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See detailThe 5-HT1A agonism potential of substituted-piperazine-ethyl-amide derivatives is conserved in the hexyl homologues: molecular modeling and pharmacological evaluation
Dilly, Sébastien ULg; Scuvée-Moreau, Jacqueline ULg; Wouters, Johan et al

in Journal of Chemical Information & Modeling (2011), 51(11), 2961-2966

In a series of carboxamide and sulphonamide alkyl (ethyl to hexyl) piperazine analogues, although the size of the linker is very different, ethyl and hexyl derivatives possess a high affinity for 5-HT1A ... [more ▼]

In a series of carboxamide and sulphonamide alkyl (ethyl to hexyl) piperazine analogues, although the size of the linker is very different, ethyl and hexyl derivatives possess a high affinity for 5-HT1A receptors. Docking studies clearly show that hexyl and ethyl compounds favourably interact with the binding site of the active conformation of 5-HT1A receptors, thus confirming a possible agonist profile. This activity is effectively detected in electrophysiological experiments in which all four compounds inhibit the activity of rat dorsal raphe serotonergic neurons. [less ▲]

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See detail5-HT1A dysfunction in borderline personality disorder.
Hansenne, Michel ULg; Pitchot, William ULg; Pinto, Emmanuel ULg et al

in Psychological Medicine (2002), 32(5), 935-41

BACKGROUND: A number of challenge studies have reported abnormalities of serotonergic function in borderline personality disorder (BPD). There are, however, problems with the pharmacological probes used ... [more ▼]

BACKGROUND: A number of challenge studies have reported abnormalities of serotonergic function in borderline personality disorder (BPD). There are, however, problems with the pharmacological probes used in these studies since fenfluramine and m-CPP are not only serotonergic agents but also induce release of catecholamines, particularly dopamine. Therefore, we tested whether subjects with BPD showed a blunted prolactin (PRL) response to flesinoxan, a highly potent and selective 5-HT1A agonist. METHODS: Flesinoxan challenge test was carried out in 20 BPD in-patients and 20 healthy controls matched for gender but not for age. Since 16 BPD in-patients exhibited major depressive co-morbidity, a group of 20 depressed in-patients matched for gender but not for age was also included. RESULTS: BPD in-patients exhibited blunted PRL responses as compared to controls, whereas depressed in-patients did not differ from controls. Moreover, PRL responses were lower among BPD in-patients than among depressed in-patients. Among the BPD in-patients, PRL responses to flesinoxan were lower in patients with past history of suicide attempts (N = 8) than in those with a negative history. CONCLUSIONS: The results show major involvement of serotonergic function in BPD and are consistent with previous studies linking lower serotonergic activity with impulsivity. More particularly, our data suggest that BPD is characterized by lower 5-HT1A receptor sensitivity. Moreover, the data support the involvement of 5-HT1A activity in suicidal behaviour. However, this conclusion is limited because other hormonal responses such as ACTH and cortisol were not assessed, and because BPD was assessed by a self-report questionnaire and not a structured clinical interview. [less ▲]

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See detail5-HT1A receptor distribution in the human brain: preliminary PET data with p-[18F]MPPF.
Fuchs, Sonia ULg; Plenevaux, Alain ULg; Degueldre, Christian ULg et al

in Society for Neuroscience / Abstracts (1999), 25

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See detail5-HT1A Receptors visualization with p-[18F]MPPF in healthy volunteers.
Plenevaux, Alain ULg; Lemaire, Christian ULg; Salmon, Eric ULg et al

in Journal of Labelled Compounds & Radiopharmaceuticals (1999), 42

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See detail5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner
Liégeois, Jean-François ULg; Ichikawa, J.; Meltzer, H. Y.

in Brain Research (2002), 947(2), 157-165

Combined serotonin (5-HT)(2A) and dopamine (DA) D-2 blockade has been shown to contribute to the ability of atypical antipsychotic drugs (APDs) to increase DA release in rat medial prefrontal cortex (mPFC ... [more ▼]

Combined serotonin (5-HT)(2A) and dopamine (DA) D-2 blockade has been shown to contribute to the ability of atypical antipsychotic drugs (APDs) to increase DA release in rat medial prefrontal cortex (mPFC). We provide additional support for this hypothesis by examining the effect of the selective 5-HT2A antagonist M100907 plus haloperidol, a potent D, antagonist APD, on DA release in the mPFC and nucleus accumbens (NAC). Haloperidol (0.01-1.0 mg/kg) produced an inverted U-shaped increase in DA release in the mPFC, with a significant increase only at 0.1 mg/kg. Haloperidol (0.1 and 1.0 mg/kg) significantly increased DA release in the NAC. M100907 (0.1 mg/kg) by itself had no effect on DA release in either region. This dose of M100907 potentiated the ability of low (0.01-0.1 mg/kg), but not high dose (0.3-1.0 mg/kg) haloperidol to increase mPFC DA release, whereas it abolished the effect of both 0.1 and 1.0 mg/ka haloperidol on NAC DA release. These results suggest that the relatively higher ratio of 5-HT2A to D-2 antagonism may contribute to the potentiation of haloperidol-induced mPFC DA release, whereas 5-HT2A antagonism can diminish haloperidol-induced NAC DA release, even when combined with extensive D, antagonism, which may not be synergistic with 5-HT2A antagonism in the mPFC. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detail5-HT2A receptor polymorphism gene in Bipolar Patients and Harm Avoidance personality trait
Blairy, Sylvie ULg; Massat, I; Staner, L et al

in American Journal of Medical Genetics Part B-Neuropsychiatric Genetics (2000), 96(3), 360-364

