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See detailHigh yield radiosynthesis of p-[F-18]MPPF, 5-HT1A antagonist, and PET studies in cat brain.
Le Bars, D.; Lemaire, Christian ULg; Plenevaux, Alain ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1997), 38

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See detailHigh yield synthesis of a new Na-channel marker, [3H]-ethylenediamine ditetrodotoxin, EDD-TTX.
Grandfils, Christian ULg; Bettendorff, Lucien ULg; Schoffeniels, Ernest et al

in Changeux, Jean-Pierre; Maelicke, A.; Neumann, E. (Eds.) Molecular Basis of Nerve Activity (1985)

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See detailHigh- and low-temperature manipulation during late incubation: effects on embryonic development, the hatching process, and metabolism in broilers.
Willemsen, H.; Kamers, B.; Dahlke, F. et al

in Poultry science (2010), 89(12), 2678-90

Temperatures continuously higher and lower than the standard incubation temperature by 3 degrees C from embryonic d 16 until embryonic d 18.5 result in differential effects on embryonic development, the ... [more ▼]

Temperatures continuously higher and lower than the standard incubation temperature by 3 degrees C from embryonic d 16 until embryonic d 18.5 result in differential effects on embryonic development, the hatching process, and embryonic metabolism. Embryos in the high-temperature group were forced into a state of malnutrition by the temperature treatment, as reflected by reduced embryo growth and yolk consumption, resulting in a significantly lower chick weight at hatch. In addition, altered air cell and blood gases as well as a retarded hatching process further indicated reduced growth of embryos exposed to higher incubation temperatures during the latter part of incubation. In addition, hatchability was significantly reduced by the high-temperature treatment due to higher embryonic mortality during the treatment period and the hatching process. Levels of blood glucose, lactate, liver glycogen, plasma triglycerides, and nonesterified fatty acids indicated an altered carbohydrate and lipid metabolism for the high-temperature group. Although the hatching process of embryos exposed to lower incubation temperatures was also significantly retarded, their embryonic development and growth were strikingly similar to those of the control group. [less ▲]

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See detailHigh-contrast Stellar Observations within the Diffraction Limit at the Palomar Hale Telescope
Mennesson, B.; Hanot, Charles ULg; Serabyn, Eugene et al

in Astrophysical Journal (2011), 743

We report on high-accuracy high-resolution (<20 mas) stellar observations obtained with the Palomar Fiber Nuller (PFN), a near-infrared (sime2.2 μm) interferometric coronagraph installed at the Palomar ... [more ▼]

We report on high-accuracy high-resolution (<20 mas) stellar observations obtained with the Palomar Fiber Nuller (PFN), a near-infrared (sime2.2 μm) interferometric coronagraph installed at the Palomar Hale telescope. The PFN uses destructive interference between two elliptical (3 m × 1.5 m) sub-apertures of the primary to reach high dynamic range inside the diffraction limit of the full telescope. In order to validate the PFN's instrumental approach and its data reduction strategy, based on the newly developed "Null Self-Calibration" (NSC) method, we observed a sample of eight well-characterized bright giants and supergiants. The quantity measured is the source astrophysical null depth, or equivalently the object's visibility at the PFN 3.2 m interferometric baseline. For the bare stars α Boo, α Her, β And, and α Aur, PFN measurements are in excellent agreement with previous stellar photosphere measurements from long baseline interferometry. For the mass-losing stars β Peg, α Ori, ρ Per, and χ Cyg, circumstellar emission and/or asymmetries are detected. Overall, these early observations demonstrate the PFN's ability to measure astrophysical null depths below 10[SUP]-2[/SUP] (limited by stellar diameters), with 1 σ uncertainties as low as a few 10[SUP]-4[/SUP]. Such visibility accuracy is unmatched at this spatial resolution in the near-infrared and translates into a contrast better than 10[SUP]-3[/SUP] within the diffraction limit. With further improvements anticipated in 2011/2012, a state-of-the-art infrared science camera and a new extreme adaptive optics system, the PFN should provide a unique tool for the detection of hot debris disks and young self-luminous sub-stellar companions in the immediate vicinity of nearby stars. [less ▲]

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See detailHigh-density lipoprotein proteome dynamics in human endotoxemia.
Levels, Johannes Hm; Geurts, Pierre ULg; Karlsson, Helen et al

in Proteome science (2011), 9(1), 34

BACKGROUND: A large variety of proteins involved in inflammation, coagulation, lipid-oxidation and lipid metabolism have been associated with high-density lipoprotein (HDL) and it is anticipated that ... [more ▼]

