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See detailHemodynamic effects of a new antiarrhythmic agent, flecainide (R-818), in coronary heart disease.
Legrand, Victor ULg; Vandormael, M.; Collignon, P. et al

in The American journal of cardiology (1983), 51(3), 422-6

The hemodynamic effects of flecainide acetate, a new class I antiarrhythmic agent, were studied in 10 patients with coronary heart disease. The drug was injected intravenously at a dose of 2 mg/kg over 30 ... [more ▼]

The hemodynamic effects of flecainide acetate, a new class I antiarrhythmic agent, were studied in 10 patients with coronary heart disease. The drug was injected intravenously at a dose of 2 mg/kg over 30 minutes. The mean drug plasma level achieved was 394 ng/ml (range 329 to 470). The heart rate did not change, but a significant increase (p less than 0.001) in P-R (+17%), QRS (+15%), and Q-T (+7%) duration occurred after drug administration. Negative inotropic effects also were observed and consisted of an increase (p less than 0.01) in pulmonary wedge pressure (+27%) and a decrease (p less than 0.01) in stroke index (-10%), left ventricular stroke work index (-12%), and left ventricular ejection rate (-11%). No significant change in mean aortic pressure or systemic and pulmonary vascular resistance occurred. Left ventriculography performed after drug infusion revealed a significant increase (p less than 0.01) in systolic volume (+9%) and a decrease in ejection fraction (-9%) and mean velocity of circumferential fiber shortening (Vcf) (-13%). A progressive and significant decrease of dP/dt was observed during drug infusion, but 15 minutes after the injection, dP/dt had returned to near basal values. Thus, flecainide acetate has slight, but significant negative inotropic effects, particularly conspicuous during drug infusion. The drug should be administered with caution in patients with poorly compensated heart. [less ▲]

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See detailHemodynamic effects of epinephrine associated to an epidural clonidine-bupivacaine mixture during combined lumbar epidural and general anesthesia.
Senard, Marc ULg; Ledoux, Didier ULg; Darmont, Pascaline ULg et al

in Acta Anaesthesiologica Belgica (1998), 49(3), 167-73

Clonidine or epinephrine are frequently combined to epidural local anesthetics to strengthen sensory block and prolong analgesia. Both drugs impair the hemodynamic profile of central neural blockade but ... [more ▼]

Clonidine or epinephrine are frequently combined to epidural local anesthetics to strengthen sensory block and prolong analgesia. Both drugs impair the hemodynamic profile of central neural blockade but the effects of their combination on arterial pressure and heart rate are not known and were examined in this double-blind prospective randomised study. Forty four patients scheduled for lumbar disc surgery were allocated to two groups. Epidural anesthesia was obtained by administration of 150 micrograms clonidine in 15 ml bupivacaine 0.25% solution without (group C) or with (group C + E) 37.5 micrograms epinephrine. Systolic, mean, diastolic arterial pressure and heart rate were measured throughout the study. Combined epidural and general anesthesia induced a significant decrease in arterial pressure and heart rate in both groups. SAP and MAP decreased significantly less in the patients receiving epinephrine. Low dose epidural epinephrine decreases arterial pressure instability during combined epidural and general anesthesia. [less ▲]

Detailed reference viewed: 69 (22 ULg)
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See detailHemodynamic effects of increasing PEEP during mechanical ventilation in anesthetized patients
LAMBERMONT, Bernard ULg; Ghuysen, Alexandre ULg; D'Orio, Vincenzo ULg et al

in American Journal of Respiratory & Critical Care Medicine (1997), 2

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See detailHemodynamic effects of intermittent or continuous positive-pressure breathing in man.
Lamy, Maurice ULg; Deghislage, J.; Lamalle, D. et al

in Acta Anaesthesiologica Belgica (1973), 24(3), 270-87

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See detailHemodynamic effects of intratracheal administration of Pasteurella haemolytica in calves
Amory, Hélène ULg; Linden, Annick ULg; Desmecht, Daniel ULg et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailHemodynamic effects of intratracheal administration of Pasteurella haemolytica in calves
Amory, Hélène ULg; Linden, Annick ULg; Desmecht, Daniel ULg et al

in Pflügers Archiv : European Journal of Physiology (1995), 430

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See detailHemodynamic effects of nifedipine on secondary pulmonary hypertension in man
garzaniti, n; EL ALLAF, Dia ULg; D'Orio, Vincenzo ULg et al

in Acta Cardiologica (1985), 40

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See detailHemodynamic profile of patients with acute myocardial infarction at risk of infarct expansion.
Pierard, Luc ULg; Albert, Adelin ULg; Gilis, F et al

in American Journal of Cardiology (1987), 60(1), 5-9

To identify patients at risk of cardiac expansion during hospital stay for a first acute myocardial infarction (AMI), 41 patients underwent right-sided cardiac catheterization soon after admission and ... [more ▼]

