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See detailEpistasis associated to inflammatory bowel disease (IBD) in humans
Gusareva, Elena ULg; Wei, Zhi; Traherne, J.A. et al

Poster (2015, October 05)

Gene-gene interactions underlie biochemical pathways and have been well demonstrated in model organisms. Very few examples exist on replicated epistasis in humans. Here, we performed genome-wide scans to ... [more ▼]

Gene-gene interactions underlie biochemical pathways and have been well demonstrated in model organisms. Very few examples exist on replicated epistasis in humans. Here, we performed genome-wide scans to detect epistasis associated to Crohn’s disease (CD) and ulcerative colitis (UC). We used extensive data of the IIBDGC consisting of 18277 and 14224 CD and UC patients, respectively, and ~34050 healthy controls from 15 European countries typed on the Immunochip. At first, we removed rare variants at MAF<0.05 and filtered common variants at linkage disequilibrium (LD) of r2>0.75. To limit our results to independent effects, SNPs on chromosome 6 (which contains the HLA locus), were furthermore pruned to ensure an LD of r2<0.35. We adjusted the binary traits, CD and UC, for population stratification by regressing out the first 5 principal components in R-3.0.1. The study cohorts were randomly stratified into two subgroups (referred as discovery and replication). We then performed screenings for epistatic interactions with new adjusted trait values in the two subgroups using multidimensional reduction tool MB-MDR with permutation-based (step-down MaxT) multiple testing correction and significance assessment at 0.05. We identified 14 and 6 SNP-pairs associated to CD and UC, respectively, which were concordant between the discovery and replication groups. All SNP-pairs involved concomitant variants located on the same chromosomes (for CD at 1p31.3, 5p13.1, 16q12.1 and for UC at 1p31.3, 6p21.3). A more detailed investigation of these findings, as well as the implementation of different analysis protocols, will further increase our understanding of possible epistatic mechanisms underpinning IBD. [less ▲]

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See detailEpistemic (un)certainty in times of crisis: The role of coherence as a social convention in the European Neighbourhood Policy after the Arab Spring
Natorski, Michal ULg

in European Journal of International Relations (2016)

Academic wisdom assumes that crises precipitate institutional and policy changes in domestic and international politics. However, the relation between crises and policy outcomes is under-theorised. This ... [more ▼]

Academic wisdom assumes that crises precipitate institutional and policy changes in domestic and international politics. However, the relation between crises and policy outcomes is under-theorised. This article conceptualises epistemic coherence as a factor that links crises and their consequences through policy continuity. Crises expose contradictions and inconsistencies, which create uncertainty. Therefore, actors seek to recover the epistemic certainty provided by coherence, which tacitly informs, structures and simplifies actors’ interpretation of reality, even during crisis. For this reason, the role of coherence in policy ideas and institutional rules remains essential to understanding policy continuity. This article illustrates the role of coherence in the policy continuity of the European Neighbourhood Policy in the context of the Arab Spring and the changes in the institutional architecture of European Union foreign policy during 2010–2011. [less ▲]

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See detailEpistemic Logic
Gochet, Paul ULg; Gribomont, Pascal ULg

in Gabbay, Dov; Woods, John (Eds.) Handbook of the History of Logic, vol. 7 (2006)

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See detailThe epistemic politics of TA institutionalization and international TA collaboration – a cosmopolitan perspective
Rosskamp, Benedikt ULg

Conference (2017, May 18)

When addressing the issue of further institutionalization of TA, two assumptions need to be empirically confronted and conceptually revisited. A first one considers the evolution of TA as a linear ... [more ▼]

When addressing the issue of further institutionalization of TA, two assumptions need to be empirically confronted and conceptually revisited. A first one considers the evolution of TA as a linear progression leading to new institutional creations in an increasing number of countries. Despite a series of calls for distributed, networked, multi-level and multi-actor TA capacities, the idea of creating more single, national, specialized and dedicated TA organizations remains dominant in TA discourse. A second assumption concerns the rationale of Technology Assessment and its performance in terms of “opening up” and “broadening out” (Ely et al. 2014) or “the reflexivity pathway” (Delvenne 2011), notably by resorting to participatory Technology Assessment. Results from case studies in Wallonia, Portugal and the Czech Republic require reconsidering the above-mentioned evolutionary assumptions for a more complex and paradoxical understanding of the future of TA. While the TA achievements in each case study are still uncertain to a high degree, we can sum up these respective TA developments under the banner of “evidence-based governance”. This particular understanding of knowledge and decision-making is coherent with a simultaneous observed shift away from the institutional deficit of TA (creating new institutions in newcomer countries) to a renewed strategy of resorbing a knowledge deficit (making TA knowledge available to a wider number of countries). This renewed approach to TA collaboration and capacity building increasingly gains traction both from a bottom-up perspective where actors try to organize themselves into a critical mass and in a top-down perspective of neoliberal and austerity policies. In such a constellation, positivistic science provides an evidence-base, which supposedly supports multi-level, multi-actor governance as it allows knowledge produced in one place to travel and serve a wide spectrum of actors and decision-making arenas. The consequences of this shift are crucially important to explore the re-makings and futures of Technology Assessment, as they put to the fore the issue of subsidiarity of both the production and the use of TA knowledge. Finally, we identify a shift from coexistence to a cosmopolitan mode of epistemic subsidiarity (Jasanoff 2013, 2014). The latter raises a series of new theoretical, practical and normative questions for the TA community. [less ▲]