BACKGROUND: A large variety of proteins involved in inflammation, coagulation, lipid-oxidation and lipid metabolism have been associated with high-density lipoprotein (HDL) and it is anticipated that changes in the HDL proteome have implications for the multiple functions of HDL. Here, SELDI-TOF mass spectrometry (MS) was used to study the dynamic changes of HDL protein composition in a human experimental low-dose endotoxemia model. Ten healthy men with low HDL cholesterol (0.7+/-0.1 mmol/L) and 10 men with high HDL cholesterol levels (1.9+/-0.4 mmol/L) were challenged with endotoxin (LPS) intravenously (1 ng/kg bodyweight). We previously showed that subjects with low HDL cholesterol are more susceptible to an inflammatory challenge. The current study tested the hypothesis that this discrepancy may be related to differences in the HDL proteome. RESULTS: Plasma drawn at 7 time-points over a 24 hour time period after LPS challenge was used for direct capture of HDL using antibodies against apolipoprotein A-I followed by subsequent SELDI-TOF MS profiling. Upon LPS administration, profound changes in 21 markers (adjusted p-value < 0.05) were observed in the proteome in both study groups. These changes were observed 1 hour after LPS infusion and sustained up to 24 hours, but unexpectedly were not different between the 2 study groups. Hierarchical clustering of the protein spectra at all time points of all individuals revealed 3 distinct clusters, which were largely independent of baseline HDL cholesterol levels but correlated with paraoxonase 1 activity. The acute phase protein serum amyloid A-1/2 (SAA-1/2) was clearly upregulated after LPS infusion in both groups and comprised both native and N-terminal truncated variants that were identified by two-dimensional gel electrophoresis and mass spectrometry. Individuals of one of the clusters were distinguished by a lower SAA-1/2 response after LPS challenge and a delayed time-response of the truncated variants. CONCLUSIONS: This study shows that the semi-quantitative differences in the HDL proteome as assessed by SELDI-TOF MS cannot explain why subjects with low HDL cholesterol are more susceptible to a challenge with LPS than those with high HDL cholesterol. Instead the results indicate that hierarchical clustering could be useful to predict HDL functionality in acute phase responses towards LPS. [less ▲]

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See detailHigh-density resolution synchrotron radiation based X-ray microtomography (SRμCT) for quantitative 3D-morphometrics in zoological sciences
Nickel, Michael; Hammel, Jörg U.; Herzen, Julia et al

in SPIE Optical Engineering+Application Conference, San Diego, California, USA, 10--14 August 2008 (2008)

best suitable methods like tomography allow for a direct representation of 3D-structures. In recent years, synchrotron radiation based x-ray microtomography (SR μCT) placed high resolutions to the ... [more ▼]

best suitable methods like tomography allow for a direct representation of 3D-structures. In recent years, synchrotron radiation based x-ray microtomography (SR μCT) placed high resolutions to the disposal of morphologists. With the development of highly brilliant and collimated third generation synchrotron sources, phase contrast SR μCT became widely available. A number of scientific contributions stressed the superiority of phase contrast over absorption contrast. However, here we demonstrate the power of high density resolution methods based on absorption-contrast SRμCT for quantitative 3D-measurements of tissues and other delicate bio-structures in zoological sciences. We used beamline BW2 at DORIS III (DESY, Hamburg, Germany) to perform microtomography on tissue and mineral skeletons of marine sponges (Porifera) which were shock frozen and/or fixed in a glutamate osmium tetroxide solution, followed by critical point drying. High density resolution tomographic reconstructions allowed running quantitative 3D-image analyses in Matlab and ImageJ. By applying contrast and shape rule based algorithms we semi-automatically extracted and measured sponge body structures like mineral spicules, elements of the canal system or tissue structures. This lead to a better understanding of sponge biology: from skeleton functional morphology and internal water flow regimes to body contractility. Our high density resolution based quantitative approach can be applied to a wide variety of biological structures. However, two prerequisites apply: (1) maximum density resolution is necessary; (2) edge effects as seen for example in phase outline contrast SR μCT must not be present. As a consequence, to allow biological sciences to fully exploit the power of SR μCT further increase of density resolution in absorption contrast methods is desirable. [less ▲]

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See detailHigh-dimensional probability density estimation with randomized ensembles of tree structured bayesian networks
Ammar, Sourour; Leray, Philippe; Defourny, Boris ULg et al

in Proc. of the 4th European Workshop on Probabilistic Graphical Models (PGM08) (2008)