To identify patients at risk of cardiac expansion during hospital stay for a first acute myocardial infarction (AMI), 41 patients underwent right-sided cardiac catheterization soon after admission and serial 2-dimensional echocardiography on days 1, 3 or 4 and between days 7 and 10. Infarct expansion was recognized by echocardiography in 11 patients (27%), most often on the second recording (day 3 or 4). Age, sex, time from onset of pain to catheterization, peak levels of creatine kinase and creatine kinase-MB isoenzyme, heart rate, mean pulmonary artery wedge pressure and left ventricular stroke work index were similar in the 2 groups. Patients in whom infarct expansion developed had a higher incidence of previous systemic hypertension (73% vs 27%, p less than 0.01) and anterior AMI (91% vs 30%, p less than 0.001) and a higher mortality rate at 1 year (73 vs 7%, p less than 0.001) than those who did not. They also had higher systolic (139 +/- 24 vs 126 +/- 18 mm Hg, p less than 0.05) and diastolic (91 +/- 14 vs 75 +/- 13 mm Hg, p less than 0.001) arterial pressures, lower stroke volume index (31 +/- 10 vs 40 +/- 10 ml/m2, p less than 0.01) and much higher systemic vascular resistance (SVR) values (1,713 +/- 380 vs 1,253 +/- 264 dynes s cm-5, p less than 0.0001). In the subgroups of patients with anterior AMI, differences were significant for diastolic arterial pressure, stroke volume index, SVR and mortality.(ABSTRACT TRUNCATED AT 250 WORDS) [less ▲]

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See detailHemodynamic Responses to Pasteurella Haemolytica Inoculation in Calves Given Type 2 Serotonergic Antagonist
Desmecht, Daniel ULg; Linden, Annick ULg; Amory, Hélène ULg et al

in Canadian Journal of Physiology & Pharmacology (1996), 74(5), 572-9

The effects of saline (control, group C) and metrenperone (treated, group M) on systemic and pulmonary hemodynamics were determined in conscious 7- to 15-day-old calves after they were intratracheally ... [more ▼]

The effects of saline (control, group C) and metrenperone (treated, group M) on systemic and pulmonary hemodynamics were determined in conscious 7- to 15-day-old calves after they were intratracheally inoculated with Pasteurella haemolytica. Metrenperone, a specific serotonin (5-hydroxytryptamine) receptor antagonist, was injected intramuscularly (100 micrograms.kg-1) 2 h after the calves were inoculated. Central venous, pulmonary arterial and capillary wedge, and systemic arterial pressures were measured, using fluid-filled catheters. Cardiac output was measured by the thermodilution technique. Heart rate, stroke volume, and pulmonary and systemic vascular resistances were calculated. The parameters were measured hourly from the 1st to the 10th h after inoculation. In group C, cardiovascular response to P. haemolytica inoculation was marked and typically consisted of two systemic hypotensive phases and two pulmonary hypertensive phases. The first phase occurred by the 2nd h post inoculation and was induced by a transient bradycardia and a systemic vasodilation, leading to profound hypotension and reduced venous return. Cardiac performance then transiently recovered, but systemic hypotension persisted. The second hypotensive hypodynamic phase occurred by the 7th h after inoculation, and was associated with a decline in stroke volume, an increase in heart rate, and pulmonary hypertension and vasoconstriction. In group M, the early response to P. haemolytica exposure was similar to that in controls, indicating that, as in sheep, 5-hydroxytryptamine does not contribute to the early hypodynamic response to endotoxemia. In contrast, metrenperone completely abolished late increases in pulmonary arterial pressure and pulmonary vascular resistance, suggesting that 5-hydroxytryptamine contributes to the late pulmonary vasoconstriction. Metrenperone treatment also allowed better restoration of heart rate, and hence, cardiac output was maintained. In conclusion, 5-hydroxytryptamine might have a role in mediating pasteurellic endotoxin induced changes in pulmonary hemodynamics through its type-2 receptors. [less ▲]