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See detailEpistemological obstacle
Schneider-Gilot, Marguerite ULg

in Lerman, S (Ed.) Encyclopedia of Mathematics Education (2014)

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See detailEpistémologie de la sociologie. Paradigmes pour le 21e siècle
Jacquemain, Marc ULg; Frère, Bruno ULg

Book published by De boeck (2008)

Comment s’articulent, dans la compréhension du monde social, la démarche « savante » du sociologue et la compréhension « ordinaire » des acteurs ? S’impose-t-il de séparer a priori les deux pour aboutir à ... [more ▼]

Comment s’articulent, dans la compréhension du monde social, la démarche « savante » du sociologue et la compréhension « ordinaire » des acteurs ? S’impose-t-il de séparer a priori les deux pour aboutir à l’objectivité scientifique ou, au contraire, de les construire en continuité et dans un dialogue réciproque ? Le développement considérable des sciences sociales au cours du dernier demi-siècle n’a pas abouti à résoudre cette question de manière univoque. Au contraire, plus les sciences sociales – et la sociologie en particulier – ont scruté avec attention des objets concrets, plus les « postures » se sont diversifiées sur cette question. Adressé prioritairement à des étudiants de deuxième cycle, mais susceptible d’intéresser aussi le public non spécialiste, ce livre introduit de manière rigoureuse mais accessible à cette irréductible pluralité. Il passe en revue quelques-unes des positions sociologiques les plus contemporaines en tentant de relever chez chacune, les promesses et les limites, familiarisant le lecteur avec la nécessaire diffraction du regard qui s’impose pour « saisir » ce qui fait le monde social. [less ▲]

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See detailEpistémologie de la théorie du complot
Jamin, Jérôme ULg

in Cahiers de l'Éducation Permanente (Les) (in press)

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See detailEpistémologie des modalités, modalités éspistémiques
Leclercq, Bruno ULg

Learning material (2015)

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See detailEpistémologie des sciences sociales - Une introduction
Jacquemain, Marc ULg

Learning material (2014)

Le texte constitue un syllabus à destination des étudiants de master. Il constitue une introduction aux trois grands "moments" de la démarche scientifique que sont l'eplication, la vérification et l ... [more ▼]

Le texte constitue un syllabus à destination des étudiants de master. Il constitue une introduction aux trois grands "moments" de la démarche scientifique que sont l'eplication, la vérification et l'intervention. Il défend l'incontournable pluralisme des paradigmes et modèles dans les sciences sociales et termine en prenant comme illustration la pluralité des explications de l'inégalité des chances scolaires. [less ▲]

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See detailEpistémologie et modèles mathématiques
Bair, Jacques ULg; Henry, Valérie ULg; Justens, Daniel

in Tangente Sup (2008), 43

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See detailL’épistémologie française et le concept de norme : de Canguilhem à Foucault
Bolmain, Thomas ULg

Scientific conference (2009, March 25)

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See detailÉpistémologie sémiotique. La théorie du langage de Louis Hjelmslev
Badir, Sémir ULg

Book published by Honoré Champion (2014)

Detailed reference viewed: 129 (8 ULg)
See detailEpistolari e carteggi cinquecenteschi : Italia e Spagna a confronto
Moreno, Paola ULg

Scientific conference (2009, October 28)

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See detailEpistolart - Criteri di trascrizione di documenti epistolari in volgare dal XIV al XVI sec.
Moreno, Paola ULg; Amendola, Cristiano ULg; Miesse, Hélène ULg et al

Diverse speeche and writing (2015)

Normes philologiques pour l'édition critique de textes épistolaire vulgaires du Moyen-Âge et de la Renaissance italienne. Il s'agit des critères adoptés par le groupe de recherche EpistolART pour le ... [more ▼]

Normes philologiques pour l'édition critique de textes épistolaire vulgaires du Moyen-Âge et de la Renaissance italienne. Il s'agit des critères adoptés par le groupe de recherche EpistolART pour le traitement philologique des documents édité ou réédités dans le cadre du projet. [less ▲]

Detailed reference viewed: 74 (38 ULg)
See detailÉpitaphe latine avec traduction française lue lors de la séance du 2 avril 1715 à l'Académie des inscriptions et médailles
Bauden, Frédéric ULg

in Bauden, Frédéric; Waller, Richard (Eds.) Le Journal d'Antoine Galland (1646-1715). La période parisienne. Volume I (1708-1709) (2011)

Detailed reference viewed: 56 (2 ULg)
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See detailEpitaxial growth of CdTe on Si by Molecular Beam Epitaxy
Samain, Louise ULg; Seldrum, Thomas; Dumont, Jacques et al

in Physicalia Magazine (2008), 30(3), 99-112

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See detailEpitaxial Si, SiGe and Ge for high-performance devices
Loo, Roger; Hikavyy, Andriy; Vincent, Benjamin et al

Conference (2010, September 23)

Detailed reference viewed: 99 (5 ULg)