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See detailHigh-dispersion infrared spectroscopic observations of comet 8P/Tuttle with VLT/CRIRES
Kobayashi, H.; Bockelée-Morvan, D.; Kawakita, H. et al

in Astronomy and Astrophysics (2010), 509

We report on the composition of the Halley-family comet (HFC) 8P/Tuttle investigated with high-dispersion near-infrared spectroscopic observations. The observations were carried out at the ESO VLT (Very ... [more ▼]

We report on the composition of the Halley-family comet (HFC) 8P/Tuttle investigated with high-dispersion near-infrared spectroscopic observations. The observations were carried out at the ESO VLT (Very Large Telescope) with the CRIRES instrument as part of a multi-wavelength observation campaign of 8P/Tuttle performed in late January and early February 2008. Radar observations suggested that 8P/Tuttle is a contact binary, and it was proposed that these components might be heterogeneous in chemistry. We determined mixing ratios of organic volatiles with respect to H[SUB]2[/SUB]O and found that mixing ratios were consistent with previous near infrared spectroscopic observations obtained in late December 2007 and in late January 2008. It has been suggested that because 8P/Tuttle is a contact binary, it might be chemically heterogeneous. However, we find no evidence for chemical heterogeneity within the nucleus of 8P/Tuttle. We also compared the mixing ratios of organic molecules in 8P/Tuttle with those of both other HFCs and long period comets (LPCs) and found that HCN, C[SUB]2[/SUB]H[SUB]2[/SUB], and C[SUB]2[/SUB]H[SUB]6[/SUB] are depleted whereas CH[SUB]4[/SUB] and CH[SUB]3[/SUB]OH have normal abundances. This may indicate that 8P/Tuttle was formed in a different region of the early solar nebula than other HFCs and LPCs. We estimated the conversion efficiency from C[SUB]2[/SUB]H[SUB]2[/SUB] to C[SUB]2[/SUB]H[SUB]6[/SUB] by hydrogen addition reactions on cold grains by employing the C[SUB]2[/SUB]H[SUB]6[/SUB]/(C[SUB]2[/SUB]H[SUB]6[/SUB]+C[SUB]2[/SUB]H[SUB]2[/SUB]) ratio. The C[SUB]2[/SUB]H[SUB]6[/SUB]/(C[SUB]2[/SUB]H[SUB]6[/SUB]+C[SUB]2[/SUB]H[SUB]2[/SUB]) ratio in 8P/Tuttle is consistent with the ratios found in other HFCs and LPCs within the error bars. We also discuss the source of C[SUB]2[/SUB] and CN based on our observations and conclude that the abundances of C[SUB]2[/SUB]H[SUB]2[/SUB] and C[SUB]2[/SUB]H[SUB]6[/SUB] are insufficient to explain the C[SUB]2[/SUB] abundances in comet 8P/Tuttle and that the abundance of HCN is insufficient to explain the CN abundances in the comet, so at least one additional parent is needed for each species, as pointed out in previous study. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Prog. 080.C-0615 and 280.C-5053).We regret to note the death of Dr. J. -M. Zucconi in 2009 May. [less ▲]

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See detailHigh-dispersion Spectroscopic Observations Of 8P/Tuttle With VLT/CRIRES
Kobayashi, Hitomi; Bockelee-Morvan, D.; Dello Russo, N. et al

in Bulletin of the American Astronomical Society (2008, September 01), 40

We present near-infrared observations of organic molecules in comet 8P/Tuttle. Comet 8P/Tuttle is a Halley-type comet and its last perihelion was in early January 2008. Our observations were carried out ... [more ▼]

We present near-infrared observations of organic molecules in comet 8P/Tuttle. Comet 8P/Tuttle is a Halley-type comet and its last perihelion was in early January 2008. Our observations were carried out on January 28 and February 4 using CRIRES (CRyogenic high-resolution InfraRed Echelle Spectrograph) at the Very Large Telescope (VLT). We used a 0.2" slit which provided a spectral resolving power of 80,000. We detected H[SUB]2[/SUB]O, OH, HCN, C[SUB]2[/SUB]H[SUB]2[/SUB] on Jan 28, and H[SUB]2[/SUB]O, OH, CH[SUB]4[/SUB], C[SUB]2[/SUB]H[SUB]6[/SUB], and CH[SUB]3[/SUB]OH on Feb 4. We find that 8P/Tuttle is depleted in HCN, C[SUB]2[/SUB]H[SUB]2[/SUB] and C[SUB]2[/SUB]H[SUB]6[/SUB] relative to H[SUB]2[/SUB]O compared with most other Oort cloud comets studied to date. Perhaps these depletions suggest that 8P/Tuttle formed in a different region from most Oort cloud comets, but it is also possible that the depletions are caused by repeated passages through the inner solar system. [less ▲]

