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See detailHeat-triggered drug release systems based on mesoporous silica nanoparticles filled with a maghemite core and phase-change molecules as gatekeepers
Liu, Ji ULg; Detrembleur, Christophe ULg; De Pauw-Gillet, Marie-Claire ULg et al

in Journal of Materials Chemistry B (2014), 2(1), 59-70

Core–shell nanoparticlesmade of a maghemite core and a mesoporous silica shell were developed as drug delivery systems (DDS). Doxorubicin® (DOX, DNA intercalating drug) was loaded within the mesoporous ... [more ▼]

Core–shell nanoparticlesmade of a maghemite core and a mesoporous silica shell were developed as drug delivery systems (DDS). Doxorubicin® (DOX, DNA intercalating drug) was loaded within the mesoporous cavities, while phase-change molecules (PCMs), e.g. 1-tetradecanol (TD) with a melting temperature (Tm) of 39 °C, were introduced as gatekeepers to regulate the release behaviours. An overall loading amount of ca. 20 wt% (TD/DOX ca. 50/50 wt/wt) was confirmed. Heat-triggered release of DOX evidenced a “zero premature release” (<3% of the entire payload in 96 h release) under physiological conditions (37°C), and however, a sustainable release (ca. 40% of the entire payload in 96 h) above Tm of TD (40 °C). It also demonstrated the possibility to deliver drug payloads in small portions (pulsatile release mode) via multiple heating on/off cycles, due to the reversible phase change of the PCMs. In vitro heattriggered release of DOX within cell culture of the MEL-5 melanoma cell line was also tested. It was found that DOX molecules were trapped efficiently within the mesopores even after internalization within the cytoplasm of MEL-5 cells at 37 °C, with the potential toxicity of DOX strongly quenched (>95% viability after 72 h incubation). However, continuous cell apoptosis was detected at cell culture temperature above Tm of TD, due to the heat-triggered release of DOX (<50% viability after 72 h incubation at 40 °C). Moreover, due to the presence of a maghemite core within the DDS, T2-weighted magnetic resonance imaging performance was also confirmed. These as-designed core–shell nanoparticles are envisaged to become promising DDS for “on-demand” heat-triggered release. [less ▲]

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See detailHeating effects on some quality caracteristics of date seed oil.
Besbes, Souhail; Blecker, Christophe ULg; Danthine, Sabine ULg et al

Poster (2004, September)

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See detailHeating effects on some quality characteristics of date seed oil
Besbes, S.; Blecker, Christophe ULg; Deroanne, Claude ULg et al

in Food Chemistry (2005), 91(3), 469-476

Effects of heating on some quality characteristics of date seed oil from two cultivars (Deglet Nour and Allig) has been investigated using an accelerated test in a Rancimat system. Fatty acid, viscosity ... [more ▼]

Effects of heating on some quality characteristics of date seed oil from two cultivars (Deglet Nour and Allig) has been investigated using an accelerated test in a Rancimat system. Fatty acid, viscosity, absorptivity at 232 and 270 nm, colour and total melting enthalpy of Deglet Nour seed oil were less changed compared to that of Allig seed oil, because the former contained a higher amount of total phenolic compounds (526 mug/g against 215 mug/g) and a lower content of unsaturated fatty acids. Viscosity and absorptivity at 232 nm and at 270 nm increased rapidly after reaching the oxidation induction time. Differential scanning calorimetry melting profiles of date seed oils were also changed after heating in the Rancimat. Melting enthalpies seemed to be constant during the initial stages of Rancimat treatment and then reduced after the induction time was reached. The obtained data shows that date seed oils were resistant to thermal treatment during a long period (similar to30-40 h). This may indicate that they could bear thermal treatments that could be applied in refining procedures or in culinary treatments such as frying and cooking conditions. We could also expect that they may have a good shelf life. (C) 2004 Elsevier Ltd. All rights reserved. [less ▲]

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See detailHeating Effects On Some Quality Characteristics Of Date Seed Oil
Besbes, Souhail; Blecker, Christophe ULg; Deroanne, Claude et al

in Food Chemistry (2005), 91(3), 469-476

Effects of heating on some quality characteristics of date seed oil from two cultivars (Deglet Nour and Allig) has been investigated using an accelerated test in a Rancimat system. Fatty acid, viscosity ... [more ▼]

