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See detailHypothèse idiographique concernant la médiation cognitive à partir du Rorschach « non valide » d’un patient schizophrène en phase de stabilisation symptomatique
Englebert, Jérôme ULg

in Evolution Psychiatrique (2011), 76(4), 631-639

Introduction The author recalls the setting for the Rorschach test meets the conditions of validity to be interpreted in accordance to the Comprehensive System. Since the work of JE Exner consensus is ... [more ▼]

Introduction The author recalls the setting for the Rorschach test meets the conditions of validity to be interpreted in accordance to the Comprehensive System. Since the work of JE Exner consensus is established to identify two categories of invalid protocols: the protocols collected from subjects who are temporarily in a serious state of disarray for contextual reasons and the brief protocols. Regarding the brief protocols, the rule is clear and precise: research findings indicate that the overwhelming majority of records of less than 14 responses will not have the level of reliability prerequisite to the assumption of interpretive validity. The test will be considered invalid if the subject does not give at least one answer to each of the cards. For the presented protocol, it is not fair to detect any structural and psychopathology data. The author's hypothesis is to propose an unique and phenomenological study of the test and to formulate an hypothesis regarding the psychological functioning of the subject. The subject is a patient of 32 years old showing a paranoid schizophrenic disorder in symptomatic stabilization for six months. The patient receives a treatment with neuroleptics and follows therapy based on knowledge of the disorder and the recognition of associated symptoms. The patient's Rorschach is invalid (less than 14 answers and no response and 3 rejections of cards). Protocol analysis From the 10 responses, each perception is reviewed, either directly or during the inquiry. Finally, each answer was rejected by a perceptual justification that will give "evidence" to challenge the response ("but not a ... because ... ") or by a simple assertion ("because it does not look like", "it cannot be right" or "it's not that"). Cognitive mediation - the process between the information processing and ideation - can be analyzed in depth for this protocol. The cognitive mediation reflects the mental operations involved in the translation or the identification of the data collected. The process requires some reconciliation (mediation) between the image that has been stored and available items from the memory of the individual so as to accomplish the task of responding to the question "What might this be?". In this protocol, the cognitive mediation responds to a simple and repetitive logic which seems to reflect an idiosyncratic psychological functioning. In general, in the Rorschach’s situation, the subject must give a "wrong" answer because the only absolutely correct answer is "the inkblot". The Rorschach’s test requires that the person to "misperceive" the stimulus (to "violate reality"). For the protocol of this study, each response – each "false perception" - is systematically reviewed by the subject and ultimately rejected with contradictory perceptual justification or arguments unsophisticated. Discussion and hypothesis An idiographic hypothesis is formulated by the author from this tendency to systematic doubt. This means identifying, through this subject, the use of a form of "methodical doubt" in the cognitive mediation. This mechanism would fit in a paradoxical context that may reflect the state of the schizophrenic patient in a symptomatic stabilization situation. This hypothesis shows that the stabilization should not be confused with any remission or "cure" (suggesting a return to a previous state to psychosis). If the subject learns to explicitly doubting against ambiguous stimuli, it is hardly possible to tolerate a moderate degree of violation and therefore meet the paradigmatic principle of the Rorschach. Finally, the analysis of the Rorschach’s test gives us an interesting information about symptomatic stabilization situation and residual component of the schizophrenic disorder. These observations appear to be incompatible with homeostatic hypothesis and demonstrate the usefulness of residual schizophrenia diagnosis. The rule of "misperception" if it is tolerable and implicit for the non-psychosis individual, it is intolerable and always explicitly questioned by our schizophrenic patients. The relation between implicit and explicit is a complexed dialectical conflict that seems to characterize the psychological functioning on a continuum showing schizophrenic subject and non-psychosis person. [less ▲]

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See detailHypothèse sur la cristallisation
Spring, Walthère ULg

in Annales de la Société Géologique de Belgique. Mémoires (1875), II

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See detailHypothesis confirmation in dyadic interaction: It may have a social value
Dardenne, Benoît ULg

Scientific conference (1998, May)

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See detailHypothesis testing identification : A new method for bad data analysis in power system state estimation
Mili, Lamine; Van Cutsem, Thierry ULg; Pavella, Mania

in IEEE Transactions on Power Apparatus and Systems (1984), 103

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See detailHypothesis Testing in Escherichia coli using Mathematical Modeling
Sauter, T.; Bullinger, Eric ULg; Allgöwer, F. et al

Poster (2001)

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See detailHypothyroïdie frustre : à partir de quand traiter?
Beckers, Albert ULg

Scientific conference (1993, December 11)

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See detailHypothyroïdie infraclinique non auto-immune et statut iodé : étude prospective d'intervention
VALDES SOCIN, Hernan Gonzalo ULg; Tudorescu, A; Lutteri, L et al

in Annales d'Endocrinologie (2013, October), 74

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See detailL'hypothyroidie subclinique.
Moreau, L.; Beckers, Albert ULg

in Revue Médicale de Liège (1995), 50(4), 171-4

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie ... [more ▼]