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See detailHigh-dose aprotinin reduces blood loss in patients undergoing total hip replacement surgery
Janssens, Marc ULg; Joris, Jean ULg; David, Jean-Louis et al

in Anesthesiology (1994), 80

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See detailHigh-Dose Riboflavin as a Prophylactic Treatment of Migraine: Results of an Open Pilot Study
Schoenen, Jean ULg; Lenaerts, M.; Bastings, E.

in Cephalalgia : An International Journal of Headache (1994), 14(5), 328-9

If the brain of migraineurs is characterized between attacks by a reduction of mitochondrial phosphorylation potential, riboflavin, which has the potential of increasing mitochondrial energy efficiency ... [more ▼]

If the brain of migraineurs is characterized between attacks by a reduction of mitochondrial phosphorylation potential, riboflavin, which has the potential of increasing mitochondrial energy efficiency, might have prophylactic effects in migraine. In this preliminary open pilot study, 49 patients suffering from migraine (45 without aura, 4 with aura) were treated with 400 mg of riboflavin as a single oral dose for at least 3 months. Twenty-three patients received in addition 75 mg of aspirin. Mean global improvement after therapy was 68.2% and there was no difference between the two groups of patients. With the exception of one patient in the riboflavin plus aspirin group who withdrew because of gastric intolerance, no drug-related side effects were reported. High-dose riboflavin could thus be an effective, low-cost prophylactic treatment of migraine devoid of short-term side effects. A placebo-controlled trial of its efficacy seems worthwhile. [less ▲]

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See detailHigh-efficiency biolistic transformation of Chlamydomonas mitochondria can be used to insert mutations in complex I genes
Remacle, Claire ULg; Cardol, Pierre ULg; Coosemans, Nadine ULg et al

in Proceedings of the National Academy of Sciences of the United States of America (2006), 103(12), 4771-4776

Mitochondrial transformation of Chlamydomonas reinhardtii has been optimized by using a particle-gun device and cloned mitochondrial DNA or PCR fragments. A respiratory-deficient strain lacking a 1.2-kb ... [more ▼]

Mitochondrial transformation of Chlamydomonas reinhardtii has been optimized by using a particle-gun device and cloned mitochondrial DNA or PCR fragments. A respiratory-deficient strain lacking a 1.2-kb mitochondrial DNA region including the left telomere and part of the cob gene could be rescued as well as a double-frameshift mutant in the mitochondrial cox1 and nd1 genes. High transformation efficiency has been achieved (100-250 transformants per microgram of DNA), the best results being obtained with linearized plasmid DNA. Molecular analysis of the transformants suggests that the right telomere sequence can be copied to reconstruct the left telomere by recombination. In addition, both nondeleterious and deleterious mutations could be introduced. Myxothiazol-resistant transformants have been created by introducing a nucleotide substitution into the cob gene. Similarly, an in-frame deletion of 23 codons has been created in the nd4 mitochondrial gene of both the deleted and frameshift recipient strains. These 23 codons are believed to encode the first transmembrane segment of the ND4 protein. This Delta nd4 mutation causes a misassembly of complex 1, with the accumulation of a subcomplex that is 250-kDa smaller than the wild-type complex 1. The availability of efficient mitochondrial transformation in Chlamydomonas provides an invaluable tool for the study of mitochondrial biogenesis and, more specifically, for site-directed mutagenesis of mitochondrially encoded subunits of complex 1, of special interest because the yeast Saccharomyces cerevisiae, whose mitochondrial genome can be manipulated virtually at will, is lacking complex 1. [less ▲]

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See detailHigh-energy forward scattering and the pomeron: Simple pole versus unitarized models
Cudell, Jean-René ULg; Ezhela, V.; Kang, K. et al

in Physical Review. D : Particles and Fields (2000), 61

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See detailHigh-energy hadron spin-flip amplitude at small momentum transfer and new A(N) data from RHIC
Cudell, Jean-René ULg; Predazzi, E.; Selyugin, Oleg Viktorovich

in European Physical Journal A -- Hadrons & Nuclei (2004), 21(3), 479-486

In the case of elastic high-energy hadron-hadron scattering, the impact of the large-distance contributions on the behaviour of the slopes of the spin-non-flip and of the spin-flip amplitudes is analysed ... [more ▼]

