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See detailIL-4Ralpha-responsive smooth muscle cells contribute to initiation of T(H)2 immunity and pulmonary pathology in Nippostrongylus brasiliensis infections.
Horsnell, W. G.; Vira, A.; Kirstein, F. et al

in Mucosal immunology (2010), 4(1), 83-92

Nippostrongylus brasiliensis infections generate pulmonary pathologies that can be associated with strong T(H)2 polarization of the host's immune response. We present data demonstrating N. brasiliensis ... [more ▼]

Nippostrongylus brasiliensis infections generate pulmonary pathologies that can be associated with strong T(H)2 polarization of the host's immune response. We present data demonstrating N. brasiliensis-driven airway mucus production to be dependent on smooth muscle cell interleukin 4 receptor-alpha (IL-4Ralpha) responsiveness. At days 7 and 10 post infection (PI), significant airway mucus production was found in IL-4Ralpha(-/lox) control mice, whereas global knockout (IL-4Ralpha(-/-)) and smooth muscle-specific IL-4Ralpha-deficient mice (SM-MHC(Cre) IL-4Ralpha(-/lox)) showed reduced airway mucus responses. Furthermore, interleukin (IL)-13 and IL-5 cytokine production in SM-MHC(Cre) IL-4Ralpha(-/lox) mice was impaired along with a transient reduction in T-cell numbers in the lung. In vitro treatment of smooth muscle cells with secreted N. brasiliensis excretory-secretory antigen (NES) induced IL-6 production. Decreased protein kinase C (PKC)-dependent smooth muscle cell proliferation associated with cell cycle arrest was found in cells stimulated with NES. Together, these data demonstrate that both IL-4Ralpha and NES-driven responses by smooth muscle cells make important contributions in initiating T(H)2 responses against N. brasiliensis infections.Mucosal Immunology advance online publication 25 August 2010. doi:10.1038/mi.2010.46. [less ▲]

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See detailIL-4R{alpha}-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis.
Marillier, Reece G; Brombacher, Tiroyaone M; Dewals, Benjamin G ULg et al

in American Journal of Physiology - Gastrointestinal and Liver Physiology (2010), 298(6), 943-51

Interleukin-(IL)-4 and IL-13 signal through heterodimeric receptors containing a common IL-4 receptor-alpha (IL-4Ralpha) subunit, which is important for protection against helminth infections, including ... [more ▼]

Interleukin-(IL)-4 and IL-13 signal through heterodimeric receptors containing a common IL-4 receptor-alpha (IL-4Ralpha) subunit, which is important for protection against helminth infections, including schistosomiasis. Previous studies demonstrated important roles for IL-4Ralpha-responsive hematopoietic cells, including T cells and macrophages in schistosomiasis. In this study, we examined the role of IL-4Ralpha responsiveness by nonhematopoietic smooth muscle cells during experimental acute murine schistosomiasis. Comparative Schistosoma mansoni infection studies with smooth muscle cell-specific IL-4Ralpha-deficient (SM-MHC(cre)IL-4Ralpha(-/flox)) mice, heterozygous control (IL-4Ralpha(-/flox)) mice, and global IL-4Ralpha-deficient (IL-4Ralpha(-/-)) mice were conducted. S. mansoni-infected SM-MHC(cre)IL-4Ralpha(-/flox) mice showed increased weight loss and earlier mortalities compared with IL-4Ralpha(-/flox) mice, despite comparable T(H)2/type 2 immune responses. In contrast to highly susceptible IL-4Ralpha-deficient mice, increased susceptibility in SM-MHC(cre)IL-4Ralpha(-/flox) mice was not accompanied by intestinal tissue damage and subsequent sepsis. However, both susceptible mutant mouse strains failed to efficiently expel eggs, demonstrated by egg reduction in the feces compared with control mice. Reduced egg expulsion was accompanied by impaired IL-4/IL-13-mediated hypercontractile intestinal responses, which was present in the more resistant control mice. Together, we conclude that IL-4Ralpha responsiveness by smooth muscle cells and subsequent IL-4- and IL-13-mediated hypercontractility are required for host protection during acute schistosomiasis to efficiently expel S. mansoni eggs and to prevent premature mortality. [less ▲]

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See detailIL10 production in cultures of lymphocytes derived from biopsies of normal exocervix, transformation zone and squamous intraepithelial lesion
Jacobs, Nathalie ULg; Renard, Isabelle; Pisvin, Sonia ULg et al

in Monsonego, J. (Ed.) 4th International Multidisciplinary Congress - Eurogin 2000 (2000)

The immune system appears to play a role in the development of squamous intraepithelial lesions (SIL) and their progression to cancer. We have developed a technique to isolate and cultivate lymphocytes ... [more ▼]

