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See detailHepatotoxicity with thiazolidinediones: is it a class effect?
Scheen, André ULg

in Drug Safety : An International Journal of Medical Toxicology & Drug Experience (2001), 24(12), 873-88

Decreased insulin sensitivity plays a major role in various human diseases. particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications ... [more ▼]

Decreased insulin sensitivity plays a major role in various human diseases. particularly type 2 diabetes mellitus, and is associated with a higher risk of atherosclerosis and cardiovascular complications. Thiazolidinediones, more commonly termed glitazones, are the first drugs to specifically target muscular insulin resistance. They have proven efficacy for reducing plasma glucose levels in patients with type 2 diabetes mellitus treated with diet alone, sulphonylureas, metformin or insulin. In addition, they are associated with some improvement of the cardiovascular risk profile. However, troglitazone, the first compound approved by the Food and Drug Administration in the US, proved to be hepatotoxic and was withdrawn from the market after the report of several dozen deaths or cases of severe hepatic failure requiring liver transplantation. It remains unclear whether or not hepatotoxicity is a class effect or is related to unique properties of troglitazone. Rosiglitazone and pioglitazone, two other glitazones, appear to have similar efficacy with regard to blood glucose control in patients with type 2 diabetes mellitus as compared with troglitazone. In controlled clinical trials, the incidence of significant (> or =3 x upper limit of normal) increases in liver enzyme levels (ALT in particular) was similar with rosiglitazone or pioglitazone as compared with placebo, whereas troglitazone was associated with a 3-fold greater incidence. In contrast to the numerous case reports of acute liver failure in patients receiving troglitzone, only a few case reports of hepatotoxicity have been reported in patients treated with rosiglitazone until now, with a causal relationship remaining uncertain. Furthermore, no single case of severe hepatotoxicity has been reported yet with pioglitazone. It should be mentioned that troglitazone, unlike pioglitazone and rosiglitazone, induces the cytochrome P450 isoform 3A4, which is partly responsible for its metabolism, and may be prone to drug interactions. Importantly enough, obesity, insulin resistance and type 2 diabetes mellitus are associated with liver abnormalities, especially non-alcoholic steatohepatitis, independent of any pharmacological treatment. This association obviously complicates the selection of patients who are good candidates for a treatment with glitazones as well as the monitoring of liver tests after initiation of therapy with any thiazolidinedione compound. While regular monitoring of liver enzymes is still recommended and more long term data are desirable, current evidence from clinical trials and postmarketing experience in the US supports the conclusion that rosiglitazone and pioglitazone do not share the hepatotoxic profile of troglitazone. [less ▲]

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See detailThe HepCar registry: report on a one-year registration program of hepatocellular carcinoma (HCC) in Belgium. What is daily practice in HCC?
Van Vlierberghe, H.; Colle, I.; Henrion, J. et al

in Acta Gastro-Enterologica Belgica (2005), 68(4), 403-411

INTRODUCTION: Due to a rise in HCV induced liver cirrhosis, hepatocellular carcinoma becomes more prevalent in Western European countries. The HepCar registry is an initiative in which patients with ... [more ▼]

INTRODUCTION: Due to a rise in HCV induced liver cirrhosis, hepatocellular carcinoma becomes more prevalent in Western European countries. The HepCar registry is an initiative in which patients with hepatocellular carcinoma, their treatment and follow up are registered. MATERIALS AND METHODS: Belgian physicians were asked to report all new cases of hepatocellular carcinoma which were seen between January 2003 and December 2003. Reporting was done on a voluntary basis. Data reported were: demographic figures, the nature of the underlying liver disease, presentation characteristics of the tumour, laboratory findings and choice of therapy. Every six months, a reminder was sent to determine survival. RESULTS: 131 patients (94 male/37 female) were reported. Mean age was 63 years +/- 13. Underlying liver disease was HCV (n = 54, 41%), HBV (n = 22, 17%), alcoholic liver disease (n = 39, 30%) and miscellaneous (n =16, 12%). Diagnosis of hepatocellular carcinoma was made by surveillance in 47 (36%) patients. After logistic regression, survival was 5 times better for patients inside the Milan criteria (one lesion less than 5 cm in diameter or less than 3 nodules each less than 3 cm in the absence of vascular invasion and metastasis). DISCUSSION: Tumours inside the Milan criteria have a better survival. The majority of the patients have an underlying cirrhosis as background for the development of a HCC. [less ▲]