Effects of heating on some quality characteristics of date seed oil from two cultivars (Deglet Nour and Allig) has been investigated using an accelerated test in a Rancimat system. Fatty acid, viscosity, absorptivity at 232 and 270 nm, colour and total melting enthalpy of Deglet Nour seed oil were less changed compared to that of Allig seed oil, because the former contained a higher amount of total phenolic compounds (526 lg/g against 215 lg/g) and a lower content of unsaturated fatty acids. Viscosity and absorptivity at 232 nm and at 270 nm increased rapidly after reaching the oxidation induction time. Differential scanning calorimetry melting profiles of date seed oils were also changed after heating in the Rancimat. Melting enthalpies seemed to be constant during the initial stages of Rancimat treatment and then reduced after the induction time was reached. The obtained data shows that date seed oils were resistant to thermal treatment during a long period ( 30–40 h). This may indicate that they could bear thermal treatments that could be applied in refining procedures or in culinary treatments such as frying and cooking conditions. We could also expect that they may have a good shelf life. [less ▲]

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See detailHeating optimal control applied to a passive solar commercial building
Kummert, M.; Andre, Philippe ULg; Nicolas, Jacques ULg

in Proceedings of EuroSun'98 (1998, September)

Passive solar features can lead to significant energy savings for building heating. However the intrinsic delay between solar gains and heating demand requires an intelligent control of auxiliary HVAC ... [more ▼]

Passive solar features can lead to significant energy savings for building heating. However the intrinsic delay between solar gains and heating demand requires an intelligent control of auxiliary HVAC system to minimise the energy consumption while preventing overheating periods. This paper describes the application of discrete-time optimal control to auxiliary heating of a passive solar commercial building. Simulation-based results using complex reference models are presented and discussed. The optimal controller is compared to classical "heatingcurve + Thermostatic valve" control. It is shown that optimal control can lead to substantial improvement of thermal comfort and energy consumption. [less ▲]

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See detailHeavy elements abundances in metal-poor stars
Magain, Pierre ULg; Jehin, Emmanuel ULg; Neuforge, Corinne et al

in American Institute of Physics Conference Series (1998, February 01)

A sample of 21 metal-poor stars have been analysed on the basis of high resolution and high signal-to-noise spectra. Correlations between relative abundances of 16 elements have been studied, with a ... [more ▼]

A sample of 21 metal-poor stars have been analysed on the basis of high resolution and high signal-to-noise spectra. Correlations between relative abundances of 16 elements have been studied, with a special emphasis on the neutron-capture ones. This analysis reveals the existence of two sub-populations of field halo stars, namely Pop IIa and Pop IIb. They differ by the behaviour of the s-process elements versus the alpha and r-process elements. We suggest a scenario of formation of these stars, which closely relates the field halo stars to the evolution of globular clusters. The two sub-populations would have evaporated the clusters during two different stages of their chemical evolution. [less ▲]

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See detailHeavy elements in halo stars: the r/s-process controversy.
Magain, Pierre ULg

in Astronomy and Astrophysics (1995), 297

It has been suggested by Truran (1981) that rapid neutron captures (the r-process) dominate the production of heavy elements in very metal-poor stars. Several spectroscopic works analyzing that hypothesis ... [more ▼]

It has been suggested by Truran (1981) that rapid neutron captures (the r-process) dominate the production of heavy elements in very metal-poor stars. Several spectroscopic works analyzing that hypothesis are reviewed and rediscussed and it is shown that there is, in fact, no secure observational evidence in support of Truran's suggestion. A method to determine the odd-to-even isotopic ratio of barium, and thus to estimate the relative contributions of the r and s-processes, is presented. It takes advantage of the hyperfine structure affecting the spectral lines of the odd isotopes to distinguish them from the even isotopes. This method, applied to the classical metal-poor subgiant HD 140283, shows that the barium isotopic ratio in that star is in agreement with a pure s-process production, and excludes any significant enhancement of the r-process contribution, in disagreement with previous works based on elemental abundances. [less ▲]

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See detailHeavy fermion behavior of U2T2X compounds
Havela, Ladislav; Sechovsky, Vladimir; Svoboda, P. et al

in Journal of Applied Physics (1994), 76(10), 6214-6215

Magnetic and specific-heat studies of U2T2X compounds show a frequent occurrence of the gamma enhancement in conjunction with the onset of antiferromagnetic ordering. The largest value of 830 mJ/mol K**2 ... [more ▼]

Magnetic and specific-heat studies of U2T2X compounds show a frequent occurrence of the gamma enhancement in conjunction with the onset of antiferromagnetic ordering. The largest value of 830 mJ/mol K**2 was observed in U2Pt2In, which is nonmagnetic down to 1.2 K. Variations of electronic structure are documented by optimized relativistic LCAO calculation. [less ▲]

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See detailHeavy fermion behavior of U2T2X compounds
Havela, Ladislav; Sechovsky, Vladimir; Svoboda, P. et al

Poster (1994, August)

Detailed reference viewed: 15 (3 ULg)
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See detailHeavy fermion behavior of U2T2X compounds
Havela, Ladislav; Sechovsky, Vladimir; Svoboda, P. et al

