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See detailExérèse microchirurgicale atraumatique intranodulaire d'un schwanome bénin du sciatique poplité externe
LEJEUNE, G; LECLERCQ, Daniel ULg; CARLIER, Alain ULg et al

in Actualités chirurgicales - 81ème Congrès Fr. Chirurgie, Orthopédie, Traumatologie (1980)

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See detailExergetic, environmental and economic analysis of a biomass cogeneration plant connected to a district heating network.
Sartor, Kevin ULg; Dewallef, Pierre ULg

in Renewable Energy in the Service of Mankind Vol II (2015)

When a district heating network is fed by natural gas boilers (or biomass boilers), the selection of the network temperature level has a slight influence on the boiler efficiency which means that ... [more ▼]

When a district heating network is fed by natural gas boilers (or biomass boilers), the selection of the network temperature level has a slight influence on the boiler efficiency which means that producing at low temperature allows only to decrease the heat losses through the network. However when a cogeneration plant based on a Rankine cycle is used, lowering the network temperature not only decreases the heat losses but also increase the electrical efficiency while decreasing the thermal efficiency. This aspect is very often overlooked when the quality of a cogeneration plant is assessed by the cogeneration efficiency namely the sum of the electrical and thermal efficiency which is misleading for decision makers. In this contribution, an existing cogeneration plant connected to a district heating network installed on the University Campus in Liège (Belgium) is used as an application test case. Based on actual operational and economic data, a detailed economic evaluation is carried out which is supported by a calibrated simulation model of the whole installation in order to study the influence of the network temperature level. As a second step, the simulation model is used again to perform a detailed exergetic analysis intended to give physical insights to the economical study. This results in a broader discussion on the several methods to assess the quality of cogeneration plants and the opportunity to develop such a technology together with district heating networks. [less ▲]

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See detailExergetic, environmental and economic analysis of a biomass cogeneration plant connected to a district heating network.
Sartor, Kevin ULg

in Book of abstracts of WREC2014 (2014, August 05)

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See detailExergetical Evaluation of Biobased Synthesis Pathways
Frenzel, P; Fayyaz, S; Hillerbrand, R et al

Conference (2011)

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See detailExergetical Evaluation of Biobased Synthesis Pathways
Frenzel, Philipp; Hillerbrand, Rafaela; Pfennig, Andreas ULg

in Polymers (2014), 6(2), 327-345

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See detailExergetische Bewertung der Routen zur stofflichen Nutzung von Biomasse
Frenzel, Philipp; Fayyaz, Sara; Hillerbrand, Rafaela et al

Conference (2011)

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See detailExergetische Bewertung der Routen zur stofflichen Nutzung von Biomasse
Fayyaz, S; Frenzel, P; Hillerbrand, R et al

Conference (2011, May 05)

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See detailExergetische Bewertung neuer Syntheserouten ausgehend von biobasierten Rohstoffen
Fayyaz, Sara; Frenzel, Philipp; Hillerbrand, Rafaela et al

Conference (2011)

See detailExergySim – Fließschemasimulationen in einem frühen Entwicklungsstadium mit dem Fokus auf Exergiebilanzen
Frenzel, P; Hillerbrand, R; Pfennig, Andreas ULg

Conference (2012, November 13)

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See detailExertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin.
Stolz, Daiana; Boersma, Wim; Blasi, Francesco et al

in Chest (2014)

BACKGROUND: The prevalence of exertional hypoxemia in unselected COPD patients is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) up regulation through the HIF-1 pathway. We aimed to assess ... [more ▼]

BACKGROUND: The prevalence of exertional hypoxemia in unselected COPD patients is unknown. Intermittent hypoxia leads to adrenomedullin (ADM) up regulation through the HIF-1 pathway. We aimed to assess the prevalence and the annual probability to develop exertional hypoxemia in stable COPD. We also hypothesized that increased ADM might be associated with exertional hypoxemia and envisioned that adding ADM to clinical variables might improve its prediction in COPD. METHODS: 1233 6-minute walking tests and circulating proadrenomedullin levels from 574 patients with clinically stable, moderate to very severe COPD enrolled in a multinational cohort study and followed-up for 2 years were concomitantly analyzed. RESULTS: The prevalence of exertional hypoxemia was 29.1%. In a matrix derived from a fitted-multi-state model, the annual probability to develop exertional hypoxemia was 21.6%. Exertional hypoxemia was associated with greater deterioration of specific domains of health-related QoL, higher severe exacerbation and death annual rates. In the logistic linear and conditional Cox-regression multivariable analyses, both FEV1% predicted and proADM proved independent predictors of exertional hypoxemia (p<0.001 for both). Adjustment for comorbidities, including cardiovascular disorders, and exacerbation-rate did not influence results. Relative to using FEV1% pred alone, adding proADM resulted in a significant improvement of the predictive properties (p=0.018). Based on the suggested non-linear nomogram, patients with moderate COPD (FEV1 predicted=50%) but high proADM levels (>2nmol/l) presented increased risk (>30%) for exertional desaturation. CONCLUSIONS: Exertional desaturation is common and associated with poorer clinical outcomes in COPD. Adrenomedullin improves prediction of exertional desaturation as compared to the use of FEV1%pred alone. [less ▲]