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See detail5-Nucleotidase activity in isolated follicular dendritic cells.
Heinen, Ernst ULg; Kinet-Denoel, C.; Simar, L. J.

in Immunology Letters (1985), 9(2-3), 75-80

Follicular dendritic cells isolated from mouse lymph nodes were incubated in the presence of AMP to test 5-nucleotidase (5-Nase) activity. Ultrastructural observations showed the presence of 5-Nase on ... [more ▼]

Follicular dendritic cells isolated from mouse lymph nodes were incubated in the presence of AMP to test 5-nucleotidase (5-Nase) activity. Ultrastructural observations showed the presence of 5-Nase on external membranes but also some activity inside the nucleus. 5-Nase was found associated to Fc receptors labelled with homologous immunoglobulins fixed on colloidal gold particles. Lymphocytes and macrophages, found in association with the follicular dendritic cells, were either 5-Nase positive or negative. The hypothetical roles played by 5-Nase in germinal centers are discussed. [less ▲]

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See detail5-Phenylacetylaminothiazolium salts and their reactions with nucleophiles
Pirotte, Bernard ULg; Delarge, J.

in Journal of Chemical Research (S) (1990)

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See detailA 5-Year Controlled Randomized Study of Prevention of Postmenopausal Trabecular Bone Loss with Nasal Salmon Calcitonin and Calcium
Reginster, Jean-Yves ULg; Meurmans, L.; Deroisy, Rita ULg et al

in European Journal of Clinical Investigation (1994), 24(8), 565-9

The aim of this paper was to evaluate the long-term (5 years) efficacy of nasal salmon calcitonin in prevention of trabecular postmenopausal bone loss, which was a follow-up of a previously published ... [more ▼]

The aim of this paper was to evaluate the long-term (5 years) efficacy of nasal salmon calcitonin in prevention of trabecular postmenopausal bone loss, which was a follow-up of a previously published study (3 years); a randomized, controlled group comparison. One hundred healthy postmenopausal women were randomly chosen from those (186) having completed the 3 year protocol. The 100 women were allocated to an additional 2 year period (total of 5 years) of treatment with either 500 mg d-1, 5 days week-1 of calcium or the same amount of calcium plus 50 IU d-1, 5 days per week of nasal salmon calcitonin, 87 (87%) women complied with the protocol throughout. The main outcome measures were the bone mineral density of the lumbar spine (1-BMD) (DPA) and biochemical parameters reflecting bone turnover (serum alkaline phosphatases, urinary calcium/creatinine and hydroxyproline/creatinine ratios). The women receiving calcium alone presented a significant decrease in 1-BMD after 6 months [-1.6 (0.5)%] [mean(SEM)] (P < 0.01) and this decrease remained significant after 36 months [-6.1(0.8)%] (P < 0.01) and until the end of the trial [-6.6(1.0)% at t60] (P < 0.01). In women receiving calcium and calcitonin, 1-BMD significantly increased after 36 months [+2(0.7%] (P < 0.01) and 42 months [+2.5(0.7)%] (P < 0.01 and was unchanged at the other times of investigation [+1.1 (1.1)% at t60] (NS). The evolution of BMD in the two groups was highly significantly different (P < 0.001) since the sixth month of the study and remained so until the end of the study.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detail5. Le smorfie del ghiaccio che si sgretola: Il montalismo di Fabio Pusterla
Benzoni, Pietro ULg

in Stilistica e metrica italiana (2005), V(5), 267-303

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See detail5. « Qu’est-ce qu’un signe linguistique? Le revers psychologique de la théorie husserlienne des actes de signification à l’époque des Recherches logiques »
Gyemant, Maria ULg

in INVESTIGACIONES FENOMENOLÓGICAS REVISTA DE LA SOCIEDAD ESPAÑOLA DE FENOMENOLOGÍA (2013), 4(1), 219-234

Dans le § 8 de la 1ère recherche logique Husserl explique qu'est-ce que c'est l'expression (Ausdruck), par opposition à un autre type de signe: l'indice (Anzeichen). Ce qu'est en jeu, c'est la spécificité ... [more ▼]

