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See detailA High Serum Concentration of Interleukin-6 Is Predictive of Relapse in Quiescent Crohn's Disease
Louis, Edouard ULg; Belaiche, Jacques ULg; Van Kemseke, Catherine ULg et al

in European Journal of Gastroenterology & Hepatology (1997), 9(10), 939-44

BACKGROUND/AIMS: Relapses of Crohn's disease are difficult to predict. We assessed the value of serum level of interleukin-6, tumour necrosis factor alpha (TNF-alpha) and soluble TNF receptors as ... [more ▼]

BACKGROUND/AIMS: Relapses of Crohn's disease are difficult to predict. We assessed the value of serum level of interleukin-6, tumour necrosis factor alpha (TNF-alpha) and soluble TNF receptors as predictors of relapse in quiescent Crohn's disease. PATIENTS/METHODS: Thirty-six patients with inactive Crohn's disease, treated or not, were included. Various clinical and biological parameters, including interleukin-6, TNF-alpha and soluble TNF receptors serum levels were measured at inclusion in the study and the patients were followed clinically for 1 year. The relapse was defined as a Crohn's Disease Activity Index (CDAI) greater than 150 with an increase greater than 100 compared to the inclusion value. We analysed the ability of these parameters to predict relapse in parallel to clinical characteristics and other laboratory parameters. RESULTS: Among the 32 variables tested, interleukin-6 serum level had the greatest ability to predict the time-to-relapse, with 17-fold chance of relapse over a 1-year period for patients with an interleukin-6 serum level greater than 20 pg/ml than for patients with a lower level (P < 0.001). A high serum level of the soluble TNF receptors p55 and p75 also had significant predictive value, in contrast to TNF-alpha serum levels. An interleukin-6 serum level greater than 20 pg/ml and either an acid alpha-1-glycoprotein level greater than 1.1 g/l or a soluble interleukin-2 receptor serum level greater than 95 pM/l were risk factors selected by a stepwise multivariate analysis. In both models a good prognosis group was defined by the absence of the two risk factors, a bad prognostic group by the presence of the two risk factors and an intermediate in between. With both models, the good prognosis group included 17 patients who experienced no relapse over the 1-year follow-up, whereas all patients (seven with the first model and six with the second) in the bad prognosis group had a relapse during the follow-up. Looking specifically at two homogeneous subgroups including either naturally/5-aminosalicylic acid (5-ASA) quiescent or corticoid quiescent patients, a very good predictive value for interleukin-6 serum concentration was also found. CONCLUSION: Interleukin-6 serum level alone or in association with other biological parameters such as acid alpha-1-glycoprotein or the soluble interleukin-2 receptor serum level may be useful for predicting the course of the disease in patients with quiescent Crohn's disease. [less ▲]

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See detailHigh serum transforming growth factor-beta 1 concentration in West Highland white terriers : a key to the breed predisposition in canine idiopathic pulmonary fibrosis
Krafft, Emilie ULg; Heikkilä, H.P.; Jespers, P et al

in Proceedings of the 21st ECVIM-CA Congress (2011, September)

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See detailHigh Speed Astronomical Photometry -- Brian Warner
Manfroid, Jean ULg

in Ciel et Terre (1989), 105

Not Available

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See detailHigh strength steel in seismic resistant building frames - HSS-SERF - Final report
Dubina, Dan; Vulcu, Cristian; Stratan, Aurel et al

Report (in press)

The aim of “HSS-SERF” project was to investigate and evaluate the seismic performance of dual-steel building frames, realized from two different steel grades: Mild Carbon Steel (MCS) and High Strength ... [more ▼]

The aim of “HSS-SERF” project was to investigate and evaluate the seismic performance of dual-steel building frames, realized from two different steel grades: Mild Carbon Steel (MCS) and High Strength Steel (HSS). A comprehensive set of dual-steel frames (moment resisting, concentrically and eccentrically braced) were designed, which allowed the identification of realistic member sizes for both MCS and HSS components. Several practical solutions for bolted and welded beam-to-column joints were identified and designed. Further, an extensive numerical program was carried out for the seismic performance evaluation of frames. The ductility and over-strength demands, and q-factors associated with different performance levels were evaluated. Furthermore, experimental and numerical investigations were carried out on joint assemblies and components. Guidelines were elaborated for the conceptual design and PBD of dual-steel frames under seismic actions, and the technical and economic efficiency of dualsteel structures vs. conventional ones were finally evaluated. The main outcomes of the project consist in: (i) development and characterisation in terms of global ductility and over-strength demands of dual-steel frames with composite columns (innovative solutions in European context); (ii) development of design recommendations; (iii) proposal of innovative solutions for beam-to-column joints with composite columns; (iv) recommendation for weld details and appropriate component method design approaches; (v) evaluation of technical and economic efficiency of the dual-steel approach. [less ▲]

