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See detailHBA1c: clinical and biological agreement for standardization of assay methode. Report by the expert of ALFEDIAM (Association de Langue française pour l'étude du diabète et des maladies métaboliques) and SFBC (Société française de Biologie clinique)
Gillery, Pierre; Bordas-Fonfrède, M.; Chapelle, Jean-Paul ULg et al

in Diabète & Métabolisme (1999), 25(3), 283-7

Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established ... [more ▼]

Glycohaemoglobin, and particularly haemoglobin A1c(HbA1c), assays have been used for many years to retrospectively evaluate the glycaemic control of diabetic patients. Cut-off values have been established for deciding treatment modifications. The techniques used in the laboratories however exhibit varying quality, and all of them are not yet standardized. The consequence is an under-utilization of this test, especially in non-hospital practice. In this context, working groups of Société Française de Biologie Clinique (SFBC), Association de Langue Française pour l'Etude du Diabète et des Maladies Métaboliques (ALFEDIAM) and Société Française d'Endocrinologie (SFE) have met together, in order to analyze the national status, and to propose practical recommendations for implementing a standardization process on the basis of international experiences. It is recommended to exclusively express results as HbA1c percentage, using methods standardized and certified by comparison to reference methods such as those using Diabetes Control and Complications Trial (DCCT) values. Simultaneously, contacts have been established with manufacturers, and the realisation of periodic quality control surveys was encouraged. [less ▲]

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See detailHBV infection in Belgium: results of the BASL observatory of 1456 HBsAg carriers.
Deltenre, P.; Laleman, W.; Van Gossum, M. et al

in Acta Gastro-Enterologica Belgica (2012), 75(1), 35-41

Introduction : Nationwide studies are mandatory to assess changes in the epidemiology of HBV infection in Europe. Aim : To describe epidemiological characteristics of HBsAgpositive patients, especially ... [more ▼]

Introduction : Nationwide studies are mandatory to assess changes in the epidemiology of HBV infection in Europe. Aim : To describe epidemiological characteristics of HBsAgpositive patients, especially inactive carriers, and to evaluate how practitioners manage HBV patients in real life. Methods : Belgian physicians were asked to report all chronically infected HBV patients during a one-year period. Results : Among 1,456 patients included, 1,035 (71%) were classified into one of four phases of chronic infection : immune tolerance (n = 10), HBeAg-positive hepatitis (n = 248), HBeAgnegative hepatitis (n = 420) and inactive carrier state (n = 357 HBeAg-negative patients with ALT < upper limit of normal (ULN) and HBV DNA < 2,000 IU/mL). Using less restrictive criteria for ALT (1-2 ULN) or HBV DNA (2,000-20,000 IU/mL), 93 unclassified patients were added to the group of inactive carriers. These 93 additional inactive carriers were younger, more frequently males, with similar risk factors for HBV infection and histological features compared to inactive carriers according to recent guidelines. Recent guidelines on management of HBV patients were generally followed, but systematic HBV DNA measurements and HDV coinfection screening should be reinforced. Conclusion : In Belgium, an inactive carrier state was a common form of chronic HBV infection. Using less restrictive criteria for classification of inactive carriers did not modify their main characteristics and seemed better adapted to clinical practice. Recent guidelines on management of HBV patients should be reinforced. [less ▲]

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See detailThe HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity.
Basbous, Jihane; Arpin, Charlotte; Gaudray, Gilles ULg et al

in Journal of Biological Chemistry (2003), 278(44), 43620-7

The human T-cell leukemia virus type I (HTLV-I)-encoded Tax protein activates transcription from the viral promoter via association with the cellular basic leucine zipper factor cAMP-response element ... [more ▼]

