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See detailHello, Dolly…
Durand, Pascal ULg

Article for general public (1998)

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See detailHELLP syndrome
Emonts, Patrick ULg; Thoumsin, H.; Foidart, Jean-Michel ULg

in Revue Médicale de Liège (1999), 54(5), 444-7

The HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelet count) is a clinical expression of a multilayered disease whose central pathophysiology is abnormal placentation. Clinical research aims ... [more ▼]

The HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelet count) is a clinical expression of a multilayered disease whose central pathophysiology is abnormal placentation. Clinical research aims logically to search for new predictive and specific markers for the early identification of pregnant women at risk of developing a HELLP syndrome, the most common cause of feto-maternal mortality and morbidity. [less ▲]

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See detailLes helminthes et la thérapeutique anthelmintique chez les carnivores domestiques
Mignon, Bernard ULg

Conference given outside the academic context (1996)

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See detailHelodermin-loaded nanoparticles: Characterization and transport across an in vitro model of the follicle-associated epithelium
des Rieux, Anne; Fievez, Virginie; Momtaz, Maryam et al

in Journal of Controlled Release (2007), 118(3), 294-302

M cells represent a potential portal for oral delivery of peptides and proteins due to their high endocytosis abilities. An in vitro model of human FAE (co-cultures) was used to evaluate the influence of ... [more ▼]

M cells represent a potential portal for oral delivery of peptides and proteins due to their high endocytosis abilities. An in vitro model of human FAE (co-cultures) was used to evaluate the influence of M cells on the transport of free and encapsulated helodermin - a model peptide - across the intestinal epithelium. M cells enhanced transport of intact helodermin (18-fold, Papp 3 X 10(-6) cm s(-1)). As pegylation increased nanoparticle transport by M cells, helodermin was encapsulated in 200 mu nanoparticles containing PEG-b-PLA:PLGA 1:1. Stability of the selected formulation was demonstrated in simulated gastric and intestinal fluids. M cells increased the transport of helodermin encapsulated in these nanoparticles by a factor of 415, as compared to Caco-2 cells. Transport of free and encapsulated helodermin occurred most probably by endocytosis. In conclusion, M cells improved helodermin transport across the intestinal epithelium, confirming their high potential for oral delivery of peptides. [less ▲]

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See detailThe HELP Survey : a true picture of the hypertensive population in Belgium.
Clement, D.; Rorive, Georges ULg; Saint-Remy, Annie ULg

Poster (1997, December)

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See detailThe HelpED Study: Degree of Agreement Between Patients, Partners, and Physicians on
Claes, Hubert; Andrianne, Robert ULg; Opsomer, Reinier

Poster (2010)

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See detailThe HelpED Study: Impact of Change in Erection Hardness on the Self-Esteem,
Opsomer, Reinier; Claes, Hubert; Andrianne, Robert ULg

Poster (2010)

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See detailHelping children to learn languages (Aider son enfant à apprendre les langues)
Blondin, Christiane ULg

in European Parents Association - Info Bulletin (2001), (Hiver 2001), 11-16

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See detailHelping Teachers Gain Autonomy in Online Course Design and Implementation
Van de Poël, Jean-François ULg; Lecomte, Béatrice ULg

Conference (2008, October 31)

We consider that providing a variety of flexible services and access to resources and training is one of the keys to helping teachers gain autonomy in the design and implementation of an online course. So ... [more ▼]

We consider that providing a variety of flexible services and access to resources and training is one of the keys to helping teachers gain autonomy in the design and implementation of an online course. So far, our system has helped initiate 176 online courses over the past two years. [less ▲]

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See detailHématome extradural cervical spontané de la femme enceinte
Mahieu, X.; Kridelka, Frédéric ULg; Pintiaux, Axelle ULg et al

in Journal de Gynécologie, Obstétrique et Biologie de la Reproduction (1994), 23(1), 99-102

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The ... [more ▼]

