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See detailEVALUATION OF SV2Alox/Cre TRANSGENIC MOUSE USING [18F]UCB-H IN IN VITRO AUTORADIOGRAPHY
Serrano Navacerrada, Maria Elisa ULg; Becker, Guillaume ULg; MENTEN, Catherine ULg et al

Poster (2015, September 04)

Background: SV2A is the most studied isoform of the Synaptic Vesicle 2 proteins, which are involved in the synaptic vesicle trafficking. Interestingly, the SV2A has been identify as the binding site for ... [more ▼]

Background: SV2A is the most studied isoform of the Synaptic Vesicle 2 proteins, which are involved in the synaptic vesicle trafficking. Interestingly, the SV2A has been identify as the binding site for the antiepileptic drug levetiracetam, showing a close relation between the epilepsy, the dysregulation of the SV2A levels and the response to antiepileptic medications. SV2A floxed-mice were developed using a cre-lox technique, leading to a strong decrease of SV2A expression in the CA3 field of the hippocampus. We aim here to validate this model using [18F]UCB-H, a novel PET imaging radiotracer with a nanomolar affinity for human SV2A. Methods: In vitro autoradiography were performed on SV2Alox/Cre+ transgenic mouse brain slices. SV2Alox/Cre- mouse was used as control. To obtain a structural reference, brain slices underwent eosin-haematoxylin staining. Images of both procedures were coregistered using π-PMOD software. Regions of interest (Dentate Gyrus, CA1, CA2 and CA3) were drawn according to a stereotaxic atlas of the mouse brain. Results: Analyses showed significant differences in radiotracer binding (p<0.001) between SV2Alox/Cre+ mouse and SV2Alox/Cre- mouse highlighting an important reduction for the labelling density in Ammon's horn, particularly in CA1, compared to Dentate Gyrus where the diminution was less marked. Conclusions: Here, we used the radiotracer [18F]UCB-H to probe the decreased expression of SV2A protein in the hippocampus of SV2Alox/Cre+ mouse versus SV2Alox/Cre- control mouse. Our results contribute to the validation of the model, and encourage us to proceed with further longitudinal and behavioural studies. [less ▲]

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See detailEvaluation of symptomatic slow-acting drugs in osteoarthritis using the GRADE system.
Bruyère, Olivier ULg; Burlet, Nansa; Delmas, Pierre D et al

in BMC Musculoskeletal Disorders (2008), 9

BACKGROUND: Symptomatic slow-acting drugs (SYSADOA) have been largely studied over the last decade. The objective of this study is to prepare a document providing recommendations for the use of SYSADOA in ... [more ▼]

BACKGROUND: Symptomatic slow-acting drugs (SYSADOA) have been largely studied over the last decade. The objective of this study is to prepare a document providing recommendations for the use of SYSADOA in osteoarthritis (OA). METHODS: The following interventions were taken into consideration: avocado/soybean unsaponifiables, chondroitin sulfate, diacereine, glucosamine sulfate, hyaluronic acid, oral calcitonin, risedronate, strontium ranelate. Recommendations were based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. The GRADE system is based on a sequential assessment of the quality of evidence, followed by assessment of the balance between benefits versus downsides and subsequent judgment about the strength of recommendations. RESULTS: Chondroitin sulfate, diacereine, glucosamine sulfate, avocado/soybean unsaponifiables and hyaluronic acid have demonstrated pain reduction and physical function improvement with very low toxicity, with moderate to high quality evidence. Even if pre-clinical data and some preliminary in vivo studies have suggested that oral calcitonin and strontium ranelate could be of potential interest in OA, additional well-designed studies are needed. CONCLUSION: In the benefit/risk ratio, the use of chondroitin sulfate, diacereine, glucosamine sulfate, avocado/soybean unsaponifiables and hyaluronic acid could be of potential interest for the symptomatic management of OA. [less ▲]

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See detailEvaluation of systolic function in calves by Doppler echocardiography: preliminary results
Brihoum, M; Rollin, Frédéric ULg; Desmecht, Daniel ULg et al

in Proceedings of the XXIVth World Buiatrics Congress (2006)