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See detailHigh temperature catalysts through sol-gel synthesis
Lecloux, A. J.; Pirard, Jean-Paul ULg

in Journal of Non-Crystalline Solids (1998), 225

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See detailHigh temperature crossover in paraconductivity of granular Y1Ba2Cu3O7-y
Ausloos, Marcel ULg; Gillet, François ULg; Laurent, Christian et al

in Zeitschrift für Physik. B, Condensed Matter (1991), 84(1), 13-16

We have examined the deviation from linearity of the temperature dependence of the electrical resistivity of a YBaCuO ceramics. We have observed at high temperature a crossover behavior toward a ... [more ▼]

We have examined the deviation from linearity of the temperature dependence of the electrical resistivity of a YBaCuO ceramics. We have observed at high temperature a crossover behavior toward a logarithmic temperature dependence at lower temperature. It seems relevant to attribute the origin of such a term to a pair breaking mechanism contribution, thus to give a lower bound to the existence of superconductivity fluctuations onset temperature. Our findings also implies that carriers are bosons above T(c). [less ▲]

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See detailHigh temperatures limit plant growth but hasten flowering in root chicory (Cichorium intybus) independently of vernalisation.
Mathieu, Anne-Sophie; Lutts, Stanley; Vandoorne, Bertrand et al

in Journal of Plant Physiology (2013), in press

An increase in mean and extreme summer temperatures is expected as a consequence of climate changes and this might have an impact on plant development in numerous species. Root chicory (Cichorium intybus ... [more ▼]

An increase in mean and extreme summer temperatures is expected as a consequence of climate changes and this might have an impact on plant development in numerous species. Root chicory (Cichorium intybus L.) is a major crop in northern Europe, and it is cultivated as a source of inulin. This polysaccharide is stored in the tap root during the first growing season when the plant grows as a leafy rosette, whereas bolting and flowering occur in the second year after winter vernalisation. The impact of heat stress on plant phenology, water status, photosynthesis-related parameters, and inulin content was studied in the field and under controlled phytotron conditions. In the field, plants of the Crescendo cultivar were cultivated under a closed plastic-panelled greenhouse to investigate heat-stress conditions, while the control plants were shielded with a similar, but open, structure. In the phytotrons, the Crescendo and Fredonia cultivars were exposed to high temperatures (35 °C day/ 28 °C night) and compared to control conditions (17 °C) over 10 weeks. In the field, heat reduced the root weight, the inulin content of the root and its degree of polymerisation in non-bolting plants. Flowering was observed in 12% of the heat stressed plants during the first growing season in the field. In the phytotron, the heat stress increased the total number of leaves per plant, but reduced the mean leaf area. Photosynthesis efficiency was increased in these plants, whereas osmotic potential was decreased. High temperature was also found to induce flowering of up to 50% of these plants, especially for the Fredonia cultivar. In conclusion, high temperatures induced a reduction in the growth of root chicory, although photosynthesis is not affected. Flowering was also induced, which indicates that high temperatures can partly substitute for the vernalisation requirement for the flowering of root chicory [less ▲]

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See detailHigh temporal coverage of carbon dioxide measurements in the Southern Bight of the North Sea
Schiettecatte, L. S.; Thomas, H.; Bozec, Y. et al

in Marine Chemistry (2007), 106(1-2), 161-173

A monthly survey of the partial pressure of CO2 (pCO2) was carried in the Southern Bight of the North Sea (SBNS) from June 2003 to May 2004. The spatial variability of the surface distribution of the pCO2 ... [more ▼]

A monthly survey of the partial pressure of CO2 (pCO2) was carried in the Southern Bight of the North Sea (SBNS) from June 2003 to May 2004. The spatial variability of the surface distribution of the pCO2 was relatively small (within a range of 10–70 μatm) compared to the amplitude in the seasonal signal (∼260 μatm). On an annual scale, the pCO2 dynamics appeared to be controlled by biological processes (primary production in springtime and respiratory processes in summer), rather than temperature (in summer). The comparison with measurements carried out in 2001 and 2002 (13 cruises) shows that the inter-annual variability of pCO2 was close to the range of the spatial variability and mostly observed in spring, associated to biological processes (primary production). Net ecosystem production estimated from dissolved inorganic carbon (DIC) temporal variations showed that the SBNS is autotrophic, at an annual rate of 6.3 mol C m−2 yr−1. The decoupling in time between autotrophy in spring and heterotrophy in summer, associated to the relatively rapid flushing time of the water mass in the area (∼70 days), might allow the export of a fraction of the springtime synthesized organic matter to the adjacent areas of the North Sea. The SBNS was on a yearly basis a sink of atmospheric CO2 at a rate of −0.7 mol C m−2 yr−1. [less ▲]

