representation of the ... [more ▼]

Estimating the impacts of climate change on groundwater represents one of the most difficult challenges faced by water resources specialists. One difficulty is that simplifying the representation of the hydrological system, or using too simple climate change scenarios often leads to discrepancies in projections. Additionally, these projections are affected by uncertainties from various sources, and these uncertainties are not evaluated in previous studies. In this context, the objective of this study is to provide an improved methodology for the estimation of climate change impact on groundwater reserves, including the evaluation of uncertainties. This methodology is applied to the case of the Geer basin catchment (480 km²) in Belgium. A physically-based surface-subsurface flow model has been developed for the Geer basin with the finite element model HydroGeoSphere. The simultaneous solution of surface and subsurface flow equations in HydroGeoSphere, as well as the internal calculation of the actual evapotranspiration as a function of the soil moisture at each node of the defined evaporative zone, improve the representation and calibration of interdependent processes like recharge, which is crucial in the context of climate change. Fully-integrated surface-subsurface flow models have recently gained attention, but have not been used in the context of climate change impact studies. This surface-subsurface flow model is combined with advanced climate change scenarios for the Geer basin. Climate change simulations were obtained from six regional climate model (RCM) scenarios assuming the SRES A2 greenhouse gases emission (medium-high) scenario. These RCM scenarios were statistically downscaled using two different methods: the 'Quantile Mapping Biased Correction' technique and a 'Weather Generator' technique. Both of them are part of the most advanced downscaling techniques. They are able to apply corrections not only to the mean of climatic variables, but also across the statistical distributions of these variables. This is important as these distributions are expected to change in the future, with more violent rainfall events, separated by longer dry periods. The 'quantile mapping bias-correction' technique generate climate change time series representative of a stationary climate for the periods 2011-2040, 2041-2070 and 2071-2100. The 'CRU' weather generator is used to generate a large number of equiprobable scenarios simulating full transient climate change between 2010 and 2085. All these scenarios are applied as input of the Geer basin model. The uncertainty is evaluated from different possible sources. Using a multi-model ensemble of RCMs and GCMs enables to evaluate the uncertainty linked to climatic models. The application of a large number of equiprobable climate change scenarios, generated with the 'weather generator', as input of the hydrological model allows assessing the uncertainty linked to the natural variability of the weather. Finally, the uncertainty linked to the calibration of the hydrological model is evaluated using the computer code 'UCODE_2005'. The climate change scenarios for the Geer basin model predict hotter and drier summers and warmer and wetter winters. Considering the results of this study, it is very likely that groundwater levels and surface flow rates in the Geer basin will decrease. This is of concern because it also means that groundwater quantities available for abstraction will also decrease. However, this study also shows that the uncertainty surrounding these projections is relatively large and that it remains difficult to state on the intensity of the decrease. [less ▲]

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See detailImpact of Climate change on inundation hazard along river Meuse
Dewals, Benjamin ULg; Detrembleur, Sylvain ULg; Archambeau, Pierre ULg et al

Conference (2010, December 16)

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See detailImpact of climate change on inundation hazard along the river Meuse
Dewals, Benjamin ULg; Drogue, Gilles; Erpicum, Sébastien ULg et al

in Transboundary Water Management in a Changing Climate (2013, March)

As a part of the effort to scientifically inform the development of the adaptation strategy for the Meuse basin, we detail hereafter the generation of integrated climate and hydrological scenarios for the ... [more ▼]

As a part of the effort to scientifically inform the development of the adaptation strategy for the Meuse basin, we detail hereafter the generation of integrated climate and hydrological scenarios for the whole basin. We also present the setup of a first coordinated hydraulic modelling from spring to mouth of the river Meuse. The latter has enabled to compute the range of change in inundation hazard under the “wet” transnational hydrological scenario for the time slices 2021-2050 and 2071-2100. A significantly higher impact of climate change has been found in the middle part of the Meuse basin, compared to the upper and the lower parts. These conclusions have been further confirmed by a refined analysis conducted for a 100 km-long stretch of the river Meuse crossing the Belgian-Dutch border. [less ▲]

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See detailImpact of climate change on water & society
Ozer, Pierre ULg

Conference given outside the academic context (2010)

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See detailImpact of climatic conditions on a winter wheat (Triticum aestivum Sp.) crop : interannual variability of CO2 fluxes, plant growth and crop yield
Dufranne, Delphine ULg; Vancutsem, Françoise ULg; Moureaux, Christine ULg et al

Poster (2008, September)

This study analyses the interannual variability of carbon dioxide fluxes, growth and productivity of a winter wheat (Triticum aestivum L.) crop. Two growing seasons (2004-2005 and 2006-2007) were compared ... [more ▼]

