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See detailEvaluation of odour impact from a landfill area and a waste treatment facility through the application of two atmospheric dispersion models.
Ubeda, Yolanda; Ferrer, M.; Sanchis, E. et al

Conference (2010, July)

Odour emission from landfill areas has a high potential to cause significant annoyance to people living in their surroundings. In order to avoid odour nuisance, it is crucial to select the best location ... [more ▼]

Odour emission from landfill areas has a high potential to cause significant annoyance to people living in their surroundings. In order to avoid odour nuisance, it is crucial to select the best location in the project phase of these facilities. In the present work, two different atmospheric dispersion models were employed to predict odour impact from a projected landfill area and a waste treatment facility. The first model used was a simplified Gaussian Atmospheric Dispersion model developed by the authors. Calculated odour concentrations were represented using GIS tools (Esri ®ArcMapTM software). Regarding to the second model, it was a commercial bi-Gaussian Atmospheric Dispersion one. The odour impact of the waste treatment facility is expected to be low, because of the high efficiency of air biofiltration treatments and the dispersion effect of the stack. The shape and the reach of odour percentile contours were quite similar, providing coherent results between two models. Concerning the landfill installation, odour concentrations were modelled for the prevailing winds. The results obtained with both models differ in the reach of odour. The maximum distance obtained by the simple dispersion model was 1.5 km, compared with the almost 5 km modelled by the commercial bi-Gaussian one. The reasons of this disparity could be caused by the difference in the dispersion coefficients employed in the two models and also an error related to ground level emission. In addition, the meteorological conditions in the Mediterranean typically present a high proportion of calm winds, which provided worse dispersion results and did not reflect the real odour dispersion. Odour emission rate seems to be overestimated, and this could explain the high distance reached by odour. Field measurements are required when landfill installation becomes operational, in order to determine the real impact of odour. Bi-Gaussian Dispersion Models may not be appropriate to quantify the odour impact from agricultural sources. [less ▲]

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See detailEvaluation of oral corticosteroids and phosphodiesterase-4 inhibitor on the acute inflammation induced by inhaled lipopolysaccharide in human.
Michel, Olivier; Dentener, Mieke; Cataldo, Didier ULg et al

in Pulmonary Pharmacology & Therapeutics (2007), 20(6), 676-83

Background Endotoxins are pro-inflammatory substances present in the environment. In man, inhalation of its purified derivative lipopolysaccharide (LPS) induces inflammation related to macrophages and ... [more ▼]

Background Endotoxins are pro-inflammatory substances present in the environment. In man, inhalation of its purified derivative lipopolysaccharide (LPS) induces inflammation related to macrophages and neutrophils. Corticosteroids and phosphodiesterase (PDE)-4 inhibitors have inhibiting effects on macrophages and neutrophils, respectively. This study investigated the effect of prednisolone and of the PDE-4 inhibitor cilomilast on the LPS-induced acute inflammation. Methods The study was a placebo-controlled, double-blind crossover design. On three occasions, at 2 weeks interval, 16 healthy subjects inhaled 50 μg LPS after a 6-day treatment with cilomilast (15 mg bd), prednisolone (10 mg bd) or placebo. For the assessment of the inflammatory response, induced sputum was obtained before inclusion and 6 h post-LPS while blood samples were collected before, 6 and 24 h post-LPS. Results Inhaled LPS induced an increase in sputum neutrophils (p<0.0001), logMMP-9 (p<0.05), logMMP-9/TIMP-1 (p<0.01) and logTNF-α (p<0.02). At the blood level there were significant rise in neutrophilia (p<0.001), E-selectin (p<0.02), C-reactive protein (CRP) (p<0.001) and LPS-binding protein (p<0.001). There was both a slight, but not significant, increase in body temperature and decrease in forced expiratory volume in 1 s (FEV1). Neither prednisolone nor cilomilast had protective effect on the LPS-induced airways’ inflammation. The LPS-induced CRP acute-phase protein of inflammation (0.58±0.13 and 3.52±0.41 mg/dL, before and after LPS, respectively) was significantly inhibited by a pre-treatment with prednisolone (1.39±0.32 mg/dL, p<0.01) and attenuated (2.65±0.30 mg/dL, p=0.09) with cilomilast. Conclusion In healthy subjects, while the LPS-induced airways’ inflammation was not modified either by oral prednisolone or by PDE-4 inhibitor cilomilast (at actual dosage), the LPS-induced acute phase of blood inflammation was reduced by prednisolone. [less ▲]