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See detailHigh Throughput determination of Levonorgestrel in human plasma using a Sensitive LC-MS/MS method
Hubert, Cédric ULg; Streel, Bruno; Sibenaler, Renilde et al

Poster (2011, June 19)

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See detailHigh throughput sequencing analysis reveals genetic variability and selection pressure in different murine norovirus genomic regions during in vitro replication
Mauroy, Axel ULg; Taminiau, Bernard ULg; Nezer, Carine et al

Poster (2014, July)

Murine norovirus (MuNoV), a single stranded positive sense RNA virus belonging to the Caliciviridae family, is considered as a representative model for human norovirus infections, one of the most ... [more ▼]

Murine norovirus (MuNoV), a single stranded positive sense RNA virus belonging to the Caliciviridae family, is considered as a representative model for human norovirus infections, one of the most important etiological cause of both epidemic and sporadic gastroenteritis cases worldwide. Four open reading frames are described into its genome: ORF1 codes the non-structural (NS) proteins, including the viral RNA dependent RNA polymerase (RdRp); ORF2 codes the single capsid protein (VP1), wherein two domains are present: a relatively conserved domain (“shell”) and a more variable domain (“protruding”); ORF3 codes a minor structural protein; and ORF4, currently only found in viruses genetically related to MuNoV codes a virulence factor. In this study, we demonstrated by high throughput sequencing that, during serial passages of MuNoV in cell culture, the substitution rates, estimated by Bayesian inferences, did not significantly differ across the five targeted genomic regions except one. These rates were similar in four genomic regions encompassing partial non-structural 1-2 protein (NS1-2)-, NS5-, NS6-, NS7 (RdRp)- and VP1-coding sequences (coding the conserved part of the protein also including the ORF4 region). In the partial minor structural protein-coding region, this substitution rate was however estimated to be at least one log higher when expressed as substitution/site/day. The precise localisation of the detected nucleotide point mutations (substitution, deletion and insertion) were reported as well as the quantitative increase or decrease of the sequences harbouring them along ten cell culture passages. The non-silent amino acid mutations were also depicted in 3D models for four out of the five studied regions. These results have important implications for different norovirus research fields, especially in terms of diagnosis, classification methodology and genetic evolution. [less ▲]

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See detailHigh Throughput sequencing and biological research: Paradigm switches from genetics to ecophysiology
Massart, Sébastien ULg

Scientific conference (2014, June)

A technological revolution is ongoing in sequencing and is deeply impacting biological research. This leads to paradigm switches in traditional « sequencing-friendly » areas, like genetic or microbiology ... [more ▼]

A technological revolution is ongoing in sequencing and is deeply impacting biological research. This leads to paradigm switches in traditional « sequencing-friendly » areas, like genetic or microbiology, but also expands the usefulness of sequencing in other areas such as ecophysiology or ecology. [less ▲]

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See detailHigh throughput sequencing of aphid haemolymph reveals endosymbiont diversity
De Clerck, Caroline ULg; Leonard, Simon; Joncour, Pauline et al

Conference (2014, May 20)

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See detailHigh TMEM45A expression is correlated to epidermal keratinization
Hayez, Aurélie; Malaisse, Jérémy; Rogiers, Edith et al

in Experimental Dermatology (2014), 23

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See detailHigh transmission efficiency for surface plasmon resonance by use of a dielectric grating
Lenaerts, Cedric ULg; Michel, Fabrice ULg; Tilkens, Bernard et al

in Applied Optics (2005), 44(28), 6017-6022

The efficiency of the transmission of surface plasmon waves by use of a dielectric diffraction grating is discussed. The Kretschmann device allows us to obtain a surface plasmon resonance that consists of ... [more ▼]

The efficiency of the transmission of surface plasmon waves by use of a dielectric diffraction grating is discussed. The Kretschmann device allows us to obtain a surface plasmon resonance that consists of an absorption peak in the reflection spectrum. When surface plasmon resonance occurs, the TM-polarization mode of the incident electromagnetic wave is neither transmitted nor reflected. The procedure to transform an absorption peak into a transmission peak is described. Transmittivity of 68% is obtained for a simple structure that consists of a thin-film layer of Ag coated on a volume diffraction grating and embedded between two dielectric media. The results presented herein were obtained by numerical simulations that were carried out by use of an algorithm based on the rigorous coupled-wave theory. [less ▲]