Spontaneous spinal extradural hematomas are rare entities, especially during pregnancy. The authors report a case of a 26 years old women who developed as Brown-Sequard syndrome during pregnancy. The patient underwent first a caesarean and thereafter a prompt spinal surgical decompression. Complete sensory-motor recovery occurred after 48 hours. Differential diagnosis of cord compression, etiology of bleeding, conditions of recovery after surgery are discussed. [less ▲]

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See detailHématomes cérébraux spontanés et malformations vasculaires cryptique de l'enfant
Misson, Jean-Paul ULg; Motte, J.; Ghislain-Capentier, Th et al

in Comptes rendus de la Société Belge de Neurologie Infantile (1985)

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See detailThe hematopoiesis-supporting activity of mesenchymal stem cells increases with the number of passages
Briquet, Alexandra ULg; Beguin, Yves ULg; Gothot, André ULg

in Experimental Hematology (2007, September), 35(9, Suppl. 2), 125-125

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See detailHematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT.
Sorror, Mohamed L; Maris, Michael B; Storb, Rainer et al

in Blood (2005), 106(8), 2912-9

We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of ... [more ▼]

We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of patients with scores of 1 or more, captured by the CCI, did not exceed 35%. Further, some comorbidities were rarely found among patients who underwent HCT. Therefore, the current study was designed to (1) better define previously identified comorbidities using pretransplant laboratory data, (2) investigate additional HCT-related comorbidities, and (3) establish comorbidity scores that were suited for HCT. Data were collected from 1055 patients, and then randomly divided into training and validation sets. Weights were assigned to individual comorbidities according to their prognostic significance in Cox proportional hazard models. The new index was then validated. The new index proved to be more sensitive than the CCI since it captured 62% of patients with scores more than 0 compared with 12%, respectively. Further, the new index showed better survival prediction than the CCI (likelihood ratio of 23.7 versus 7.1 and c statistics of 0.661 versus 0.561, respectively, P < .001). In conclusion, the new simple index provided valid and reliable scoring of pretransplant comorbidities that predicted nonrelapse mortality and survival. This index will be useful for clinical trials and patient counseling before HCT. [less ▲]

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See detailHematopoietic cell transplantation after reduced-intensity conditioning for older adults with acute myeloid leukemia in complete remission
Baron, Frédéric ULg; Storb, R.

in Current Opinion in Hematology (2007), 14(2), 145-151

Purpose of review Allogeneic hematopoietic cell transplantation with myeloablative conditioning is a well established therapy for patients with acute myeloid leukemia. Its efficacy depends, in part, on ... [more ▼]

Purpose of review Allogeneic hematopoietic cell transplantation with myeloablative conditioning is a well established therapy for patients with acute myeloid leukemia. Its efficacy depends, in part, on the destruction of recipient acute myeloid leukemia cells by the conditioning regimen and, in part on their removal by donor immune cells contained in the graft (graft-versus-tumor effect). Due to regiment related toxicities, the use of myeloablative allogeneic hematopoietic cell transplantation has been restricted to younger patients in good condition. More recently, the introduction of allogeneic hematopoietic cell transplantation following reduced-intensity or nonmyeloablative conditioning regimens, which rely mainly on graft-versus-tumor effects for tumor cell eradication, has permitted extending hematopoietic cell transplantation to include older patients and those with medical comorbidities. Recent findings Early results with allogeneic hematopoietic cell transplantation after nonmyeloablative and reduced-intensity conditioning for patients with acute myeloid leukemia in first complete remission are encouraging, with 2-year survivals after hematopoietic cell transplantation ranging from 48 to 79% among studies. Further, retrospective studies have demonstrated similar outcomes in adult patients with acute myeloid leukemia in complete remission given either myeloablative or nonmyeloablative conditioning. Summary Prospective studies are needed to define the place of allogeneic hematopoietic cell transplantation after nonmyeloablative or reduced-intensity conditioning in patients with acute myeloid leukemia in complete remission, and to determine a role for consolidation chemotherapy before hematopoietic cell transplantation, if any. [less ▲]

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See detailHematopoietic cell transplantation: five decades of progress.
Baron, Frédéric ULg; Storb, Rainer; Little, Marie-Terese

in Archives of Medical Research (2003), 34(6), 528-44

During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative ... [more ▼]