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See detailL'hémofiltration continue
Krzesinski, Jean-Marie ULg; Theelen, Bernadette ULg

in Néphrologie, Dialyse et Transplantation (1993)

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See detailHémoglobine glyquée : le temps de la standardisation est venu
Gillery, P.; Bordas-Fonfrède, M.; Chapelle, Jean-Paul ULg et al

in Annales de Biologie Clinique (1998), 56(3), 249-51

Le dosage de l'hémoglobine glyquée est utilisé en pratique quotidienne pour le suivi à long terme de l'équilibre glycémique chez les patients atteints de diabète sucré. De nombreuses techniques ont été ... [more ▼]

Le dosage de l'hémoglobine glyquée est utilisé en pratique quotidienne pour le suivi à long terme de l'équilibre glycémique chez les patients atteints de diabète sucré. De nombreuses techniques ont été décrites depuis une vingtaine d'années, fondées sur différents principes, et dosant différentes formes glyquées de l'hémoglobine. Cela explique que, bien que ce test très informatif soit utilisé au quotidien par les diabétologues, il existe encore une grande disparité des résultats d'un laboratoire à l'autre, rendant leur comparaison impossible. [less ▲]

Detailed reference viewed: 92 (1 ULg)
See detailHémoglobine glyquée décentralisée
Gillery, P.; Bordas-Fonfrère, M.; Chapelle, Jean-Paul ULg et al

Poster (1999, November)

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See detailHemolytic activity of new linear surfactin analogs
Dufour, Samuel; Deleu, Magali ULg; Wathelet, Bernard ULg et al

Poster (2005)

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See detailHemolytic activity of new linear surfactin analogs in relation to their physico-chemical properties
Dufour, Samuel; Deleu, Magali ULg; Nott, Katherine ULg et al

in Biochimica et Biophysica Acta - General Subjects (2005), 1726

New linear analogs of surfactin have been synthesized. Their physico-chemical parameters were determined. The results indicate that these linear products show surface activities although they are lowered ... [more ▼]

New linear analogs of surfactin have been synthesized. Their physico-chemical parameters were determined. The results indicate that these linear products show surface activities although they are lowered compared to those of cyclic compounds. The hemolytic activities have also been assayed. In contrast with cyclic surfactins, no significant hemolysis occurs for the linear products in the range of concentrations tested. Moreover, a protective effect against Triton X-100 induced hemolysis has been highlighted for linear surfactins. The concentration at which this protective effect happens is correlated directly to the CMC, and inversely to the acyl chain length of the product. In a hypotonic medium, analogs having a long acyl chain tend to increase the hemolysis, meanwhile the product with the shortest chain tends to decrease it. [less ▲]

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See detailHemolytic crisis induced by rasburicase administration revealing G-6-PD deficiency.
SID, Sélim ULg; Dugauquier, D.; DE PRIJCK, Bernard ULg et al

in Belgian Journal of Hematology (2014)

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See detailHemolytic uremic syndrome with an atypical presentation.
NOGUE KAMDJE, Alain ULg; BRASSEUR, Edmond ULg; fournier et al

in Revue Médicale de Liège (2010), 65(12), 676-80

RÉ SUMÉ : Le syndrome hémolytique urémique (SHU ) est une affection assez rare chez l’adulte, mais de pronostic réservé. Il traduit une microangiopathie thrombotique essentiellement rénale. Nous ... [more ▼]

RÉ SUMÉ : Le syndrome hémolytique urémique (SHU ) est une affection assez rare chez l’adulte, mais de pronostic réservé. Il traduit une microangiopathie thrombotique essentiellement rénale. Nous rapportons l’histoire d’un jeune patient dont la présentation et l’exploration cliniques rendent le diagnostic de SHU probable. La présentation quelque peu atypique offre non seulement l’occasion de discuter des différents éléments qui plaident en faveur du diagnostic selon les hypothèses physiopathologiques les plus récentes, mais aussi de redéfinir les recommandations de la prise en charge en urgence de cette affection sévère. [less ▲]

Detailed reference viewed: 41 (4 ULg)