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See detailHD 97658 and its super-Earth: Spitzer transit analysis and seismic modeling of the host star
Van Grootel, Valérie ULg; Gillon, Michaël ULg; Valencia, Diana et al

Conference (2013, December)

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See detailHD160529 - a New Galactic Luminous Blue Variable
Sterken, C.; Gosset, Eric ULg; Juttner, A. et al

in Astronomy and Astrophysics (1991), 247

The galactic early-type A hypergiant HD 160529 has been photometrically monitored in the Strömgren system during the past 18 years. HD 160529 has become fainter in the optical range by 0.5 mag during the ... [more ▼]

The galactic early-type A hypergiant HD 160529 has been photometrically monitored in the Strömgren system during the past 18 years. HD 160529 has become fainter in the optical range by 0.5 mag during the past eight years. In addition, pulsation-like variations with a quasi-period of 57 days and with a peak-to-peak amplitude of about 0.1 mag in b and y were found. The fading was not completely monotonous a fall of at least 0.2 mag in b and y within about 40 days around JD2446500 is particularly remarkable. This jump is accompanied by a change in the temperature-sensitive c[SUB]1[/SUB] index of about -0.14 mag. HD 160529 has become visually fainter and hotter during the past eight years, thus becoming a new case of a galactic Luminous Blue Variable (LBV). Model calculations on the basis of the photometry and previously published as well as new spectroscopic observations have shown HD 160529 to be a close counterpart of R 110, a recently discovered LBV in the LMC. From this comparison an absolute magnitude of M[SUB]V[/SUB] = -8.9 and a distance of 2.5 kpc is derived. The stellar parameters characterising the maximum state are estimated to be T[SUB]eff[/SUB] ≍ 8000 K, log g ≍ 0.55, R ≍ 330 R[SUB]sun[/SUB], from which the mass is estimated to be only M ≍ 13 M[SUB]sun[/SUB]. From the Hα profile a lower limit of the mass-loss rate of HD 160529 was calculated, which is about 10 times higher than that of R 110; this could be a consequence of the higher metallicity of the galactic LBV. The low mass of HD 160529 makes this luminous blue star a good candidate for a post-RSG (red supergiant phase) object, providing some evidence that (as sometimes argued) low metallicity is not a necessary prerequisite for evolution of massive stars backward to higher temperatures. [less ▲]

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See detailHD160529: a new galactic Luminous Blue Variable
Stahl, O.; Sterken, C.; Gosset, Eric ULg et al

(1992)

Not Available

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See detailHD46407 - the First Eclipsing Binary Barium Star
Jorissen, A.; Manfroid, Jean ULg; Sterken, C.

in Evolutionary Processes in Interacting Binary Stars (1992)

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See detailHDA cycloadditions of 1-diethoxyphosphonyl-1,3-butadiene with nitroso heterodienophiles: a computational investigation
Monbaliu, Jean-Christophe ULg; Dive, Georges ULg; Marchand-Brynaert, Jacqueline et al

in Journal of Molecular Structure : Theochem (2010), 959

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See detailThe HDAC inhibitor panobinostat (LBH589) inhibits mesothelioma and lung cancer cells in vitro and in vivo with particular efficacy for small cell lung cancer
Crisanti, Cecilia; Wallace, Africa; Kapoor, Veena et al

in Molecular Cancer Therapeutics (2009), 8(8), 2221-2231

Lung cancer is the leading cause of cancer deaths in the United States. Current therapies are inadequate. Histone deacetylase inhibitors (HDACi) are a recently developed class of anticancer agents that ... [more ▼]

Lung cancer is the leading cause of cancer deaths in the United States. Current therapies are inadequate. Histone deacetylase inhibitors (HDACi) are a recently developed class of anticancer agents that cause increased acetylation of core histones and nonhistone proteins leading to modulation of gene expression and protein activityin - volved in cancer cell growth and survival pathways. We examined the efficacyof the HDACi panobinostat (LBH589) in a wide range of lung cancers and mesotheliomas. Panobinostat was cytotoxic in almost all 37 cancer cell lines tested. IC50 and LD50 values were in the low nmol/L range (4–470 nmol/L; median, 20 nmol/L). Small cell lung cancer (SCLC) cell lines were among the most sensitive lines, with LD50 values consistently <25 nmol/L. In lung cancer and mesothelioma animal models, panobinostat significantlyde creased tumor growth byan average of 62% when compared with vehicle control. Panobinostat was equallye ffective in immunocompetent and severe combined immunodeficiencymic e, indicating that the inhibition of tumor growth by panobinostat was not due to direct immunologic effects.Panobinostat was, however, particularlyeffective in SCLC xenografts, and the addition of the chemotherapyag ent etoposide augmented antitumor effects. Protein analysis of treated tumor biopsies revealed elevated amounts of cell cycle regulators such as p21 and proapoptosis factors, such as caspase 3 and 7 and cleaved poly[ADP-ribose] polymerase, coupled with decreased levels of antiapoptotic factors such as Bcl-2 and Bcl-XL. These studies together suggest that panobinostat maybe a useful adjunct in the treatment of thoracic malignancies, especiallySCLC. [less ▲]