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See detailHeracleia Salbakè, centre médical au Haut-Empire
Nissen, Cécile ULg

in Sari, Nil (Ed.) Proceedings of the 38th International Congress on the History of Medicine : Istanbul, 1st-6th September 2002 (2005)

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See detailHéraclès à la croisée des chemins. Un topos dans la littérature gréco-latine
Rochette, Bruno ULg

in Etudes Classiques (Namur, Belgium) (1998), 66

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See detailHeralded entanglement of arbitrary degree in remote atoms by detection of emitted photons
Schilling, U.; Thiel, C.; Solano, E. et al

Poster (2010)

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See detailHeralded entanglement of arbitrary degree in remote qubits
Schilling, U.; Thiel, C.; Solano, E. et al

in Physical Review. A (2009), 80

Incoherent scattering of photons off two remote atoms with a -level structure is used as a basic Young-type interferometer to herald long-lived entanglement of an arbitrary degree. The degree of ... [more ▼]

Incoherent scattering of photons off two remote atoms with a -level structure is used as a basic Young-type interferometer to herald long-lived entanglement of an arbitrary degree. The degree of entanglement, as measured by the concurrence, is found to be tunable by two easily accessible experimental parameters. Fixing one of them to certain values unveils an analog to the Malus’ law. An estimate of the variation in the degree of entanglement due to uncertainties in an experimental realization is given. [less ▲]

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See detailHerbaceous Plant Availability and Use by Western Lowland Gorillas in South East Cameroon
Willie, Jacob; Tagg, Nikki; Petre, Charles-Albert ULg et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailHerbal medicines and vitamins
Schoenen, Jean ULg; Magis, Delphine ULg

in Lipton, R. B.; Bigal, M. E. (Eds.) Migraines and Other headache disorders (2006)

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See detailL'herbe pâturée en production laitière: valeur nutritive, ingestion et complémentation.
Thewis, André ULg

Scientific conference (1989, February)

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See detailHerbe, diguettes, pesticides et pomme de terre
Maugnard, Alexandre; Bodson, Bernard ULg; Goffart, Jean-Pierre et al

in Phytoma : La Défense des Végétaux (2008), 611

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See detailHerbicides, régulateurs, fongicides, azote: que penser du regroupement des traitements ... en culture de froment?
Seutin, Benoit ULg; Vancutsem, Françoise ULg; Bodson, Bernard ULg

in de Neuville (Ed.) Le Sillon Belge (2010)

Réaliser, en un passage, des interventions utiles à la culture à un même stade de développement, répond à une simple question de bons sens pratique et économique. Mais cette stratégie n'est pas dénuée de ... [more ▼]

Réaliser, en un passage, des interventions utiles à la culture à un même stade de développement, répond à une simple question de bons sens pratique et économique. Mais cette stratégie n'est pas dénuée de risques de perte de rendement à la récolte. Coup d'oeil sur les résultats d'essais réalisés à Gembloux. [less ▲]

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See detailLes herbivores, transformateurs de produits fourragers et de coproduits issus de l'agro-industrie en aliments nobles pour l'homme
Decruyenaere, Virginie; Lessire, Françoise ULg; Beckers, Yves ULg et al

in CRA-W (Ed.) La viande bovine remise en question: De sa production à sa consommation (2014, February 19)

Les prairies recouvrent près de 50% de la surface agricole utile en Wallonie. Dans certaines régions, la prépondérance des prairies dans le paysage wallon se justifie par des contraintes climatiques. Pour ... [more ▼]

