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See detailHome-to-work commuting, urban form and potential energy savings: A local scale approach to regional statistics
Dujardin, Sébastien; Pirart, François; Brevers, Florence et al

in Transportation Research. Part A : Policy & Practice (2012), 46

The link between transport energy consumption and land use patterns has been the focus of a considerable amount of academic works over the past decades. While many empirical researches are backed up with ... [more ▼]

The link between transport energy consumption and land use patterns has been the focus of a considerable amount of academic works over the past decades. While many empirical researches are backed up with solid statistical techniques, most of them do not fully consider the influence of scale underlying empirical quantitative investigations. Using fine-scale home-to-work commuting data for Wallonia (Belgium), this paper re-evaluates Breheny’s (1995) assertion that urban structure should hold the characteristics of major cities if substantial energy savings are to be achieved. A local scale approach highlights efficient settlements in terms of transport energy consumption not only within major towns, butalso within remote rural areas. Furthermore, results suggest that influencing the urban form following local energy efficient examples rather than regional ones could also yield significant gains, without an extreme policy stance of re-urbanisation in major cities. [less ▲]

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See detailHomeland-oriented activities and integration in the host society
Perrin, Nathalie ULg; Martiniello, Marco ULg

in Féron, Elise; Orrnert, Anna (Eds.) The INFOCON Mousebook. Transnational Communities and Conflicts. Challenges and how to address them (2011)

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See detailHomenaje conmemorativo a Manuel Sacristán
Ceballos Viro, Alvaro ULg

in Revista de Hispanismo Filosófico (2006)

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See detailEl homenaje de 1930 a Juan Ruiz: sinécdoque y silepsis
Ceballos Viro, Alvaro ULg

in Toro Ceballos, Francisco; Godinas, Laurette (Eds.) Juan Ruiz, Arcipreste de Hita, y el "Libro de buen amor". Congreso homenaje a Jacques Joset (2011)

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See detailHomeobox Genes: Potential Candidates for the Transcriptional Control of the Transformed and Invasive Phenotype
Castronovo, Vincenzo ULg; Kusaka, Masami; Chariot, Alain ULg et al

in Biochemical Pharmacology (1994), 47(1), 137-43

The transformation of a cell and the acquisition of the invasive and metastatic phenotype result from the activation of a group of complex cellular processes rather than from the effect of a single gene ... [more ▼]

The transformation of a cell and the acquisition of the invasive and metastatic phenotype result from the activation of a group of complex cellular processes rather than from the effect of a single gene product. It is likely that the coordination of the multiple genes involved in malignancy is under the control of a few genes that act as master genes or orchestrator genes. The latter probably code for transcription factors that control the genetic program for tumor invasion and metastasis. Homeobox genes are a family of transcription factors that contain a 183 bp highly conserved nucleotide sequence coding for a 61 amino acid domain that binds specifically to DNA. First discovered in Drosophila as genes controlling segmentation and segment identity, homeobox genes have since been identified in many other species including nematodes, frog, mouse and human. There is strong support for the suggestion that homeobox genes play a key role in development and differentiation. In humans, there are 38 homeobox genes organized in four clusters that are localized on chromosomes 2, 7, 12 and 17. The specific functions of each of these genes are generally unknown. Alterations in expression of several homeobox genes have been reported in a variety of malignant lesions, suggesting that they could play a role in the development of cancer. Using reverse transcriptase reaction coupled with polymerase chain reaction and degenerate oligonucleotides corresponding to the 5' and 3' ends of the highly conserved homeodomain, we amplified 130 bp cDNA fragments from the human breast cancer cell line MCF7 that were subsequently cloned into pBluescript vector. Sequencing of the clones, resulted in the identification of the homeodomains of four different human homeobox genes: HOXB6, HOXA1, HOXA10 and HOXC6. Further studies should determine the specific role of these four homeobox genes in the development and progression of human breast cancer and potentially determine if they might be good targets for gene therapy. [less ▲]

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See detailThe homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity.
Twizere, Jean-Claude ULg; Lefebvre, Laurent; Collete, Delphine et al

in Journal of Biological Chemistry (2005), 280(33), 29804-11

Bovine leukemia virus (BLV) tax is an essential gene involved in the transcriptional activation of viral expression. Tax is also believed to be implicated in leukemogenesis because of its ability to ... [more ▼]