The human T-cell leukemia virus type I (HTLV-I)-encoded Tax protein activates transcription from the viral promoter via association with the cellular basic leucine zipper factor cAMP-response element-binding protein-2. Tax is also able to induce cellular transformation of T lymphocytes probably by modulating transcriptional activity of cellular factors, including nuclear factor-kappaB, E2F, activator protein-1 (AP-1), and p53. Recently, we characterized in HTLV-I-infected cells the presence of a novel viral protein, HBZ, encoded by the complementary strand of the HTLV-I RNA genome (Gaudray, G., Gachon, F., Basbous, J., Biard-Piechaczyk, M., Devaux, C., and Mesnard, J.-M. (2002) J. Virol. 76, 12813-12822). HBZ is a nuclear basic leucine zipper protein that down-regulates Tax-dependent viral transcription by inhibiting the binding of cAMP-response element-binding protein-2 to the HTLV-I promoter. In searching for other cellular targets of HBZ, we identified two members of the Jun family, JunB and c-Jun. Co-immunoprecipitation and cellular colocalization confirmed that HBZ interacts in vivo with JunB and c-Jun. When transiently introduced into CEM cells with a reporter gene containing the AP-1 site from the collagenase promoter, HBZ suppressed transactivation by c-Jun. On the other hand, the combination of HBZ with Jun-B had higher transcriptional activity than JunB alone. Consistent with the structure of its basic domain, we demonstrate that HBZ decreases the DNA-binding activity of c-Jun and JunB. Last, we show that c-Jun is no longer capable of activating the basal expression of the HTLV-I promoter in the presence of HBZ in vivo. Our results support the hypothesis that HBZ could be a negative modulator of the Tax effect by controlling Tax expression at the transcriptional level and by attenuating activation of AP-1 by Tax. [less ▲]

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See detailHCCI engine modeling and experimental investigations - Part 1: The reduction, composition and validation of a n-heptane/iso-octane mechanism
Machrafi, Hatim ULg; Guibert, P.; Cavadias, S. et al

in Combustion Science And Technology (2007), 179(12), 2561-2580

A certain possible approach for the control of HCCI chemistry is to use kinetic chemistry mechanisms. This opens a field of interest that lead to the composition of a validated reduced PRF chemistry ... [more ▼]

A certain possible approach for the control of HCCI chemistry is to use kinetic chemistry mechanisms. This opens a field of interest that lead to the composition of a validated reduced PRF chemistry mechanism. For this purpose a skeletal chemical reaction mechanism for n-heptane and for iso-octane are constructed from a detailed n-heptane and iso-octane mechanism of the Chalmers University of Technology. Subsequently these two mechanisms are forged into one reduced chemical reaction mechanism for mixtures of n-heptane and isooctane (39 species and 47 reactions). This mechanism is numerically validated against the Chalmers mechanisms, respecting the HCCI application range. The reduced mechanism is also successfully numerically validated against another more detailed mechanism provided by LLNL. Engine experiments are performed validating this mixture mechanism with respect to the fuel composition containing n-heptane and iso-octane. The influence of the compression ratio and the equivalence ratio is also studied and used to validate the reduced PRF mechanism. [less ▲]

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See detailHCCI engine modeling and experimental investigations - Part 2: The composition of a NO-PRF interaction mechanism and the influence of NO in EGR on auto-ignition
Machrafi, Hatim ULg; Guibert, Philippe; Cavadias, Simeon

in Combustion Science And Technology (2008), 180(7), 1245-1262

This article presents an investigation of the effect of NO in EGR on HCCI auto-ignition, by means of experiments and a NO-PRF interaction mechanism. The influence is investigated both numerically and ... [more ▼]

This article presents an investigation of the effect of NO in EGR on HCCI auto-ignition, by means of experiments and a NO-PRF interaction mechanism. The influence is investigated both numerically and experimentally. The numerical part is effected by a composition of a NO submechanism and the subsequent addition of this sub mechanism to a reduced validated n-heptane/iso-octane PRF mechanism, the latter of which is presented in a previous article, named article 1 (Machrafi et al., submitted 2006). The experimental part is effected on a CFR engine, operating at HCCI conditions, with an inlet temperature of 70 degrees C and a compression ratio of 10.2. Hereby n-heptane and PRF40 are used as the fuels, using different equivalence ratios in order to extend the interpretation domain. The NO adding concentration is experimentally varied between 0 and 160 ppm. The results showed that adding NO at low concentrations advances the ignition delays, the promoting reactions being more reactive than the inhibitory ones. The promoting effect seems to be at its maximum at an addition of 45 ppm concerning the fuel PRF40. At higher adding concentrations of NO the promoting effect becomes less and the inhibitory reactions become more reactive. The effect of NO on the auto-ignition of n-heptane seemed, however, to be unsignificant. The effect of NO was qualitatively well represented by the mechanism, while quantitatively the mechanism predicted a lower effect of NO at an addition of 45 ppm. [less ▲]