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See detailEvaluation of organic dust components cytotoxicity on thp1 monocytes-derived-macrophages using high content analysis
Ramery, Eve ULg; O'Brien, Peter James

in Veterinary Clinical Pathology (2011, December), 40(4), 583

Background: Organic dust contains pathogen associated molecular patterns (PAMPs) which can induce, following chronic exposure, significant airway diseases. Mononuclear phagocytes are key protecting cells ... [more ▼]

Background: Organic dust contains pathogen associated molecular patterns (PAMPs) which can induce, following chronic exposure, significant airway diseases. Mononuclear phagocytes are key protecting cells of the respiratory tract. Several studies have investigated the effects of PAMPs, and mainly endotoxins, on cytokine production. However the sub-lethal cytotoxicity of organic dust components on macrophages has not been tested yet. The novel technology of high content analysis (HCA) is already used to assess subclinical drug-induced toxicity. It combines the capabilities of flow cytometry, intracellular fluorescence probes, and image analysis and enables to perform rapid multiple analysis in large numbers of samples. Objectives: The purpose of the present study was, by using HCA, to investigate the cytotoxicity of the 3 major PAMPs contained in organic dust, ie. endotoxin (LPS), peptidoglycan (PGN) and β-glucans (zymosan) on THP-1 monocyte-derived macrophages. Methods: LPS was used at concentrations of 0.005, 0.01, 0.02, 0.05, 0.1 and 1 μg/ml; PGN and zymosan were used at concentrations of 1, 5, 10, 50, 100 and 500 μg/ml. Cells were exposed to PAMPs for 24 hours. In addition, the oxidative burst and the phagocytic capabilities of the cells were tested. Results: An overlap between PGN intrinsic fluorescence and red/far-red fluorescent dyes occurred, rendering the evaluation of some parameters impossible for PGN. LPS induced sub-lethal cytotoxicity at the lowest dose (from 10 ng/ml). However, the most spectacular changes occurred with zymosan. In addition, zymosan, but not LPS, induced phagosome maturation and oxidative burst. Conclusions: Given the fact that β-glucans can be up to 100 fold more concentrated in organic dust than LPS, these results suggest that β-glucans could play a major role in macrophages impairment following heavy dust exposure and will deserve further investigation in the near future. [less ▲]

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See detailEvaluation of original dual thromboxane A2 modulators as anti-angiogenic agents
Dassesse, Thibaut; de Leval, Xavier; Dogné, Jean-Michel et al

Scientific conference (2006)

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See detailEvaluation of original dual thromboxane A2 modulators as antiangiogenic agents
de Leval, Xavier; Dassesse, Thibaut; Dogné, Jean-Michel ULg et al

in Journal of Pharmacology and Experimental Therapeutics (The) (2006), 318(3), 1057-1067

Angiogenesis is a promising target for the therapy of several diseases including cancer. This study was undertaken to characterize the antiangiogenic properties of a series of original dual thromboxane A ... [more ▼]

Angiogenesis is a promising target for the therapy of several diseases including cancer. This study was undertaken to characterize the antiangiogenic properties of a series of original dual thromboxane A(2) (TXA(2)) inhibitors derived from torasemide, a marketed loop diuretic with TXA(2) antagonistic properties, by evaluating their effects on human endothelial cell migration, adhesion, and viability in vitro, as well as in the ex vivo rat aortic ring assay. All drugs tested exhibited a marked affinity toward human platelet TXA(2) receptor, significantly prevented platelet aggregation induced by U-46,619, a stable TXA(2) receptor agonist, and inhibited platelet TXA(2) synthase without affecting cyclooxygenase (COX)-1 or COX-2 enzymatic activities. These dual TXA(2) inhibitors dose dependently inhibited endothelial cell migration in chemotaxis assays using vascular endothelial growth factor ( VEGF) as a chemoattractant but failed to affect cell adhesion and viability. The highest rates of cell migration inhibition were obtained with original compounds BM-567 and BM-573 (50.3 and 59.4% inhibition, respectively) when used at the final concentration of 10 mu M. In addition, pretreatment of endothelial cells with these two drugs significantly prevented U-46,619-induced intracellular Ca2+ pool mobilization, thus suggesting a mechanistic link between inhibition of the TXA(2) pathway and reduced endothelial cell migration. Treatment of rat aortic explants with U-46,619 (9,11- dideoxy- 9,11- methanoepoxyprostaglandin F 2) significantly enhanced vessel sprouting whereas aortic rings treated with some of the compounds, including BM-567 (N-n-pentyl-N'-[2-(cyclohexylamino)-5-nitrobenzenesulfonyl] urea) and BM-573 (N-tert-butyl-N'-[5-nitro-2p- toluylaminobenzenesulfonyl]urea), showed a significant decrease in vessel sprouting, which was not reversed by the addition of VEGF. These data suggest that our original dual TXA(2) inhibitors bear antiangiogenic properties, mainly by inhibiting endothelial cell migration. [less ▲]