Bovine leukemia virus (BLV) tax is an essential gene involved in the transcriptional activation of viral expression. Tax is also believed to be implicated in leukemogenesis because of its ability to immortalize primary cells in vitro. To gain insight into the molecular pathways mediating the activities of this important gene, we identified cellular proteins interacting with Tax. By means of a two-hybrid approach, we show that Tax specifically interacts with MSX2, a general repressor of gene expression. GST pull-down experiments and co-immunoprecipitation assays further confirmed binding specificity. Furthermore, the N-terminal residues 1-79 of MSX2 are required for binding, whereas the C-terminal residues 201-267 of MSX2 do not play a critical role. Whereas the oncogenic potential of Tax in primary cells was only slightly affected by overexpression of MSX2, the other function of Tax, namely LTR-dependent transcriptional activation, was inhibited by MSX2 in human HeLa and bovine B-lymphoblastoid (BL3) cell lines. This MSX2 repression function can be counteracted by overexpression of transcription factors CREB2 and RAP74. The Tax/MSX2 interplay thus results in repression of viral transcriptional activation possibly acting as a regulatory feedback loop. Importantly, this viral gene silencing is not strictly associated with a concomitant loss of Tax oncogenicity as measured by its ability to immortalize primary cells. And interestingly, MSX2 also interacts with and inhibits the transactivation function of the related Tax1 protein encoded by the Human T-cell leukemia virus type 1 (HTLV-1). [less ▲]

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See detailThe homeodomain transcription factor Hoxa2 interacts with and promotes the proteasomal degradation of the E3 ubiquitin protein ligase RCHY1.
Bergiers, Isabelle; Bridoux, Laure; Nguyen, Nathan et al

in PloS one (2013), 8(11), 80387

Hox proteins are conserved homeodomain transcription factors known to be crucial regulators of animal development. As transcription factors, the functions and modes of action (co-factors, target genes) of ... [more ▼]

Hox proteins are conserved homeodomain transcription factors known to be crucial regulators of animal development. As transcription factors, the functions and modes of action (co-factors, target genes) of Hox proteins have been very well studied in a multitude of animal models. However, a handful of reports established that Hox proteins may display molecular activities distinct from gene transcription regulation. Here, we reveal that Hoxa2 interacts with 20S proteasome subunits and RCHY1 (also known as PIRH2), an E3 ubiquitin ligase that targets p53 for degradation. We further show that Hoxa2 promotes proteasome-dependent degradation of RCHY1 in an ubiquitin-independent manner. Correlatively, Hoxa2 alters the RCHY1-mediated ubiquitination of p53 and promotes p53 stabilization. Together, our data establish that Hoxa2 can regulate the proteasomal degradation of RCHY1 and stabilization of p53. [less ▲]

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See detailThe homeodomain-containing proteins: an update on their interacting partners
Chariot, Alain ULg; Gielen, Jacques; Merville, Marie-Paule ULg et al

in Biochemical Pharmacology (1999), 58

Homeodomain-containing proteins are transcription regulators controlling the coordinated expression of genes involved in development, differentiation, and cellular transformation. They share a highly ... [more ▼]

Homeodomain-containing proteins are transcription regulators controlling the coordinated expression of genes involved in development, differentiation, and cellular transformation. They share a highly conserved 60-amino-acid region (the "homeodomain"), which allows them to bind DNA and modulate the expression of multiple target genes, whose identities remain largely unknown. Although each HOX gene product exhibits in vivo specificity, they harbor very similar DNA-binding affinities in vitro, suggesting that other mechanisms such as protein-protein interactions are critical to modulate their function. In this commentary, we describe the proteins that can interact with the HOX gene products, including newly identified partners such as CREB binding protein and the NF-kappaB/IkappaB-alpha proteins. We also outline the molecular programs that are regulated by the transcriptional complexes involving the HOX gene products and where new pharmacological tools could find interesting targets. [less ▲]

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See detailL'homeopathie est-elle superieure au placebo? Controverse a propos d'une meta-analyse des etudes controlees.
Scheen, André ULg; Lefebvre, Pierre ULg

in Bulletin et Mémoires de l'Académie Royale de Médecine de Belgique (1999), 154(7-9), 295-304304-7

