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See detailHic et Nunc. Naevus ou melanome?
Pierard, Claudine ULg; Pierard, Gérald ULg; Quatresooz, Pascale ULg et al

in Revue Médicale de Liège (2006), 61(1), 43-7

In Wallonia, the incidence of cutaneous melanoma has steadily increased over the past decades. Hopefully, the early diagnosis made at the premetastatic stage has benefited from great advances both in the ... [more ▼]

In Wallonia, the incidence of cutaneous melanoma has steadily increased over the past decades. Hopefully, the early diagnosis made at the premetastatic stage has benefited from great advances both in the clinical and laboratory fields. Thanks to the "Groupement Oncologique Universitaire Wallonie-Liege" (GOUWL) organization, some efforts are currently made in order to better frame and normalize the management of cancer patients. Some medical staffs involved in prospective clinical research bring by their own experience further practical insights for the benefit to the patients. In this field, Belgium is not destituted. We report a brief review of the contribution of the Mosan Study Group of Pigmentary Tumors (GMETP) at the University Hospital of Liege. [less ▲]

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See detailHidden focal abnormalities of smooth muscles in human GI motility disorders revealed by novel immunomarkers
Wedel, Théo; van Eys, G.; Glénisson, Wendy et al

Conference (2005)

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See detailThe hidden function of NIK (NF-κB-Inducing Kinase) in cell death
Boutaffala, Layla; Bertrand, Mathieu; Remouchamps, Caroline ULg et al

Conference (2011)

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See detailThe hidden half of flowering
Bouché, Frédéric ULg; Mistiaen, Kevin ULg; D'Aloia, Maria ULg et al

Poster (2013, June)

Flowering is one of the most important developmental steps in plant life cycle and is therefore tightly controlled by environmental cues. The involvement of the aerial part of the plant in the molecular ... [more ▼]

Flowering is one of the most important developmental steps in plant life cycle and is therefore tightly controlled by environmental cues. The involvement of the aerial part of the plant in the molecular mechanisms leading to floral transition is well documented while participation of the roots received less attention. Nevertheless, the induction of flowering by photoperiod is known to involve systemic signals that move in phloem sap towards sinks, throughout the plants, including the roots. Transcriptomic analysis of roots tissues during the floral induction of flowering by a single long day of in Arabidopsis thaliana by a single long day allowed us to identify a large number of differentially expressed genes. How mutations We subsequently selected in some candidate genes affect plant development - including root architecture and flowering time - is being to analyze their flowering timefurther analyzed. Further analysis of those genes will permit us to unravel their role in the flowering induction process. [less ▲]

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See detailA hidden markov model combining linkage and linkage disequilibrium information for haplotype reconstruction and quantitative trait locus fine mapping.
Druet, Tom ULg; Georges, Michel ULg

in Genetics (2010), 184(3), 789-98

Faithful reconstruction of haplotypes from diploid marker data (phasing) is important for many kinds of genetic analyses, including mapping of trait loci, prediction of genomic breeding values, and ... [more ▼]

Faithful reconstruction of haplotypes from diploid marker data (phasing) is important for many kinds of genetic analyses, including mapping of trait loci, prediction of genomic breeding values, and identification of signatures of selection. In human genetics, phasing most often exploits population information (linkage disequilibrium), while in animal genetics the primary source of information is familial (Mendelian segregation and linkage). We herein develop and evaluate a method that simultaneously exploits both sources of information. It builds on hidden Markov models that were initially developed to exploit population information only. We demonstrate that the approach improves the accuracy of allele phasing as well as imputation of missing genotypes. Reconstructed haplotypes are assigned to hidden states that are shown to correspond to clusters of genealogically related chromosomes. We show that these cluster states can directly be used to fine map QTL. The method is computationally effective at handling large data sets based on high-density SNP panels. [less ▲]

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See detailA hidden Markov model to predict early mastitis from test-day somatic cell scores
Detilleux, Johann ULg

in Animal (2011), 5(2), 175-181

In many countries, high somatic cell scores (SCS) in milk are used as an indicator for mastitis because they are collected on a routine basis. However, individual test-day SCS are not very accurate in ... [more ▼]

In many countries, high somatic cell scores (SCS) in milk are used as an indicator for mastitis because they are collected on a routine basis. However, individual test-day SCS are not very accurate in identifying infected cows. Mathematical models may improve the accuracy of the biological marker by making better use of the information contained in the available data. Here, a simple hidden Markov model (HMM) is described mathematically and applied to SCS recorded monthly on cows with or without clinical mastitis to evaluate its accuracy in estimating parameters (mean, variance and transition probabilities) under healthy or diseased states. The SCS means were estimated at 1.96 (s.d.50.16) and 4.73 (s.d.50.71) for the hidden healthy and infected states, and the common variance at 0.83 (s.d.50.11). The probability of remaining uninfected, recovering from infection, getting newly infected and remaining infected between consecutive test days was estimated at 78.84%, 60.49%, 11.70% and 15%, respectively. Three different health-related states were compared: clinical stages observed by farmers, subclinical cases defined for somatic cell counts below or above 250 000 cells/ml and infected stages obtained from the HMM. The results showed that HMM identifies infected cows before the appearance of clinical and subclinical signs, which may critically improve the power of the studies on the genetic determinants of SCS and reduce biases in predicting breeding values for SCS. [less ▲]

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See detailThe Hidden Recess of a Global City: La République Marseille
Van Cauwenberge, Geneviève ULg

Conference (2011, August 13)

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See detailHide-working in the Late Palaeolithic site at Rekem (Belgium): confrontation with ethnoarchaelogical observations
Caspar, Jean-Paul; Beyries, Sylvie; De Bie, Marc et al

Conference (2000)

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See detailHier Dinaso! Les fascistes flamands et la guerre civile en espagne
Spinoy, Erik ULg

Conference (2008, March 13)

This paper reconstructs the ambivalent attitude taken by the Flemish fascist movement Verdinaso towards the Spanish Civil War, through articles published in its weekly organ.