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See detailHigh Vibration Sensors: Modelling, Design and Integration
Rochus, Véronique ULg; Gutschmidt, Stefanie; Golinval, Jean-Claude ULg et al

in Proceedings of Thermal, Mechanical and Multiphysics Simulation and Experiments in Micro-Electronics and Micro-systems EuroSime (2009)

Since many years, the University of Liège is involved in micro-electronics and microelectromechanical systems modelling, design and integration. Recently, the University of Liege had received the ... [more ▼]

Since many years, the University of Liège is involved in micro-electronics and microelectromechanical systems modelling, design and integration. Recently, the University of Liege had received the opportunity to build a brand new infrastructure (clean rooms – ISO 7) with specific equipments for packaging and MEMS characterisation. This new facility (clean rooms and equipments) enables the University to be very well positioned in the nano/micro-electronics modelling, analysis and packaging world and is now able to answer specific research and related industrial needs. In this paper we consider the design of a vibration sensor in its significantly vibrating surroundings and investigate in its dynamical behaviour. Environmental vibrations affect the sensor part of the MEMS device and influence the choice of the “best” packaging methods for the application. Within the framework of packaging, we consider a simple test application ensuring best interconnection technology. Dynamical investigations include a preliminary analysis of the packaging and a separate finite-element analysis of the MEMS device (inside the package), testing the device under the condition of a harsh environment (high vibration spectral level). Computations are proposed in combination with experimental observations. [less ▲]

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See detailHigh Voltage overhead lines. Three mechanisms to avoid bundle galloping.
Lilien, Jean-Louis ULg; Chabart, Olivier

in Proceedings of the 1st ISCD 1995 (1995, October)

Galloping of power lines on bunde conductor may be subject to galloping. In this paper three mechanisms of galloping which may occor with bundle conductor lines are described and explained, which helps to ... [more ▼]

Galloping of power lines on bunde conductor may be subject to galloping. In this paper three mechanisms of galloping which may occor with bundle conductor lines are described and explained, which helps to think about prevention of these galloping. [less ▲]

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See detailThe High Water-Holding Capacity Of Pea Inner Fibers Affects The Ileal Flow Of Endogenous Amino Acids In Pigs
Leterme, Pascal; Froidmont, Eric; Rossi, Florence et al

in Journal of Agricultural and Food Chemistry (1998), 46(5), 1927-1934

Pigs were fed protein-free diets containing different pea inner fiber (PIF) isolates (from wrinkled or smooth peas, unprocessed or micronized) or different PIF levels (from 50 to 200 g/kg diet), and the ... [more ▼]

Pigs were fed protein-free diets containing different pea inner fiber (PIF) isolates (from wrinkled or smooth peas, unprocessed or micronized) or different PIF levels (from 50 to 200 g/kg diet), and the flows of endogenous N and amino acids were measured at the ileum level. The flows were better correlated to the water-holding capacity (WHC) of the diet than to fiber intake (R2 = 0.996 vs 0.76, respectively). The relationship with WHC was of the exponential type, with a high increase when the WHC exceeded 3 g of water/g diet. A similar pattern and correlation (R2 = 0.98) was obtained for the ileal flow of nucleobases (markers of epithelial cells and bacteria), whereas the relationships with crude mucus (R2 = 0.96) and diaminopimelic acid (marker of bacteria, R2 = 0.55) were linear. N retention by pigs fed with 0, 30, 60, or 90 g/kg of dry matter (DM) of the same protein isolates did not differ significantly in pigs receiving a 40 or 160 g of PIF/kg diet, despite significant differences in ileal N and amino acid flows between the two fiber levels (2.0 and 3.1 g of N/kg of DM intake, on average). These results and those of the flow of endogenous N compounds suggest an effect of the swollen fibers on the intestinal wall rather than a disturbance of the digestive processes. [less ▲]

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See detailHigh yield radiosynthesis of p-[F-18]MPPF, 5-HT1A antagonist, and PET studies in cat brain.
Le Bars, D.; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1997), 38

Detailed reference viewed: 18 (2 ULg)
See detailHigh yield synthesis of a new Na-channel marker, [3H]-ethylenediamine ditetrodotoxin, EDD-TTX.
Grandfils, Christian ULg; Bettendorff, Lucien ULg; Schoffeniels, Ernest et al

in Changeux, Jean-Pierre; Maelicke, A.; Neumann, E. (Eds.) Molecular Basis of Nerve Activity (1985)

Detailed reference viewed: 10 (3 ULg)