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See detailEvaluation of oscillometric devices for detection of hypotension in anaesthetized dogs.
Gommeren, Kris ULg; Peyron, Clémence ULg; Lacoste-Garanger, Nicolas ULg et al

in Proceedings of the 9th EVECCS Annual meeting (2010)

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See detailEvaluation of oxygen consumption during field exercise tests in Standardbred trotters
Van Erck, Emmanuelle; Votion, Dominique ULg; Serteyn, Didier ULg et al

in Equine & Comparative Exercise Physiology (2007), 4(1), 43-49

Reasons for performing the study: In human exercise physiology, the current gold standard for evaluating aerobic capacity is the measurement of oxygen consumption (VO2max) and maximal oxygen uptake ... [more ▼]

Reasons for performing the study: In human exercise physiology, the current gold standard for evaluating aerobic capacity is the measurement of oxygen consumption (VO2max) and maximal oxygen uptake (VO2max). The evaluation of VO2, in horses is performed in some laboratories equipped with a treadmill but has only been exceptionally reported in field conditions because of the lack of adapted equipment. Objectives: The aim of this study was (1) to assess the feasibility of VO2 measurement on the track using a recently validated portable breath-by-breath gas analyser system adapted to horses (Cosmed K4b® and Equimask®), (2) to compare these results with those obtained during a treadmill exercise test and (3) to study correlations between VO2 and physiological parameters usually measured in field condition such as heart rate (HR), lactataemia (LA) and the speed at which HR equals 200 beats per minute (bpm) (V200) or LA 4 mmol-1 (VLA4). Methods: Five healthy Standardbred trotters in training were submitted to two stepwise incremental exercise tests, one driven on the racetrack and the other on a high-speed treadmill with a 4% incline. Speed (v), HR, ventilatory parameters and VO2 were continu¬ously recorded throughout the duration of the tests and LA was evaluated after each step. Results: All horses com¬pleted the test satisfactorily after an initial acclimatization to the mask. There were marked individual differences in ventilatory strategy, and breathing frequency (Rf) at the higher levels of exercise was noticeably low. The VCO2 measurements were incoherent. There were no significant differences between track and treadmill maximal data obtained during the last stop [VO2peak (track: 139.9 ± 8.9 ml kg-1min-1; treadmill: 139.9 ± 13.4 ml kg-1min-1), LAmax (track: 6.5 ± 1.6mmol-1; treadmill: 7.3 ± 3.Ommol-1-1), HRma (track: 229 ± 6.2 bpm; treadmill:222 ± 13 bpm)], although the maximal speed required to reach similar workloads was significantly higher on the track (11.9 ± 0.6 ms-1 vs. 9.7 ± 0.4 ms-1). The correlation between VO, and HR (r= 0.87; P < 0.001) and VO2 and LA (r = 0.75; P < 0,001) during both tests was good but no correlation was found between VO2peak and HRmax, LAmax, V200 or VLA4. Conclusions: This is the first report of a practical portable system to measure VO2 and ventilation continuously during high-speed field exercise tests. However, current mask design markedly influences ventilation and could have prohibited the attainment of VO2max Furthermore, consistent VCO2 measurements should be implemented by the manufacturers. Potential relevance: Continuous breath-by-breath ventilation and VO2 measurements can be recorded in horses in the field at submaximal levels. With necessary adaptations to the system entailed, this study opens new perspectives in the analysis of physiological and metabolic mechanisms of exercise in the equine species in genuine track conditions. [less ▲]

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See detailEvaluation of p-[F-18]MPPF, 5-HT1A antagonist, in rats: tissue distribution, autoradiography and metabolism.
Plenevaux, Alain ULg; Aerts, Joël ULg; Lemaire, Christian ULg et al

in Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine (1997), 38

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See detailEvaluation of pairwise calibration techniques for range cameras and their ability to detect a misalignment
Lejeune, Antoine ULg; Grogna, David ULg; Van Droogenbroeck, Marc ULg et al

in International Conference on 3D Imaging (IC3D) (2014, December)