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See detailEvaluation of tactile sensors in apple firmness measurement
Petit, Catherine; Leemans, Vincent ULg; Kleynen, Olivier et al

in Proceedings of the Conference 'Physical Methods in Agriculture, Appoach to precision and quality' (2001)

The objective of the work consists to develop a non-destructive fruit firmness measurement. The tactile sensor technology was chosen. The force measurement acting between the fruit-sensor as well as the ... [more ▼]

The objective of the work consists to develop a non-destructive fruit firmness measurement. The tactile sensor technology was chosen. The force measurement acting between the fruit-sensor as well as the contact area are coupled with other meaqsurements, like the color of the fruit. The results of the measurements are compared with the firmness reference values (Magness-Taylor test) and also with the acoustic impulse response technique. Several parameters correlated with firmness are proposed. [less ▲]

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See detailEvaluation of Temocillin for treatment of nosocomial infections
LAYIOS, Nathalie ULg; CIUTEA, Mirela ULg; LONGUEVILLE, Manon et al

in Intensive Care Medecine (2014), 40(supplément 1), 1940704

Detailed reference viewed: 47 (18 ULg)
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See detailEvaluation of the acoustic comfort of air-treatment systems with a multi-task procedure
Minard, Antoine; Robin, Benjamin; Fournier, Francette et al

in E.A.A. (Ed.) Proceedings of the 2012 Euronoise Congress (2012, June)

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See detailEvaluation of the aging patient’s voice by means of the VHI correlated to the DS16 and the SF-36
Morsomme, Dominique ULg; Provin, Sarah; Verduyckt, Ingrid et al

Conference (2008, May 31)

Objective vocal changes linked to the age have been largely studied these last 20 years. However, few authors have showed an interest in the subjective evaluation of the aging voice. Our research aimed ... [more ▼]

Objective vocal changes linked to the age have been largely studied these last 20 years. However, few authors have showed an interest in the subjective evaluation of the aging voice. Our research aimed the study of the aging voice by means of the Voice Handicap Index (VHI) Jacobson et al., (1997) in 90 subjects divided into three groups: « 30 elderly subjects in a nursing home », « 30 elderly subjects living at home » and « 30 young subjects » as the control group. We compared the results from these three groups and controlled for several variables such as age, living place, personality, dependency and repetition, that can have an impact on the VHI score. The DS16 (Denollet, 1998) and the SF-36 (Ware et al, 1993) were used to test personality and dependency. Our results showed that the scores on the global and physical scales are higher for all groups at the retest (p=0,046; p=0,015). Although the VHI seems adapted to the aging subject, some improvements are suggested concerning the items addressing the professional life and social life (F8, F16, F22, E24 et E29). We also observe correlations between the three subscales (p<0,001). Concerning the DS16, the personality trait « negative affect » and « social inhibition » are correlated to the global score at the test and the retest (P=0,002 ; P =0,001 and P=0,048 ; P=0,015). Type-D personality raises the physical scores (P=0,018 ; P=0,006) and the global scores (P=0,014 ; P=0,003). Moreover, the VHI is correlated to 6 dimensions of general health related quality of life and with the global score of the SF-36 (P<0,001). The elderly subjects obtain higher functional (P=0,007 ; P=0,006), physical (P=0,009 ; P<0,001) and global (P=0,003 ; P<0,001) scores than the young subjects. Moreover, the subjects living in a nursery home obtain a higher emotional score on the univariate analysis (P=0,008 ; P=0,02) than those living at home. At the multivariate analysis, the variable « nursery home » has a significant impact on the functional score (P=0,02). Finally, a multivariate linear regression shows that the variable sex increases all the scores at the VHI (P=0,048 ; P=0,044 ; P=0,03 ; P=0,023) and the variable « dependency » (P<0,001) increases the emotional, physical and global score. Although vocal quality in the elderly might seem only slightly altered, age is a factor that increases functional, physical and global scores at the VHI. However, sex, dependency and personality type are also influencing vocal self-evaluation and can moderate the effect of age. [less ▲]

