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See detailImmunoreactive trypsin in the adult respiratory distress syndrome
Deby, Ginette ULg; Haas, M.; Pincemail, Joël ULg et al

in Intensive Care Medicine (1984), 10

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See detailImmunosuppression in Pancreas Transplantation The Euro SPK Trials and Beyond
Malaise, J.; De Roover, Arnaud ULg; Squifflet, Jean-Paul ULg et al

in Acta Chirurgica Belgica (2008), 108

The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies ... [more ▼]

The Immunosuppression in Pancreas Transplantation was historically based on the fact that the pancreas is an extremely immunogenic organ. Quadruple drug therapy with polyclonal or monoclonal antibodies induction was the mainstay therapy since the introduction of Cyclosporine A. In the modern era of Immunosuppression, Mycophenolate Mofetil replaced Azathioprine while Tacrolimus-another potent calcineurin inhibitor-had-and still has-a difficult challenge to replaced Cyclosporine A, due to its potential diabetogenic effect. Thanks to the first two EuroSPK studies which prospectively tried to answer several questions in that field. But, the future challenge will be in understanding the impact of innate immunity and ischemic reperfusion injuries on the long term graft function. Hopefully, new drugs will be available and tested to block unspecific deleterious reactions to attenuate the proinflammatory response. It will be the aim of the third Euro SPK Stud [less ▲]

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See detailImmunothérapie après greffe de cellules souches hématopoïétiques
Baron, Frédéric ULg

Doctoral thesis (2001)

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See detailImmunothérapie dans le cancer parathyroïdien
Beckers, Albert ULg

Scientific conference (2005, June)

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See detailImmunothérapie dans les cancers parathyroïdiens
Beckers, Albert ULg; Bradwell, A.

Scientific conference (2006, September)

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See detailImmunotherapie du cancer par minigreffe de cellules souches hematopoietiques.
Willems, Evelyne ULg; Baron, Frédéric ULg; Vanstraelen, Gaëtan et al

in Revue Médicale Suisse (2005), 1(30), 1973-7

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected haematological malignancies. Its curative potential is based on two different mechanisms, i.e. the ... [more ▼]

Allogeneic hematopoietic stem cell transplantation (HSCT) is used for the treatment of selected haematological malignancies. Its curative potential is based on two different mechanisms, i.e. the conditioning regimen and the graft-versus-host immunologic reactions. However, because of its toxicity, it is restricted to younger and fitter patients. These observations led several groups to set up new (less toxic) transplant protocols. These transplants are called nonmyeloablative HSCT or minitransplants. These are feasible with a relatively low transplant-related mortality even in patients up to 70 years. In addition, strong anti-tumor responses are observed in several haematological malignancies. [less ▲]

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See detailImmunotoxicology of methylmercury and other contaminants in harbour seals (Phoca vitulina) from the North Sea
Dupont, Aurélie ULg

Doctoral thesis (2013)

Environmental contaminants are suspected to have detrimental effects on marine mammal health. They were notably hypothesised to be involved in the severity and extent of catastrophic viral epidemics that ... [more ▼]