This study analyses the interannual variability of carbon dioxide fluxes, growth and productivity of a winter wheat (Triticum aestivum L.) crop. Two growing seasons (2004-2005 and 2006-2007) were compared. Continuous eddy covariance fluxes, leaf scale photosynthesis measurements and crop development monitoring were performed during the two vegetation seasons until harvest at the Lonzée (Belgium) experimental site. The winter wheat was sown and harvested at similar dates (about mid-October and in early August); crop management by the farmer was similar and corresponded at standard. Globally, the two years were characterised by a higher than normal air temperature (9.9 °C and 11.9 °C against 9.4 °C) and lower than normal rainfalls (595.1 mm and 675.1 mm against 772 mm). In addition, 2006-2007 was characterised by exceptionally mild and dry winter and spring. This induced not only earlier growth stages but also a larger Gross Primary Productivity. On the contrary, lower Net Primary Productivity and crop productivity were observed on this year. This could be explained, on one hand by the drought in April 2007 and on the other hand to cloudy and humid conditions from end May to harvest. The first induced a stress in wheat plant which produced an unusually small flag leaf. The second induced an assimilation reduction due to low radiation and favoured disease development. The higher GPP and the lower productivity in 2006-2007 raise the question of carbon allocation. We supposed that, as the excess of carbon assimilated in 2006-2007 was not stored in grain or straw, it should have been stored in the roots. However, our biomass measurements did not allow confirming this hypothesis [less ▲]

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See detailImpact of close habitat on the entomological diversity and abundance in carrot open fields.
Colignon, P.; Gaspar, Charles ULg; Haubruge, Eric ULg et al

in Mededelingen van de Faculteit Landbouwkundige en Toegepaste Biologische Wetenschappen (Rijksuniversiteit te Gent) (2002), 67(3), 481-6

Vegetable open fields areas have been increasing for the last decade in Wallonia (South part of Belgium), mainly in Hesbaye. To be in accordance with quality standards, especially in terms of agrochemical ... [more ▼]

Vegetable open fields areas have been increasing for the last decade in Wallonia (South part of Belgium), mainly in Hesbaye. To be in accordance with quality standards, especially in terms of agrochemical residues (R.M.L.), biological pest control was developed and reduces the insecticide use, leading to have safer fresh products. Carrot represents an important cultivated species in Wallonia. To asses the impact of close habitat on both pest (mainly aphids) and beneficial insects, carrot fields were investigated during all the production duration in 2000. Twelve fields between Waremme and Hannut were visited weekly from June to October. Insects were caught using yellow traps and determined to the family level. Approximately 90,000 insects belonging to 109 families were identified. Significant differences linked to field closed habitat were observed on 31 families. An increase of biodiversity in term of family number near set-asides and woody borders was observed. Evaluation of pest and beneficial diversity and density in vegetable crops was discussed to promote future IPM program. [less ▲]

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See detailImpact of closed habitat on the entomological diversity and abundance in carrot open fields
Colignon, Pierre; Gaspar, Charles; Haubruge, Eric ULg et al

in Med. Fac. Landbouw. Univ. Gent (2002), 67(3), 481-486

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See detailImpact of co-transplantation of mesenchymal stem cells on lung function after unrelated allogeneic hematopoietic stem cell transplantation following non-myeloablative conditioning
MOERMANS, Catherine ULg; LECHANTEUR, Chantal ULg; BAUDOUX, Etienne ULg et al

in Transplantation (in press)

Background: In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft- versus-host-disease. However, in animal ... [more ▼]

Background: In the context of hematopoietic stem cell transplantation (HSCT), mesenchymal stem cells (MSC) have been used to promote engraftment and prevent graft- versus-host-disease. However, in animal models, MSC were shown to cause pulmonary alterations after systemic administration. The impact of MSC infusion on lung function has not been studied in humans. The objective of the study was to investigate the impact of MSC co-infusion on lung function and airway inflammation as well as on the incidence of pulmonary infections and cytomegalovirus (CMV) reactivation after HSCT. Methods: We have prospectively followed 30 patients who underwent unrelated HSCT with MSC co-infusion after non-myeloablative conditioning (NMA). Each patient underwent detailed lung function testing (FEV1, FVC, FEV1/FVC, RV, TLC, DLCO and KCO) and measurement of exhaled nitric oxide before HSCT and 3, 6 and 12 months posttransplant. The incidence of pulmonary infections and CMV reactivation were also monitored. This group was compared with another group of 28 patients who underwent the same type of transplantation but without MSC co-infusion. Results: Lung function tests did not show important modifications over time and did not differ between the MSC and control groups. There was a higher 1-year incidence of infection, particularly of fungal infections, in patients having received a MSC co-infusion. There was no difference between groups regarding the 1-year incidence of CMV reactivation. Conclusions: MSC co-infusion does not induce pulmonary deterioration 1 year after HSCT with NMA conditioning. MSC appear to be safe for the lung but close monitoring of pulmonary infections remains essential. [less ▲]

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See detailThe impact of complete revascularization on long-term survival is strongly dependent on age
Girerd, N.; Magne, Julien ULg; Rabilloud, M. et al

in Annals of Thoracic Surgery (2012), 94(4), 1166-1172

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See detailThe Impact of Complexity on Sentence Comprehension in Children with Specific Language Impairment
Leclercq, Anne-Lise ULg; Majerus, Steve ULg; Jacob, Laura et al

