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See detailGénétic causes : Awareness, who and how to screen
Beckers, Albert ULg

Scientific conference (2007, September 28)

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See detailGenetic causes of familial pituitary adenomas
Vandeva, Silvia; Zacharieva, S.; Daly, Adrian ULg et al

in Growth Hormone Related Diseases and Therapy - Contemporary Endocrinology (2011)

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See detailGenetic Causes of Pituitary Adenmas; Focus on the Roe of AIF Status in Multiple Tumor Types
Ansaneli Naves, L.; Ferreira Azevedo, M.; Faria de Castro, L. et al

in ENDO 2008: 90th Annual Meeting of the Endocrine Society - Abstract book (2008)

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See detailGenetic causes of pituitary diseases
Beckers, Albert ULg

Scientific conference (2010, October)

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See detailGenetic characterization of the Indian cattle breeds, Ongole and Deoni (Bos indicus), using microsatellite markers - a preliminary study.
Metta, Muralidhar ULg; Kanginakudru, Sriramana; Gudiseva, Narasimharao et al

in BMC Genetics (2004), 5

BACKGROUND: Molecular characterization of cattle breeds is important for the prevention of germplasm erosion by cross breeding. The Indian zebu cattle have their significant role in evolution of present ... [more ▼]

BACKGROUND: Molecular characterization of cattle breeds is important for the prevention of germplasm erosion by cross breeding. The Indian zebu cattle have their significant role in evolution of present day cattle breeds and development of some of the exotic breeds. Microsatellites are the best available molecular tools for characterization of cattle breeds. The present study was carried out to characterize two Indian cattle breeds, Ongole and Deoni, using microsatellite markers. RESULTS: Using 5 di- and 5 tri-nucleotide repeat loci, 17 Ongole and 13 Deoni unrelated individuals were studied. Of the ten loci, eight revealed polymorphism in both the breeds. The di-nucleotide repeat loci were found to be more polymorphic (100%) than tri-nucleotide repeat loci (60%). A total of 39 polymorphic alleles were obtained at 4.5 alleles per locus in Ongole and 4.1 in Deoni. The average expected heterozygosity was 0.46 (+/-0.1) and 0.50 (+/-0.1) in Ongole and Deoni breeds, respectively. The PIC values of the polymorphic loci ranged from 0.15 to 0.79 in Ongole and 0.13 to 0.80 in Deoni breeds. Six Ongole specific and three Deoni specific alleles were identified. The two breeds showed a moderate genetic relationship between themselves with a FST value of 0.117 (P = 0.01). CONCLUSIONS: This preliminary study shows that microsatellite markers are useful in distinguishing the two zebu breeds namely, Ongole and Deoni. Further studies of other zebu breeds using many microsatellite loci with larger sample sizes can reveal the genetic relationships of Indian breeds. [less ▲]

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See detailGenetic Characterization Of The Yeast Pichia Anomala (Strain K), An Antagonist Of Postharvest Diseases Of Apple
Friel, D.; Vandenbol, Micheline ULg; Jijakli, Mohamed ULg

in Journal of Applied Microbiology (2005), 98(3),

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See detailGenetic control of flowering time in maize
Périlleux, Claire ULg; Colasanti, J.; Irish, E.

in Prioul, J.-L.; Thévenot, C.; Molnar, T. (Eds.) Advances in Maize (2011)

Flowering in temperate maize occurs largely autonomously after the plant has accumulated a given amount of vegetative growth. Mutants affected in leaf initiation rate or in phyllotaxy however indicate ... [more ▼]

Flowering in temperate maize occurs largely autonomously after the plant has accumulated a given amount of vegetative growth. Mutants affected in leaf initiation rate or in phyllotaxy however indicate that total leaf number can vary independently of flowering time, e.g. in relation with cytokinin signalling. By contrast, heterochronic mutants in which juvenile-to-adult and/or adult vegetative-to-reproductive phase changes are abnormal aided in the identification of key regulators of endogenous developmental timing in maize. These regulators include gibberellins and micro-RNAs, such as miR156 and miR172, which have been identified more recently. Progress towards unravelling the maize flowering time genetic network is also emerging from comparison with other species. Although maize expansion beyond domestication centres implied reduction in photoperiod sensitivity, molecular genetic studies indicated conservation of genes which, in Arabidopsis or rice, act in a signalling cascade whereby flowering is controlled by photoperiod. Several gene sequences are now available to assess functionality of such a pathway in maize and evaluate its contribution to flowering time control. [less ▲]

