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See detailHiSea: High resolution merged satellite sea surface temperature fields
Alvera Azcarate, Aïda ULg; Barth, Alexander ULg; Toussaint, Marie-Eve ULg et al

Conference (2011, May 25)

Several satellites measure Sea Surface Temperature (SST), each of these with different technical specificities and error sources. Together with in situ data, they form a highly complementary data set. The ... [more ▼]

Several satellites measure Sea Surface Temperature (SST), each of these with different technical specificities and error sources. Together with in situ data, they form a highly complementary data set. The creation of merged SST products, integrating the strengths of each of its components and minimising their weaknesses, is however not an easy task, but it is certainly a desirable goal that has generated a large amount of research over the last years. The main objectives of this project are, among others: 1.To develop a technology, based on DINEOF (Data Interpolating Empirical Orthogonal Functions), that allows to merge different data sets at very different sampling intervals (in space and time) and create an integrated product at the highest sampling frequency and with the highest quality possible. 2.To provide improved, merged analyses of variables such as SST and chlorophyll. 3.Obtain a better understanding of the diurnal cycle of the studied variables. 4.To better understand the relation between variables (and take advantage of these relationship to improve the analyses). 5.Using the above-mentioned developments, explore the capability of the developed technology to produce SST forecasts based on multi-variate EOFs and model forecasts. We will present the first preliminary results for merging different SST data sets, as well as our plans for future developments and applications. Website of the project: http://www.gher.ulg.ac.be/HiSea/ [less ▲]

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See detailHistamine et bronchospasme d'effort
Bury, Thierry ULg

Master of advanced studies dissertation (1989)

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See detailHistamine H3 antagonist thioperamide dose-dependently enhances memory consolidation and reverses amnesia induced by dizocilpine or scopolamine in a one-trial inhibitory avoidance task in mice
Bernaerts, P.; Lamberty, Y.; Tirelli, Ezio ULg

in Behavioural Brain Research (2004), 154(1), 211-219

In the literature, there is some evidence indicating that H3 histamine receptor antagonists, in particular thioperamide, can facilitate learning and memory retrieval in laboratory rodents. The present ... [more ▼]

In the literature, there is some evidence indicating that H3 histamine receptor antagonists, in particular thioperamide, can facilitate learning and memory retrieval in laboratory rodents. The present study aimed at verifying whether this also holds for memory consolidation, a phase of memory for which there is scarcity of convincing data on the effects of H3 receptor antagonists given systemically. To that end, memory consolidation was assessed in C57BL/6J mice using the one-trial step-through inhibitory avoidance task, the compounds being injected immediately after training (foot-shock) and performance measured 24 h later. More specifically, the following effects of thioperamide (1.25-20 mg/kg) were dose-dependently analysed: (1) its potential direct effects on memory consolidation; (2) its potential reversing effects on retrograde amnesia induced by the NMDA antagonist dizocilpine (MK-801, 0.5 mg/kg) and (3) its potential reversing effects on the well-known amnesia induced by the muscarinic antagonist scopolamine (0.25 mg/kg). We found that thioperamide exerted a dose-dependent facilitative effect on memory consolidation. Furthermore, the H3 receptor antagonist reversed scopolamine- and especially dizocilpine-induced amnesia. The results strongly support the view that the brain mechanisms of memory consolidation involve a functional interaction between the NMDA and the H3 sites. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailThe histamine H3-receptor inverse agonist Pitolisant improves fear memory in mice
Brabant, Christian ULg; Charlier, Yana ULg; Tirelli, Ezio ULg

in Behavioural Brain Research (2013), 243

Numerous studies have demonstrated that brain histamine plays a crucial role in learning and memory and histamine H3 receptor inverse agonists (H3R inverse agonists) have been proposed to treat cognitive ... [more ▼]