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See detailHDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism.
Mottet, Denis ULg; Pirotte, Sophie ULg; Lamour, Virginie ULg et al

in Oncogene (2009), 28(2), 243-56

Cancer cells have complex, unique characteristics that distinguish them from normal cells, such as increased growth rates and evasion of anti-proliferative signals. Global inhibition of class I and II ... [more ▼]

Cancer cells have complex, unique characteristics that distinguish them from normal cells, such as increased growth rates and evasion of anti-proliferative signals. Global inhibition of class I and II histone deacetylases (HDACs) stops cancer cell proliferation in vitro and has proven effective against cancer in clinical trials, at least in part, through transcriptional reactivation of the p21(WAF1/Cip1)gene. The HDACs that regulate p21(WAF1/Cip1) are not fully identified. Using small interfering RNAs, we found that HDAC4 participates in the repression of p21(WAF1/Cip1) through Sp1/Sp3-, but not p53-binding sites. HDAC4 interacts with Sp1, binds and reduces histone H3 acetylation at the Sp1/Sp3 binding site-rich p21(WAF1/Cip1) proximal promoter, suggesting a key role for Sp1 in HDAC4-mediated repression of p21(WAF1/Cip1). Induction of p21(WAF1/Cip1) mediated by silencing of HDAC4 arrested cancer cell growth in vitro and inhibited tumor growth in an in vivo human glioblastoma model. Thus, HDAC4 could be a useful target for new anti-cancer therapies based on selective inhibition of specific HDACs. [less ▲]

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See detailHDAC5 depletion modulates heterochromatin plasticity and triggers programmed cell death of human cancer cells
Peixoto, P; Castronovo, V; Matheus, N et al

Poster (2012)

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See detailHDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells
Peixoto, Paul ULg; Castronovo, Vincenzo ULg; Matheus, Nicolas ULg et al

in Cell Death & Differentiation (2012)

Histone deacetylases (HDACs) form a family of enzymes, which have fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer ... [more ▼]

Histone deacetylases (HDACs) form a family of enzymes, which have fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. In this study, we further investigated the biological function of HDAC5 in cancer cells. We found HDAC5 is associated with actively replicating pericentric heterochromatin during late S phase. We demonstrated that specific depletion of HDAC5 by RNA interference resulted in profound changes in the heterochromatin structure and slowed down ongoing replication forks. This defect in heterochromatin maintenance and assembly are sensed by DNA damage checkpoint pathways, which triggered cancer cells to autophagy and apoptosis, and arrested their growth both in vitro and in vivo. Finally, we also demonstrated that HDAC5 depletion led to enhanced sensitivity of DNA to DNA-damaging agents, suggesting that heterochromatin de-condensation induced by histone HDAC5 silencing may enhance the efficacy of cytotoxic agents that act by targeting DNA in vitro. Together, these results highlighted for the first time an unrecognized link between HDAC5 and the maintenance/assembly of heterochromatin structure, and demonstrated that its specific inhibition might contribute to increase the efficacy of DNA alteration-based cancer therapies in clinic. [less ▲]

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See detailHDAC6 Inhibition compensates for the transport deficit in Huntington’s Disease by increasing tubulin acetylation
Godin, Juliette ULg; Dompierre; Charrin, Bénédicte C. et al

Conference (2008, March)

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See detailHDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis.
Dequiedt, Franck ULg; Kasler, Herbert; Fischle, Wolfgang et al

in Immunity (2003), 18(5), 687-98

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and ... [more ▼]

We report that HDAC7, a class II histone deacetylase, is highly expressed in CD4(+)CD8(+) double-positive thymocytes. HDAC7 inhibits the expression of Nur77, an orphan receptor involved in apoptosis and negative selection, via the transcription factor MEF2D. HDAC7 is exported from the nucleus during T cell receptor activation, leading to Nur77 expression. A triple HDAC7 mutant (S155A, S318A, S448A) is not exported from the nucleus in response to TCR activation and suppresses TCR-mediated apoptosis. Conversely, a fusion of HDAC7 to the transcriptional activator VP16 activates Nur77 expression. Inhibition of HDAC7 expression by RNA interference causes increased apoptosis in response to TCR activation. These observations define HDAC7 as a regulator of Nur77 and apoptosis in developing thymocytes. [less ▲]

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See detailHDAC8 is required for myofibroblastic differentiation induced by TGFß
Glénisson, Wendy; Tran, Syv Li; Castronovo, Vincenzo ULg et al

Conference (2004)