During the past 50 years, the role of allogeneic hematopoietic cell transplantation (HCT) has changed from a desperate therapeutic maneuver plagued by apparently insurmountable complications to a curative treatment modality for thousands of patients with hematologic diseases. Now, cure rates following human leukocyte antigen (HLA) allogeneic HCT with matched siblings exceed 85% for some otherwise lethal diseases, such as chronic myeloid leukemia, aplastic anemia, or thalassemia. In addition, the recent development of non-myeloablative conditioning and stem cell transplantation has opened the way to include elderly patients with a wide variety of hematologic malignancies. Further progress in adoptive transfer of T cell populations with relative tumor specificity would make the transplant procedure more effective and would extend the use of allogeneic HCT for treatment of non-hematopoietic malignancies. [less ▲]

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See detailHematopoietic recovery in cancer patients after transplantation of autologous peripheral blood CD34+ cells or unmanipulated peripheral blood stem and progenitor cells.
Beguin, Yves ULg; Baudoux, Etienne ULg; Sautois, Brieuc ULg et al

in Transfusion (1998), 38(2), 199-208

BACKGROUND: A study of CD34+ cell selection and transplantation was carried out with particular emphasis on characteristics of short- and long-term hematopoietic recovery. STUDY DESIGN AND METHODS ... [more ▼]

BACKGROUND: A study of CD34+ cell selection and transplantation was carried out with particular emphasis on characteristics of short- and long-term hematopoietic recovery. STUDY DESIGN AND METHODS: Peripheral blood stem and progenitor cells (PBPCs) were collected from 32 patients, and 17 CD34+ cell-selection procedures were carried out in 15 of the 32. One patient in whom two procedures failed to provide 1 x 10(6) CD34+ cells per kg was excluded from further analysis. After conditioning, patients received CD34+ cells (n = 10, CD34 group) or unmanipulated (n = 17, PBPC group) PBPCs containing equivalent amounts of CD34+ cells or progenitors. RESULTS: The yield of CD34+ cells was 53 percent (18-100) with a purity of 63 percent (49-82). The CD34+ fraction contained 66 percent of colony-forming units--granulocyte-macrophage (CFU-GM) and 58 percent of CFU of mixed lineages, but only 33 percent of burst-forming units-erythroid (BFU-E) (p < 0.05). Early recovery of neutrophils and reticulocytes was identical in the two groups, although a slight delay in platelet recovery may be seen with CD34+ cell selection. Late hematopoietic reconstitution, up to 1.5 years after transplant, was also similar. The two groups were thus combined for analyses of dose effects. A dose of 40 x 10(4) CFU-GM per kg ensured recovery of neutrophils to a level of 1 x 10(9) per L within 11 days, 15 x 10(4) CFU of mixed lineages per kg was associated with platelet independence within 11 days, and 100 x 10(4) BFU-E per kg predicted red cell independence within 13 days. However, a continuous effect of cell dose well beyond these thresholds was apparent, at least for neutrophil recovery. CONCLUSION: CD34+ cell selection, despite lower efficiency in collecting BFU-E, provides a suitable graft with hematopoietic capacity comparable to that of unmanipulated PBPCs. In both groups, all patients will eventually show hematopoietic recovery of all three lineages with 1 x 10(6) CD34+ cells per kg or 5 x 10(4) CFU-GM per kg, but a dose of 5 x 10(6) CD34+ cells or 40 x 10(4) CFU-GM per kg is critical to ensure rapid recovery. [less ▲]

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See detailHematopoietic stem cell transplantation in the treatment strategy of acute leukemia
Baron, Frédéric ULg; Beguin, Yves ULg

in Belgian Journal of Medical Oncology [=BJMO] (2010), 4

This review article discusses the current indications for allogeneic hematopoietic stem cell transplantation in adult patients with acute myeloid or lymphoblastic leukemia

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See detailHématotoxicité médicamenteuse
Fillet, Georges ULg

in Revue Médicale de Liège (1987), 42

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