Environmental contaminants are suspected to have detrimental effects on marine mammal health. They were notably hypothesised to be involved in the severity and extent of catastrophic viral epidemics that recently affected the harbour seal (Phoca vitulina) population from the North Sea. High levels were indeed found in their tissues. However, the exact effects of those pollutants on free-ranging harbour seal health are not yet elucidated. In the field of immunotoxicology, in vitro cell culture techniques have been developed and are considered as valuable tools to assess specific toxicity mechanisms. The first objective of this study was to investigate the relationships between environmental contaminant levels found in harbour seal blood and lymphocyte proliferation responses in vitro. Indeed, wild harbour seal cells used in the framework of in vitro culture studies are isolated from the blood of animals that are contaminated, but little is known about the possible relationships between them. They were thus investigated in harbour seals from the North Sea. Peripheral blood leucocytes were isolated and cultured during 72h with Concanavalin A (ConA), a mitogen agent, to evaluate the lymphocyte proliferative responses as a stimulation index. The ConA-induced lymphocyte proliferation assay evaluates their ability to proliferate in response to a polyclonal stimulation, which is considered to reflect the activation of the immune response after an antigenic stimulation in vivo. No statistically significant relationship was found between the lymphocyte stimulation index and blood pollutants or class of pollutants studied (i.e. mercury, lead, persistent organic pollutants, pentachlorophenol, tribromoanisole) in harbour seals sampled while in good body condition and presenting no sign of disease. However, the number of lymphocytes per milliliter of whole blood appeared to be negatively correlated to pentachlorophenol, an organochlorine pesticide. A high interindividual variability of lymphocyte stimulation indexes was observed although cells were isolated in the same way and cultured in identical conditions. This is probably linked to a whole set of parameters such as precise age, sex, life history leading to particular immune status (probably partly related to pollutant loads), physiological parameters and inevitable experimental variability. So, in a general manner, experiments with in vitro immune cell cultures of wild marine mammals should be designed so as to minimise confounding factors in which case they remain a valuable tool to study pollutant effects in vitro. The second objective of this study was to determine underlying mechanisms of methylmercury immunotoxicity. Indeed, among the numerous contaminants found in harbour seal tissues, methylmercury is one of the most hazardous organic compounds known to have numerous detrimental effects on living organisms. It has the property to bioaccumulate and biomagnify in the trophic chain, and can reach very high levels in harbour seal tissues. Peripheral blood leucocytes exposed to relatively low concentrations of methylmercury chloride (MeHg) in vitro revealed a significant decrease of viable cell counts with obvious ultrastructural effects. A higher frequency of apoptosis was observed in lymphocytes, in which mitochondria and nuclei may have been targeted, as demonstrated by ultrastructural analysis. These results were in accordance with the significant decrease of the mitochondrial membrane potential and of lymphocyte proliferation (BrdU assay) observed. The toxicity of this compound was shown to be counteracted by selenium. However, little is known about that interaction in marine mammal blood and the underlying mechanisms still remain unclear. The present study aimed to investigate the in vitro effects of relatively low (0.75 µM) MeHgCl levels on harbour seal ConA-stimulated leucocytes while added concomitantly to Se. Two different forms of Se were studied: selenite and selenomethionine. Their concentrations were within the range of those measured in free-ranging harbour seal blood, and in a Hg:Se ratio of 1:10. Lymphocyte proliferation as well as the mitochondrial membrane potentials were significantly reduced following in vitro exposure to MeHgCl during 72h. No significant difference was found when sodium selenite or selenomethionine was added concomitantly to MeHgCl. Conversely, on average, Se alone did not lead to significant decreased proliferation and mitochondrial membrane potentials. The absence of protection of Se, either in organic or inorganic form, against Hg toxicity in harbour seal blood leucocytes in vitro raises concern as regards the deleterious effects this toxic compound could have on marine mammal immune system. The range of current Hg levels found in free-ranging harbour seals from the North Sea encompasses exposure levels which elicited deleterious effects on lymphocytes in the present study. This highlights the potential for effects on host resistance to disease. [less ▲]

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See detailImmununoassay using a biofunctionnalized alumina-coated capacitive biosensor: towards a microfluidic detection of the h5n1 influenza virus
Overstraeten-Schlögel, Nancy; Dupuis, Pascal; Lefévre, Olivia et al

Scientific conference (2011, December 02)

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See detailIMONIC Spin-off Project
Goffin, Dorothée ULg

Speech (2012)

Présentation du projet de spin-off IMONIC à un jury de sélection

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See detailImpact and potential of community scale low-energy retrofit: case study in Cairo
Attia, Shady ULg; De Herde, André

in Proceedings of the 3rd CIB International Conference on Smart and Sustainable Built Environment (2009, June)

There are extraordinary opportunities to reduce the consumption of fossil energy as a result of retrofitting the existing buildings in Egypt. For instance, Cairo falls in the arid climate zone with an ... [more ▼]

There are extraordinary opportunities to reduce the consumption of fossil energy as a result of retrofitting the existing buildings in Egypt. For instance, Cairo falls in the arid climate zone with an annual total radiation above 2409 bankable kWh/m2 per annum with approximately 3300 hours of full sunshine. However, the poorly insulated fabric of most buildings shows relatively high demand for cooling and heating energy. To overcome this problem and to examine these opportunities, this study evaluates the retrofit of a middle-income urban residential case in Cairo. The aim of the study is to investigate the potential and impact of retrofits on two different scales. The first is on the building scale, intending to reach a low-energy performance. The second is on a community scale, intending to increase the dependence on renewable sources. The case study employed TRNSYS to evaluate the performance and energy/carbon emissions savings. The research took in consideration passive and active design strategies such as envelope retrofit, internal loads reduction, and natural ventilation; in addition to domestic water heating, photovoltaic panels and solar thermal air conditioning. The results were evaluated to assess the suitability of each strategy based on energy performance. The final result of this study shows the feasibility of improving the envelope performance and installing solar hot water collectors and solar thermal air conditioning. The low-energy retrofit for old residential buildings leads to significant savings in energy consumption when applied on community scale rather than building scale. However, it is urgent to set energy conservation and code-enforced retrofit measures to start a national retrofit process. [less ▲]