Poster (2012, June)

In recent years, there has been growing evidence that children with specific language impairment (SLI) show poor sentence comprehension performance. However, factors determining sentence comprehension in ... [more ▼]

In recent years, there has been growing evidence that children with specific language impairment (SLI) show poor sentence comprehension performance. However, factors determining sentence comprehension in SLI remain unclear. Limited processing capacities have been suggested as a potential cause of their syntactic problem (Ellis Weismer & Hesketh, 1996; Montgomery, 2000), but this hypothesis has not been directly addressed by manipulating inner sentence complexity. This study aims at investigating the limited capacity theory of language impairment in a sentence comprehension task, by manipulating various aspects of inner sentence complexity, as defined by the Capacity Constrained Comprehension theory (Just & Carpenter, 1992). Fifteen children with SLI, 15 age-and-IQ-matched controls, and 15 controls matched for receptive lexical and grammatical abilities performed an auditory sentence comprehension task in which lexical frequency, sentence length, and the type of relative clause (subject- or object-relativized clauses) were manipulated. Results showed a main effect of group (F(2,42)=25.40, p<.001): children with SLI performed worse than language-matched and age-matched control groups. Main effects of relative clause type (F(1,42)=198.37, p<.001) and sentence length (F(1,42)=46.29, p<.001) were also found, showing overall better performances for sentences with a subject rather than an object relative clause and for short rather than long sentences. However, the SLI group was affected to the same extent by these variables as the control groups. At the same time, a significant group-by-frequency interaction effect was found (F(2,42)=4.03, p<.05), revealing that only the SLI group showed poorer sentence comprehension performance for sentences containing low frequency words. These data confirm the severity and specificity of sentence comprehension difficulties in children with SLI (e.g., van der Lely 2005). Given that our SLI group showed impaired sentence comprehension performance relative to younger children performing at the same level on a standardized test of grammatical comprehension, it appears that processing full reversible relative clauses is especially difficult for children with specific language impairment. Moreover, SLI children’s sentence comprehension abilities are particularly affected by the presence of low frequency but familiar words, even when compared to children matched on vocabulary knowledge. [less ▲]

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See detailImpact of components of the metabolic syndrome on knee osteoarthritis progression in the SEKOIA study
Eymard, F; Edwards, M; Parsons, C et al

in Osteoarthritis and Cartilage (2014), 22(1), 376

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See detailImpact of components of the metabolic syndrome on progression of knee osteoarthritis in the SEKOIA study
Edwards, MH; Parsons, C; Eymard, F et al

in Rheumatology (2014), 53(1), 31

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See detailImpact of components of the metabolic syndrome on progression of knee osteoarthritis in the Sekoia study
Parsons, C; Edwards, MH; Eymard, F et al

in Osteoporosis International (2014), 25(2), 230

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See detailThe impact of concomitant rhinitis on asthma-related quality of life and asthma control.
Vandenplas, O.; Dramaix, M.; Joos, G. et al

in Allergy (2010)

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and ... [more ▼]

To cite this article: Vandenplas O, Dramaix M, Joos G, Louis R, Michils A, Verleden G, Vincken W, Vints A-M, Herbots E, Bachert C. The impact of concomitant rhinitis on asthma-related quality of life and asthma control. Allergy 2010; DOI: 10.1111/j.1398-9995.2010.02365.x. Abstract Background: Characterizing the interactions between the upper and lower airways is important for the management of asthma. This study aimed at assessing the specific impact of concomitant rhinitis on asthma-related quality of life (QOL) and asthma control. Methods: A cross-sectional, observational survey was conducted among 1173 patients with asthma (aged 12-45) recruited by general practitioners and chest physicians. AR was defined by self-reported rhinitis symptoms and previously documented sensitization to inhalant allergens. The primary outcomes were (1) asthma control assessed by the Asthma Control Questionnaire (ACQ) and (2) asthma-specific QOL evaluated through the Mini Asthma Quality of Life Questionnaire (mAQLQ). Results: AR was present in 73.9% of the population with asthma and nonallergic rhinitis (NAR) in 13.6%. AR and NAR were associated with an increased risk of uncontrolled asthma (i.e. ACQ score > 1.5) with adjusted odds ratios (OR) of 2.00 (95% confidence interval [CI]: 1.35-2.97) and 1.77 (95%CI: 1.09-2.89), respectively. Multivariate linear regression analysis showed that AR and NAR had a modest, although significant, negative impact on the global mAQLQ score (beta coefficient: -0.293, standard error [SE]: 0.063 and beta coefficient: -0.221, SE: 0.080, P < 0.001, respectively), even after adjustment for the level of asthma control and demographic characteristics. Conclusion: This survey provides direct evidence that AR and NAR are associated with an incremental adverse impact on the disease-specific QOL of patients with asthma and the level of asthma control. Further investigations are required to determine whether appropriate treatment of rhinitis would efficiently reduce asthma morbidity. [less ▲]

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