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See detailGenetic control of isozymes in the primary gene pool Phaseolus lunatus L.
Bi, Irié Zoro; Maquet, Alain; Wathelet, Bernard ULg et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (1999)

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See detailGenetic correlations among body condition score, yield and fertility in multiparous cows using random regression models
Bastin, Catherine ULg; Gillon, Alain ULg; Massart, Xavier et al

in Proceedings of the 9th World Congress on Genetics Applied to Livestock Production (2010, August)

Genetic correlations between body condition score (BCS) in lactation 1 to 3 and four economically important traits (days open, 305-days milk, fat, and protein yields recorded in the first 3 lactations ... [more ▼]

Genetic correlations between body condition score (BCS) in lactation 1 to 3 and four economically important traits (days open, 305-days milk, fat, and protein yields recorded in the first 3 lactations) were estimated on about 12,500 Walloon Holstein cows using 4-trait random regression models. Results indicated moderate favorable genetic correlations between BCS and days open (from -0.46 to -0.62) and suggested the use of BCS for indirect selection on fertility. However, unfavorable genetic correlations between BCS and yields (from -0.16 to -0.71) indicated that selection on BCS would have deleterious effects on milk, fat, and protein yields, especially in lactation greater than 1. [less ▲]

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See detailGenetic correlations of days open with production traits and contents in milk of major fatty acids predicted by mid-infrared spectrometry.
Bastin, Catherine ULg; Berry, D. P.; Soyeurt, Hélène ULg et al

in Journal of Dairy Science (2012), 95(10), 6113-21

The objective of this study was to estimate the genetic relationships between days open (DO) and both milk production traits and fatty acid (FA) content in milk predicted by mid-infrared spectrometry. The ... [more ▼]

The objective of this study was to estimate the genetic relationships between days open (DO) and both milk production traits and fatty acid (FA) content in milk predicted by mid-infrared spectrometry. The edited data set included 143,332 FA and production test-day records and 29,792 DO records from 29,792 cows in 1,170 herds. (Co)variances were estimated using a series of 2-trait models that included a random regression for milk production and FA traits. In contrast to the genetic correlations with fat content, those between DO and FA content in milk changed considerably over the lactation. The genetic correlations with DO for unsaturated FA, monounsaturated FA, long-chain FA, C18:0, and C18:1 cis-9 were positive in early lactation but negative after 100 d in milk. For the other FA, genetic correlations with DO were negative across the whole lactation. At 5 d in milk, the genetic correlation between DO and C18:1 cis-9 was 0.39, whereas the genetic correlations between DO and C6:0 to C16:0 FA ranged from -0.37 to -0.23. These results substantiated the known relationship between fertility and energy balance status, explained by the release of long-chain FA in early lactation, from the mobilization of body fat reserves, and the consequent inhibition of de novo FA synthesis in the mammary gland. At 200 d in milk, the genetic correlations between DO and FA content ranged from -0.38 for C18:1 cis-9 to -0.03 for C6:0. This research indicates an opportunity to use FA content in milk as an indicator trait to supplement the prediction of genetic merit for fertility. [less ▲]

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See detailGenetic Determinants Of Bovine Leukemia Virus Pathogenesis
Willems, Luc ULg; Burny, A.; Collete, Delphine et al

in Aids Research and Human Retroviruses (2000), 16(16), 1787-95

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been ... [more ▼]

The understanding of HTLV-induced disease is hampered by the lack of a suitable animal model allowing the study of both viral replication and leukemogenesis in vivo. Although valuable information has been obtained in different species, such as rabbits, mice, rats, and monkeys, none of these systems was able to conciliate topics as different as viral infectivity, propagation within the host, and generation of leukemic cells. An alternate strategy is based on the understanding of diseases induced by viruses closely related to HTLV-1, like bovine leukemia virus (BLV). Both viruses indeed belong to the same subfamily of retroviruses, harbor a similar genomic organization, and infect and transform cells of the hematopoietic system. The main advantage of the BLV system is that it allows direct experimentation in two different species, cattle and sheep. [less ▲]

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See detailGenetic determination and localization of multiple bacteriocins produced by Enterococcus faecium CWBI-B1430 and Enterococcus mundtii CWBI-B1431
Aguilar Galvez, Ana Consuelo; Dubois Dauphin, Robin ULg; Campos Gutierrez, David Carlos et al

in Food Science and Biotechnology (2011), 20(2), 289-296

Enterococcus faecium CWBI-B1430 and Enterococcus mundtii CWBI-B1431 from artisanalproduced Peruvian cheeses showed the presence of 4 putative bacteriocin genes: enterocin A, enterocin B, enterocin P, and ... [more ▼]