Les prairies recouvrent près de 50% de la surface agricole utile en Wallonie. Dans certaines régions, la prépondérance des prairies dans le paysage wallon se justifie par des contraintes climatiques. Pour celles-ci bien souvent, les sommes de température et la durée de végétation active sont faibles et limitent considérablement le choix des cultures susceptibles d’atteindre la maturité avant récolte avec certitude. Dans d’autres régions, les prairies s’imposent davantage en raison de contraintes agronomiques : nature du sol, disposition des parcelles, relief du territoire, intérêt dans la rotation pour les prairies temporaires… Ainsi, la grande majorité des prairies de notre Région ne peut pas être remplacée par des cultures ; elles doivent dès lors être perçues comme une bonne alternative à la valorisation du territoire. Grâce à la présence du rumen en amont de l’estomac, les ruminants ont la capacité de transformer des productions non éligibles pour l’homme, tels que les fourrages et les co-produits des industries agro-alimentaires. Ces aliments, de nature essentiellement fibreuse mais pas pour autant pauvres en protéine et en énergie, sont largement fermentés par les micro-organismes du rumen qui les dégradent en composés plus simples, valorisables ensuite par l’animal. Par ce mécanisme, les ruminants contribuent à transformer ces aliments grossiers en produits nobles, tels que le lait et la viande. On comprend dès lors aisément que la présence des ruminants est étroitement liée aux superficies enherbées, elles-mêmes dépendantes des conditions pédo-climatiques d’une région. Malgré des systèmes de production intensifs et l’amélioration continue du potentiel génétique des animaux, les bovins restent peu dépendants des aliments du commerce comparativement aux autres spéculations animales. Ainsi, selon l’APFACA, de l’ordre de 16% des aliments composés produits en Belgique et importés sont utilisés pour les bovins, dont seulement 1/3 est écoulé dans la filière viande bovine. L’herbe, les produits herbagers et les aliments produits sur l’exploitation tels que le maïs restent donc majoritaires dans la ration des bovins élevés pour la production de viande. La valorisation de l’herbe et des produits herbagers dépend fortement des performances zootechniques recherchées. Les objectifs de croissance sont établis, en autre, sur base des prix offerts par la cheville variant avec les catégories d’âge et de poids d’abattage. Ces dernières années, il semble que les animaux abattus un peu plus tardivement soient moins dépréciés qu’auparavant, facilitant la formulation de rations à base de matières premières herbagères. A l’inverse, l’intensification dans le but de produire des animaux abattus plus jeunes ou à un poids supérieur, implique une croissance plus soutenue, et de ce fait la distribution de rations plus denses en énergie. Pour la formulation de telles rations, certains coproduits disposent de valeurs nutritionnelles intéressantes, permettant de satisfaire des besoins nutritionnels élevés, tout en conservant une certaine autonomie alimentaire. Leur valorisation au niveau local représente en outre un intérêt considérable pour la rentabilité des industries agro-alimentaires qui, sans la présence de l’animal, devraient trouver d’autres débouchés pour les coproduits sous peine d’être dans l’obligation de financer leur élimination. Cet exposé a pour objectif d’illustrer les potentiels, mais aussi les limites, des aliments produits localement pour les bovins viande, que ce soit selon leur type (vache de réforme- taurillon…), leur race et leurs performances zootechniques, mais aussi l’intérêt de ces aliments en termes d’efficiences alimentaire et économique. Il analyse les atouts et faiblesses de la spéculation viande bovine en ne se limitant pas à l’échelle de l’animal seul, mais en le replaçant en tant que véritable maillon de la chaîne agro-alimentaire. Ce positionnement permet non seulement de mieux cerner les enjeux de ces élevages au niveau de la production primaire, mais aussi leur importance dans les secteurs amont et aval. [less ▲]

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See detailLes herbivores, transformateurs de produits fourragers et de coproduits issus de l'agro-industrie en aliments nobles pour l'homme
Decruyenaere, Virginie; Lessire, Françoise ULg; Beckers, Yves ULg et al

in CRA-W (Ed.) La viande bovine remise en question: De sa production à sa consommation (2014, February 19)

Les prairies recouvrent près de 50% de la surface agricole utile en Wallonie. Dans certaines régions, la prépondérance des prairies dans le paysage wallon se justifie par des contraintes climatiques. Pour ... [more ▼]