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not ... [more ▼]

At a time when scientists support Evidence-Based Medicine, the Parliament of Belgium has recently decided to recognize four alternative medicines, among which homeopathy. Whereas this discipline does not rely on any scientific basis, it appears to be popular, especially in general practice. The homeopaths have recently taken arguments from a meta-analysis published in 1997 in the Lancet of 89 placebo-controlled trials. This study indeed concluded that the results are not compatible with the hypothesis that the clinical effects of homeopathy are completely due to placebo. However, this meta-analysis contains several methodological flaws. Furthermore, it is recognized that results of a meta-analysis may not be confirmed in large well-performed clinical trials. Thus, homeopathy should still provide the evidence that conventional medicine has regularly brought during the last two decades in many fields of therapeutics, with the respect of the rigorous rules of "Good Clinical Practice", leading to "Evidence-Based Medicine". [less ▲]

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See detailL'homeopathie peut-elle trouver sa legitimite dans les resultats "positifs" d'une meta-analyse?
Scheen, André ULg

in Revue Médicale de Liège (1997), 52(11), 694-7

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See detailHomeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area.
Schmidt, Christina ULg; Collette, Fabienne ULg; Leclercq, Yves ULg et al

in Science (2009), 324(5926), 516-9

Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in ... [more ▼]

Throughout the day, cognitive performance is under the combined influence of circadian processes and homeostatic sleep pressure. Some people perform best in the morning, whereas others are more alert in the evening. These chronotypes provide a unique way to study the effects of sleep-wake regulation on the cerebral mechanisms supporting cognition. Using functional magnetic resonance imaging in extreme chronotypes, we found that maintaining attention in the evening was associated with higher activity in evening than morning chronotypes in a region of the locus coeruleus and in a suprachiasmatic area (SCA) including the circadian master clock. Activity in the SCA decreased with increasing homeostatic sleep pressure. This result shows the direct influence of the homeostatic and circadian interaction on the neural activity underpinning human behavior. [less ▲]

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See detailHomesick again - Homesick James
Sacré, Robert ULg

in Soul Bag (1984), (99), 14

Homesick James : photo

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See detailHommage à Danielle Gourevitch (Paris, 16-17 mars 2006)
Marganne, Marie-Hélène ULg

in Lettre d'informations du Centre Jean-Palern (2006), NS 4

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See detailHommage à Henri KOCH
Sacré, Robert ULg

Learning material (1985)

Ecole du violon à Liège

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See detailHommage à Hubert Nyssen
Durand, Pascal ULg; De Decker, Jacques; Outers, Jean-Luc

Speech (2012)

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See detailHommage à Hubert Nyssen (1925-2011)
Durand, Pascal ULg; Savigneau, Josyane; Manguel, Alberto

Conference given outside the academic context (2012)

Débat public en compagnie de Josyane Savigneau, critique littéraire au Monde, et l'écrivain Alberto Manguel, à l'invitation de la Bibliothèque Nationale de France, en hommage à l'écrivain et éditeur ... [more ▼]

Débat public en compagnie de Josyane Savigneau, critique littéraire au Monde, et l'écrivain Alberto Manguel, à l'invitation de la Bibliothèque Nationale de France, en hommage à l'écrivain et éditeur Hubert Nyssen, un an après sa disparition. Lectures par le comédien Gérard Desarthe. [less ▲]

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See detailHommage à Luc Collès
Defays, Jean-Marc ULg; Géron, Geneviève

Book published by Editions Modulaires Européennes (in press)

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See detailHommage à M.D. Grmek
Marganne, Marie-Hélène ULg

in Histoire des Sciences Médicales (2001), 35(4), 345-346

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See detailHommage à Mohammed Arkoun
Nachi, Mohamed ULg

in Nachi, Mohamed (Ed.) Les figures du compromis dans les sociétés islamiques: Perspectives historiques et socio-anthropologiques (2011)

Detailed reference viewed: 14 (1 ULg)
See detailHommage à Pierre FROIDEBISE
Sacré, Robert ULg

Learning material (1982)

Vie et oeuvre de P. Froidebise

Detailed reference viewed: 11 (0 ULg)