The immune system appears to play a role in the development of squamous intraepithelial lesions (SIL) and their progression to cancer. We have developed a technique to isolate and cultivate lymphocytes either from the epithelium or from the underlying stroma of small biopsies from the normal exocervix, the transformation zone (TZ) and SIL. The majority of cells derived from the epithelium of all biopsies were CD8+ T cells. No major difference was observed for the lymphocyte phenotype. Among all cytokines tested by ELISA (IL10, IL4 and IFNγ), only IL10 was significantly higher in the TZ in comparison with the exocervix. In cultures derived from the stroma, a decreased percentage in T cells was observed in the TZ and SIL in comparison with the exocervix. This decrease in T cells concerned CD8+ (SIL) and TCRγδ+ T cells (TZ and SIL). We did not observe any difference in IL10 or IL4 production, although patients with SIL produced more IFNγ. The higher levels of IL10 production by lymphocytes derived from the epithelium of the TZ might contribute to the predisposition of this region to cervical carcinogenesis. [less ▲]

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See detailIL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use?
Orlent, Hans; Reynaert, Hendrik; Bourgeois, Stefan et al

in Acta Gastro-Enterologica Belgica (2011), 74(2), 317-322

Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of ... [more ▼]

Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents. [less ▲]

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See detailIL6 and IL4: localization and production in human tonsils
Bosseloir, A.; Hooghe-Peters, E.; Heinen, Ernst ULg et al

in Lymphatic tissues and in vivo immune responses (1991)

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See detailL'Île aux Corsaires et ses trésors naturels
Delcourt, Johann ULg; Destinay, Philippe; Dirick, Alain et al

Book published by Natagora (Liège et Basse-Meuse) - éditeur responsable: Pierre Tomasovic - natagora Liège et basse meuse (2010)

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See detailIleo-caecal actinomycosis: Report of a case simulating complicated inflammatory bowel disease
Postal, Alain; Detry, Olivier ULg; Louis, Edouard ULg et al

in Acta Gastro-Enterologica Belgica (2001), 64(4, Oct-Dec), 318-320

Abdominal actinomycosis is a rare infectious disease caused by Actinomyces israelii, a gram-positive anaerobic saprophyte germ that is a normal inhabitant of the upper intestinal tract in humans ... [more ▼]

Abdominal actinomycosis is a rare infectious disease caused by Actinomyces israelii, a gram-positive anaerobic saprophyte germ that is a normal inhabitant of the upper intestinal tract in humans. Actinomyces israelii rarely cause abdominal infections or actinomycosis. Abdominal actinomysosis is characterised by fistulae and abscesses and may mimic cancer or inflammatory bowel disease. Abdominal actinomycosis is difficult to diagnose preoperatively, and often require surgical removal of the diseased tissue, allowing pathologists for giving the definitive diagnosis, revealed by characteristic "sulfur granules". The authors report herein the case of a 47-year-old man who presented with diarrhoea and abdominal pain. Abdominal computed tomography evoked complicated inflammatory bowel disease and surgical procedure was decided. Laparoscopic exploration did not provide further significant information, and laparotomy with diseased bowel resection was performed. Pathology demonstrated "sulfur granules" and allowed the diagnosis of abdominal actinomycosis. This case demonstrated that abdominal actinomycosis should be included in the differential diagnosis when computed tomography shows an infiltrative and inflammatory mass. [less ▲]

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See detailIlithyie au travail : de la mère à l'enfant
Pironti, Gabriella; Pirenne-Delforge, Vinciane ULg

in Mètis : Revue d’Anthropologie des Mondes Grecs Anciens (2013), 11

Among the Greek deities related to motherhood, Eileithyia seems to be specifically concerned with parturition. If we carefully take into account her association with Artemis and with Hera, it becomes ... [more ▼]

Among the Greek deities related to motherhood, Eileithyia seems to be specifically concerned with parturition. If we carefully take into account her association with Artemis and with Hera, it becomes evident that Eileithyia is involved both at the same time during labour and in the tokos, the critical moment of childbirth itself. Moreover, she is thought to safeguard the child too. Accordingly, Eileithyia’s task, which is to assist in bringing a child to the light, persists throughout the process of filiation and the later development of children. [less ▲]

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See detail"Illegalisation, visibilisation and appropriation: a few thoughts on the politics of migrant labor in South China"
Florence, Eric ULg

Conference (2012, October 26)

Practices of legal and bureaucratic categorisation, as well normative practices of naming are key within the endless construction and reinvention of nation-states. Such practices are part of larger and ... [more ▼]