Les prairies recouvrent près de 50% de la surface agricole utile en Wallonie. Dans certaines régions, la prépondérance des prairies dans le paysage wallon se justifie par des contraintes climatiques. Pour celles-ci bien souvent, les sommes de température et la durée de végétation active sont faibles et limitent considérablement le choix des cultures susceptibles d’atteindre la maturité avant récolte avec certitude. Dans d’autres régions, les prairies s’imposent davantage en raison de contraintes agronomiques : nature du sol, disposition des parcelles, relief du territoire, intérêt dans la rotation pour les prairies temporaires… Ainsi, la grande majorité des prairies de notre Région ne peut pas être remplacée par des cultures ; elles doivent dès lors être perçues comme une bonne alternative à la valorisation du territoire. Grâce à la présence du rumen en amont de l’estomac, les ruminants ont la capacité de transformer des productions non éligibles pour l’homme, tels que les fourrages et les co-produits des industries agro-alimentaires. Ces aliments, de nature essentiellement fibreuse mais pas pour autant pauvres en protéine et en énergie, sont largement fermentés par les micro-organismes du rumen qui les dégradent en composés plus simples, valorisables ensuite par l’animal. Par ce mécanisme, les ruminants contribuent à transformer ces aliments grossiers en produits nobles, tels que le lait et la viande. On comprend dès lors aisément que la présence des ruminants est étroitement liée aux superficies enherbées, elles-mêmes dépendantes des conditions pédo-climatiques d’une région. Malgré des systèmes de production intensifs et l’amélioration continue du potentiel génétique des animaux, les bovins restent peu dépendants des aliments du commerce comparativement aux autres spéculations animales. Ainsi, selon l’APFACA, de l’ordre de 16% des aliments composés produits en Belgique et importés sont utilisés pour les bovins, dont seulement 1/3 est écoulé dans la filière viande bovine. L’herbe, les produits herbagers et les aliments produits sur l’exploitation tels que le maïs restent donc majoritaires dans la ration des bovins élevés pour la production de viande. La valorisation de l’herbe et des produits herbagers dépend fortement des performances zootechniques recherchées. Les objectifs de croissance sont établis, en autre, sur base des prix offerts par la cheville variant avec les catégories d’âge et de poids d’abattage. Ces dernières années, il semble que les animaux abattus un peu plus tardivement soient moins dépréciés qu’auparavant, facilitant la formulation de rations à base de matières premières herbagères. A l’inverse, l’intensification dans le but de produire des animaux abattus plus jeunes ou à un poids supérieur, implique une croissance plus soutenue, et de ce fait la distribution de rations plus denses en énergie. Pour la formulation de telles rations, certains coproduits disposent de valeurs nutritionnelles intéressantes, permettant de satisfaire des besoins nutritionnels élevés, tout en conservant une certaine autonomie alimentaire. Leur valorisation au niveau local représente en outre un intérêt considérable pour la rentabilité des industries agro-alimentaires qui, sans la présence de l’animal, devraient trouver d’autres débouchés pour les coproduits sous peine d’être dans l’obligation de financer leur élimination. Cet exposé a pour objectif d’illustrer les potentiels, mais aussi les limites, des aliments produits localement pour les bovins viande, que ce soit selon leur type (vache de réforme- taurillon…), leur race et leurs performances zootechniques, mais aussi l’intérêt de ces aliments en termes d’efficiences alimentaire et économique. Il analyse les atouts et faiblesses de la spéculation viande bovine en ne se limitant pas à l’échelle de l’animal seul, mais en le replaçant en tant que véritable maillon de la chaîne agro-alimentaire. Ce positionnement permet non seulement de mieux cerner les enjeux de ces élevages au niveau de la production primaire, mais aussi leur importance dans les secteurs amont et aval. [less ▲]

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See detailHerd-level seroprevalence and risk-mapping of bovine hypodermosis in Belgian cattle herds
Haine, D.; Boelaert, F.; Pfeiffer, D. U. et al

in Preventive Veterinary Medicine (2004), 65(1-2), 93-104

Our objective was to determine the seroprevalence of Hypoderma spp. and to develop a spatial model describing the risk surface of warble-fly infection in Belgian cattle herds (adjusting for herd size ... [more ▼]