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See detailExfoliated polylactide/clay nanocomposites by in-situ coordination-insertion polymerization
Paul, Marie-Amélie; Alexandre, Michaël ULg; Degée, Philippe et al

in Macromolecular Rapid Communications (2003), 24(9), 561-566

Poly(L-lactide)/layered aluminosilicate nanocomposites were synthesized in bulk by ring-opening polymerization in the presence of two organo-modified montmorillonites. When the organo-modifier consisted ... [more ▼]

Poly(L-lactide)/layered aluminosilicate nanocomposites were synthesized in bulk by ring-opening polymerization in the presence of two organo-modified montmorillonites. When the organo-modifier consisted of an ammonium cation bearing primary hydroxyl groups, polymerization was initiated by the alcohol functions after adequate activation. The growing polymer chains were directly "grafted" onto the clay surface through the hydroxyl-functionalized ammonium cations yielding exfoliated nano-composites with enhanced thermal stability. [less ▲]

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See detailExfoliation of clays in poly(dimethylsiloxane) rubber using an unexpected couple: a silicone surfactant and water
Labruyère, Céline ULg; Monteverde, Fabien; Alexandre, Michaël ULg et al

in Journal of Nanoscience and Nanotechnology (2009), 9(4), 2731-2738

Poly(dimethylsiloxane) (PDMS)/montmorillonite (MMT) composites have been prepared using a newly synthesized ω-ammonium functionalized poly(dimethylsiloxane) compatibilizer coupled with a dispersion ... [more ▼]

Poly(dimethylsiloxane) (PDMS)/montmorillonite (MMT) composites have been prepared using a newly synthesized ω-ammonium functionalized poly(dimethylsiloxane) compatibilizer coupled with a dispersion technique in water. The organoclay containing the new siloxane surfactant was characterized by TGA and XRD. For the first time, a nanoscopic dispersion of MMT nanoplatelets in the PDMS composite cured by hydrosilylation and a good compatibility between clay layers and matrix were obtained. The beneficial effect of both the surfactant and the water onto clay nanoplatelet dispersion was evaluated by different microscopy techniques and by measuring different properties such as the viscosity of the uncured PDMS/MMT nanodispersions, and the swelling rate and Young's modulus of the cured PDMS/MMT nanocomposites. [less ▲]

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See detailExforge® (amlodipine/valsartan combination) in hypertension: the evidence of its therapeutic impact
Krzesinski, Jean-Marie ULg; Cohen, Eric P.

in Core Evidence (2008), 3(2), 117-126

Abstract Introduction: Hypertension is an important risk factor for cardiovascular disease and its management requires improvement. New treatment strategies are needed. Aims: This review analyses one of ... [more ▼]

Abstract Introduction: Hypertension is an important risk factor for cardiovascular disease and its management requires improvement. New treatment strategies are needed. Aims: This review analyses one of these strategies, which is the development of effective and safe combination therapy. Indeed, at least two antihypertensive agents are often needed to achieve blood pressure control. Exforge® (Novartis) is a new drug combination of the calcium channel blocker, amlodipine, and the angiotensin II receptor blocker, valsartan. Evidence review: The amlodipine/valsartan combination is an association of two well-known antihypertensive products with specific targets in cardiovascular protection, namely calcium channel blockade and antagonism of the renin-angiotensin-aldosterone system. This kind of association, with neutral metabolic properties and significant antihypertensive efficacy, could be a useful new antihypertensive product. Currently available data have shown that this new combination is well-tolerated and effective even in severe hypertension. Clinical value: Clinical trials are ongoing for further assessment of the efficacy, compliance, and safety of this combination and its congeners. No data exist to prove that the amlodipine/valsartan combination is better than other antihypertensive strategies for cardiovascular or renal protection, but some trials with other combination therapies show such potential advantage. [less ▲]

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See detailExhaled nitric oxide as a marker of asthma control in smoking patients.
Michils, A.; Louis, Renaud ULg; Peche, R. et al

in European Respiratory Journal (2009), 33(6), 1295-301

Exhaled nitric oxide fraction (F(eNO)), which is a reliable marker of eosinophilic airway inflammation, is partially suppressed by tobacco smoking. Consequently, its potential as a biomarker in asthma ... [more ▼]