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See detailhCG: a pregnancy-related hormone stimulating angiogenesis and pericyte recruitment
Berndt, S; Blacher, Silvia ULg; Perrier d’Hauterive, S et al

Poster (2010)

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See detailHCMV seroprevalence and associated risk factors in pregnat women, Havana City, 2007 to 2008
Correa, C. B.; Kouri, V.; Verdasquera, D. et al

in Prenatal Diagnosis (2010), 30(9), 888-92

Objective To prenatally identify pregnant women at risk of developing congenital infection due to human cytomegalovirus (HCMV). Methods One thousand one hundred and thirty-one pregnant women from three ... [more ▼]

Objective To prenatally identify pregnant women at risk of developing congenital infection due to human cytomegalovirus (HCMV). Methods One thousand one hundred and thirty-one pregnant women from three municipalities from Havana City were serologically screened for HCMV infection (IgM/IgG, IgG avidity) from January 2007 to January 2008. Demographical, epidemiological, and clinical variables were correlated to serologic status to identify predictors of seroconversion in pregnancy. Results The majority of women were seropositive to HCMV (92.6%); 27 women (2.4%) developed HCMV active infection during pregnancy, defined by the detection of IgG+ and IgM+ (7 women), IgM+ and IgG− (2 women), and IgG seroconversion (18 women). Susceptibility of active HCMV infection during pregnancy was associated with maternal age <20 years and nulligravidity. Primary infection was detected in 20 pregnant women (1.8%), whereas 7 patients (0.6%) had active non-primary infection. Conclusion Although pregnant women in Cuba have high seroprevalence rates for HCMV, those younger than 20 years and nulligravidae are at risk of acquiring infection during pregnancy. [less ▲]

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See detailHCV genotype 4 in Belgium: epidemiological characteristics
REENAERS, Catherine ULg; DELWAIDE, Jean ULg; GERARD, Christiane ULg et al

in Acta Gastro-Enterologica Belgica (2004), (67), 03

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See detailHCV genotype 4 in Belgium: three distinct patterns among patients from European and African origin
Delwaide, Jean ULg; Reenaers, Catherine ULg; Gerard, Christiane ULg et al

in European Journal of Gastroenterology & Hepatology (2006), 18(7), 707-712

Background Considered uncommon in western countries some years ago, hepatitis C virus of genotype 4 is now spreading in some areas of Europe. This is assumed to be due to immigration from a region of high ... [more ▼]

Background Considered uncommon in western countries some years ago, hepatitis C virus of genotype 4 is now spreading in some areas of Europe. This is assumed to be due to immigration from a region of high prevalence for this genotype and to propagation among drug users. In the south of Belgium, genotype 4 currently accounts for 10% of hepatitis C virus patients and its prevalence is increasing with time. Objective To better define the genotype 4 carriers' characteristics. Methods In a database comprising 1726 viraemic hepatitis C virus patients, the files of 85 genotype 4 carriers were reviewed. Results Beside the African (58%) and European drug user (15%) subgroups classically described, a third subgroup consisting of European nondrug users (26%) was identified as peculiar: these patients were older, had been mostly contaminated sporadically, presented a great diversity of subtypes, and were mainly of Italian origin. In this subgroup, contamination was supposed to be ancient, having occurred probably in Italy before immigration into Belgium. By contrast, European drug users were infected with only two subtypes (4c/4d and 4), an observation in favour of recent spread. Africans had a great diversity of subtypes, were young, and were mostly contaminated sporadically in their home countries. Despite their epidemiological differences, the clinical management, and in particular the rates of eligibility for treatment, were similar for these three groups. Conclusions Three different patterns of genotype 4 carriers were observed, corresponding to three different spreading profiles. They did not induce, however, different clinical management. [less ▲]