Our objective was to determine the seroprevalence of Hypoderma spp. and to develop a spatial model describing the risk surface of warble-fly infection in Belgian cattle herds (adjusting for herd size, herd type, local temperature, rainfall, relative air humidity and land-cover). This survey was carried out in 390 selected herds of all types (dairy, mixed and beef) from December 1997 to March 1998, which were included in a national infectious bovine rhinotracheitis and paratuberculosis (Johne's-disease) survey. All animals >24 months old were blood sampled and an ELISA was used on pooled serum samples (10 animals per pool). The herd seroprevalence was 48.7% (95% confidence interval: 43.6-53.8); positive herds were mainly in the south of the country and along the North Sea coast. The logistic multiple-regression model of herd-level seropositivity indicated that mixed-type and beef-cattle herds have more than four-fold and two-fold increases in the odds of being Hypoderma-positive, respectively, compared with dairy herds. (C) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailHerd-test-day variability of methane emissions predicted from milk MIR spectra in Holstein cows
Vanrobays, Marie-Laure ULg; Kandel, Purna Bhadra ULg; Soyeurt, Hélène ULg et al

Poster (2013, August 26)

The aim of this study was to estimate the herd-test-day (HTD) effect on milk yield, fat and protein content, and methane (CH4) emissions of Walloon Holstein first-parity cows. A total of 412,520 test-day ... [more ▼]

The aim of this study was to estimate the herd-test-day (HTD) effect on milk yield, fat and protein content, and methane (CH4) emissions of Walloon Holstein first-parity cows. A total of 412,520 test-day records and milk mid-infrared (MIR) spectra of 69,223 cows in 1,104 herds were included in the data set. The prediction equation developed by Vanlierde et al. (Abstract submitted to EAAP 2013; R² of cross-validation=0.70) was applied on the recorded spectral data to predict CH4 emissions (g/d). Daily CH4 emissions expressed in g/kg of milk were computed by dividing CH4 emissions (g/d) by daily milk yield of cows. Several bivariate (a CH4 trait with a production trait) random regression test-day models including HTD and classes of days in milk and age at calving as fixed effects and permanent environment and genetic as random effects were used. HTD solutions of studied traits obtained from these models were studied and presented large deviations (CV=17.54%, 8.93%, 4.68%, 15.51%, and 23.18% for milk yield, fat and protein content, MIR CH4 (g/d), and MIR CH4 (g/kg of milk), respectively) indicating differences among herds, especially for milk yield and CH4 traits. HTD means per month of milk yield and fat and protein contents presented similar patterns within year. The maximum of monthly HTD means corresponded to the spring (pastern release) for milk yield and to the winter for fat and protein contents. The minimum corresponded to the month of November for milk yield and to the summer for the other traits. For MIR CH4 (g/d), monthly HTD means showed similar patterns as fat and protein content within year. MIR CH4 (g/kg of milk) presented maximum values of monthly HTD means in November and minimum values in May. Finally, results of this study showed that HTD effects on milk production traits and on MIR CH4 emissions varied through herds and seasons. [less ▲]

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See detailHerd-test-day variability of methane emissions predicted from milk MIR spectra in Holstein cows
Vanrobays, Marie-Laure ULg; Kandel, Purna Bhadra ULg; Soyeurt, Hélène ULg et al

in Book of Abstracts of the 64th Annual Meeting of the European Federation of Animal Science (2013, August)

The aim of this study was to estimate the herd-test-day (HTD) effect on milk yield, fat and protein content, and methane (CH4) emissions of Walloon Holstein first-parity cows. A total of 412,520 test-day ... [more ▼]

The aim of this study was to estimate the herd-test-day (HTD) effect on milk yield, fat and protein content, and methane (CH4) emissions of Walloon Holstein first-parity cows. A total of 412,520 test-day records and milk mid-infrared (MIR) spectra of 69,223 cows in 1,104 herds were included in the data set. The prediction equation developed by Vanlierde et al. (Abstract submitted to EAAP 2013; R² of cross-validation=0.70) was applied on the recorded spectral data to predict CH4 emissions (g/d). Daily CH4 emissions expressed in g/kg of milk were computed by dividing CH4 emissions (g/d) by daily milk yield of cows. Several bivariate (a CH4 trait with a production trait) random regression test-day models including HTD and classes of days in milk and age at calving as fixed effects and permanent environment and genetic as random effects were used. HTD solutions of studied traits obtained from these models were studied and presented large deviations (CV=17.54%, 8.93%, 4.68%, 15.51%, and 23.18% for milk yield, fat and protein content, MIR CH4 (g/d), and MIR CH4 (g/kg of milk), respectively) indicating differences among herds, especially for milk yield and CH4 traits. HTD means per month of milk yield and fat and protein contents presented similar patterns within year. The maximum of monthly HTD means corresponded to the spring (pastern release) for milk yield and to the winter for fat and protein contents. The minimum corresponded to the month of November for milk yield and to the summer for the other traits. For MIR CH4 (g/d), monthly HTD means showed similar patterns as fat and protein content within year. MIR CH4 (g/kg of milk) presented maximum values of monthly HTD means in November and minimum values in May. Finally, results of this study showed that HTD effects on milk production traits and on MIR CH4 emissions varied through herds and seasons. [less ▲]