Poster (1994, June)

Detailed reference viewed: 14 (4 ULg)
See detailHeavy meatal dynamics in the Calvi Bay seagrass bed.
Nélissen, Jean-Pierre; Gobert, Sylvie ULg; Bouquegneau, Jean-Marie ULg et al

Conference (1994, January)

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See detailHeavy metal and endocrine disrupter impact on marine mammals
Das, Krishna ULg; Siebert, Ursula

in Cielikiewicz, Witold; Connolly, Niamh; Ollier, Gilles (Eds.) et al Proceedings of the EurOCEAN 2004. European Conference on Marine Science and Ocean Technology (2007)

Due to their top position in the trophic network, their long life span and their low rate of pollutant elimination, marine mammals can accumulate high levels of chemicals, such as organic compounds and ... [more ▼]

Due to their top position in the trophic network, their long life span and their low rate of pollutant elimination, marine mammals can accumulate high levels of chemicals, such as organic compounds and heavy metals. In the North Sea, high levels of mercury, PCBs, methyl sulfonyl PCBs, perfluorinated organochemicals, DDT and toxaphene have been found in the liver and blubber of the harbour porpoise Phocoena phocoena and the harbour seal Phoca vitulina. Such compounds may affect the immune and the endocrine systems of these species leading to e.g. an increase susceptibility to infectious diseases, cancers, reproductive and other endocrine dysfunctions. [less ▲]

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See detailHeavy metal hypersensitive mutants in Chlamydomonas reinhardtii.
Hanikenne, Marc ULg

Scientific conference (2002, December 16)

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See detailHeavy Metals Contamination and Body Condition of Wintering Guillemots (Uria Aalge) at the Belgian Coast from 1993 to 1998
Debacker, Virginie ULg; Jauniaux, Thierry ULg; Coignoul, Freddy ULg et al

in Environmental Research (2000), A84(3), 310-317

A sample of 166 common guillemots (Uria aalge) recovered from Belgian beaches during five wintering seasons, from 1993-1994 to 1997-1998, were examined. At necropsy, postmortem examination including body ... [more ▼]

A sample of 166 common guillemots (Uria aalge) recovered from Belgian beaches during five wintering seasons, from 1993-1994 to 1997-1998, were examined. At necropsy, postmortem examination including body mass, fat reserves, presence or not of intestinal contents, eventual status of oiling, and pathological changes (cachexia, acute hemorrhagic gastroenteropathy (GEAH)) was attributed to each individual. Mild to severe cachexia, a pathology characterized by moderate to severe atrophy of the pectoral muscle as well as reduced amounts or absence of subcutaneous and/or abdominal fat, was observed for most specimens (85.8%). Heavy metal analyses (Cu, Zn, Fe, Cd, Ni, Cr, and Pb) of the tissues (typically liver, kidney, and pectoral muscle) were performed, and total lipids were determined (liver and pectoral muscle). The guillemots collected at the Belgian coast exhibited higher Cu and Zn concentrations compared to individuals collected in more preserved areas of the North Sea such as the northern colonies. A general decrease of their total body mass as well as liver, kidney, and pectoral muscle mass was associated to increasing cachexia severity. Moreover, significantly increasing heavy metal levels (Cu and Zn) in the tissues as well as depleted muscle lipid contents were observed parallel to increasing cachexia severity. On the contrary the organs' total metal burden barely correlates to this status. These observations tend to indicate a general redistribution of heavy metals within the organs as a result of prolonged starvation and protein catabolism (cachectic status). Such a redistribution could well be an additional stress to birds already experiencing stressfull conditions (starvation, oiling). [less ▲]

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See detailHeavy metals in marine mammals
Das, Krishna ULg; Debacker, Virginie ULg; Pillet, Stéphane et al

in Vos, Joseph G.; Bossart, Gregory D.; Fournier, Michel (Eds.) et al Toxicology of marine mammals (2003)

Detailed reference viewed: 65 (30 ULg)
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See detailHeavy metals, organochlorines and polycyclic aromatic hydrocarbons in sperm whales stranded in Southern North sea during the 1994/1995 winter,
Hoolsbeek, L.; Joiris, C. R.; Debacker, Virginie ULg et al

in Marine Pollution Bulletin (1999), 38

Detailed reference viewed: 41 (0 ULg)
See detailHeavy n-type doping of SiGe for SIMS calibration
Nguyen, Ngoc Duy ULg

Report (2007)

Detailed reference viewed: 7 (0 ULg)
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See detailHeavy water tracing test in the underground coal gasification process at Thulin (Belgium)
Dufaux, Anne; Gaveau, Bénédicte; Létolle, René et al

in Fuel (1990), 69

Detailed reference viewed: 30 (1 ULg)