Enterococcus faecium CWBI-B1430 and Enterococcus mundtii CWBI-B1431 from artisanalproduced Peruvian cheeses showed the presence of 4 putative bacteriocin genes: enterocin A, enterocin B, enterocin P, and mundticin KS. The multiple bacteriocin producer E. faecium CWBI-B1430 presented 1 plasmid of 34.6 kb, whereas E. mundtii CWBI-B1431 contained 1 plasmid of 11.0 kb. The structural gene responsible for mundticin KS production was located on 5.6 and 3.1 kb HindIII plasmid fragments. The reverse transcription-PCR analysis showed the expression of the bacteriocin genes enterocin A, enterocin B, and mundticin KS in E. faecium CWBI-B1430 and the bacteriocin genes enterocin P and mundticin KS in E. mundtii CWBI-B1431. To our knowledge, this is the first report of the expression of mundticin KS in E. faecium and enterocin P in E. mundtii. [less ▲]

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See detailGenetic diagnosis of Duchenne and Becker muscular dystrophy using multiplex ligation-dependent probe amplification in Rwandan patients.
Uwineza, Annette ULg; Hitayezu, Janvier; Murorunkwere, Seraphine et al

in Journal of tropical pediatrics (2013)

Duchenne and Becker muscular dystrophies are the most common clinical forms of muscular dystrophies. They are genetically X-linked diseases caused by a mutation in the dystrophin (DMD) gene. A genetic ... [more ▼]

Duchenne and Becker muscular dystrophies are the most common clinical forms of muscular dystrophies. They are genetically X-linked diseases caused by a mutation in the dystrophin (DMD) gene. A genetic diagnosis was carried out in six Rwandan patients presenting a phenotype of Duchenne and Becker muscular dystrophies and six asymptomatic female carrier relatives using multiplex ligation-dependent probe amplification (MLPA). Our results revealed deletion of the exons 48-51 in one patient, an inherited deletion of the exons 8-21 in two brothers and a de novo deletion of the exons 46-50 in the fourth patient. No copy number variation was found in two patients. Only one female carrier presented exon deletion in the DMD gene. This is the first cohort of genetic analysis in Rwandan patients affected by Duchenne and Becker muscular dystrophies. This report confirmed that MLPA assay can be easily implemented in low-income countries. [less ▲]

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See detailGenetic disorders and cerebellar structural abnormalities in childhood
RAMAEKERS, Vincent ULg; Heimann, G.; Reul, J. et al

in Brain : a journal of neurology (1997), 120 ( Pt 10)

Amongst 78 patients with either unilateral or bilateral (ponto-) cerebellar hypoplasia, atrophy or lesions on neuro-imaging (CT and/or MRI), 16 showed unilateral hypoplasia or lesions, 15 vermis defects ... [more ▼]

Amongst 78 patients with either unilateral or bilateral (ponto-) cerebellar hypoplasia, atrophy or lesions on neuro-imaging (CT and/or MRI), 16 showed unilateral hypoplasia or lesions, 15 vermis defects, nine pontocerebellar hypoplasia, 10 non-progressive conditions with bilateral cerebellar hemisphere hypoplasia or lesions and 28 progressive cerebellar atrophy. Known genetic conditions did not occur with unilateral cerebellar involvement, whereas a high incidence of mostly autosomal recessively inherited diseases could be diagnosed in more than half of the patients with either pontocerebellar hypoplasia or progressive bilateral cerebellar atrophy. A minority of patients with vermis defects or non-progressive cerebellar hypoplasia suffered from genetic conditions. An overview of the literature is presented describing genetic and non-genetic syndromes, or metabolic disorders associated with cerebellar structural abnormalities. From these data, new proposals for improved diagnostic investigations will be presented. [less ▲]

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See detailGenetic diversity among some wild populations of lima bean (Phaseolus lunatus L.) proceeding from Central Valley of Costa Rica
Maquet, Alain; Wathelet, Bernard ULg; Dubois, Sophie et al

in Annual Report of the Bean Improvment Cooperative (1994)

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See detailGenetic diversity analysis of wild Arracacia species according to morphological and molecular markers
Blas, R.; Ghislain, M.; del Rosario Herrera, M. et al

in Genetic Resources and Crop Evolution (2008), 55(5), 625-642

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