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See detailHere I am: the cortical correlates of visual self-recognition.
Devue, Christel ULg; Collette, Fabienne ULg; Balteau, Evelyne ULg et al

in Brain Research (2007), 1143

Recently, interest in the neural correlates of self-recognition has grown. Most studies concentrate on self-face recognition. However, there is a lack of convergence as to precise neuroanatomical ... [more ▼]

Recently, interest in the neural correlates of self-recognition has grown. Most studies concentrate on self-face recognition. However, there is a lack of convergence as to precise neuroanatomical locations underlying self-face recognition. In addition, recognition of familiar persons from bodies has been relatively neglected. In the present study, cerebral activity while participants performed a task in which they had to indicate the real appearance of themselves and of a gender-matched close colleague among intact and altered pictures of faces and bodies was measured. The right frontal cortex and the insula were found to be the main regions specifically implicated in visual self-recognition compared with visual processing of other highly familiar persons. Moreover, the right anterior insula along with the right anterior cingulate seemed to play a role in the integration of information about oneself independently of the stimulus domain. The processing of self-related pictures was also compared to scrambled versions of these pictures. Results showed that different areas of the occipito-temporal cortex were more or less recruited depending on whether a face or a body was perceived, as it has already been reported by several recent studies. The implication of present findings for a general framework of person identification is discussed. [less ▲]

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See detail"Here, There, and Everywhere": Michelle Cliff's (Con)version of Caribbean Identity
Ledent, Bénédicte ULg

in Ghosh-Schellhorn, Martina (Ed.) Writing Women Across Borders and Categories (2000)

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See detailHereditary motor and sensory neuropathy with absence of large myelinated fibers due to absence of large neurons in dorsal root ganglia and anterior horns, clinically associated with deafness, mental retardation, and epilepsy (HMSN-ADM).
Muller, H. D.; Mugler, M.; RAMAEKERS, Vincent ULg et al

in Journal of the peripheral nervous system : JPNS (2000), 5(3), 147-57

Hereditary motor and sensory neuropathy (HMSN) with autosomal recessive inheritance represents a genetically heterogeneous group of disorders with variable clinical, pathologic and electrophysiologic ... [more ▼]

Hereditary motor and sensory neuropathy (HMSN) with autosomal recessive inheritance represents a genetically heterogeneous group of disorders with variable clinical, pathologic and electrophysiologic manifestations. A new variant of autosomal recessive HMSN, clinically defined by sensorimotor polyneuropathy associated with deafness and mental retardation, has recently been described. We report on the first autopsy case with this type of HMSN: a girl of non-consanguineous parents with a presumably autosomal recessive type of motor and sensory neuropathy clinically associated with deafness, mental retardation, and epilepsy. The autopsy showed complete absence of large myelinated fibers in peripheral motor and sensory nerves corresponding to a lack of large neurons in dorsal root ganglia and anterior horns of the spinal cord, moderate neurogenic muscle atrophy, and nearly complete absence of neurons in the dentate nucleus of the cerebellum. Molecular genetic analyses in our case revealed neither genetic alterations in the survival motor neuron gene nor in the PMP-22 gene. [less ▲]

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See detailHereditary muscular hypertrophy in cattle is associated with a reduced myocardial contractility
AMORY, H; ENTEE, K Mc; LINDEN, AS et al

in Pflügers Archiv : European Journal of Physiology (1994), 426

Detailed reference viewed: 9 (1 ULg)