Many applications require the use of multiple cameras to cover a larger volume. In this paper, we evaluate several pair-wise calibration techniques dedicated to range cameras. We compare the precision of ... [more ▼]

Many applications require the use of multiple cameras to cover a larger volume. In this paper, we evaluate several pair-wise calibration techniques dedicated to range cameras. We compare the precision of a self-calibration technique based on the movement in front of the cameras to object based calibration. While the self-calibration method is less precise than its counterparts, it yields a first estimation of the transformation between the cameras and permits to detect when the cameras become mis-aligned. Therefore it is useful in a practical situations. [less ▲]

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See detailEvaluation of particle translocation across the alveolo-capillary barrier in isolated perfused rabbit lung model
Nemmar, A.; Hamoir, J.; Nemery, B. et al

in Toxicology (2005), 208(1), 105-113

Particulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. It has been suggested that ultrafine particles are able to translocate from the airways into the ... [more ▼]

Particulate air pollution is associated with respiratory and cardiovascular morbidity and mortality. It has been suggested that ultrafine particles are able to translocate from the airways into the bloodstream in vivo. We have investigated this in an isolated perfused and ventilated rabbit lung preparation lacking pulmonary lymphatic flow. Fluorescent polystyrene particles of different diameters (24, 110 or 190 nm) and surface chemistry (carboxylate or amine modified) were injected either intratracheally (i.t.) or intravascularly (i.v.) and, after a period of 2 h, their presence in the perfusion liquid or in the bronchoalveolar lavage (BAL) fluid, was assessed by spectrofluorimetry. Vascular pressures and lung weights were monitored. Following the i.t. administration, no particle translocation was observed from the alveoli into the vascular compartment. Similarly, no particle translocation was found after i.v. administration of particles. However, when microvascular permeability was pharmacologically increased by administering histamine (10(-4) M) in the vascular compartment, inducing a positive driving force provided by fluid filtration, a fluorescent signal in BAL was recorded (2.5 +/- 1% of the dose of particles administered), suggesting a translocation of particles through the alveolo-capillary barrier. We conclude that ultrafine polystyrene particles cannot significantly diffuse from lung into the vascular compartment in our model, but they are able to translocate in the opposite direction when the microvascular permeability is increased by histamine. The relevance of these ex vivo findings for the in vivo translocation of inhaled ultrafine particles remains to be established [less ▲]

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See detailEVALUATION OF PERFORMANCES OF HYBRID ELECTRIC ENERGY STORAGE SYSTEM (LI-ION BATTERIES/ SUPERCAPACITORS) EV AND HEV APPLICATIONS
Lemaire, Julien ULg; Nzisabira, Jonathan ULg; Duysinx, Pierre ULg

Conference (2013, June)

Electric and hybrid electric vehicles sound the best alternative to internal combustion engines. However, energy storage systems must have a sufficient power and energy density (to answer accelerations ... [more ▼]

Electric and hybrid electric vehicles sound the best alternative to internal combustion engines. However, energy storage systems must have a sufficient power and energy density (to answer accelerations, regenerate breaking power and have sufficient autonomy). The advantage of batteries is their relatively large energy capacity. But batteries life time and capacity are limited by the number and the magnitude of current peaks [1]. The efficiency also depends on the discharge current regime. More there is high peak current, more the efficiency decreases [2]. Electrical double layer capacitors (EDLC) have a huge specific power and long life cycle because of their internal working principles especially based on charges transfer [3]. The main disadvantage is low specific energy. A combination of the two systems is interesting to gain energy capacity and lengthens the life of the batteries by limiting current peaks inside. The aim of this study is to evaluate the performances of a hybrid energy storage system (Li-ion batteries and EDLC) using a simulation tool. Batteries and EDLC are assembled in parallel in a high power bus. Batteries are directly linked on the bus because their nearly constant voltage. Conversely EDLC have to be connected with a DC/DC converter. Efficiencies of the elements are dependent on the actual current within each component. Given a total energy capacity and a current profile, the difference in final energy capacity may vary from about 15% whether the storage system is composed of batteries and EDLC or not. With hybrid energy storage the batteries are less discharged because of presence of EDLC (particularly due to efficiency difference) and their life cycle is longer. [less ▲]

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See detailEvaluation of phosphorus bioavailability according to the soil organic matter content
Barbieux, Sophie ULg; Colinet, Gilles ULg

Poster (2015, July)