Exhaled nitric oxide fraction (F(eNO)), which is a reliable marker of eosinophilic airway inflammation, is partially suppressed by tobacco smoking. Consequently, its potential as a biomarker in asthma management has never been evaluated in smoking patients. In the present study, the authors tested the validity of F(eNO) to predict asthma control in this population. F(eNO) and the Asthma Control Questionnaire (ACQ) were recorded at least once in 411 nonsmoking (345 with at least two visits) and 59 smoking (51 with at least two visits) asthma patients. Despite similar mean ACQ scores (1.5 versus 1.7), F(eNO) was reduced in smoking asthmatics (18.1 ppb versus 33.7 ppb). A decrease in F(eNO) of <20% precludes asthma control improvement in nonsmoking (negative predictive value (NPV) 78%) and in smoking patients (NPV 72%). An increase in F(eNO) <30% is unlikely to be associated with deterioration in asthma control in both groups of patients (NPV = 86% and 84% in nonsmoking and smoking patients, respectively). It is concluded that, even in smokers, sequential changes in F(eNO) have a relationship with asthma control. The present study is the first to indicate that cigarette smoking does not obviate the clinical value of measuring F(eNO) in asthma among smokers. [less ▲]

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See detailExhaled nitric oxide thresholds associated with a sputum eosinophil count >=3% in a cohort of unselected patients with asthma.
Schleich, FLorence ULg; Seidel, Laurence ULg; Sele, Jocelyne ULg et al

in Thorax (2010), 65(12), 1039-1044

Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value that ... [more ▼]

Background It has been claimed that exhaled nitric oxide (FeNO) could be regarded as a surrogate marker for sputum eosinophil count in patients with asthma. However, the FeNO threshold value that identifies a sputum eosinophil count >/=3% in an unselected population of patients with asthma has been poorly studied. Methods This retrospective study was conducted in 295 patients with asthma aged 15-84 years recruited from the asthma clinic of University Hospital of Liege. Receiver-operating characteristic (ROC) curve and logistic regression analysis were used to assess the relationship between sputum eosinophil count and FeNO, taking into account covariates such as inhaled corticosteroids (ICS), smoking, atopy, age and sex. Results Derived from the ROC curve, FeNO >/=41 ppb gave 65% sensitivity and 79% specificity (AUC=0.777, p=0.0001) for identifying a sputum eosinophil count >/=3%. Using logistic regression analysis, a threshold of 42 ppb was found to discriminate between eosinophilic and non-eosinophilic asthma (p<0.0001). Patients receiving high doses of ICS (>/=1000 mug beclometasone) had a significantly lower FeNO threshold (27 ppb) than the rest of the group (48 ppb, p<0.05). Atopy also significantly altered the threshold (49 ppb for atopic vs 30 ppb for non-atopic patients, p<0.05) and there was a trend for a lower threshold in smokers (27 ppb) compared with non-smokers (46 ppb, p=0.066). Age and sex did not affect the relationship between FeNO and sputum eosinophilia. When combining all variables into the logistic model, FeNO (p<0.0001), high-dose ICS (p<0.05) and smoking (p<0.05) were independent predictors of sputum eosinophilia, while there was a trend for atopy (p=0.086). Conclusion FeNO is able to identify a sputum eosinophil count >/=3% with reasonable accuracy and thresholds which vary according to dose of ICS, smoking and atopy. [less ▲]

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See detailExhaust Heat Recovery Rankine System for passenger cars: modelling and design
Glavatskaya, Yulia; Lemort, Vincent ULg; Podevin, Pierre et al

(2011, July)

Nowadays, in average, one third of the fuel energy consumed by an engine is wasted throughout the exhaust gases. The recovery of this amount of energy would enable a reduction of the fuel consumption. One ... [more ▼]

Nowadays, in average, one third of the fuel energy consumed by an engine is wasted throughout the exhaust gases. The recovery of this amount of energy would enable a reduction of the fuel consumption. One solution is to integrate an exhaust heat recovery system based on a Rankine cycle. The first and most crucial step in the design is the definition of its architecture, the definition of the rated operating conditions and the sizing of the different components whilst considering the heat recovery over customer driving cycles. This paper presents a steady-state model of a steam Rankine cycle built by interconnecting sub-models of the heat exchangers, the pump and the expander. All the models were developed under EES (Engineering Equation Solver) environment. The models of heat exchanger are developed using the ε-NTU method. A heat exchanger is subdivided into three zones, each of them being characterized by both the exhaust gases and water side pressure drop as well as heat transfer coefficient. The evaluation of the two-phase zone pressure drop and heat transfer with respect to the vapour quality was carried out. The model of rotary piston expander describes the evolution of the fluid through the device and was split into three global steps: pressure drop across the supply port, isentropic and expansion at constant volume, internal and external heat transfers. The overall simulation model is finally used to predict the performance of the heat recovery system as the operating conditions and geometrical characteristics of each component are modified. An optimal sizing of the system is proposed and the underlying methodology is discussed. The analysis of the results pointed out that the levels of high/low pressure and the amount of superheat are the main parameters that impact the performance of the cycle and the sizing of the components. [less ▲]

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