Numerous studies have demonstrated that brain histamine plays a crucial role in learning and memory and histamine H3 receptor inverse agonists (H3R inverse agonists) have been proposed to treat cognitive disorders. Pitolisant (BF2.649, 1-{3-[3-(4-chlorophenyl)propoxy]propyl}piperidine, hydrochloride) was the first H3R inverse agonist that has been tested in human trials and is well tolerated. The present study investigated whether Pitolisant (0.625–20 mg/kg, i.p.) improves consolidation and reconsolidation processes in the fear conditioning task in female C57BL/6J mice. We also tested whether Pitolisant reverses memory deficits induced by the non-competitive N-methyl-d-aspartate (NMDA) antagonist dizocilpine (MK-801). Our results indicate that post-training systemic injections of Pitolisant facilitated consolidation of contextual fear memory and reversed amnesia induced by an i.p. injection of 0.12 mg/kg dizocilpine. In addition, none of the doses of Pitolisant we have tested after reactivation (reexposure to the context in which training took place 48 h earlier) affected reconsolidation, whereas dizocilpine disrupted it. However, Pitolisant was able to reverse the deficit in reconsolidation induced by 0.12 mg/kg dizocilpine. The present results are the first demonstration that Pitolisant is effective in improving consolidation processes in the fear condition task and add further evidence to its potential for treating cognitive disorders. [less ▲]

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See detailHistamine liberation related to cardiopulmonary bypass in children: Possible relation to transient postoperative arrhythmias
Seghaye, Marie-Christine ULg; Duchateau, J.; Grabitz, R. G. et al

in Journal of Thoracic and Cardiovascular Surgery (1996), 111(5), 971-981

Tumor necrosis factor-α production and products of mast cell, basophil, and eosinophil degranulation (prostaglandin D2, histamine, and eosinophil cationic protein) were prospectively studied in 26 ... [more ▼]

Tumor necrosis factor-α production and products of mast cell, basophil, and eosinophil degranulation (prostaglandin D2, histamine, and eosinophil cationic protein) were prospectively studied in 26 children undergoing cardiac operations. The relationship between inflammatory response to cardiopulmonary bypass and transient postoperative arrhythmias was analyzed. Cardiopulmonary bypass was conducted with circulatory arrest and deep hypothermia in 10 patients and with continuous low-flow and moderate hypothermia in 16 patients. Transient postoperative arrhythmias diagnosed on standard or atrial electrocardiograms (or both) were seen in eight of the 26 examined children: accelerated junctional rhythm (n = 3), junctional ectopic tachycardia (n = 3), second-degree atrioventricular block (n = 1), and third- degree atrioventricular block (n = 1). Children with transient postoperative arrhythmias were younger than those without (p < 0.05). Compared with baseline values, there was in all patients a significant release of histamine and eosinophil cationic protein (p < 0.05) related to cardiopulmonary bypass, reaching peak values 4 hours after the operation. In contrast, tumor necrosis factor-α production and prostaglandin D2 release were not significant. This suggests that activated basophils but not mast cells are the major sources of histamine liberated during and after cardiopulmonary bypass. Histamine release but not eosinophil cationic protein release correlated with circulatory arrest and deep hypothermia (p < 0.05), suggesting the participation of physicochemical alterations of circulating basophils leading to histamine liberation. Four hours after the operation, patients with transient postoperative arrhythmias had significantly higher blood concentrations of histamine (p < 0.02) and eosinophil cationic protein (p < 0.05) than did those without transient postoperative arrhythmias. On the first postoperative day, four of the eight patients with transient postoperative arrhythmias had persisting elevated histamine levels, whereas in patients without transient postoperative arrhythmias histamine reached baseline values. The multivariate analysis retained histamine release and eosinophil cationic protein variations related to cardiopulmonary bypass for the emerging model to predict transient postoperative arrhythmias. The results of this study show significant histamine release related to cardiopulmonary bypass. Furthermore, they document a possible relationship between circulating histamine and transient postoperative arrhythmias. The latter may therefore be suspected among the consequences of the inflammatory response to cardiopulmonary bypass. [less ▲]