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See detailEvaluation of the anesthetic-lipid association constant. A monolayer approach.
Guilmin, T.; Goormaghtigh, E.; Brasseur, Robert ULg et al

in Biochimica et Biophysica Acta (1982), 685(2), 169-76

A new approach is presented which allows to describe the binding of different local anesthetics to lipids. Lipids (DL- alpha-dipalmitoylphosphatidylcholine, phosphatidylserine, cardiolipin) are spread at ... [more ▼]

A new approach is presented which allows to describe the binding of different local anesthetics to lipids. Lipids (DL- alpha-dipalmitoylphosphatidylcholine, phosphatidylserine, cardiolipin) are spread at the air-water interface and the anesthetic (procaine, butacaine, tetracaine) injected into the aqueous subphase. The equilibrium constants associated to the interfacial reaction: D+ (subphase) +L- (monolayer) in equilibrium DL (monolayer) (where D+ denotes the anesthetics, L- the lipid anionic site and DL the complex) are calculated from an experimental evaluation of the surface potential of the lipid monolayer. This mode of determination is based essentially on the good correlation between the experimental values of the surface potential and the theoretical predictions from the Gouy-Chapman theory. Fluorescence measurements on liposomes are carried out in order to locate the position of the drug in the lipid layer. This method can be extended to any positively charged drug-anionic lipid interaction. [less ▲]

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See detailEvaluation of the antiproliferative effects of infusions and essential oil of Aloysia gratissima
Hister, CAL; Laughinghouse IV, Haywood ULg; Silva, CB et al

in Pakistan Journal of Biological Sciences (2009), 12(24), 1581-1584

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See detailEvaluation of the antitrypanosomal activity of several plants traditionally used in Benin to treat sleeping sickness
Hoet, Sarah; Cottem, D; Opperdoes, F et al

Poster (2001)

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See detailEvaluation of the antitumor activity of 16K prolactin
Kinet, Virginie; Nguyen, Ngoc-Quynh-Nhu ULg; Sabatel, Céline et al

Poster (2009)

Detailed reference viewed: 27 (15 ULg)
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See detailEvaluation of the antitumor activity of 16K prolactin
Kinet, Virginie; Nguyen, Ngoc-Quynh-Nhu ULg; Cornet, Anne ULg et al

Poster (2007)

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See detailEvaluation of the aphid and aphidophagous beneficials diversity in a pea and potato association
Bosquée, Emilie ULg; Chevalier Mendes Lopes, Thomas ULg; Serteyn, Laurent ULg et al

Poster (2014, May 20)

Crop associations can have beneficial effects on the control of insect pests. This study was conducted in the Shandong province (China) to assess the impact of potatoes and peas association on the ... [more ▼]

Crop associations can have beneficial effects on the control of insect pests. This study was conducted in the Shandong province (China) to assess the impact of potatoes and peas association on the populations of aphids and aphidophagous beneficials. Observations on potato plants and trapping were performed. During the season, the degree of infestation didn’t differ significantly between the association and the pure stand. However, the aphidophagous beneficials were more abundant in the association comparing to the pure stand. Trapping results give a more general idea about the richness and diversity of natural enemies present in the environment. Aphidius gifuensis (Ashmead) and Aphelinus abdominalis Dalman are the most abundant parasitoids. Among predators, Propylea japonica (Thunberg) and Harmonia axyridis (Pallas) are prevalent. Few hoverflies and lacewings were trapped. Results from the observations on plants do not support the resource concentration hypothesis. However, the enemy hypothesis was confirmed for the aphidophagous beneficials. Therefore, this association can have a beneficial effect on the control of aphid populations. [less ▲]

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See detailEVALUATION OF THE AUTOMATIC IMAGE REGISTRATION FEATURES OF A KV CONE-BEAM CT IMAGING SYSTEM
JANVARY, Zsolt Levente ULg; JANSEN, Nicolas ULg; MATHOT, Michel ULg et al

in Radiotherapy & Oncology (2010), 96(supp 1),

Detailed reference viewed: 37 (11 ULg)