Practices of legal and bureaucratic categorisation, as well normative practices of naming are key within the endless construction and reinvention of nation-states. Such practices are part of larger and complex configurations of power along with institutions, more or less formal-informal practices of social control and governing. Today’s production and circulation of categories such “illegal migrant”, “refugee”, “young delinquent”, etc. need to be thought of in relation to categories such as “the national citizen” and the core values and principles attached to such categories. In this paper, I will explore how the dialectics of legality-illegality ─ and practices of visibilisation and invisibilisation ─ can be problematized in relation to a dual process: the ritual affirmation of the Party-state authority and the identity formation of rural migrant workers in South-China. I will argue that such politics ought to be read within the political economy of South-China or what Lee Ching-Kwan has called “decentralized legal authoritarianism” (Lee 2007). By looking at the production and circulation of the category of “the three no’s” (sanwu), I will show that the ambiguity and the flexibility of how this category is used is central in order to account for its symbolic and performative power. [less ▲]

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See detailAn illumination device formed by cutting and laminating coated plates
Vandormael, Denis; Habraken, Serge ULg

Patent (2004)

An illumination device based on multi facet plastic optics is proposed.The fabrication principle is novative and based on specific cutting geometry and coating lamination

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See detailIllumination of murine gammaherpesvirus-68 cycle reveals a sexual transmission route from females to males in laboratory mice.
Francois, Sylvie; Vidick, Sarah ULg; Sarlet, Mickael et al

in PLoS Pathogens (2013), 9(4), 1003292

Transmission is a matter of life or death for pathogen lineages and can therefore be considered as the main motor of their evolution. Gammaherpesviruses are archetypal pathogenic persistent viruses which ... [more ▼]

Transmission is a matter of life or death for pathogen lineages and can therefore be considered as the main motor of their evolution. Gammaherpesviruses are archetypal pathogenic persistent viruses which have evolved to be transmitted in presence of specific immune response. Identifying their mode of transmission and their mechanisms of immune evasion is therefore essential to develop prophylactic and therapeutic strategies against these infections. As the known human gammaherpesviruses, Epstein-Barr virus and Kaposi's Sarcoma-associated Herpesvirus are host-specific and lack a convenient in vivo infection model; related animal gammaherpesviruses, such as murine gammaherpesvirus-68 (MHV-68), are commonly used as general models of gammaherpesvirus infections in vivo. To date, it has however never been possible to monitor viral excretion or virus transmission of MHV-68 in laboratory mice population. In this study, we have used MHV-68 associated with global luciferase imaging to investigate potential excretion sites of this virus in laboratory mice. This allowed us to identify a genital excretion site of MHV-68 following intranasal infection and latency establishment in female mice. This excretion occurred at the external border of the vagina and was dependent on the presence of estrogens. However, MHV-68 vaginal excretion was not associated with vertical transmission to the litter or with horizontal transmission to female mice. In contrast, we observed efficient virus transmission to naive males after sexual contact. In vivo imaging allowed us to show that MHV-68 firstly replicated in penis epithelium and corpus cavernosum before spreading to draining lymph nodes and spleen. All together, those results revealed the first experimental transmission model for MHV-68 in laboratory mice. In the future, this model could help us to better understand the biology of gammaherpesviruses and could also allow the development of strategies that could prevent the spread of these viruses in natural populations. [less ▲]

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See detailIllusio
Durand, Pascal ULg

in COnTEXTES : Revue de Sociologie de la Littérature (in press)

Définition et discussion du concept d'« Illusio » dans la sociologie de Pierre Bourdieu.

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See detailIllusion biographique et biographie construite
Durand, Pascal ULg

in COnTEXTES : Revue de Sociologie de la Littérature (2008)

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See detailL’illusoire qui nous habille. Des vêtements et des corps.
Strivay, Lucienne ULg

Conference given outside the academic context (2011)

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See detailIllusory recollection: The compelling subjective remembrance of things that never happened. Insights from the DRM paradigm.
Dehon, Hedwige ULg

in Psychologica Belgica (2012)

Illusory recollection is the subjective detailed feeling of remembering that sometimes accompanies false remembering of events that never happened (e.g., high confidence, “Remember” judgements, or even ... [more ▼]

Illusory recollection is the subjective detailed feeling of remembering that sometimes accompanies false remembering of events that never happened (e.g., high confidence, “Remember” judgements, or even remembrance of precise details supposedly associated with the false event). In this review, typical illusory recollection measures obtained from laboratory studies will be depicted, with a focus on the DRM paradigm (Deese, 1959; Roediger & McDermott, 1995), one of the most largely used procedures to study memory distortion and its associated illusory recollection. The theoretical explanations of illusory recollection will be described and contrasted in light of factors affecting the phenomenon, in order to shown their strengths and limits. Although the focus on the origins of illusory recollection is relatively recent, overall, this review suggests that DRM false memories can be an excellent tool to study this phenomenon under controlled conditions and to gain insights on false memories occurring in everyday life. [less ▲]

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See detailIllustrated Courses of Natural Philosophy in the Southern Low Countries (1670-1797)
Opsomer, Carmélia ULg

in Shea, William R. (Ed.) Science and the Visual Image in the Enlightenment (2000)

Detailed reference viewed: 12 (6 ULg)