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See detailHistamine modulation of neutrophil chemotaxis and T-lymphocyte proliferation in man
Bury, Thierry ULg; Radermecker, Maurice ULg

in Schweizerische Medizinische Wochenschrift (1991), 121(9), 35

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See detailHistamine plasmatique et bronchospasme d'effort.
Bury, Thierry ULg; PIRNAY, Freddy ULg; CORHAY, Jean-Louis ULg et al

in Revue des Maladies Respiratoires (1990), 7(6), 559-62

The pathogenesis of bronchospasm of effort is not yet elucidated and it is probable that is determined by multiple factors. In this study we have tested the role of mastocytes in taking as an index of ... [more ▼]

The pathogenesis of bronchospasm of effort is not yet elucidated and it is probable that is determined by multiple factors. In this study we have tested the role of mastocytes in taking as an index of their activation the fluctuation of plasma histamine levels during repeated exercise tests. We will show that asthmatic subjects who develop bronchospasm on effort have a significant rise (times 3) in their level of serum histamine whilst normal subjects don't show much change. Furthermore in a repeated effort test we have observed a strict parallelism between the occurrence of bronchospasm of effort and a rise in plasma histamine levels. These different observations enable us to consider that the activation of mastocytes and the liberation of mediators which follow play an important role in the pathogenesis of bronchospasm of effort. [less ▲]

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See detailHistamine-induced inhibition of neutrophil chemotaxis and T-lymphocyte proliferation in man.
Bury, Thierry ULg; CORHAY, Jean-Louis ULg; Radermecker, Maurice ULg

in Allergy (1992), 47(6), 624-9

Histamine inhibits in vitro human neutrophil chemotaxis and T-lymphocyte proliferation via H2 receptors. The aim of this study was to verify these inhibitory effects of histamine in man in vivo. Healthy ... [more ▼]

Histamine inhibits in vitro human neutrophil chemotaxis and T-lymphocyte proliferation via H2 receptors. The aim of this study was to verify these inhibitory effects of histamine in man in vivo. Healthy volunteers were challenged with histamine by intravenous (1 mg), subcutaneous (1 mg) and inhalatory (2.4 mg) routes. Venous blood was taken before and at different times after challenge. Neutrophil chemotaxis was studied by the Boyden assay and T-lymphocyte proliferation by counting H3-thymidine incorporation in cultured mononuclear cells. Plasma histamine was measured by radioimmunoassay. Histamine infusion caused transient systemic symptoms as well as a significant decrease of neutrophil chemotaxis (mean - 26% +/- 6) and of PHA-pulsed T-lymphocyte proliferation (mean - 16% +/- 6) 4 h after histamine challenge. Subcutaneous injection of histamine caused only a significant decrease of neutrophil chemotaxis (mean - 24% +/- 15) 4 h after injection. Histamine inhalation was well tolerated and caused a significant depression of neutrophil chemotaxis (mean - 40% +/- 15) and of T-lymphocyte proliferation (mean - 27% +/- 6) 2 and 4 h after the challenge. Histamine challenges were always accompanied by a rapid and transient rise in plasma histamine. Inhalation of an H2 agonist (impromidine) but not of an H1 agonist (betahistine) caused a decrease of neutrophil chemotaxis and of T-lymphocyte proliferation. Oral pretreatment with an H2 antagonist (cimetidine) before histamine inhalation prevented histamine-induced decrease of neutrophil chemotaxis and T-lymphocyte proliferation, whereas astemizole, an H1 antagonist, had no effect. In conclusion, during the few hours following administration, exogenous histamine in man causes a depression of neutrophil chemotaxis and T-lymphocyte proliferation via H2 receptors.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailHistamine: from neuron-mast cell to allergy
Bury, Thierry ULg; Radermecker, Marc ULg

Book published by UCB Institute of Allergy (1990)