Dans le § 8 de la 1ère recherche logique Husserl explique qu'est-ce que c'est l'expression (Ausdruck), par opposition à un autre type de signe: l'indice (Anzeichen). Ce qu'est en jeu, c'est la spécificité de l'expression, entendue par Husserl comme une sorte de signe qui présente un caractère clair. Mais afin de determiner l'expression Husserl effectue une opération interpretée par Derrida comme un premier type de réduction: réduction du langage a une forme du soliloque. En d'autres termes, au moment où Husserl doit expliquer ce qu'est un signe linguistique, met entre parenthèses précisément la fonction symbolique des expressions. Je tiens à souligner dans cet article les raisons qui conduisent Husserl à ce surprenant geste de mettre entre parenthèses l'une des fonctions les plus essentielles des actes significatifs, la fonction comunicative de contenus intentionnels au moyen de signes dans un contexte intersubjectif. Je montrerai après ce que conduit Husserl à examiner à nouveau cette décision et à la critiquer dans les textes de 1913-1914 lors de la préparation de la deuxième édition des Recherches logiques et publiés aujourd'hui dans le volume XX/2 de Husserliana. [less ▲]

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See detail5. Les régulateurs de croissance
Meza Morales, Walter; Seutin, Benoît ULg; Monfort, Bruno et al

in Bodson, Bernard; Destain, Jean-Pierre (Eds.) Livre Blanc - Céréales (2013, February 27)

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See detail5. Les régulateurs de croissance
Seutin, Benoit ULg; Vancutsem, Françoise ULg; Monfort, Bruno et al

in Livre Blanc - Céréales - Gembloux (2012, February 29)

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See detail5. Les régulateurs de croissance
Vancutsem, Françoise ULg; Seutin, Benoit ULg; Monfort, Bruno et al

in Livre Blanc: Céréales - Gembloux (2011, February 23)

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See detail5. Régulateurs de croissande
Meza Morales, Walter ULg; Monfort, Bruno; Mahieu, Olivier et al

in Bodson, Bernard; Destain, Jean-Pierre (Eds.) Livre Blanc Céréales (2014, February 26)

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See detail5.04 - Carbon Dioxide and Methane Dynamics in Estuaries
Borges, Alberto ULg; Abril, Gwenaël

in Wolanski, Eric; McLusky, Donald (Eds.) Treatise on Estuarine and Coastal Science, Volume 5: Biogeochemistry (2011)

Estuaries profoundly transform the large amounts of carbon delivered from rivers before their transfer to the adjacent coastal zone. As a consequence of the complex biogeochemical reworking of ... [more ▼]

Estuaries profoundly transform the large amounts of carbon delivered from rivers before their transfer to the adjacent coastal zone. As a consequence of the complex biogeochemical reworking of allochthonous carbon in the sediments and the water column, CO2 and CH4 are emitted into the atmosphere. We attempt to synthesize available knowledge on biogeochemical cycling of CO2 and CH4 in estuarine environments, with a particular emphasis on the exchange with the atmosphere. Unlike CH4, the global emission of CO2 to the atmosphere from estuaries is significant compared to other components of the global carbon cycle [less ▲]

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See detailLes 50 ans de la CAAMI
Coninckx, Daniël; Eelen, kristof; Devos, Carl et al

Book published by Academia Press (2005)

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See detail50 Hz Magnetic Field Exposure Influence on Human Performance and Psychophysiological Parameters: Two Double-Blind Experimental Studies
Crasson, Marion ULg; Legros, Jean-Jacques ULg; Legros, Willy ULg et al

in Bioelectromagnetics (1999), 20(8), 474-86

Two double-blind studies were performed to examine magnetic field (MF) exposure effects and to determine the impact of temporal variation (continuous vs. intermittent exposure) of 100 mu T(rms) 50 Hz MF ... [more ▼]

Two double-blind studies were performed to examine magnetic field (MF) exposure effects and to determine the impact of temporal variation (continuous vs. intermittent exposure) of 100 mu T(rms) 50 Hz MF diurnal exposure on psychological and psychophysiological parameters in healthy humans. Three cephalic exposure sessions of 30-min, i.e., sham, continuous, and intermittent (15 s ON/OFF cycles) MF conditions, were involved. Each subject participated in all sessions, which were spaced at 1-wk intervals. In each session, mood ratings and performance measures were obtained before, during, or after exposure and several electrophysiological data (event-related brain potentials [ERP]) were recorded after each exposure session. These criteria were chosen to evaluate sensory functions as well as automatic and voluntary attentional processes. In experiment 1, 21 healthy male volunteers (20 to 27 years of age) were studied. Ten subjects were exposed at 13:30 h, and 11 subjects were exposed at 16:30 h. Statistically significant changes in the amplitude of ERP were observed after MF exposure in the dichotic listening task, indexing selective attention processes. Eighteen of the 21 original male volunteers took part in experiment 2, undertaken to better understand the results related to information processing involved in selective attention and control for ultradian rhythmicity. Exposure time for all the subjects was at 13:30 h. The analysis of the data again revealed significant amplitude changes of the ERP recorded in the dichotic listening task. Moreover, they demonstrated ERP latency and reaction time slowing in the oddball paradigm, a visual discrimination task after real MF exposure. These results also indicate that a low level 50 Hz MF may have a slight influence on event-related potentials and reaction time under specific circumstances of sustained attention. [less ▲]

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See detail50 jaar HZIV
Coninckx, Daniël; Eelen, kristof; Devos, Carl et al

Book published by Academia Press (2005)

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