Phosphorus (P) is an essential nutrient for plants. The organic matter contains significant amounts of P which can be mineralized and supply soil solution. We hypothesize that increasing P organic pools ... [more ▼]

Phosphorus (P) is an essential nutrient for plants. The organic matter contains significant amounts of P which can be mineralized and supply soil solution. We hypothesize that increasing P organic pools in soils is a way to improve its progressive release for plants and alleviate risks of immobilization in mineral forms. The main objective of this study is to evaluate the P bioavailability and its uptake by plants according to the soil organic matter (SOM) content. The experimental protocol is based on a micro-culture in pots. The test-plant used is ryegrass (Lolium perenne L.). Eight silty soils were selected from vegetable gardens (5) and from a long-term fertilization trial on field (3). They present a gradient of SOM (from 2 to 9 %) and available P content (from 5 to 55 mg/100g). Plants were first grown in pure sand and P-free Hoagland nutritive solution. Ten days after plant emergence, roots were brought into contact with the studied soil during about one month. The experiment was stopped after three harvests (every 10 days) and three growth cycles. At the end of the experimentation, analyses were performed on plant material (biomass, P content) and on soil (soluble P, available P, microbial P, pH, phosphatase activity, hot water carbon, nitrate). Besides this study, an incubation experiment was carried out with the same soils without plant to assess soil P status at each harvest time. Paper will present the main findings of the experiment. Especially, the following issues should find answers: (1) do higher levels of SOM and organic phosphorus modify the evolution of P content in soil solution and its uptake by plants?, (2) are the biological processes involved in P cycling promoted in soils with higher SOM content? [less ▲]

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See detailEvaluation of Physiological Amino Acids Profiling by Tandem Mass Spectrometry
Filee, Romain; Schoos, Roland; BOEMER, François ULg

in Journal of Inherited Metabolic Disease Reports (2013)

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See detailEvaluation of pitch accuracy in solfeggio examinations: What about non-musical variables?
Larrouy, Pauline ULg

Poster (2015, March 24)

Background and aims In experimental settings, 81% of the variance of judges’ rating of pitch accuracy is explained by musical variables (precision of pitch intervals and respect of tonality) (Larrouy ... [more ▼]

Background and aims In experimental settings, 81% of the variance of judges’ rating of pitch accuracy is explained by musical variables (precision of pitch intervals and respect of tonality) (Larrouy-Maestri, Lévêque, Schön, Giovanni, & Morsonne, 2013). In ecological settings, non-musical variables influence judgments of music performances (i.e., McPherson & Thompson, 1998; Platz & Kopiez, 2012). This study aims to better understand the evaluation of pitch accuracy in the context of formative and summative solfeggio examinations at tertiary music level, for which live performances are evaluated. Method Twenty-one participants of conservatory were asked to learn simple melodies during solfeggio classes. They were evaluated two times (formative and summative examinations) by 3 judges. Each performance was also objectively analyzed regarding pitch accuracy (number of contour errors, precision of pitch intervals and respect of the tonal centre) with a computer-assisted method (Larrouy-Maestri & Morsomme, 2014). Results The 3 judges provided strongly and significantly correlated ratings. The musical criteria objectively analyzed explained 56% of the variance of the jury’s rating when the examination purpose was formative (p < .001) and 31% of the variance when the purpose was summative (p = .009). Interestingly, the predictive musical criteria differed depending on the examination’s purpose. In addition, the variance explained by our statistical model increased (from 56% to 67% and from 31% to 46%) when taking into account non-musical variables such as the gender of the music students. Conclusions Besides the educational perspectives, the proposed method appears interesting for examining the influence of non-musical variables on the pitch accuracy assessment in ecological contexts. [less ▲]

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See detailEvaluation of pitch accuracy: from occasional to operatic singers
Larrouy, Pauline ULg; Nowak, Marion; Roig-Sanchis, Virginie et al

Conference (2014, January 15)

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See detailAn evaluation of pixel-based methods for the detection of floating objects on the sea surface
Borghgraef, Alexander; Barnich, Olivier ULg; Lapierre, Fabian et al

in EURASIP Journal on Advances in Signal Processing (2010), 2010

Ship-based automatic detection of small floating objects on an agitated sea surface remains a hard problem. Our main concern is the detection of floating mines, which proved a real threat to shipping in ... [more ▼]