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See detailHistidine modification and mutagenesis point to the involvement of a large conformational change in the mechanism of action of phage lambda lysozyme
Evrard, Christine ULg; Fastrez, Jacques; Soumillion, Patrice

in FEBS Letters (1999), 460

Phage lambda lysozyme is structurally related to other known lysozymes but its mechanism of action is different from the classical lysozyme mechanism, acting as a transglycosidase rather than a hydrolase ... [more ▼]

Phage lambda lysozyme is structurally related to other known lysozymes but its mechanism of action is different from the classical lysozyme mechanism, acting as a transglycosidase rather than a hydrolase. As two conformations have been revealed by the crystal structure, we investigated the effect of mutating and modifying a histidine located near to or far from the active site in the respective closed and open conformations. Whereas its asparagine mutation has little or no effect on activity, its N-carbethoxylation inactivates the enzyme. This provide further evidence for the involvement of the closed conformation and for the need of conformational mobility in lambda lysozyme function. [less ▲]

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See detailHistochemical and immunohistochemical characterisation of canine nasopharyngeal lymphoid tissue
Billen, Frédéric ULg; Peeters, Dominique ULg; Dehard, Sandrine ULg et al

in Proceedings of the 15th ECVIM-CA Congress (1-3/09/2005), Glasgow, Scotland (2005, September)

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See detailHistochemical and immunohistochemical characterization of canine nasopharyngeal lymphoid tissue
Billen, Frédéric ULg; Peeters, Dominique ULg; Dehard, Sandrine ULg et al

in 15th ESVIM Meeting - Glasgow - Ecosse - Septembre 2005 (2005, September)

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See detailHistochemical changes of substance P, FRAP, serotonin and succinic dehydrogenase in the spinal cord of rats with adjuvant arthritis.
Schoenen, Jean ULg; Van Hees, J.; Gybels, J. et al

in Life Sciences (1985), 36(13), 1247-54

Various histochemical changes were found in spinal segments L4-L5 of rats with adjuvant arthritis, predominantly 30 days after inoculation. A slight to marked increase of substance P immunoreactivity ... [more ▼]

Various histochemical changes were found in spinal segments L4-L5 of rats with adjuvant arthritis, predominantly 30 days after inoculation. A slight to marked increase of substance P immunoreactivity occurred in laminae I, II and X. FRAP activity was enhanced in lamina II. Serotonin immunoreactivity was heavier in laminae I, VIII and IX in a few animals. The intensity of the histoenzymological reaction for succinic dehydrogenase increased in certain laminae VIII and X neurons. At day 15 of the disease the increase of substance P and FRAP activities was chiefly restricted to the medial portion of the superficial dorsal horn. There was a significant positive correlation between the scratching behaviour of arthritic rats and the substance P immunoreactivity in laminae X and I. If one accepts that scratching is pain-related, the data are consistent with a possible role of substance P in the chronic pain associated with adjuvant arthritis. They leave undetermined the significance of the other histochemical changes. [less ▲]

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See detailHistochemical study of cobalt-induced focal epilepsy
Brotchi, Jacques; Scuvée-Moreau, Jacqueline ULg; Dresse, Albert ULg et al

in Experimental Brain Research (1978), 32

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See detailHistodynamics of bone tissue formation around immediately loaded cylindrical implants in the rabbit.
Vandamme, Katleen; Naert, Ignace; Geris, Liesbet ULg et al

in Clinical Oral Implants Research (2007), 18(4), 471-80

OBJECTIVES: The local mechanical environment influences early peri-implant tissue formation. It is still unclear whether immediate loading limits or promotes peri-implant osteogenesis and which mechanical ... [more ▼]

