Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?

Conference (2009, November)

Is ultra-short cold ischemia the key to IBDL avoidance in DCD-LT?

Poster (2013, February 08)

Is volition the missing link in the management of low back pain?

in Joint Bone Spine (2011), 78

Patients with nonspecific chronic low back pain are typically prescribed a regimen of regular physical exercises to improve pain and function, increase workability, and prevent pain recurrence. However ... [more ▼]

Patients with nonspecific chronic low back pain are typically prescribed a regimen of regular physical exercises to improve pain and function, increase workability, and prevent pain recurrence. However, adherence to home exercise programs is often partial at best. Patients often fail to translate their intention to exercise (motivation) into action (implementation). Volition is the mental activity by which intentions are implemented. In this review, we argue that volition may be crucial to the successful rehabilitation of patients with low back pain. Obstacles to the implementation of intentions are described, as well as factors that promote implementation, most notably the conscious formation of implementation intentions. [less ▲]

Is1151, an Is-Like Element of Clostridium Perfringens

in Nucleic Acids Research (1993), 21(2), 352

Description of a new insertion sequence, named IS1151, associated with cpe gene from Clostridium perfringens

Isaac Bashevis Singer, ou la littérature comme illustration d'une théorie du droit

in Liber amicorum Paul Martens. L'humanisme dans la résolution des conflits. Utopie ou réalité? (2007)

Illustration de la théorie de la pluralité des ordres juridiques de Santi Romano par une nouvelle d'Isaac Bashevis Singer tiré du recueil "Au tribunal de mon père"

Isabel Stuart, Duchess of Brittany

in Viennot, Elianne (Ed.) Dictionnaire des femmes de l'Ancien Régime (2006)

Isadyle : Manuel d'application

Book published by Solal (2010)

ISADYLE est une batterie de langage construite en appui sur les théories développementales de la parole, du lexique, de la syntaxe et de la métalinguistique chez l’enfant. La batterie ISADYLE comporte ... [more ▼]

ISADYLE est une batterie de langage construite en appui sur les théories développementales de la parole, du lexique, de la syntaxe et de la métalinguistique chez l’enfant. La batterie ISADYLE comporte deux parties complémentaires : une batterie abrégée (screening) destinée au bilan en première ligne, rapide, du lexique, de la phonologie et de la syntaxe et une batterie approfondie consacrée à l’analyse soigneuse des structures et du fonctionnement des divers modules dont l’intégration permet un exercice harmonieux du langage. La batterie approfondie offre le choix parmi 52 épreuves. Chaque épreuve a fait l’objet d’un étalonnage distinct. Le clinicien sélectionnera parmi ces épreuves celles qui sont les plus pertinentes pour affiner l’évaluation des diverses facettes du langage de son patient, en fonction de ses objectifs diagnostiques et thérapeutiques. Ces outils sont destinés aux enfants de 3 à 12 ans. La batterie a été élaborée par quatre enseignants et chercheurs impliqués dans les programmes de formation des masters en logopédie des universités belges. [less ▲]

Ischaemic Colitis Following Aortoiliac Surgery

in Acta Chirurgica Belgica (2000), 100(1), 21-7

Ischaemic colitis following aortoiliac surgery is a feared complication. Its frequency varies from 7% after repair of ruptured abdominal aortic aneurysm (AAA) to 0.6% after bypass for aortoiliac occlusive ... [more ▼]

Ischaemic colitis following aortoiliac surgery is a feared complication. Its frequency varies from 7% after repair of ruptured abdominal aortic aneurysm (AAA) to 0.6% after bypass for aortoiliac occlusive disease (AOD). In order to analyse predisposing factors and outcome of ischaemic colitis, the authors reviewed their clinical experience from 1988 to 1998. It concerns 28 cases (16 ruptured AAA, 7 elective AAA, 5 OAD) of clinically evident colonic ischaemia. This means an incidence of 7% after repair of ruptured AAA, 0.6% after elective AAA repair, and 0.8% after bypass for AOD. Transmural necrosis (grade 3) was observed in 21 patients, grade 2 ischaemia in 5 patients, and grade 1 ischaemia in 2 patients. Fifteen patients with grade 3 ischaemia underwent colectomy (Hartmann's procedure) with a mortality rate of 66%. All non operated grade 3 patients died. Overall, 16 of the 28 patients died at hospital (57% mortality rate). None of the patients with mild (grade 2 or 1) colonic ischaemia died. Profound hypovolaemic shock and inflammatory AAA were the only significant predisposing factors leading to colonic ischaemia. Associated colon revascularization could not avoid the evolution to colon necrosis in four patients. Reimplantation of a patent inferior mesenteric artery or an internal iliac artery was performed in only 4.8% of all aortoiliac reconstructions, and did not influence the development of ischaemic colitis. The authors conclude that a more liberal use of postoperative sigmoidoscopy could allow detecting colonic ischaemia at an earlier stage and reduce ensuing mortality. A reinforced effort to restore or preserve colonic vascularization could lower the incidence of colonic ischaemia following aortoiliac surgery. [less ▲]

Ischaemic mitral regurgitation: pathophysiology, outcomes and the conundrum of treatment.

in European Heart Journal (2010), 31

Ischaemic mitral regurgitation is a frequent complication of left ventricular global or regional pathological remodelling due to chronic coronary artery disease. It is not a valve disease but represents ... [more ▼]

Ischaemic mitral regurgitation is a frequent complication of left ventricular global or regional pathological remodelling due to chronic coronary artery disease. It is not a valve disease but represents the valvular consequences of increased tethering forces (papillary muscles displacement leading to a more apical position of the leaflets and their coaptation point) and reduced closing forces (reduced contractility, dyssynchrony of the papillary muscles, intra-left ventricular dyssynchrony). Although mitral regurgitation has an unloading effect and reduces impedance, the volume overload begets further left ventricular dilatation, increases ventricular wall stress leading to worsened performance. Ischaemic mitral regurgitation is characteristically dynamic: its severity may vary with haemodynamic conditions. Both the severity of ischaemic mitral regurgitation and its dynamic component worsen prognosis. There are numerous possible treatment modalities, but the management of the individual patient remains difficult. Medical therapy is mandatory; revascularization procedures are frequently not sufficient to reduce mitral regurgitation; the role of combined surgical therapy by mitral valve repair is not yet defined in the absence of large randomized trial. Some patients are good candidates for cardiac resynchronization therapy that may reduce the amount of regurgitation. New therapeutic targets are under investigation. [less ▲]

Ischemic mitral regurgitation: A complex multifaceted disease

in Cardiology (2009), 112(4), 244-259