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See detailHCV genotype 5: an easy to treat population
REENAERS, Catherine ULg; DELWAIDE, Jean ULg; GERARD, Christiane ULg et al

in Acta Gastro-Enterologica Belgica (2004), 67

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See detailHCV genotypes 2 and 3: the predominant genotypes at the horizon 2020?
Delwaide, Jean ULg; Gerard, Christiane ULg; Vaira, Dolorès ULg et al

in Acta Gastro-Enterologica Belgica (2005, January), 68(1), 25

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See detailHCV screening in African (Malian) women : relevancy of the HCV NS3 epitope
BOUHARE, NOUHOUM; VAIRA, Dolorès ULg; GOTHOT, André ULg et al

Poster (2012)

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See detailHD 108: The mystery deepens with XMM-Newton observations
Nazé, Yaël ULg; Rauw, Grégor ULg; Vreux, Jean-Marie ULg et al

in Astronomy and Astrophysics (2004), 417(2), 667-677

In 2001, using a large spectroscopic dataset from an extensive monitoring campaign, we discovered that the peculiar Of star HD 108 displayed extreme line variations. This strange behaviour could be ... [more ▼]

In 2001, using a large spectroscopic dataset from an extensive monitoring campaign, we discovered that the peculiar Of star HD 108 displayed extreme line variations. This strange behaviour could be attributed to a variety of models, and an investigation of the high energy properties of HD 108 was needed to test the predictions from these models. Our dedicated XMM-Newton observation of HD 108 shows that its spectrum is well represented by a two temperature thermal plasma model with kT(1) similar to 0.2 keV and kT(2) similar to 1.4 keV. In addition, we find that the star does not display any significant short-term changes during the XMM-Newton exposure. Compared to previous Einstein and ROSAT detections, it also appears that HD 108 does not present long-term flux variations either. While the line variations continue to modify HD 108's spectrum in the optical domain, the X-ray emission of the star appears thus surprisingly stable: no simple model is for the moment able to explain such an unexpected behaviour. Thanks to its high sensitivity, the XMM-Newton observatory has also enabled the serendipitous discovery of 57 new X-ray sources in the field of HD 108. Their properties are also discussed in this paper. [less ▲]

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See detailHD 148937: A multiwavelength study of the third galactic member of the Of?p class
Nazé, Yaël ULg; Walborn, Nolan R.; Rauw, Grégor ULg et al

in Astronomical Journal (The) (2008), 135(5), 1946-1957

Three Galactic O-type stars belong to the rare class of Of? p objects: HD 108, HD 191612, and HD 148937. The first two stars show a wealth of phenomena, including strong X-ray emission, light variability ... [more ▼]

Three Galactic O-type stars belong to the rare class of Of? p objects: HD 108, HD 191612, and HD 148937. The first two stars show a wealth of phenomena, including strong X-ray emission, light variability, and dramatic periodic spectral variability. We present here the first detailed optical and X-ray study of the third Galactic Of? p star, HD 148937. Spectroscopic monitoring has revealed low-level variability in the Balmer and He II lambda 4686 lines, but constancy at He I and C III lambda 4650. The H alpha line exhibits profile variations at a possible periodicity of similar to 7 days. Model atmosphere fits yield T-eff = 41000 +/- 2000 K, log(g) = 4.0 +/- 0.1, M-sph less than or similar to 10(-7) M-circle dot yr(-1), and an overabundance of nitrogen by a factor of 4. At X-ray wavelengths, HD 148937 resembles HD 108 and HD 191612 in having a thermal spectrum dominated by a relatively cool component (kT = 0.2 keV), broad lines (>= 1700 km s(-1)), and an order-of-magnitude overluminosity compared to normal O stars (log[L-X(unabs) / L-BOL]similar to -6). [less ▲]

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See detailHD 150136: towards one of the most massive systems?
Mahy, Laurent ULg; Gosset, Eric ULg; Sana, Hugues et al

in Neiner, Coralie; Wade, G.; Meynet, G. (Eds.) et al Active OB stars: structure, evolution, mass loss and critical limits (2011, July 01)

We present the preliminary results of an intensive monitoring devoted to HD 150136. Already quoted as an O3+O6 binary, we detected a third O-type component physically linked to the system, making it one ... [more ▼]

We present the preliminary results of an intensive monitoring devoted to HD 150136. Already quoted as an O3+O6 binary, we detected a third O-type component physically linked to the system, making it one of the nearest (1.3 kpc) most massive systems known until now (~134M[SUB]solar[/SUB]). To determine the physical parameters of this system, we applied a disentangling program to study individually the three components. It allows us to constrain their spectral types and to derive a new orbital solution for the short-period system. [less ▲]