OBJECTIVES: The local mechanical environment influences early peri-implant tissue formation. It is still unclear whether immediate loading limits or promotes peri-implant osteogenesis and which mechanical parameters are important herein. The present study evaluated the influence of well-controlled mechanical stimuli on the tissue response around immediately loaded cylindrical turned titanium implants at two different observation periods. MATERIAL AND METHODS: A repeated sampling bone chamber, consisting of dual-structure perforated hollow cylinders with a cylindrical implant, was installed in the tibia of 14 rabbits and used to conduct three displacement-controlled immediate loading experiments: (i) 30 microm - 400 cycles/day - 1 Hz frequency - 2 x/week - 6 weeks; (ii) 30 microm - 400 cycles/day - 1 Hz - 2 x/week - 6 weeks, followed by another 6 weeks with a 50 microm - 800 cycles/day - 1 Hz - 2 x/week loading protocol; and (iii) 0 microm implant displacement for 12 weeks. A linear mixed model and logistic mixed model with alpha=5% were conducted on the data set. RESULTS: The tissue area fraction was significantly the highest after 12 weeks of loading. The bone area fraction was significantly different between all three loading conditions, with the highest values for the 12-week loading experiment. Twelve-week stimulation resulted in a significantly higher mineralized bone fraction than 6 weeks. Loading did have a significantly positive effect on the mineralized bone fraction. The incidence of osteoid-to-implant and bone-to-implant contact increased significantly when loading the implant for 12 weeks. CONCLUSION: Immediate loading had a positive effect on the tissue differentiation and bone formation around cylindrical turned titanium implants. Controlled implant micro-motion up to 50 microm had a positive effect on the bone formation at its interface. [less ▲]

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See detailHistoenzymology of the developing rat spinal cord.
Schoenen, Jean ULg

in Neuropathology & Applied Neurobiology (1978), 4(1), 37-46

Using histochemical methods the activity of acetycholinesterase, acid phosphatase and various dehydrogenases was investigated in the developing rat spinal cord. At the ninth embryonic day (E9) only the ... [more ▼]

Using histochemical methods the activity of acetycholinesterase, acid phosphatase and various dehydrogenases was investigated in the developing rat spinal cord. At the ninth embryonic day (E9) only the activity of the lactate dehydrogenase slow-moving isoenzymes was prominent in spinal neurons. Between E13 and E15 an increase was observed in the activity of most of the dehydrogenases and of acid phosphatase in motoneurons and posterior root ganglion cells. Between E15 and E17 acetylcholinesterase activity increased markedly. On E17 and E20, this enzyme was also detectable in anterior and posterior roots and in neurons of the intermediate grey matter. On E20, although all grey matter neurons were cytologically fully differentiated, their enzymatic content was found to be still incomplete. The prominent acid phosphatase reaction within laminae I and II, which is characteristic of the adult rat, was absent in the fetal spinal cord. These findings indicate that the spinal cord metabolism is predominantly anaerobic during the first two-thirds of gestation. The histoenzymological maturation of grey-matter neurons is delayed in comparison to their cytological differentiation. Furthermore, the ontogenesis of motoneuronal acetylcholinesterase activity correlates well with the development of motor activities in the rat fetus. [less ▲]

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See detailHistogenèse du cortex cérébral et migration neuronale
Misson, Jean-Paul ULg; Takahashi, Takao; Austin, Chris et al

in Acta Paediatrica Belgica (1990), 22

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See detailHistoire
Donneau, Olivier ULg

Learning material (2011)

Ce cours d’histoire « universelle » est initialement destiné aux étudiants de l’enseignement supérieur non-universitaire (Belgique). Il tente de combler une lacune dans la mesure où il n’existe pas de ... [more ▼]

Ce cours d’histoire « universelle » est initialement destiné aux étudiants de l’enseignement supérieur non-universitaire (Belgique). Il tente de combler une lacune dans la mesure où il n’existe pas de manuel d’histoire destiné à ce public. Il n’est, au départ, pas conçu comme une somme d’éléments à maîtriser en fin de cycle, mais plutôt comme un horizon heuristique que l’étudiant peut parcourir afin de résoudre des problèmes historiques ou afin de construire sa vision synthétique de l’histoire humaine. [less ▲]

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See detailL’histoire à l’école : rien ne va plus ? !
Jadoulle, Jean-Louis ULg

Article for general public (2008)

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