In the case of elastic high-energy hadron-hadron scattering, the impact of the large-distance contributions on the behaviour of the slopes of the spin-non-flip and of the spin-flip amplitudes is analysed. It is shown that the long tail of the hadronic potential in impact parameter space leads to a value of the slope of the reduced spin-flip amplitude larger than that of the spin-non-flip amplitude. This effect is taken into account in the calculation of the analysing power in proton-nucleus reactions at high energies. It is shown that the preliminary measurement of A(N) (for p 12C obtained by the E950 Collaboration indeed favours a spin-flip amplitude with a large slope. Predictions for A)(N) (at P)(L) = 250 GeV/c are given. [less ▲]

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See detailHigh-Energy Physics with Particles Carrying Non-Zero Orbital Angular Momentum
Ivanov, Igor ULg

in Few-Body Systems (2011)

Thanks to progress in optics in the past two decades, it is possible to create photons carrying well-defined non-zero orbital angular momentum (OAM). Boosting these photons into high-energy range ... [more ▼]

Thanks to progress in optics in the past two decades, it is possible to create photons carrying well-defined non-zero orbital angular momentum (OAM). Boosting these photons into high-energy range preserving their OAM seems feasible. Intermediate energy electrons with OAM have also been produced recently. One can, therefore, view OAM as a new degree of freedom in high-energy collisions and ask what novel insights it can bring. Here we discuss generic features of scattering processes involving twisted particles in the initial state. We show that they make it possible to perform a Fourier analysis of a plane wave cross section with respect to the azimuthal angles of the initial particles, and to probe the autocorrelation function of the amplitude, a quantity inaccessible in plane wave collisions. [less ▲]

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See detailHigh-energy X-ray tomography analysis of a metal packing biofilm reactor for the production of lipopeptides by Bacillus subtilis
Zune, Quentin ULg; Soyeurt, Delphine; Toye, Dominique ULg et al

in Journal of Chemical Technology & Biotechnology (2014), 89

BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the ... [more ▼]

BACKGROUND: Whereas multi-species biofilm reactors are commonly used for the treatment of liquid and solid wastes, new strategies are progressing for the development of single species biofilm for the production of high-value metabolites. Technically, this new concept relies on the design of bioreactors able to promote biofilm formation and on the identification of the key physico-chemical parameters involved in biofilm formation. RESULTS: An experimental setting comprising a liquid continuously recirculated on a metal structured packing has been used to promote Bacillus subtilis GA1 biofilm formation. The colonization of the packing has been visualized non-invasively by X-ray tomography. This analysis revealed an uneven, conical, distribution of the biofilm inside the packing. Compared with a submerged culture carried out in a stirred tank reactor, significant modification of the lipopeptide profile has been observed in the biofilm reactorwith the disappearance of fengycin and iturin fractions and an increase of the surfactin fraction. In addition, considering the biofilm reactor design, no foam formation has been observed during the culture. CONCLUSIONS: The configuration of this biofilm reactor set-up allows for a higher surfactin production by comparison with a submerged culture while avoiding foam formation. Additionally, scale-up could easily be performed by increasing the number of packing elements. [less ▲]

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See detailHigh-field magnetization of U2T2X compounds (T = Co, Ni, Rh, Pd, Ir, Pt and X = In, Sn)
Nakotte, Heinz; Prokes, Karel; Brück, E. et al

Poster (1993, November)

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See detailHigh-field magnetization of U2T2X compounds (T = Co, Rh, Ni, Pd, Ir, Pt and X = In, Sn)
Nakotte, Heinz; Prokes, Karel; Brück, E. et al

in Physica B: Condensed Matter (1994), 201

Structure parameters and magnetization in quasistatic fields up to 38 T at 4.2 K are reported for U2T2X compounds with T = Co, Rh, Ni, Pd, Ir, Pt and X = In, Sn, which crystalline in the tetragonal U3Si2 ... [more ▼]

Structure parameters and magnetization in quasistatic fields up to 38 T at 4.2 K are reported for U2T2X compounds with T = Co, Rh, Ni, Pd, Ir, Pt and X = In, Sn, which crystalline in the tetragonal U3Si2 structure. Even the highest applied fields are not sufficient to achieve saturation of the magnetization in any of these compounds of which the majority is antiferromagnetic and some are Pauli paramagnets. The importance of 5f-ligand hybridization for the magnetism in these compounds is discussed. [less ▲]

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