L'hypothiroïdie subclinique associe, chez des patients asymptomatiques, une élévation de la TSH sérique et une hormonologie thyroïdienne dans les limites de la normale. Le traitement de cette pathologie affectant surtout les personnes âgées est justifié par l'existence de troubles du bilan lipidique, de goitres et de perturbations neuropsychologiques. Celui-ci repose sur l'administration de lévothyroxine à dose minimale pour normaliser la TSH [less ▲]

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See detailHypothyroidism and Major Depression: A Common Executive Dysfunction?
Constant, Eric; Adam, Stéphane ULg; Seron, Xavier et al

in Journal of Clinical & Experimental Neuropsychology : Official Journal of the International Neuropsychological Society (2006), 28(5), 790-807

Little is known about the possible link between the cognitive disorders associated with hypothyroidism and those encountered in depression. This study examines attentional and executive functions as well ... [more ▼]

Little is known about the possible link between the cognitive disorders associated with hypothyroidism and those encountered in depression. This study examines attentional and executive functions as well as the intensity of anxiety and depressive symptoms in hypothyroidism and major depression and the possible link between these symptoms and cognitive disturbances. This study confirms the existence of psychomotor slowing associated with attentional and executive disturbance in major depression as well as in hypothyroidism. However, while depressed subjects manifested a conscious bias with material of negative emotional valence, no such bias was found in the hypothyroid subjects. While the hypothyroid state is accompanied by anxiety/depressive symptoms, it seems that the latter are too discrete for an attentional bias to be observed with material with a negative emotional valence. [less ▲]

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See detailHypovitaminose D du patient brûlé : une équation à plusieurs inconnues.
ROUSSEAU, Anne-Françoise ULg; LEDOUX, Didier ULg; DAMAS, Pierre ULg et al

in Revue Médicale de Liège (2013), 68(11), 574-578

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See detailHypovitaminosis D and osteoporosis in burn patients: are the current practices enough ?
ROUSSEAU, Anne-Françoise ULg; LEDOUX, Didier ULg; DAMAS, Pierre ULg et al

in Osteoporosis International (2013), 24(Suppl 1), 377

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See detailHypoxia and biogeochemical processes concurrently impact acidification in a seasonally stratified coastal marine lake
Hagens, M; Slomp, CP; Meysman, FJR et al

Conference (2014, February 23)

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See detailHypoxia and hypercapnia during incubation of chicken eggs on development and subsequent performance
Decuypere, E.; Onagbesan, O.; De Smit, L. et al

Conference (2006)

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See detailHypoxia in macrophytodetritus accumulation: Species specific harpacticoid copepod adaptation?
Mascart, Thibaud ULg; De Troch, Marleen; Gobert, Sylvie ULg et al

Poster (2014, May 05)

Mediterranean Posidonia oceanica seagrass meadows generate high primary production and support large biodiversity of associated fauna and flora. The majority of the foliar material falls on the ... [more ▼]

Mediterranean Posidonia oceanica seagrass meadows generate high primary production and support large biodiversity of associated fauna and flora. The majority of the foliar material falls on the unvegetated sea floor during the autumnal leaf senescence, fuelling the detrital food web. Whilst laying on the sea floor the freshly formed macrophytodetritus pile up into accumulations according to the local hydrodynamics and seafloor geomorphology. In these litter accumulations, harpacticoid copepods (Crustacea, Copepoda) are the main meiofaunal players (metazoans in the size range of 38µm – 1mm) and show a high specific diversity. They are primarily grazers, but their high specific diversity suggests that they occupy also a large variety of trophic niches. This large morphological and trophic diversity can partly be promoted by the complexity of the phytodetritus in seagrass accumulations. On the other hand, macrophytodetritus degradation and flux of reduced compounds from the sediments is responsible for oxygen consumption inside the accumulation of seagrass litter. Therefore, concentration of oxygen inside the accumulation is very variable and often under the concentration observed in the water column just above the litter. Frequently, oxygen levels reach very low values. The present study aims to link the oxygen variability inside the accumulation to the densities of the five most dominant harpacticoid copepods found living in the P. oceanica litter. Standardized samples were collected seasonally in two contrasting sites of the Calvi Bay (Corsica) during one year. Our results showed no correlation between the oxygen concentrations and harpacticoid community diversity or their total abundances. The five most dominant species showed divergent results, but none had a clear correlation with the oxygen concentration. This contrasts with observation done for sediment meiofaunal community where most harpacticoid copepods are sensitive to oxygen level and where nematodes often dominate the community. This could be explained by their high mobility and the patchiness and variability of the oxygen concentrations present in the accumulations. Harpacticoid copepods, whilst being sensitive to hypoxia and anoxia developed a strategy to live in this fast oxygen changing environment. To conclude, our results underline the importance of species-specific analysis of correlation data. Especially in complex and dynamic environments where a variety of potential trophic niches are present and species competition is very likely to occur. The overall abundance pattern and diversity of the copepod community showed no relation to the oxygen concentration while the most abundant copepod species did not responded to fluctuating oxygen concentrations. [less ▲]

