Is there anybody in there? Detecting awareness in disorders of consciousness.

in Expert Review of Neurotherapeutics (2008), 8(11), 1719-30

The bedside detection of awareness in disorders of consciousness (DOC) caused by acquired brain injury is not an easy task. For this reason, differential diagnosis using neuroimaging and ... [more ▼]

The bedside detection of awareness in disorders of consciousness (DOC) caused by acquired brain injury is not an easy task. For this reason, differential diagnosis using neuroimaging and electrophysiological tools in search for objective markers of consciousness is being employed. However, such tools cannot be considered as diagnostic per se, but as assistants to the clinical evaluation, which, at present, remains the gold standard. Regarding therapeutic management in DOC, no evidence-based recommendations can be made in favor of a specific treatment. The present review summarizes clinical and paraclinical studies that have been conducted with neuroimaging and electrophysiological techniques in search of residual awareness in DOC. We discuss the medical, scientific and ethical implications that derive from these studies and we argue that, in the future, the role of neuroimaging and electrophysiology will be important not only for the diagnosis and prognosis of DOC but also in establishing communication with these challenging patients. [less ▲]

Is there potential for strontium ranelate in the management of osteoarthritis ?

in Clinical Practice (2013), 10(2), 201-207

Is there value in maintaining small populations ? Example of the Dual-Purpose Belgian Blue breed.

in Journal of Dairy Science (2011), 94(E-suppl.1), 664

Current status of thinking on genomic selection in dairy cattle is mostly major breed centric (e.g., Holstein) and only for traditional traits (e.g., milk yields). Once you depart from this, it becomes ... [more ▼]

Current status of thinking on genomic selection in dairy cattle is mostly major breed centric (e.g., Holstein) and only for traditional traits (e.g., milk yields). Once you depart from this, it becomes obvious that different, often related, issues appear (e.g., lack of large training populations, need for expensive recording of new phenotypes). Also, there is an urgent need to rethink issues that are important for sustainability of dairy production (e.g., added value foods, animal robustness). In this context, small populations (breeds/lines) could represent a potential source of extra information to justify their maintenance. As marker densities increase, efficient dissection of different selection histories of divergent breeds or lines, potentially identifying pockets of unexploited variability will increase. A current example from the Belgian (Walloon) perspective is the Dual Purpose (DP) line of the Belgian Blue Breed (BBB), with presently around 4500 breeding females, for historical reason of which only 1500 have good pedigrees, and which is present in Belgium and northern France. Recent research, done on this line, showed its tendency to produce less saturated milk fat and to have better fertility. Results indicated that it could stay competitive in specific markets, especially because of largely increased meat value. Currently, the myostatin mutation is largely used for breeding purposes. To assess the genetic diversity of the breed, recently, over 200 genotypes (SNP50K) for nearly all breeding bulls of the last 20 years became available. HD genotypes should be available in the near future, also allowing to access selection history of this breed as being in between the 2 extreme breeds: Beef BBB (with which it shares a recent history) and Holstein-Friesian (which is related through its geographic proximity over centuries). Finally, genomic selection for DP-BBB will need to consider a single step type approach without the need of reference population and potentially relying heavily on SNP3K of cows, also with the objective to recreate relationships between animals of interest. [less ▲]

Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?

Conference (2009, November)

Is ultra-short cold ischemia the key to IBDL avoidance in DCD-LT?

Poster (2013, February 08)

Is volition the missing link in the management of low back pain?

in Joint Bone Spine (2011), 78

Patients with nonspecific chronic low back pain are typically prescribed a regimen of regular physical exercises to improve pain and function, increase workability, and prevent pain recurrence. However ... [more ▼]

Patients with nonspecific chronic low back pain are typically prescribed a regimen of regular physical exercises to improve pain and function, increase workability, and prevent pain recurrence. However, adherence to home exercise programs is often partial at best. Patients often fail to translate their intention to exercise (motivation) into action (implementation). Volition is the mental activity by which intentions are implemented. In this review, we argue that volition may be crucial to the successful rehabilitation of patients with low back pain. Obstacles to the implementation of intentions are described, as well as factors that promote implementation, most notably the conscious formation of implementation intentions. [less ▲]

Is1151, an Is-Like Element of Clostridium Perfringens

in Nucleic Acids Research (1993), 21(2), 352

Description of a new insertion sequence, named IS1151, associated with cpe gene from Clostridium perfringens

Isaac Bashevis Singer, ou la littérature comme illustration d'une théorie du droit

in Liber amicorum Paul Martens. L'humanisme dans la résolution des conflits. Utopie ou réalité? (2007)

Illustration de la théorie de la pluralité des ordres juridiques de Santi Romano par une nouvelle d'Isaac Bashevis Singer tiré du recueil "Au tribunal de mon père"

Isabel Stuart, Duchess of Brittany

in Viennot, Elianne (Ed.) Dictionnaire des femmes de l'Ancien Régime (2006)

Isadyle : Manuel d'application

Book published by Solal (2010)

ISADYLE est une batterie de langage construite en appui sur les théories développementales de la parole, du lexique, de la syntaxe et de la métalinguistique chez l’enfant. La batterie ISADYLE comporte ... [more ▼]

ISADYLE est une batterie de langage construite en appui sur les théories développementales de la parole, du lexique, de la syntaxe et de la métalinguistique chez l’enfant. La batterie ISADYLE comporte deux parties complémentaires : une batterie abrégée (screening) destinée au bilan en première ligne, rapide, du lexique, de la phonologie et de la syntaxe et une batterie approfondie consacrée à l’analyse soigneuse des structures et du fonctionnement des divers modules dont l’intégration permet un exercice harmonieux du langage. La batterie approfondie offre le choix parmi 52 épreuves. Chaque épreuve a fait l’objet d’un étalonnage distinct. Le clinicien sélectionnera parmi ces épreuves celles qui sont les plus pertinentes pour affiner l’évaluation des diverses facettes du langage de son patient, en fonction de ses objectifs diagnostiques et thérapeutiques. Ces outils sont destinés aux enfants de 3 à 12 ans. La batterie a été élaborée par quatre enseignants et chercheurs impliqués dans les programmes de formation des masters en logopédie des universités belges. [less ▲]