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See detailHE 0435-1223 lensed QSO VRi light curves (Ricci+, 2011)
Ricci, Davide ULg; Poels, Joël ULg; Elyiv, Andrii ULg et al

Textual, factual or bibliographical database (2011)

We present VRi photometric observations of the quadruply imaged quasar HE0435-1223, carried out with the Danish 1.54m telescope at the La Silla Observatory. Our aim was to monitor and study the magnitudes ... [more ▼]

We present VRi photometric observations of the quadruply imaged quasar HE0435-1223, carried out with the Danish 1.54m telescope at the La Silla Observatory. Our aim was to monitor and study the magnitudes and colors of each lensed component as a function of time. [less ▲]

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See detailHe and Si surface inhomogeneities of four Bp variable stars
Briquet, Maryline ULg; Aerts, C.; Lüftinger, T. et al

in Astronomy and Astrophysics (2004), 413

We present ground-based multi-colour Geneva photometry and high-resolution spectra of four variable B-type stars: HD 105382, HD 131120, HD 138769 and HD 55522. All sets of data reveal monoperiodic stars ... [more ▼]

We present ground-based multi-colour Geneva photometry and high-resolution spectra of four variable B-type stars: HD 105382, HD 131120, HD 138769 and HD 55522. All sets of data reveal monoperiodic stars. A comparison of moment variations of two spectral lines, one silicon line and one helium line, allows us to exclude the pulsation model as being the cause of the observed variability of the four stars. We therefore delete the four stars from the list of candidate slowly pulsating B stars. We attribute the line-profile variations to non-homogeneous distributions of elements on the stellar surface and we derive abundance maps for both elements on the stellar surface by means of the Doppler Imaging technique. We confirm HD 131120 to be a He-weak star and we classify HD 105382, HD 138769 as new He-weak stars. HD 55522 has the solar helium abundance but the mean abundance value of He varies by 0.8 dex during the stellar rotation. For HD 131120 and HD 105382, helium is enhanced in regions of the stellar surface where silicon is depleted and depleted in regions where silicon is enhanced. Based on observations obtained with the Swiss photometric telescope and ESO's CAT/CES telescope, both situated at La Silla, Chile. Appendix A, Tables 1 and 2 and Figs. 9, 11, 13 are only available in electronic form at http://www.edpsciences.org [less ▲]

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See detailhe influence of transformational leadership on commitment: New underlying processes
Marique, Géraldine; Stinglhamber, Florence; Hanin, Dorothée et al

Poster (2012, April)

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See detailA He(I) Photoelectron Spectroscopic Study of the X2A"2state of NH3+ and ND3+. A Reanalysis and evidence for the Coriolis Coupling between the Bending nu2 and nu4 Modes.
Locht, Robert ULg; Leyh, Bernard ULg; Hottmann, K. et al

in Chemical Physics (1998), 233

In the He(I) photoelectron spectrum of NH3 and its isotopomer ND3 the complete vibrational structure of the X2A"2 state of NH3+ and ND3+ is examined in detail. Three vibrational progressions are ... [more ▼]

In the He(I) photoelectron spectrum of NH3 and its isotopomer ND3 the complete vibrational structure of the X2A"2 state of NH3+ and ND3+ is examined in detail. Three vibrational progressions are identified. The well-known strongest progression, already unambiguously assigned to the nu2 out-of-plane bending mode, is observed from v=0-17 in NH3+ and v=0-20 in ND3+. For NH3+ this vibration could be characterized not only by its energy hcomega2= 0.109+/-0.001 eV (or omega2= 878+/-7 cm-1) but also by its first anharmonicity constant hcomega22x22=-(16.2+/-1.2)10-4 eV (or omega22x22=-13.0+/-1.0 cm-1). The best fit of the experimental data required the introduction of a second anharmonicity constant, i.e. hcomega22y22= -(30.7+/-4.2)x10-6 eV (or omega22y22=-0.248+/-0.034 cm-1). The earlier reported weak progression assigned to the vibrational combination nu1+nnu2 transitions has been reexamined. Suitable handling of the data leads to two possible energies for the nu1 degenerate NH stretching vibrational normal mode, i.e. hcomega1 =0.306+/-0.006 eV or 0.422+/-0.005 eV. Several arguments are brought to favour the value of hcomega1=0.422 eV (or omega1=3404 cm-1). Finally a third weak progression, reported for the first time, is assigned to nu4+nnu2 transitions where the nu4 in-plane bending mode is optically forbidden. This vibrational normal mode is characterized by an energy hcomega4=0.186+/-0.010 eV (omega4=1500+/-80 cm-1). In agreement with the theoretical predictions, this transition becomes allowed through a strong Coriolis vibro-rotational coupling between the nu4 and the nu2 vibrational normal modes. The same measurements and the isotope effect on the molecular constants are investigated in ND3+ too. [less ▲]

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