Ship-based automatic detection of small floating objects on an agitated sea surface remains a hard problem. Our main concern is the detection of floating mines, which proved a real threat to shipping in confined waterways during the first Gulf War, but applications include salvaging, search-and-rescue operation, perimeter, or harbour defense. Detection in infrared (IR) is challenging because a rough sea is seen as a dynamic background of moving objects with size order, shape, and temperature similar to those of the floating mine. In this paper we have applied a selection of background subtraction algorithms to the problem, and we show that the recent algorithms such as ViBe and behaviour subtraction, which take into account spatial and temporal correlations within the dynamic scene, significantly outperformthe more conventional parametric techniques, with only little prior assumptions about the physical properties of the scene. [less ▲]

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See detailEvaluation of plasma carboxy-terminal cross-linking telopeptide of type I collagen concentration in horses.
Carstanjen, Bianca; Hoyle, Nicholas R; Gabriel, Annick ULg et al

in American Journal of Veterinary Research (2004), 65(1), 104-9

OBJECTIVE: To evaluate a human assay for quantification of carboxy-terminal cross-linking telopeptide of type I collagen (CTX-I), assess the influence of age on plasma CTX-I concentration, investigate the ... [more ▼]

OBJECTIVE: To evaluate a human assay for quantification of carboxy-terminal cross-linking telopeptide of type I collagen (CTX-I), assess the influence of age on plasma CTX-I concentration, investigate the relationship between plasma CTX-I and serum osteocalcin concentrations, and determine whether concentrations of plasma CTX-I or serum osteocalcin fluctuate in circadian manner in horses. HORSES: 75 clinically normal horses. PROCEDURE: Cross-reactivity between equine serum CTX-I and CTX-I antibodies in an automated electrochemiluminescent sandwich antibody assay (ECLIA) was evaluated via a specificity test (ie, dilution test) and recovery calculation. Serum osteocalcin concentration was measured with an equine-specific osteocalcin radioimmunoassay. To analyze diurnal variations in plasma CTX-I and serum osteocalcin concentrations, blood samples were obtained hourly during a 24-hour period. RESULTS: Results of the dilution test indicated good correlation (r > 0.99) between expected serum CTX-I concentrations and measured serum CTX-I concentrations. The calculated CTX-I recovery was 97.6% to 109.9%. Plasma CTX-I and serum osteocalcin concentrations were correlated. Plasma CTX-I concentration was inversely correlated with age of the horse. No significant circadian variations in plasma CTX-I and serum osteocalcin concentrations were detected. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that the fully automated CTX-I ECLIA can be used for evaluation of plasma and serum samples from horses and may be a useful tool to monitor bone metabolism changes. Horses in this study did not have notable diurnal fluctuations in serum osteocalcin and plasma CTX-I concentrations. [less ▲]

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See detailEvaluation of pleural disease with 18-fluorodeoxyglucose positron emission tomography imaging
Duysinx, Bernard ULg; Nguyen, Delphine; Louis, Renaud ULg et al

in CHEST (2004), 125(2), 489-493

STUDY OBJECTIVES: To study the ability of positron emission tomography (PET) using 18-fluorodeoxyglucose (FDG) to distinguish between benign and malignant disease in exudative pleural effusions and ... [more ▼]

STUDY OBJECTIVES: To study the ability of positron emission tomography (PET) using 18-fluorodeoxyglucose (FDG) to distinguish between benign and malignant disease in exudative pleural effusions and pleural thickening. DESIGN: Prospective study of 98 consecutive patients presenting with either pleural thickening or an exudative pleural effusion. SETTING: Department of pulmonary medicine of a university hospital. METHODS: FDG-PET was performed on each subject before invasive procedures were used to determine the etiologic diagnosis. FDG-PET data were analyzed by visual interpretation. RESULTS: Sixty-three of 98 patients were found to have malignant pleural disease after histologic analysis. Sixty-one of 63 patients with histologically confirmed malignant disease showed FDG uptake within the area of pleural thickening. Uptake was graded as intense in 51 cases and moderate in 10 cases. Only two patients with malignant pleural disease did not show increased FDG uptake. FDG-PET imaging showed an absence of FDG uptake, and correctly classified 31 of 35 benign lesions. For the remaining four lesions, intense FDG uptake was seen in one case of parapneumonic effusion, while moderate and localized uptake was observed in one parapneumonic, one tuberculous, and one uremic pleurisy. The sensitivity of the method to identify malignancy was 96.8% with a negative predictive value of 93.9%, while its specificity was 88.5% and its positive predictive value was 93.8%. CONCLUSIONS: Our results suggest that FDG-PET is an effective tool for differentiating between benign and malignant pleural diseases. [less ▲]

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