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See detailHD 150136: towards one of the most massive systems?
Mahy, Laurent ULg; Gosset, Eric ULg; Rauw, Grégor ULg et al

Poster (2010)

The improvement of the astronomical instrumentation allowed scientists to develop new analysis techniques to investigate binary and multiple stars. In this context, we present the preliminary results of ... [more ▼]

The improvement of the astronomical instrumentation allowed scientists to develop new analysis techniques to investigate binary and multiple stars. In this context, we present the preliminary results of an intense monitoring devoted to the triple system, HD 150136. Supposed to be the nearest O3 star (1.3 kpc), this object is also composed of two other early O-type stars, making it one of the most massive systems known until now (~ 134Mʘ). This multiple star is a non-thermal radio emitter and presents a colliding wind interaction zone. To determine the physical parameters of this system, we applied a disentangling program to study individually the three components. It allows us to revise their spectral classification and to derive a new orbital solution for the short-period system but also the first one for the entire system. [less ▲]

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See detailHD 151932 variability revisited
Vreux, Jean-Marie ULg; Manfroid, Jean ULg; Scuflaire, Richard ULg et al

in Astronomy and Astrophysics (1987), 180

The observation of variations in the blue absorption component of the He I lines as well as in the Si IV 4089 emission line of HD 151932 is reported. Possible explanations for these variations are ... [more ▼]

The observation of variations in the blue absorption component of the He I lines as well as in the Si IV 4089 emission line of HD 151932 is reported. Possible explanations for these variations are addressed, and it is concluded that none is satisfactory. The possibility of a periodicity in the variations is briefly considered. [less ▲]

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See detailHD 152248: Evidence for a colliding wind interaction
Sana, H.; Rauw, Grégor ULg; Gosset, Eric ULg

in Astronomy and Astrophysics (2001), 370

We present the results of a four year spectroscopic campaign on the early-type binary system HD 152248. Our analysis yields a new classification as O7.5III(f) + O7III(f), in contradiction with previous ... [more ▼]

We present the results of a four year spectroscopic campaign on the early-type binary system HD 152248. Our analysis yields a new classification as O7.5III(f) + O7III(f), in contradiction with previous classifications of the components as supergiants. We derive improved orbital elements and the corresponding masses (M_1=29.6 M[SUB]sun[/SUB] and M_2=29.9 M[SUB]sun[/SUB]) are somewhat larger than previously reported in the literature, although they are still significantly lower than the ones expected from evolutionary tracks. Both components of the system are close to filling their Roche lobe at periastron passage. We also investigate the equivalent width variations of the lines of the two components and we discuss their relation to the Struve-Sahade effect. Finally, we show that the line profile variability of the He Iil4686 and Halpha lines is consistent with a strong wind interaction between the two stars, quite as predicted by current colliding wind models. Based on data collected at the European Southern Observatory (La Silla, Chile) and at the Cerro Tololo Inter-American Observatory (Cerro Tololo, Chile). [less ▲]

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See detailHD 166181 = V815 Herculis, a Single-lined Spectroscopic Multiple System
Fekel, Francis C.; Barlow, D. J.; Scarfe, C. D. et al

in Astronomical Journal (The) (2005), 129

We have obtained extensive spectroscopic and velocity spectrometer observations of HD 166181, a previously known single-lined spectroscopic binary. Our improved orbit for the G6 V primary has a period of ... [more ▼]

We have obtained extensive spectroscopic and velocity spectrometer observations of HD 166181, a previously known single-lined spectroscopic binary. Our improved orbit for the G6 V primary has a period of 1.8098343 days and is circular. Although the lines of additional components have not been detected, radial velocity measurements confirm that the system has additional velocity variations with a period of 2092 days, or 5.73 yr. This long-period orbit has an eccentricity of 0.76. An analysis of the Hipparcos observations produces a well-determined astrometric orbit for the long-period system that has an inclination of 78°. Mass estimates of the components in this zero-age main-sequence multiple system indicate that the unseen secondary in the 5.73 yr orbit may also be a binary. Thus, HD 166181 is at least a triple system and possibly quadruple. [less ▲]

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