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See detailThe impact and rotational light curves of Comet 9P/Tempel 1
Manfroid, Jean ULg; Hutsemekers, Damien ULg; Jehin, Emmanuel ULg et al

in Icarus: International Journal of Solar System Studies (2007), 191

UVES and HIRES high-resolution spectra of Comet 9P/Tempel 1 are used to investigate the impact and rotational light curves of various species with a view toward building a simple model of the distribution ... [more ▼]

UVES and HIRES high-resolution spectra of Comet 9P/Tempel 1 are used to investigate the impact and rotational light curves of various species with a view toward building a simple model of the distribution and activity of the sources. The emission by OH, NH, CN, C[SUB]3[/SUB], CH, C[SUB]2[/SUB], NH[SUB]2[/SUB], and OI, are analyzed, as well as the light scattered by the dust. It is found that a simple model reproduces fairly well the impact light curves of all species combining the production of the observed molecules and the expansion of the material throughout the slit. The impact light curves are consistent with velocities of 400 600 m/s. Their modeling requires a three-step dissociation sequence ``Grand-Parent --> Parent --> Daughter'' to produce the observed molecules. The rotational light curve for each species is explained in terms of a single model with three sources. The dust component can however not easily be explained that way. [less ▲]

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See detailThe impact and rotational light curves of Comet 9P/Tempel 1
Manfroid, Jean ULg; Hutsemekers, Damien ULg; Jehin, Emmanuel ULg et al

in Icarus: International Journal of Solar System Studies (2007), 187

UVES and HIRES high-resolution spectra of Comet 9P/Tempel 1 are used to investigate the impact and rotational light curves of various species with a view toward building a simple model of the distribution ... [more ▼]

UVES and HIRES high-resolution spectra of Comet 9P/Tempel 1 are used to investigate the impact and rotational light curves of various species with a view toward building a simple model of the distribution and activity of the sources. The emission by OH, NH, CN, C[SUB]3[/SUB], CH, C[SUB]2[/SUB], NH[SUB]2[/SUB], and OI, are analyzed, as well as the light scattered by the dust. It is found that a simple model reproduces fairly well the impact light curves of all species combining the production of the observed molecules and the expansion of the material throughout the slit. The impact light curves are consistent with velocities of 400 600 m/s. Their modeling requires a three-step dissociation sequence ``Grand-Parent --> Parent --> Daughter'' to produce the observed molecules. The rotational light curve for each species is explained in terms of a single model with three sources. The dust component can however not easily be explained that way. [less ▲]

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See detailImpact assessment and remediation of anthropogenic interventions on fish populations (FISHGUARD)
Blust, Ronny; Verbiest, Hilde; Volckaert, Filip et al

Report (2006)

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See detailImpact assessment and remediation of anthropogenic interventions on fish populations - (FISHGUARD)
DeBoeck, Gudrun; Blust, Ronny; Todorache, Christian et al

Report (2006)

The disruption of longitudinal river connectivity by man-made obstacles and the stocking of fish communities with non-indigenous species or genotypes threaten the fish fauna of Belgian rivers to various ... [more ▼]

The disruption of longitudinal river connectivity by man-made obstacles and the stocking of fish communities with non-indigenous species or genotypes threaten the fish fauna of Belgian rivers to various extents. Obstacles impede migrations between habitats that are vital for populations, and they may restrict the gene flow between populations, thereby reducing the effective size and genetic diversity of populations and increasing the risk of local extinction. Restocking programs often involve the introduction of non-indigenous genotypes in native populations. Moreover, although stocking programs lead to the temporal and superficial enrichment of local fish communities or gene pools, they generally result in a loss of biodiversity on a regional or international scale through the homogenisation of communities and the breakdown of genetic differentiation between populations. Thus, stocking programs cannot compensate for the loss of free migration by artificial obstructions. The impact of these changes on fish populations remains largely unknown, which complicates the priorisation of spots to preserve and spots to restore. Here, we present an integrated study on Belgian waters, both in Flanders and Wallonia, which analyses fish communities, gene flow and migration patterns in the field, as well as the swimming and leaping performances of fishes under controlled conditions. [less ▲]

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See detailImpact assessment of breeding European kingfisher (Alcedo atthis) on prey fish
Hallet, Catherine; Libois, Roland ULg

in Cowx, Ian (Ed.) Interaction between fish and birds: implications for management (abstracts) (2001, April)

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See detailImpact climatique sur les ulcères veineux de jambe.
FRANCHIMONT, Claudine ULg; Hermanns-Le, Trinh ULg; LESUISSE, Marianne et al

in Revue Médicale de Liège (2012), 67

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See detailImpact d’antagonistes du thromboxane A2 dérivés du torasémide sur la fonction plaquettaire
Dogne, J. M.; Neven, Ph.; Rolin, S. et al

Poster (1999, May)

Detailed reference viewed: 5 (0 ULg)