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See detailHier, da und dort - regionale Variation und standardsprachlicher Gebrauch bei den primären Lokaldeiktika im Deutschen
Möller, Robert ULg

in Zeitschrift für Germanistische Linguistik (2011), 39(2011), 1-23

Detailed reference viewed: 49 (7 ULg)
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See detailHierarchical aluminosilicate macrochannels with structured mesoporous walls: Towards a single catalyst for multistep reactions
Léonard, Alexandre ULg; Su, B.-L.

in Colloids and Surfaces A : Physicochemical and Engineering Aspects (2007), 300(1-2 SPEC. ISS.), 129-135

Two novel and simple synthesis pathways, one surfactant-assisted and one template-free, have recently been developed for the formation of aluminosilicate macrochannels with mesoporous walls. These ... [more ▼]

Two novel and simple synthesis pathways, one surfactant-assisted and one template-free, have recently been developed for the formation of aluminosilicate macrochannels with mesoporous walls. These thermally stable materials are made of straight tubular macrochannels separated by wormhole-like mesopores. This paper gives a comparative study of the materials obtained by both ways in order to determine the role played by the surfactant. High specific surface area materials with homogeneous tubular macrochannels are spontaneously formed without needing any templating procedure. The use of a non-ionic surfactant favors the incorporation of Al atoms in tetrahedral sites and also controls the homogeneity of the mesopores. The formation of the macrochannels is believed to result from the spontaneous and strong release of alcohol molecules due to high hydrolysis and condensation rates of the inorganic sources, which creates a hydrodynamic flow, thus channels of the solvent. The mesopores are generated by interparticular voids. © 2006 Elsevier B.V. All rights reserved. [less ▲]

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See detailHierarchical Cluster Analysis of Environmental Pollutants through P450 Induction in Cultured Hepatic Cells
Dubois, Marilyn; Plaisance, H.; Thomé, Jean-Pierre ULg et al

in Ecotoxicology & Environmental Safety (1996), 34(3), 205-15

Environmental pollutants are classically associated with increased drug metabolism. Cultures of rat hepatocytes, quail hepatocytes, and human hepatoma (Hep G2) cells were used to study the effects of ... [more ▼]

Environmental pollutants are classically associated with increased drug metabolism. Cultures of rat hepatocytes, quail hepatocytes, and human hepatoma (Hep G2) cells were used to study the effects of pesticides on drug-metabolizing enzymes. Membrane integrity and mitochondrial activity were evaluated and induction of ethoxycoumarin-O-deethylase and ethoxyresorufin-O-deethylase activities were measured. Induced P450s were identified by immunoblotting. Pentachlorophenol and lindane appeared as the strongest inducers. On the immunoblots, specific antibodies revealed induced CYP1A1 in fetal rat hepatocytes, CYP2B in quail hepatocytes, and CYP3A7 in Hep G2 cells. Pesticide effects on these different activities in each type of cultured cells were compared by cluster analysis. Results obtained under similar conditions with reference inducers phenobarbital (PB) and benzo[a]anthracene and other environmental pollutants (polychlorobiphenyls) were added to previous data prior to multivariate analysis. The tested products fell into four major groups: a first group with pentachlorophenol, identified as a CYP3A inducer; a second group containing the methylcholanthrene-type inducers that increase CYP1A-related activities; a third class represented by dieldrin, a PB-type inducer; a fourth group including inert compounds or weak inducers. Lindane shares the criteria of the second and third groups and seems to induce both CYP1A and CYP2B activities. The current study results highlight the advantage of using several types of cultured hepatocytes to evaluate the short-term toxicity of environmental pollutants in vitro and constitute a useful model for predicting the potential toxicity of pesticides in humans (Hep G2 cells) and wildlife (fetal quail hepatocytes). [less ▲]

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See detailHierarchical clustering of brain activity during human nonrapid eye movement sleep.
Boly, Mélanie ULg; Perlbarg, V; Marrelec, G et al

in Proceedings of the National Academy of Sciences of the United States of America (2012)

Consciousness is reduced during nonrapid eye movement (NREM) sleep due to changes in brain function that are still poorly understood. Here, we tested the hypothesis that impaired consciousness during NREM ... [more ▼]

Consciousness is reduced during nonrapid eye movement (NREM) sleep due to changes in brain function that are still poorly understood. Here, we tested the hypothesis that impaired consciousness during NREM sleep is associated with an increased modularity of brain activity. Cerebral connectivity was quantified in resting-state functional magnetic resonance imaging times series acquired in 13 healthy volunteers during wakefulness and NREM sleep. The analysis revealed a modification of the hierarchical organization of large-scale networks into smaller independent modules during NREM sleep, independently from EEG markers of the slow oscillation. Such modifications in brain connectivity, possibly driven by sleep ultraslow oscillations, could hinder the brain's ability to integrate information and account for decreased consciousness during NREM sleep. [less ▲]

Detailed reference viewed: 47 (3 ULg)