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See detailHypoxia in the Black Sea northwestern shelf: From eutrophication to climatic stressors.
Capet, Arthur ULg; Beckers, Jean-Marie ULg; Grégoire, Marilaure ULg

in 40th CIESM congress proceedings (2013, October)

Abstract The dynamics of seasonal hypoxia, which affects the Black Sea north-western shelf since the mid 1970's until present days, is investigated by means of a 3D biogeochemical model. Comparison of the ... [more ▼]

Abstract The dynamics of seasonal hypoxia, which affects the Black Sea north-western shelf since the mid 1970's until present days, is investigated by means of a 3D biogeochemical model. Comparison of the model results with in -situ data reveals that the phenomenon may have been underestimated after the mid 1990's due to the distribution of observations. We investigate the mechanism of hypoxia at seasonal scale, and identify the main drivers of its interannual variability. While high nutrients discharge caused severe hypoxia in the 1980's, it was sustained in the 1990's by the pool of organic matter accumulated during the previous years in the sediments layer. With an increasing intensity, climatic stressors intensifies the response of hypoxia to nutrient discharge, and affect the seasonal dynamics of hypoxia by extending its temporal scale. [less ▲]

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See detailHypoxia induces a phase transition within a kinase signaling network in cancer cells
Wei, Wei; Shia, Qihui; Remacle, Françoise ULg et al

in Proc. Natl. Acad. Sci. USA (2013)

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See detailHypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity
Sermeus, Audrey; Cosse, Jean-Philippe ULg; Crespin, Marianne et al

in Molecular Cancer (2008), 7

Background: it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. However, few elements are currently available as for the mechanisms underlying this ... [more ▼]

Background: it is now well established that hypoxia renders tumor cells resistant to radio- but also chemotherapy. However, few elements are currently available as for the mechanisms underlying this protection. Results: in this study, physiological hypoxia was shown to inhibit apoptosis induced in HepG2 cells by etoposide. Indeed, hypoxia reduced DNA fragmentation, caspase activation and PARP cleavage. The DNA binding activity of 10 transcription factors was followed while the actual transcriptional activity was measured using specific reporter plasmids. Of note is the inhibition of the etoposideinduced activation of p53 under hypoxia. In parallel, data from low density DNA microarrays indicate that the expression of several pro- and anti-apoptotic genes was modified, among which are Bax and Bak whose expression profile paralleled p53 activity. Cluster analysis of data unravels several possible pathways involved in the hypoxia-induced protection against etoposide-induced apoptosis: one of them could be the inhibition of p53 activity under hypoxia since caspase 3 activity parallels Bax and Bak expression profile. Moreover, specific downregulation of HIF-1α by RNA interference significantly enhanced apoptosis under hypoxia possibly by preventing the hypoxia mediated decrease in Bak expression without altering Bax expression. Conclusion: these results are a clear demonstration that hypoxia has a direct protective effect on apoptotic cell death. Moreover, molecular profiling points to putative pathways responsible for tumor growth in challenging environmental conditions and cancer cell resistance to chemotherapeutic agents. [less ▲]

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See detailHypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation.
Coudyzer, Pauline; Lemoine, Pascale; Jordan, Benedicte F. et al

in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2013), sous presse

Menstrual endometrial breakdown induced by estradiol and progesterone withdrawal is regularly attributed to vasospasm of spiral arteries causing ischemia and hypoxia. We investigated whether hypoxia ... [more ▼]

Menstrual endometrial breakdown induced by estradiol and progesterone withdrawal is regularly attributed to vasospasm of spiral arteries causing ischemia and hypoxia. We investigated whether hypoxia actually occurred in an in vivo model of menstruation. Three complementary approaches were used to look for signs of hypoxia in fragments of human functionalis xenografted to ovariectomized immunodeficient mice bearing pellets-releasing estradiol and progesterone, and then deprived of ovarian steroids. Hormone withdrawal 21 d after grafting induced menstrual breakdown and MMP expression within 4 d. Local partial oxygen pressure (pO2) was measured by electron paramagnetic resonance using implanted lithium phtalocyanine crystals. In mice with hormone maintenance until sacrifice, pO2 was low one week after grafting (14.8+/-3.4 mmHg) but increased twofold from the second week when tissue was largely revascularized. After 3 wk, pO2 was not modified by hormone withdrawal but was slightly increased on hormone reimpregnation 4 d after removal (34.7+/-6.1 mmHg) by comparison with hormone maintenance (27.1+/-8.6 mmHg). These results were confirmed using fluorescence quenching-based OxyLite measurements. In a further search for signs of hypoxia, we did not find significant HIF1-alpha immunostaining, nor pimonidazole adducts after hormone withdrawal. We conclude that hypoxia is not needed to trigger menstrual-like tissue breakdown or repair in human endometrial xenograft.-Coudyzer, P., Lemoine, P., Jordan, B. F., Gallez, B., Galant, C., Nisolle, M., Courtoy, P. J., Henriet, P., and Marbaix, E. Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation. [less ▲]

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